Viruses and Bioinformatics from Virology.uvic.ca
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Viruses and Bioinformatics from Virology.uvic.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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Evolutionary conservation of Ebola virus proteins predicts important functions at residue level

Abstract
MOTIVATION:
The recent outbreak of Ebola virus disease (EVD) resulted in a large number of human deaths. Due to this devastation, the Ebola virus has attracted renewed interest as model for virus evolution. Recent literature on Ebola virus (EBOV) has contributed substantially to our understanding of the underlying genetics and its scope with reference to the 2014 outbreak. But no study yet, has focused on the conservation patterns of EBOV proteins.

RESULTS:
We analyzed the evolution of functional regions of EBOV and highlight the function of conserved residues in protein activities. We apply an array of computational tools to dissect the functions of EBOV proteins in detail, i) protein sequence conservation ii) protein-protein interactome analysis iii) structural modeling iv) kinase prediction. Our results suggest the presence of novel post-translational modifications in EBOV proteins and their role in the modulation of protein functions and protein interactions. Moreover, on the basis of the presence of ATM recognition motifs in all EBOV proteins we postulate a role of DNA damage response pathways and ATM kinase in EVD. The ATM kinase is put forward, for further evaluation, as novel potential therapeutic target.
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Dynamic Phosphorylation of VP30 is essential for Ebola virus life cycle

Importance The current Ebola virus outbreak in West Africa has caused more than 28,000 cases and 11,000 fatalities. Very little is known regarding the molecular mechanisms of how the Ebola virus transcribes and replicates its genome. Previous investigations showed that the transcriptional support activity of VP30 is activated upon VP30 dephosphorylation. This current study reveals that the situation is more complex and that primary transcription as well as the rescue of recombinant Ebola virus also requires transient phosphorylation of VP30. VP30 encodes six N-proximal serine residues that serve as phosphorylation acceptor sites. The present study shows that dynamic phosphorylation of serine at position 29 alone is sufficient to activate primary viral transcription. Our results indicate a series of phosphorylation/dephosphorylation events that trigger binding to and release from the nucleocapsid and transcription complex to be essential for the full activity of VP30.
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Transcriptional Regulation in Ebola Virus: Effects of Gene Border Structure and Regulatory Elements on Gene Expression and Polymerase Scanning Behavior

Here, we analyzed how diverse gene borders and noncoding regions surrounding the gene borders influence transcript levels and govern polymerase behavior during viral transcription.
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American doctor cured of Ebola finds the virus in eye - CNN.com

American doctor cured of Ebola finds the virus in eye  - CNN.com | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
American doctor Ian Crozier was treated for Ebola last year and declared free of the virus. But he had no way of knowing it still lurked in his eye.
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Ebola vaccine trial 'interrupted'

Ebola vaccine trial 'interrupted' | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

The clinical trial of an Ebola vaccine in Switzerland has been interrupted after some patients complained of joint pains in their hands and feet.

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Footage From 1976 Documents Discovery of Ebola Virus

Footage From 1976 Documents Discovery of Ebola Virus | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
In 1976, a group of health workers took a pair of film cameras to what was then known as Zaire and documented their discovery of a new, deadly virus. Today we know that virus as Ebola.
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Study suggests 21-day Ebola quarantine period is not enough

Study suggests 21-day Ebola quarantine period is not enough | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
A new study has suggested that the standard 21-day quarantine period that’s currenty being used for cases of Ebola might not be enough.
Hannah Davis's insight:

No need to panic: quarantine period just needs to be extended a bit. The main problem in the current outbreak is not that people aren't being quarantined for long enough, but that they're not being quarantined at all.

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Ebola Doctor Shortage Eases as Volunteers Step Forward

Ebola Doctor Shortage Eases as Volunteers Step Forward | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Even with the volunteers, experts say, there will be a long gap before hospitals can be fully staffed to care for the growing numbers of Ebola patients.
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VDU's blog: Ebola Virus Disease (EVD) 2014 West African outbreak..

VDU's blog: Ebola Virus Disease (EVD) 2014 West African outbreak.. | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
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Science/AAAS | Special Collection: Ebola

Science/AAAS | Special Collection: Ebola | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Science/AAAS | Special Collection: Ebola #medicine #virology #onehealth http://t.co/vPrJoGhvfY
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How lethal is Ebola virus?

