The CBR is a multidisciplinary unit with an emphasis on genetics, molecular biology, and biotechnology. The centre was created to promote interdisciplinary basic and translational biomedical research. Our members span several UVic departments, the UVic Division of Medical Sciences, the Vancouver Island Health Authority and the BC Cancer Agency.
This topic will provide general info on a variety health and science related subjects, mirroring the interests of the CBR members.
Aims We investigated whether sprint interval training (SIT) was a time-efficient exercise strategy to improve insulin sensitivity and other indices of cardiometabolic health to the same extent as traditional moderate-intensity continuous training (MICT). SIT involved 1 minute of intense exercise within a 10-minute time commitment, whereas MICT involved 50 minutes of continuous exercise per session. Methods Sedentary men (27±8y; BMI = 26±6kg/m 2 ) performed three weekly sessions of SIT (n = 9) or MICT (n = 10) for 12 weeks or served as non-training controls (n = 6). SIT involved 3x20-second ‘all-out’ cycle sprints (~500W) interspersed with 2 minutes of cycling at 50W, whereas MICT involved 45 minutes of continuous cycling at ~70% maximal heart rate (~110W). Both protocols involved a 2-minute warm-up and 3-minute cool-down at 50W. Results Peak oxygen uptake increased after training by 19% in both groups (SIT: 32±7 to 38±8; MICT: 34±6 to 40±8ml/kg/min; p<0.001 for both). Insulin sensitivity index (CS I ), determined by intravenous glucose tolerance tests performed before and 72 hours after training, increased similarly after SIT (4.9±2.5 to 7.5±4.7, p = 0.002) and MICT (5.0±3.3 to 6.7±5.0 x 10 −4 min -1 [μU/mL] -1 , p = 0.013) (p<0.05). Skeletal muscle mitochondrial content also increased similarly after SIT and MICT, as primarily reflected by the maximal activity of citrate synthase (CS; P<0.001). The corresponding changes in the control group were small for VO 2 peak (p = 0.99), CS I (p = 0.63) and CS (p = 0.97). Conclusions Twelve weeks of brief intense interval exercise improved indices of cardiometabolic health to the same extent as traditional endurance training in sedentary men, despite a five-fold lower exercise volume and time commitment.
It is well documented that a healthy diet and exercise are key in cancer prevention and management, but the exact mechanism hasn’t been clear. Now, researchers have found an explanation in the tiny protective ends of chromosomes called telomeres.
Researchers discovered that an enzyme called SIRT3 that is located in mitochondria — the cell's powerhouse — may protect mice brains against the kinds of stresses believed to contribute to energy loss.
People often complain they don’t have time to exercise or fit a work-out routine into their busy schedules, but a new study may throw that excuse out of the window. Researchers say just one minute of high intensity exercise results in similar health benefits as 45 minutes of moderate-intensity training.
Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules--the enzymes. In a new study, scientists presents clever means of localizing and confining enzymes and the substrate molecules they bind with, speeding up reactions essential for life processes.
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