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Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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Rescooped by Ken Yaw Agyeman-Badu from Host Cell & Pathogen Interactions
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Scientists 'delete' HIV virus from human DNA for the first time

Scientists 'delete' HIV virus from human DNA for the first time | Virology and Bioinformatics from Virology.ca | Scoop.it
A team at Temple University in Philadelphia used a combination of a DNA-snipping enzyme to eradicate the viral genome from the human cell.
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Geranium extracts inhibit HIV-1

Geranium extracts inhibit HIV-1 | Virology and Bioinformatics from Virology.ca | Scoop.it
Extracts of the geranium plant Pelargonium sidoides inactivate human immunodeficiency virus type 1 (HIV-1) and prevent the virus from invading human cells. Scientists report that these extracts represent a potential new class of anti-HIV-1 agents for the treatment of AIDS.
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Virology institute to offer free HIV testing in hardest hit communities - Baltimore Sun

Virology institute to offer free HIV testing in hardest hit communities - Baltimore Sun | Virology and Bioinformatics from Virology.ca | Scoop.it
Virology institute to offer free HIV testing in hardest hit communities
Baltimore Sun
... from 11 a.m. to 6 p.m. St. Matthew's New Life United Methodist Church will test from 12 p.m. to 7 p.m..
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Rescooped by Ken Yaw Agyeman-Badu from Virology News
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Child born with HIV cured by US doctors

Child born with HIV cured by US doctors | Virology and Bioinformatics from Virology.ca | Scoop.it

Medical history made with first 'functional cure' of unnamed two-year-old born with the virus but now needing no medication.

Doctors began treating the baby 30 hours after birth. Unusually, they put the child on a course of three antiretroviral drugs, given as liquids through a syringe. The traditional treatment to try to prevent transmission after birth is a course of a single antiretroviral drug. The doctor opted for the more aggressive treatment because the mother had not received any during her pregnancy.

Several days later, blood drawn from the baby before treatment started showed the child was infected, probably shortly before birth. The doctors continued with the drugs and expected the child to take them for life.

However, within a month of starting therapy, the level of HIV in the baby's blood had fallen so low that routine lab tests failed to detect it.


Via Ed Rybicki
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Ed Rybicki's curator insight, March 4, 2013 3:01 AM

It would be SO good if this were generalisable to all children born to HIV+ mothers - but it's going to need a clinical trial to find out, and that is many millions of $$ and years down the track.

Chris Upton + helpers's comment, March 5, 2013 1:35 PM
Need to know the facts, remember cold fusion?
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How cells' DNA repair machinery can destroy viruses

How cells' DNA repair machinery can destroy viruses | Virology and Bioinformatics from Virology.ca | Scoop.it
Researchers have decoded a system that makes certain types of immune cells impervious to HIV infection.
Ken Yaw Agyeman-Badu's insight:

A team of researchers based at Johns Hopkins has decoded a system that makes certain types of immune cells impervious to HIV infection. The system's two vital components are high levels of a molecule that becomes embedded in viral DNA like a code written in invisible ink, and an enzyme that, when it reads the code, switches from repairing the DNA to chopping it up into unusable pieces. The researchers, who report the find in the Jan. 21 early edition of the Proceedings of the National Academy of Sciences, say the discovery points toward a new approach to eradicating HIV from the body.

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Immune cells engineered in lab to resist HIV infection, study shows

Immune cells engineered in lab to resist HIV infection, study shows | Virology and Bioinformatics from Virology.ca | Scoop.it
Researchers have found a novel way to engineer key cells of the immune system so they remain resistant to infection with HIV, the virus that causes AIDS.
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Scooped by Ed Rybicki
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The Choreography of HIV-1 Proteolytic Processing and Virion Assembly

The Choreography of HIV-1 Proteolytic Processing and Virion Assembly | Virology and Bioinformatics from Virology.ca | Scoop.it
I thank Russell Kightley Media for the HIV matrix graphic
Ed Rybicki's insight:

"For HIV-1, the Gag protein has the role of a polyprotein precursor that contains all of the structural proteins of the virion, Matrix (MA), Capsid (CA), Spacer Peptide 1 (SP1), Nucleocapsid (NC), Spacer Peptide 2 (SP2), and p6 which contains protein binding domains that interact with host proteins during budding. Similarly, the Gag-Pro-Pol precursor encodes most of the Gag protein but now includes the viral enzymes: protease (PR), reverse transcriptase (RT, with its associated RNase H activity), and integrase (IN). Gag and Gag-Pro- Pol are the substrates of the viral PR, which is responsible for cleaving these precursors into their mature and fully active forms."

