Virology and Bioinformatics from Virology.ca
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Virology and Bioinformatics from Virology.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus

We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.

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Chinese bats likely source of SARS virus, researchers report - Fogarty International Center @ NIH

Chinese bats likely source of SARS virus, researchers report - Fogarty International Center @ NIH | Virology and Bioinformatics from Virology.ca | Scoop.it

Scientists say they've produced "the clearest evidence yet" the SARS virus originated in Chinese horseshoe bats and that direct bat-to-human transmission is "plausible." The 2002 severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic was one of the most significant public health events in recent history and researchers have been studying the virus to better understand how it is transmitted to prepare for future outbreaks.

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A novel coronavirus capable of lethal human infections

A novel coronavirus capable of lethal human infections | Virology and Bioinformatics from Virology.ca | Scoop.it
In September 2012, a novel coronavirus was isolated from a patient in Saudi Arabia who had died of an acute respiratory illness and renal failure.  

The clinical presentation was reminiscent of the outbreak caused by the SARS-coronavirus (SARS-CoV) exactly ten years ago that resulted in over 8000 cases. Sequence analysis of the new virus revealed that it was indeed a member of the same genus as SARS-CoV. By mid-February 2013, 12 laboratory-confirmed cases had been reported with 6 fatalities. The first 9 cases were in individuals resident in the Middle East, while the most recent 3 cases were in family members resident in the UK. The index case in the UK family cluster had travel history to Pakistan and Saudi Arabia. Although the current evidence suggests that this virus is not highly transmissible among humans, there is a real danger that it may spread to other parts of the world. Here, a brief review of the events is provided to summarize the rapidly emerging picture of this new virus.

 Coronavirus graphic courtesy of Russell Kightley Media


Via Ed Rybicki
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Ed Rybicki's curator insight, March 3, 2013 12:23 PM

It is truly amazing how fast things can be done these days: it was only in SEPTEMBER that the new virus was isolated; the latest fatality was literally in the last couple of weeks.  It remains to be seen whether or not it will spread - given its apparent lethality, we can only hope it does not!

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Zoonoses series

Zoonoses series | Virology and Bioinformatics from Virology.ca | Scoop.it

Zoonoses – pathogenic organisms such as bacteria or viruses which we share with animals – cause more than 60% of human infectious diseases, and have been responsible for some of the most devastating disease outbreaks in recent years, including HIV, Ebola, and SARS. However, despite their huge, and rising, impact on human health, there are still huge gaps in our understanding of how zoonoses spread and develop, which need to be urgently addressed if we are to be able to reduce the impact of the next zoonotic pandemic. In a new Lancet Series, leading experts discuss the ecology, drivers and dynamics of zoonoses, while also addressing how we might predict the next zoonotic pandemic, and reduce the potentially catastrophic human and economic cost of such an outbreak.

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Detection of human coronavirus strain HKU1 in a 2 years old girl with asthma exacerbation caused by acute pharyngitis

Respiratory viral infections can trigger asthma attack which may lead to sever morbidity.
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Towards a safe and efficient SARS-coronavirus vaccine

Towards a safe and efficient SARS-coronavirus vaccine | Virology and Bioinformatics from Virology.ca | Scoop.it

"his paper analyzes the mechanisms by which an attenuated SARS-CoV reverted to a virulent phenotype and describes the introduction of attenuating deletions that maintained virus stability. The virus, engineered with two safety guards, provided full protection against challenge with a lethal SARS-CoV. The viruses generated in this work express all virus proteins, except for small regions deleted in the E and nsp1 proteins, and therefore have the potential of inducing both antibody and T cell responses, making this type of live vaccine more attractive than subunit or non replicating virus vaccines."

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10 Emerging Viruses With No Licensed Vaccine

10 Emerging Viruses With No Licensed Vaccine | Virology and Bioinformatics from Virology.ca | Scoop.it

Vaccination has been successful at controlling many of the world’s diseases. However, there are many emerging viral diseases for which no licensed (US or EU) vaccine exists. Here I’ve selected 10 emerging or re-emerging viruses which I think are especially important due to their incidence, prevalence, morbidity, mortality and suitability of current treatment.


Via Ed Rybicki
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Ed Rybicki's curator insight, April 2, 2013 9:10 AM

Nice account, if brief!  I note Lassa, RFV, WNV and others have been covered in ViroBlogy (http://rybicki.wordpress.com) in recent years as well.

 

All candidates for Going Green...B-)

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WHO | Novel coronavirus infection – update

WHO | Novel coronavirus infection – update | Virology and Bioinformatics from Virology.ca | Scoop.it
The United Kingdom (UK) has informed WHO of another confirmed case of infection with the novel coronavirus (NCoV). The patient is a UK resident and a relative of the case announced on 11 February 2013.
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ProMED Update on New Coronavirus

ProMED Update on New Coronavirus | Virology and Bioinformatics from Virology.ca | Scoop.it

[1] WHO update
Date: 26 Sep 2012
Source: WHO GAR [edited]
<http://www.who.int/csr/don/2012_09_25/en/index.html>;

Novel coronavirus infection - update
- -----------------
As of [25 Sep 2012], no additional cases of acute respiratory syndrome with renal failure due to infection with a novel coronavirus have been reported to WHO. WHO is continuing investigations into 2 recently confirmed infections identified as a novel coronavirus. Today WHO issued an interim case definition to help countries strengthen health protection measures against the new virus. The case definition, based on the cases so far, includes criteria for identifying a 'patient under investigation', a 'probable case' and a 'confirmed case'. 


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