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Virology and Bioinformatics from Virology.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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The Next Wave of Cancer Cures Could Come From Nasty Viruses - Smithsonian

The Next Wave of Cancer Cures Could Come From Nasty Viruses
Smithsonian
“The field has finally reached a stage … where many of the fundamental problems have been partially addressed,” Russell says.
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Taming Measles Virus to Create an Effective Cancer Therapeutic - Mayo Clinic Proceedings

Taming Measles Virus to Create an Effective Cancer Therapeutic - Mayo Clinic Proceedings | Virology and Bioinformatics from Virology.ca | Scoop.it

"Measles virus (MV) has been a longtime bane of the human race. Once described by Rhazes (10th century Persian physician) as “more dreaded than smallpox,” it remains globally one of the leading causes of death among young children. In the 5 years before the introduction of the 1963 measles vaccination program, there were over 4 million cases of measles reported in the United States, and nearly twice as many deaths were attributed to measles as to polio infections during that same period. Yet for all the misery MV has caused and continues to inflict on mankind, it now appears that a genetically engineered version of the virus may be on its way to becoming an effective treatment for another deadly human malady, late-stage incurable myeloma."

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Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis


Via Chris Upton + helpers
Kenzibit's insight:

MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers; however, miRNA regulation of virus-related cancer development and progression remains poorly understood. Here, we report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote cancer growth and metastasis in a mouse model of hepatocellular carcinoma (HCC). Hematopoietic pre–B cell leukemia transcription factor–interacting protein (HPIP) is an important regulator of cancer cell growth.

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HPV shots don't make girls promiscuous, study says - San Jose Mercury News

HPV shots don't make girls promiscuous, study says - San Jose Mercury News | Virology and Bioinformatics from Virology.ca | Scoop.it

CHICAGO -- Shots that protect against cervical cancer do not make girls promiscuous, according to the first study to compare medical records for vaccinated and unvaccinated girls.

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A virus that kills cancer: the cure that's waiting in the cold - Telegraph

A virus that kills cancer: the cure that's waiting in the cold - Telegraph | Virology and Bioinformatics from Virology.ca | Scoop.it
Sitting in a refrigerator in a Swedish laboratory is what promises to be a cheap and effective cancer treatment. So why are the trials to bring it to market not going ahead?
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Oncolytic virotherapy for ovarian cancer

Oncolytic virotherapy for ovarian cancer | Virology and Bioinformatics from Virology.ca | Scoop.it

In the past two decades, more than 20 viruses with selective tropism for tumor cells have been developed as oncolytic viruses (OVs) for treatments of a variety of malignancies. Of these viruses, eleven have been tested in human ovarian cancer models in preclinical studies. So far, nine phase I or II clinical trials have been conducted or initiated using four different types of OVs in patients with recurrent ovarian cancers.

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Oncolytic Viruses: The Power of Directed Evolution

Oncolytic Viruses: The Power of Directed Evolution | Virology and Bioinformatics from Virology.ca | Scoop.it
Attempts at developing oncolytic viruses have been primarily based on rational design. However, this approach has been met with limited success.
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Poxviral vectors for cancer immunother... [Expert Opin Biol Ther. 2012]

Poxviral vaccines have been given to over 1 billion people in the successful global eradication of smallpox. Recombinant poxviruses have been investigated extensively as a novel immunotherapy for cancer, undergoing several iterations to optimize their immunogenicity and efficacy.

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Virology - Papillomaviruses in the causation of human cancers — a brief historical account

Approximately 35 years ago a role of human papillomaviruses (HPV) in cervical cancer has been postulated. Today it is well established that this very heterogeneous virus family harbours important human carcinogens, causing not only the vast majority of cervical, but also a substantial proportion of other anogenital and head and neck cancers.

 

2009 review

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Viruses Kill Pancreatic Tumors in Preclinical Model | News Room

An intra-tumor injection of a virus prevented further growth of some pancreatic tumors and eradicated others in mouse models of pancreatic ductal adenocarcinoma.
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A world within a tumour – new study shows just how complex cancer can be

A world within a tumour – new study shows just how complex cancer can be | Virology and Bioinformatics from Virology.ca | Scoop.it

Cancer is a puzzle of staggering complexity. Every move towards a solution seems to reveal yet another layer of mystery. For a start, cancer isn’t a single disease, so we can dispense with the idea of a single “cure”. There are over 200 different types, each with their own individual quirks. Even for a single type – say, breast cancer – there can be many different sub-types that demand different treatments. Even within a single subtype, one patient’s tumour can be very different from another’s. They could both have very different sets of mutated genes, which can affect their prognosis and which drugs they should take.


