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Viruses and Bioinformatics from
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure
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Easy Jump for H5N1 from Bird to Mammal

Easy Jump for H5N1 from Bird to Mammal | Viruses and Bioinformatics from |
Hybrid viruses derived from an H5N1 bird flu strain can infect guinea pigs through the air.
Ed Rybicki's curator insight, May 3, 2013 11:14 AM

It is rather concerning that these guys did NOT have to make HA mutations to get their viruses easily transmissible - they just to make reassortants with H5N1 and H1N1pdm viruses.  As could happen in pigs or poultry anywhere both viruses occur....

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H5N1 virus: Transmission studies resume for avian flu : Nature : Nature Publishing Group

H5N1 virus: Transmission studies resume for avian flu : Nature : Nature Publishing Group | Viruses and Bioinformatics from |
Chris Upton + helpers's comment, January 23, 2013 2:45 PM
Rescooped by Ed Rybicki from Virology News!

A geographic analysis of population density thresholds in the influenza pandemic of 1918-19

A geographic analysis of population density thresholds in the influenza pandemic of 1918-19 | Viruses and Bioinformatics from |

Geographic variables play an important role in the study of epidemics. The role of one such variable, population density, in the spread of influenza is controversial.

Prior studies have tested for such a role using arbitrary thresholds for population density above or below which places are hypothesized to have higher or lower mortality. The results of such studies are mixed.

The objective of this study is to estimate, rather than assume, a threshold level of population density that separates low-density regions from high-density regions on the basis of population loss during an influenza pandemic. We study the case of the influenza pandemic of 1918--19 in India, where over 15 million people died in the short span of less than one year.


Pandemic recombinant influenza virus graphic from Russell Kightley Media

Ed Rybicki's curator insight, February 25, 2013 3:00 AM

This is an interesting paper, because it is one of the ONLY ones I have ever seen that analyses ANYTHING to do with the 1918 H1N1 pandemic, that comes from a developing country.  Moreover, it makes what I think is possibly quite a valuable contribution to "health geographics", especially for high-denisty low-income populations.

I also note that 15 MILLION PEOPLE were estimated to have died in India ALONE: this is close to the old estimate for the WORLD total (20 million), which was revised upwards to 50-100 million after developing country stats were taken into account, in the late 1990s.

Makes you wonder what a new version might do....



Max Minard's curator insight, March 22, 2015 11:52 PM

This analysis focuses on population density in regards to the influenza pandemic of 1918-1919. After extensive research and experimenting, researchers found that "districts on the low side of the threshold experienced rates of population loss (3.72%) that were lower than districts on the high side of the threshold (4.69%)". With the results from these experiments, geographers will be able to predict future pandemic patterns in population and how to stop virus at form spreading further. By determining techniques to stop the pandemic while observing the population density of the outbreak, they might be able to successfully stop the disease at its source. Personally, I see this as not only a medical break through, but a geographical innovation that allows us to study population density in a much more extensive fashion. 

Rescooped by Chris Upton + helpers from anti-bacteria and virus infections!

How is H1N1 vaccine made - by Dr Pandula Siribaddana - Helium

When the swine flu became known to the world as the next possible pandemic, many were expecting the world authorities, the pharmaceutical agencies..., Dr Pandula Siribaddana (How is H1N1 vaccine made -

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