How lethal is Ebola virus? | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
After we discussed newly discovered entry factors for ebolavirus and hepatitis C virus on TWiV 166, the New York Times covered part of the story. (RT @815wrldtrvlr: How lethal is ebolavirus?
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Characterization of human and murine T-cell immunoglobulin mucin domain 4 (TIM-4) IgV domain residues critical for Ebola virus entry

IMPORTANCE With more than 28,000 cases and over 11,000 deaths during the largest and most recent Ebola virus (EBOV) outbreak, there has been increased emphasis on the development of therapeutics against filoviruses. Many therapies under investigation target EBOV cell entry. T-cell immunoglobulin mucin domain (TIM) proteins are cell surface factors important for entry of many enveloped viruses, including EBOV. TIM family member, TIM-4, is expressed on macrophages and dendritic cells, which are early cellular targets during EBOV infection. Here, we performed a mutagenesis screen of the IgV domain of murine and human TIM-4 to identify residues that are critical for EBOV entry. Surprisingly, we identified more human TIM-4 IgV domain residues that are required for EBOV entry than murine TIM-4 residues. Defining TIM IgV residues needed for EBOV entry clarifies the virus/receptor interactions and paves the way for the development of novel therapeutics targeting virus binding to this cell surface receptor.
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Ebola survivors feel long-term effects of virus

Ebola survivors feel long-term effects of virus | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
WASHINGTON, Feb. 26 (UPI) -- The Ebola virus remains in the bodies of survivors at low levels after recovery, causing symptoms and leaving open the possibility of spreading it, according to three recent studies of survivors in West Africa.

Post-Ebola syndrome continues to affect some of the approximately 17,000 people who survived the virus as many have eye, musculoskeletal or neurological symptoms, researchers have found in recent months.

Ebola has been found in the eyes, semen, spines and brains of survivors for six months or more after recovery. The World Health Organization suggests patients wait at least 90 days after recovery before having sex, or to practice safe sex, because doctors suspect the virus has been spread by sexual contact.

Via Ed Rybicki
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Colorado Arts & Sciences Magazine » An evolutionary arms race between Ebola virus, bats

Colorado Arts & Sciences Magazine records the news in the College of Arts and Sciences at CU-Boulder.
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Chimps And Gorillas Desperately Need Ebola Vaccine Too – Virus Has Wiped Out A Third Of Them | IFLScience

Chimps And Gorillas Desperately Need Ebola Vaccine Too – Virus Has Wiped Out A Third Of Them | IFLScience | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
There is a side to the Ebola crisis that, perhaps understandably, has received little media attention: the threat it poses to our nearest cousins, the great apes of Africa. At this moment in time Ebola is the single greatest threat to the survival of gorillas and chimpanzees.
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We Have Nothing: The Human Cost Of Ebola

We Have Nothing: The Human Cost Of Ebola | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Harrowing personal stories reveal the catastrophic impact of the deadly virus on one of the world's poorest regions.
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LRB · Paul Farmer · Diary: Ebola

LRB · Paul Farmer · Diary: Ebola | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
I have just returned from Liberia with a group of physicians and health activists. We are heading back in a few days. The country is in the midst of the largest ever epidemic of Ebola haemorrhagic fever. It’s an acute and brutal affliction. Ebola is a zoonosis – it leaps from animal . . .
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Why Ebola may pose a greater threat in the ICU

Why Ebola may pose a greater threat in the ICU | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
The nature of the Ebola virus makes it a grave threat to those who have the most intimate contact with patients' bodies -- health care workers, family caregivers and grave diggers.
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Virus Variation Resource pages for Ebolavirus, MERS coronoavirus give quick and easy access to related sequences and other data

Virus Variation Resource pages for Ebolavirus, MERS coronoavirus give quick and easy access to related sequences and other data | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
NCBI has created resource pages for Ebolavirus and MERS coronavirus, giving users an easy way to find all sequences related to these pathogens. These pages aggregate links to virus data at NCBI and also provide important links out to other information at the CDC, WHO, and HealthMap.
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Ebola Protein Discovery Could Clear Path For Treatment - YouTube

Researchers found Ebola's VP24 protein interferes with the body's immune response system. It's a finding that could lead to future treatment. Follow Jay Stru...
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How A Computer Algorithm Predicted West Africa's Ebola Outbreak Before It Was Announced

How A Computer Algorithm Predicted West Africa's Ebola Outbreak Before It Was Announced | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
The Ebola outbreak in West Africa is focusing a spotlight on a unique online tool run by experts in Boston that flagged a "mystery hemorrhagic fever" in forested areas of southeastern Guinea nine d...
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Samuel Viana's curator insight, August 15, 2014 2:53 PM

Um interessante algoritmo que combina fontes noticiosas, relativamente à frequência de notícias sobre surtos e à proveniência desses mesmos surtos, ajuda a prever a possibilidade de evolução de potenciais pandemias, antes de estas poderem escalar para níveis incontroláveis.

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We'll never find an Ebola vaccine without taking some risks

We'll never find an Ebola vaccine without taking some risks | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
The current West African ebolavirus outbreak, which has now reached more than 1,000 cases and resulted in more than 800 deaths, is a reminder of the often unpredictable nature of viruses and the difficulties…
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Estimating and Predicting Epidemic Behavior for the 2014 West African Ebola Outbreak

Estimating and Predicting Epidemic Behavior for the 2014 West African Ebola Outbreak | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
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