The HTRIdb is implemented as a relational database PostgreSQL that is connected to a web interface via the JBOSS AS that dynamically generates user-friendly HTML front-end queries using the Apache Tomcat web server. For the network visualization of interactions, HTRIdb uses the web version of the popular Cytoscape visualization tool (Cytoscape Web). The TF-TG interactions data currently present in HTRIdb have been collected from original research articles.