The CBR is a multidisciplinary unit with an emphasis on genetics, molecular biology, and biotechnology. The centre was created to promote interdisciplinary basic and translational biomedical research. Our members span several UVic departments, the UVic Division of Medical Sciences, the Vancouver Island Health Authority and the BC Cancer Agency.
This topic will provide general info on a variety health and science related subjects, mirroring the interests of the CBR members.
The story of cancer care seems so simple: find the mutated gene that causes cancer and turn it off or fix it. But rarely does a single gene cause cancer. More often, many genes are altered together to drive the disease. So the challenge becomes sorting out which altered genes are the most to blame in which cancers. A new study takes an important step toward answering this question in bladder cancer.
Scientists have used special tracer viruses to show that contamination of just a single doorknob can leads to the spread of viruses throughout an entire office building. The idea was to see how easily something unpleasant like norovirus spreads.
The Canadian Public Health Association, Immunize Canada and the Ottawa Hospital Research Institute collaborated to develop an app for mobile devices that will help Canadians keep track of their vaccinations. The app is FREE and can be downloaded from iTunes, Google Play of BlackBerry World.
Unexpected results from an ongoing experiment in the lab of Kristi Neufeld, Ph.D., co-leader of the Cancer Biology Program, led to a potentially important discovery that could have an impact on how cancer researchers test anti-cancer therapies in mice, and possibly prevent colon cancer in people.
Wild aquatic bird populations have long been considered the natural reservoir for influenza A viruses with virus transmission from these birds seeding other avian and mammalian hosts. While most evidence still supports this dogma, recent studies in bats have suggested other reservoir species may also exist. Extensive surveillance studies coupled with an enhanced awareness in response to H5N1 and pandemic 2009 H1N1 outbreaks is also revealing a growing list of animals susceptible to infection with influenza A viruses. Although in a relatively stable host-pathogen interaction in aquatic birds, antigenic, and genetic evolution of influenza A viruses often accompanies interspecies transmission as the virus adapts to a new host. The evolutionary changes in the new hosts result from a number of processes including mutation, reassortment, and recombination. Depending on host and virus these changes can be accompanied by disease outbreaks impacting wildlife, veterinary, and public health.
Here's our 60 look at why Ebola is so deadly. The World Health Organization (WHO) has called for "drastic action" to contain an Ebola outbreak in West Africa that has killed nearly 500 people. It is the world's largest outbreak in terms of cases, deaths and geographical spread.
Scientists have found that eating almonds in your diet can reduce the risk of heart disease by keeping blood vessels healthy and significantly increasing the amount of antioxidants in the blood stream.
PARV4 was first reported in 2005 in a hepatitis B virus–infected injecting drug user (IDU) . It was detected by a screening process that aimed to identify new DNA viruses in subjects reporting risk factors for HIV combined with nonspecific symptoms of “viral infection syndrome”, including fatigue, malaise, and headache .
This is an excellent piece on that quack, Dr Oz, by John Oliver. The first 5 minutes is spent mocking the fraud, but then, the last ten minutes are all about the real problem: the evisceration of the FDA’s regulatory power over supplements, thanks to Senators Hatch and Harkin. OK, there is a silly bit…
In ecology, disease tolerance is defined as a host strategy not to fight a pathogen tooth and nail, but rather tolerate it to live (and survive) better in the long term. One key feature of tolerance is that the disease only progresses very slowly -- if at all -- even if the host carries a high pathogen load. In some HIV sufferers, this approach is evident. A research team has now determined how strongly patients differ in their tolerance and upon which factors it depends.
For years, neuroscientists have been trying to develop tools that would allow them to clearly view the brain's circuitry in action— from the first moment a neuron fires to the resulting behavior in a whole organism.
Researchers have found that the genetic mutation BRAFV600E , frequently found in metastatic melanoma, not only secretes a protein that promotes the growth of melanoma tumor cells, but can also modify the network of normal cells around the tumor to support the disease's progression.
Over the years researchers have made tremendous strides in the understanding and treatment of cancer by searching genomes for links between genetic alterations and disease. Now, a team of researchers has mined "junk DNA" sequences to identify a non-protein-coding RNA whose expression is linked to ovarian cancer.
On July 1, 2014, the National Institutes of Health (NIH) notified the appropriate regulatory agency, the Division of Select Agents and Toxins (DSAT) of the Centers for Disease Control and Prevention (CDC), that employees discovered vials labeled ”variola,” commonly known as smallpox, in an unused portion of a storage room in a Food and Drug Administration (FDA) laboratory located on the NIH Bethesda campus.
Since the first pandemic outbreak of avian influenza A virus (H5N1 subtype) in 1997, the National Center for Biotechnology Information (NCBI) has provided a large number of influenza virus sequences with well-organized annotations. Using the time-series sequences of influenza A viruses, we developed a simulation tool for influenza virus, named SimFlu, to predict possible future variants of influenza viruses. SimFlu can create variants from a seed nucleotide sequence of influenza A virus using the codon variation parameters included in the SimFlu package. The SimFlu library provides pre-calculated codon variation parameters for the H1N1, H3N2, and H5N1 subtypes of influenza A virus isolated from 2000 to 2011, allowing the users to simulate their own nucleotide sequences by selecting their preferred parameter options. SimFlu supports three operating systems - Windows, Linux, and Mac OS X. SimFlu is publicly available at http://lcbb.snu.ac.kr/simflu.
The immune system includes natural killer cells (NK cells), which recognize and eliminate tumor or virus-infected cells. NK cells combat the body’s own stressed cells to prevent them from becoming a potential hazard. However, this bears its risks.
1– Herpes viruses are old. They are ooooooold. Like, hundreds of millions of years old. Specifically, about 400 million years old. 2– Herpes viruses are everywhere. Fish, reptiles, birds, cows, humans, everywhere. And there are lots of different kinds that humans have to deal with– CMV, EBV, HHV-8, VZV, HSV… 3– And, though herpes viruses should…
Chris Upton + helpers's insight:
If herpes is that old, then what does that tell us about the other Large DNA viruses?
Cytomegalovirus, or CMV, is perhaps one of the biggest pathogens you’ve never heard of—big, both proportionately and epidemiologically. If you’re healthy, it’s harmless, but if you have an impaired immune system, the virus can assert itself with a vengeance. Now, researchers have discovered a menu of tactical secrets CMV employs.