Viruses and Bioinformatics from Virology.uvic.ca
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Viruses and Bioinformatics from Virology.uvic.ca
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets

Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
From molecules to physiology
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PLoS Pathogens: A New Evolutionary Model for Hepatitis C Virus Chronic Infection

PLoS Pathogens: A New Evolutionary Model for Hepatitis C Virus Chronic Infection | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

"Hepatitis C virus (HCV) infects an estimated 3% of humanity [1] and is a leading global cause of liver disease and liver cancer [2]. Intervention is currently limited by the lack of a vaccine and of universally successful drug treatments. Although several next-generation drugs (e.g., direct-acting protease-inhibitors) are already improving outcomes, a number of factors will affect overall treatment success [3]. Among these, viral genetic variation and the emergence of drug resistance are of major importance."

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Irving Millman Dies at 88; Created Hepatitis Vaccine | Virology News

Irving Millman Dies at 88; Created Hepatitis Vaccine | Virology News | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
"Dr. Millman also helped create a test for hepatitis B that substantially reduced the risk of infection from blood transfusions. Hepatitis B is one of five viruses known to cause liver inflammation; it can lead to cancer.
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PLoS ONE: High Prevalence of Human Parvovirus 4 Infection in HBV and HCV Infected Individuals in Shanghai

Human parvovirus 4 (PARV4) has been detected in blood and diverse tissues samples from HIV/AIDS patients who are injecting drug users. Although B19 virus, the best characterized human parvovirus, has been shown to co-infect patients with hepatitis B or hepatitis C virus (HBV, HCV) infection, the association of PARV4 with HBV or HCV infections is still unknown.

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Analysis of Hepatitis C Virus Intrahost Diversity across the Coding Region by Ultradeep Pyrosequencing

Analysis of Hepatitis C Virus Intrahost Diversity across the Coding Region by Ultradeep Pyrosequencing | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

Hepatitis C virus (HCV) is the leading cause of liver disease worldwide. In this study, we analyzed four treatment-naïve patients infected with subtype 1a and performed Roche/454 pyrosequencing across the coding region. We report the presence of low-level drug resistance mutations that would most likely have been missed using conventional sequencing methods. The approach described here is broadly applicable to studies of viral diversity and could help to improve the efficacy of direct-acting antiviral agents (DAA) in the treatment of HCV-infected patients.

 

Image by Russell Kightley Media

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The Scientist Who Discovered Hepatitis C Says He's Now Discovered the Vaccine

The Scientist Who Discovered Hepatitis C Says He's Now Discovered the Vaccine | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
In a poetic turn of virology, the scientist who discovered hepatitis C in 1989 has now also discovered a vaccine that will hopefully treat and prevent the disease.

 

Shows you - stick with something long enough...

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Short hairpin-looped oligodeoxynucleotides reduce hepatitis C virus replication

Short hairpin-looped oligodeoxynucleotides reduce hepatitis C virus replication | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

"Persistent infection with hepatitis C virus (HCV) is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Standard therapy consists of a combination of interferon-alpha and ribavirin, but many patients respond poorly, especially those infected with HCV genotypes 1 and 4. Furthermore, standard therapy is associated with severe side-effects. Thus, alternative therapeutic approaches against HCV are needed. Findings: Here, we studied the effect of a new class of antiviral agents against HCV, short, partially double-stranded oligodeoxynucleotides (ODNs), on viral replication. We targeted the 5' nontranslated region (5' NTR) of the HCV genome that has previously been shown as effective target for small interfering RNAs (siRNAs) in vitro. One of the investigated ODNs, ODN 320, significantly and efficiently reduced replication of HCV replicons in a sequence-, time- and dose-dependent manner. ODN 320 targets a genomic region highly conserved among different HCV genotypes and might thus be able to inhibit a broad range of genotypes and subtypes.

ODNs provide an additional approach for inhibition of HCV, might be superior to siRNAs in terms of stability and cellular delivery, and suitable against HCV resistant to standard therapy. This study underlines the potential of partially double-stranded ODNs as antiviral agents."

 

Slowly, slowly, another pernicious virus is coming under control: I remember lecturing on antiviral agents in the 80s, and having to tell people that there were precious few.  Now there are LOTS - and not only antiretrovirals..

 

HCV graphic courtesy of Russell Kightley Media

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Detection of hepatitis C virus RNA in dried blood spots

Detection of hepatitis C virus RNA in dried blood spots | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
Journal of Clinical Virology, An estimated 130–170 million people worldwide are chronically infected with HCV
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Virology Journal | Current status and future directions in the management of chronic hepatitis C

Hepatitis C virus (HCV) is endemic worldwide, and it causes cirrhosis and other complications that often lead to death; nevertheless, our knowledge of the disease and its mechanisms is limited.
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MicrobiologyBytes » BExperimental hepatitis C vaccine tested

MicrobiologyBytes » BExperimental hepatitis C vaccine tested | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

Currently, no vaccine exists for hepatitis C virus (HCV), a major pathogen thought to infect 170 million people globally.

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Full-length sequences of eleven HCV genotype 2 isolates representing 5 subtypes and 6 unclassified lineages with unique geographic distributions and genetic variation patterns

Full-length sequences of eleven HCV genotype 2 isolates representing 5 subtypes and 6 unclassified lineages with unique geographic distributions and genetic variation patterns | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it

In this study, we characterized full-length HCV genome sequences for 11 genotype 2 isolates. They were isolated in the sera of 11 patients residing in Canada of whom 4 had an African origin. Full-length genomes were obtained by PCR amplification each with 18-25 overlapping fragments. Five isolates represent the first complete genomes of subtypes 2d, 2e, 2j, 2m, and 2r, while the other 6 correspond to variants that do not group within any assigned subtypes. These sequences had lengths of 9508-9825 nucleotides and each contained a single ORF encoding 3012-3106 amino acids. Predicted amino acids were carefully inspected and unique variation patterns were recognized, especially for a 2e isolate QC64. Phylogenetic analysis of complete genome sequences provides the evidence that there are a total of 16 subtypes, of which 11 have been here described. Co-analysis with 68 partial NS5B sequences also differentiated 18 assigned subtypes, 2a-2r, and 8 additional lineages within genotype 2, which is consistent with the analysis of complete genome sequences. The data from this study now allows for 10 assigned subtypes and for 6 additional lineages of HCV genotype 2 to have their full-length genomes defined.

 

Image courtesy of Russell Kightely Media

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Hepatitis C Now Killing More Americans than HIV | Observations, Scientific American Blog Network

Hepatitis C Now Killing More Americans than HIV | Observations, Scientific American Blog Network | Viruses and Bioinformatics from Virology.uvic.ca | Scoop.it
The number of people who die from HIV-related causes each year in the U.S. is now down to about 12,700—from a peak of more than 50,000 ...
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