 

 

Great paper - explains a complicated process very well.

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Direct and Dynamic Detection of HIV-1 in Living Cells

Direct and Dynamic Detection of HIV-1 in Living Cells | Virology and Bioinformatics from Virology.ca | Scoop.it
In basic and applied HIV research, reliable detection of viral components is crucial to monitor progression of infection. While it is routine to detect structural viral proteins in vitro for diagnostic purposes, it previously remained impossible to directly and dynamically visualize HIV in living cells without genetic modification of the virus.
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Designing of novel antigenic peptide cocktail for the detection of antibodies to HIV-1/2 by ELISA

Designing of novel antigenic peptide cocktail for the detection of antibodies to HIV-1/2 by ELISA | Virology and Bioinformatics from Virology.ca | Scoop.it

HIV (human immunodeficiency virus) infection has now become endemic worldwide and AIDS ranks fourth among the world's top killers of mankind. A rapid and accurate HIV testing assay is a pre-requisite for practical applicability of diagnostic tests. The aim of this present study was to design peptide cocktail as an antigen and to develop ELISA test for HIV-1/2 antibody detection, with enhanced sensitivity and specificity. A novel peptide stretch V3-I, covering immunodominant epitope corresponding to V3 hypervariable loop of gp120 antigens of selected Indian isolates, has been studied and incorporated in an antigenic cocktail of gp36, gp41, and rp24 of HIV-1/2.

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A look at molecules that replicate the HIV virus genome

A look at molecules that replicate the HIV virus genome. I created this animation for display on a planetarium dome at the 2012 Biophysical Society meeting i...
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HIV-1 transmission graph

HIV-1 transmission graph | Virology and Bioinformatics from Virology.ca | Scoop.it
A graph representing the transmission of HIV among patients from Europe. Vertices represent patients and are coloured by country of origin. Edges indicate transmission between connected patients.
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Rescooped by Chris Upton + helpers from Virology News
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U.S. Medics Support Botswana HIV Prevention Efforts

U.S. Medics Support Botswana HIV Prevention Efforts | Virology and Bioinformatics from Virology.ca | Scoop.it

"Today, 17.6 percent of the general population is infected with HIV, and the rate continues to climb by 2.2 percent per year, Maj. Mooketsi Ditsela, the Botswana Defense Force’s HIV coordinator, told American Forces Press Service. Men ages 30 to 45 suffer the highest infection rates, topping 40 percent, according to Health Ministry statistics."

 

17.6 percent of the whole Botswana population is HIV positive: that is HORRIFYING.  But possibly not as bad as Swaziland....


Via Ed Rybicki
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Only 1 in 4 Americans with HIV has virus under control: CDC - WZVN-TV

Only 1 in 4 Americans with HIV has virus under control: CDC - WZVN-TV | Virology and Bioinformatics from Virology.ca | Scoop.it
The GuardianOnly 1 in 4 Americans with HIV has virus under control: CDCWZVN-TVFRIDAY, July 27 (HealthDay News) -- Among the 1.1 million Americans living with HIV, just one in four has the virus under control, U.S.
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Catching HIV budding from cells: it all comes down to ALIX - National Science Foundation (press release)

Catching HIV budding from cells: it all comes down to ALIX - National Science Foundation (press release) | Virology and Bioinformatics from Virology.ca | Scoop.it
Catching HIV budding from cells: it all comes down to ALIX National Science Foundation (press release) "We watch one cell at a time" and use a digital camera and special microscope to make movies and photos of the budding process, says virologist...
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Rescooped by Leah Nicholson from Virology News
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ARV treatment helps reduce TB in HIV patients

ARV treatment helps reduce TB in HIV patients | Virology and Bioinformatics from Virology.ca | Scoop.it
South African Broadcasting Corporation ARV treatment helps reduce TB in HIV patients: study South African Broadcasting Corporation A University of Cape Town study has found that anti-retroviral treatment helps reduce incidents of tuberculosis in...

Via Ed Rybicki
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Rescooped by Ken Yaw Agyeman-Badu from Host Cell & Pathogen Interactions
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Overexpression of PRMT6 does not suppress HIV-1 Tat transactivation in cells naturally lacking PRMT6

Protein arginine methyltransferase 6 (PRMT6) can methylate the HIV-1 Tat, Rev and nucleocapsid proteins in a manner that diminishes each of their functions in in vitro assays, and increases the stability of Tat in human cells.
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Blue-sky HIV test chip will upload results to the cloud : Spoonful of Medicine

Blue-sky HIV test chip will upload results to the cloud : Spoonful of Medicine | Virology and Bioinformatics from Virology.ca | Scoop.it
In Rwanda, the most densely populated country in Africa, there are approximately 190,000 people living with HIV, with electronic records facilitating care for over 90,000 of them.
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Characterization of HIV-1 gag and nef in Cameroon: further evidence of extreme diversity at the origin of the HIV-1 group M epidemic

Cameroon, in west central Africa, has an extraordinary degree of HIV diversity, presenting a major challenge for the development of an effective HIV vaccine.
Ed Rybicki's insight:

...and it's partially from Cape Town, making it doubly interesting.

