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Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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World Hepatitis Day Virtual Special Issue - Journal of Clinical Virology - Elsevier

World Hepatitis Day Virtual Special Issue - Journal of Clinical Virology - Elsevier | Virology and Bioinformatics from Virology.ca | Scoop.it
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Viral hepatitis leads to liver disease and kills almost 1.4 million people every year. It is caused by...
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JCI - Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis

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Kenzibit's curator insight, January 18, 2013 10:18 AM

MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers; however, miRNA regulation of virus-related cancer development and progression remains poorly understood. Here, we report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote cancer growth and metastasis in a mouse model of hepatocellular carcinoma (HCC). Hematopoietic pre–B cell leukemia transcription factor–interacting protein (HPIP) is an important regulator of cancer cell growth.

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16th-century Korean mummy provides clue to hepatitis B virus genetic code

16th-century Korean mummy provides clue to hepatitis B virus genetic code | Virology and Bioinformatics from Virology.ca | Scoop.it
The discovery of a mummified Korean child with relatively preserved organs enabled an Israeli-South Korean scientific team to conduct a genetic analysis on a liver biopsy which revealed a unique hepatitis B virus (HBV) genotype C2 sequence common...
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Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis


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Kenzibit's insight:

MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers; however, miRNA regulation of virus-related cancer development and progression remains poorly understood. Here, we report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote cancer growth and metastasis in a mouse model of hepatocellular carcinoma (HCC). Hematopoietic pre–B cell leukemia transcription factor–interacting protein (HPIP) is an important regulator of cancer cell growth.

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Short hairpin-looped oligodeoxynucleotides reduce hepatitis C virus replication

Short hairpin-looped oligodeoxynucleotides reduce hepatitis C virus replication | Virology and Bioinformatics from Virology.ca | Scoop.it

"Persistent infection with hepatitis C virus (HCV) is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Standard therapy consists of a combination of interferon-alpha and ribavirin, but many patients respond poorly, especially those infected with HCV genotypes 1 and 4. Furthermore, standard therapy is associated with severe side-effects. Thus, alternative therapeutic approaches against HCV are needed. Findings: Here, we studied the effect of a new class of antiviral agents against HCV, short, partially double-stranded oligodeoxynucleotides (ODNs), on viral replication. We targeted the 5' nontranslated region (5' NTR) of the HCV genome that has previously been shown as effective target for small interfering RNAs (siRNAs) in vitro. One of the investigated ODNs, ODN 320, significantly and efficiently reduced replication of HCV replicons in a sequence-, time- and dose-dependent manner. ODN 320 targets a genomic region highly conserved among different HCV genotypes and might thus be able to inhibit a broad range of genotypes and subtypes.

ODNs provide an additional approach for inhibition of HCV, might be superior to siRNAs in terms of stability and cellular delivery, and suitable against HCV resistant to standard therapy. This study underlines the potential of partially double-stranded ODNs as antiviral agents."

 

Slowly, slowly, another pernicious virus is coming under control: I remember lecturing on antiviral agents in the 80s, and having to tell people that there were precious few.  Now there are LOTS - and not only antiretrovirals..

 

HCV graphic courtesy of Russell Kightley Media

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Detection of hepatitis C virus RNA in dried blood spots

Detection of hepatitis C virus RNA in dried blood spots | Virology and Bioinformatics from Virology.ca | Scoop.it
Journal of Clinical Virology, An estimated 130–170 million people worldwide are chronically infected with HCV
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