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Remission of Disseminated Cancer After Systemic Oncolytic Virotherapy - Mayo Clinic Proceedings

Remission of Disseminated Cancer After Systemic Oncolytic Virotherapy - Mayo Clinic Proceedings | Virology and Bioinformatics from Virology.ca | Scoop.it

"MV-NIS is an engineered measles virus that is selectively destructive to myeloma plasma cells and can be monitored by noninvasive radioiodine imaging of NIS gene expression. Two measles-seronegative patients with relapsing drug-refractory myeloma and multiple glucose-avid plasmacytomas were treated by intravenous infusion of 1011 TCID50(50% tissue culture infectious dose) infectious units of MV-NIS. Both patients responded to therapy with M protein reduction and resolution of bone marrow plasmacytosis. Further, one patient experienced durable complete remission at all disease sites. Tumor targeting was clearly documented by NIS-mediated radioiodine uptake in virus-infected plasmacytomas. Toxicities resolved within the first week after therapy. Oncolytic viruses offer a promising new modality for the targeted infection and destruction of disseminated cancer."

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Association of human papillomavirus type 16 long control region mutation and cervical cancer

The variation of human papillomavirus (HPV) genes or HPV variants demonstrates different risks of cervical cancer.
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JCI - Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis

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Kenzibit's curator insight, January 18, 2013 10:18 AM

MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers; however, miRNA regulation of virus-related cancer development and progression remains poorly understood. Here, we report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote cancer growth and metastasis in a mouse model of hepatocellular carcinoma (HCC). Hematopoietic pre–B cell leukemia transcription factor–interacting protein (HPIP) is an important regulator of cancer cell growth.

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Can a virus cause cancer? A brief introduction to tumor virology

Can a virus cause cancer? A brief introduction to tumor virology | Virology and Bioinformatics from Virology.ca | Scoop.it

Can a virus cause cancer in humans? In a word, yes. In fact, at this point multiple viruses have been identified as playing a role in the progression of many different cancers. 

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New research sheds light on the molecular mechanisms by which a virus contributes to cancer

New research sheds light on the molecular mechanisms by which a virus contributes to cancer | Virology and Bioinformatics from Virology.ca | Scoop.it
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and is associated with exposure to hepatitis B virus (HBV).
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HPV Might Raise Risk of Form of Skin Cancer - iVillage

FRIDAY, July 20 (HealthDay News) -- Infection with cutaneous human papillomavirus (HPV) is linked to a type of skin cancer known as squamous cell carcinoma, according to a new study.  Risk factors for squamous cell carcinoma include exposure to the sun's harmful ultraviolet radiation, older age, light skin and a suppressed immune system. The international group of researchers found that having antibodies to certain types of cutaneous HPV may be an additional risk factor for this common form of skin cancer.
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The study investigated the links between cutaneous HPV antibodies in the blood and HPV infection in skin tumors.
The researchers tested 159 tissue samples with squamous cell carcinoma for the presence of cutaneous HPV infection. They found the skin cancer was significantly associated with antibodies to three different types of cutaneous HPV.
Additional links were found between antibodies to two other types of cutaneous HPV when compared to blood samples from people without skin cancer, according to the researchers.

Read More http://www.ivillage.com/hpv-might-raise-risk-form-skin-cancer/4-a-474766#ixzz21QyPa7yS


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70% of oral cancers now traced to HPV virus | HPV Treatment Association

70% of oral cancers now traced to HPV virus | HPV Treatment Association | Virology and Bioinformatics from Virology.ca | Scoop.it

An estimated 7% of American teens and adults carry the human papilloma virus in their mouths, an infection that puts them at heightened risk of developing cancer of the mouth and throat, researchers say.

 

HPV image courtesy of Russell Kightely Media

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ScienceDirect.com - Virology - The role of polyomaviruses in human disease

The human polyomaviruses, BK virus and JC virus, have long been associated with serious diseases including polyomavirus nephropathy and progressive multifocal leukoencephalopathy. Both viruses establish ubiquitous, persistent infections in healthy individuals.

 

2009 review. the whole journal issue has related papers

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"Opposing views": Cancer quackery versus...HIV/AIDS denialism : Respectful Insolence

"Opposing views": Cancer quackery versus...HIV/AIDS denialism : Respectful Insolence | Virology and Bioinformatics from Virology.ca | Scoop.it
Since when did Opposing Views become NaturalNews.com? Anyone who's read this blog for a while knows that NaturalNews.com is one of the wretchedest hives of scum and quackery anywhere on the Internet, surpassing even The Huffington Post.

 

Just what I like: someone not scared of beating irrational skeptics with a big stick.  Several times.

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Evolution and Medicine - MDIBL

Evolution and Medicine - MDIBL | Virology and Bioinformatics from Virology.ca | Scoop.it

Evolutionary Foundations of Medicine and Public Health: Focus on Infection and CancerDate: August 6-10, 2012
Location: Mount Desert Island Biological Laboratory

 

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Tasmanian Devils fight hardest battle yet | Nature | The Earth Times

Tasmanian Devils fight hardest battle yet | Nature | The Earth Times | Virology and Bioinformatics from Virology.ca | Scoop.it
The Tasmanian Devil, an animal with a ferocious reputation is fighting for its life against an infectious cancer that is now beyond culling control according to a new study.

Via Education 4 Conservation
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