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HIV drug may be effective against MRSA

HIV drug may be effective against MRSA | Virology and Bioinformatics from Virology.ca | Scoop.it

Researchers have found that a current HIV drug called maraviroc could be a potential therapy for Staphylococcus aureus, a pathogen linked to hundreds of thousands of hospitalizations each year as well as being a common hospital ‘superbug’.


Via Dr. Stefan Gruenwald
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Lessons from vaccine history : Nature Medicine : Nature Publishing Group

In spite of years of effort, we still lack highly efficacious vaccines against HIV, tuberculosis, malaria and numerous other widespread pathogens.
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MSD Introduces New HIV Drug, Atripla - AllAfrica.com

MSD Introduces New HIV Drug, Atripla - AllAfrica.com | Virology and Bioinformatics from Virology.ca | Scoop.it
MSD Introduces New HIV Drug, AtriplaAllAfrica.comEndorsing the product, Head Clinical of Services Department of the Institute of Human Virology Nigeria, IHVN, at the University of Maryland, Prof.
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cynthia's curator insight, March 25, 2013 1:02 PM

not really kidding

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Zoonoses series

Zoonoses series | Virology and Bioinformatics from Virology.ca | Scoop.it

Zoonoses – pathogenic organisms such as bacteria or viruses which we share with animals – cause more than 60% of human infectious diseases, and have been responsible for some of the most devastating disease outbreaks in recent years, including HIV, Ebola, and SARS. However, despite their huge, and rising, impact on human health, there are still huge gaps in our understanding of how zoonoses spread and develop, which need to be urgently addressed if we are to be able to reduce the impact of the next zoonotic pandemic. In a new Lancet Series, leading experts discuss the ecology, drivers and dynamics of zoonoses, while also addressing how we might predict the next zoonotic pandemic, and reduce the potentially catastrophic human and economic cost of such an outbreak.

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Vaccine trial reveals chinks in HIV's armour

Vaccine trial reveals chinks in HIV's armour | Virology and Bioinformatics from Virology.ca | Scoop.it
Analysis identifies target for immune response that could improve AIDS vaccines.
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Virology Journal | Abstract | LTR point mutations in the Tax-responsive elements of HTLV-1 isolates from HIV/HTLV-1-coinfected patients

In Virology Journal 2011, 8:535, Neto et al. described point mutations into Tax-responsive elements (TRE) of the LTR region of HTLV-1 isolates from asymptomatic carriers from Sao Paulo, Brazil, and hypothesized that the presence of the G232A mutation in the TRE-1 increase viral proliferation and consequently the proviral load (PvL), while the A184G mutation in the TRE-2 do not have such effect.

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Hyperthermia Stimulates HIV-1 Replication

Hyperthermia Stimulates HIV-1 Replication | Virology and Bioinformatics from Virology.ca | Scoop.it
HIV-infected individuals may experience fever episodes. Fever is an elevation of the body temperature accompanied by inflammation. It is usually beneficial for the host through enhancement of immunological defenses. In cultures, transient non-physiological heat shock (42–45°C) and Heat Shock Proteins (HSPs) modulate HIV-1 replication, through poorly defined mechanisms. The effect of physiological hyperthermia (38–40°C) on HIV-1 infection has not been extensively investigated. Here, we show that culturing primary CD4+ T lymphocytes and cell lines at a fever-like temperature (39.5°C) increased the efficiency of HIV-1 replication by 2 to 7 fold. Hyperthermia did not facilitate viral entry nor reverse transcription, but increased Tat transactivation of the LTR viral promoter. Hyperthermia also boosted HIV-1 reactivation in a model of latently-infected cells. By imaging HIV-1 transcription, we further show that Hsp90 co-localized with actively transcribing provirus, and this phenomenon was enhanced at 39.5°C. The Hsp90 inhibitor 17-AAG abrogated the increase of HIV-1 replication in hyperthermic cells. Altogether, our results indicate that fever may directly stimulate HIV-1 replication, in a process involving Hsp90 and facilitation of Tat-mediated LTR activity.
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