The CBR is a multidisciplinary unit with an emphasis on genetics, molecular biology, and biotechnology. The centre was created to promote interdisciplinary basic and translational biomedical research. Our members span several UVic departments, the UVic Division of Medical Sciences, the Vancouver Island Health Authority and the BC Cancer Agency.
This topic will provide general info on a variety health and science related subjects, mirroring the interests of the CBR members.
A team of researchers has mapped out a universal dynamic that explains the production and distribution of proteins in a cell, a process that varies in detail from protein to protein and cell to cell, but that always results in the same statistical pattern. The findings potentially offer new insights into explaining the variability in phenotypes, or physical appearances.
Like a bad teenager, in 95 percent of all amyotrophic lateral sclerosis (ALS) cases, a protein called TDP-43 leaves its home— the nucleus of motor neuron cells—to congregate, in suspect fashion, in the cytoplasm. In a study published in Science this summer, the Johns Hopkins University (JHU) team of pathologist Phillip Wong, Ph.D., offered new insight into this molecular rebellion.
At the flip of a switch, neuroscientists can send a sleeping mouse into dreamland. The researchers inserted an optogenetic switch into a group of nerve cells located in the ancient part of the brain called the medulla, allowing them to activate or inactivate the neurons with laser light.
In the largest, most comprehensive genomic analysis of autism spectrum disorder (ASD) conducted to date, an international research team has identified 65 genes that play a role in the disorder, 28 of which are reported with “very high confidence,” meaning that there is 99 percent certainty that these genes contribute to the risk of developing ASD.
Prolonged sitting time as well as reduced physical activity contribute to the prevalence of non-alcoholic fatty liver disease (NAFLD) in a study of middle-aged Koreans. These findings support the importance of both reducing time spent sitting and increasing physical activity, say researchers.
A government task force says a daily low-dose aspirin could help certain people in their 50s and 60s prevent a first heart attack or stroke - and they might get some protection against colon cancer at the same time.
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One reason ovarian cancer is so deadly: it turns off immune cells that try to fight it. A Weill Cornell Medical College team has found that disarming a gene called XBP1 rearms immune cells—which successfully combat ovarian cancer.
Centre for Biomedical Research's insight:
Still being considered in the experimental stage but very exciting if it will work eventually!
Researchers discovered that an enzyme called SIRT3 that is located in mitochondria — the cell's powerhouse — may protect mice brains against the kinds of stresses believed to contribute to energy loss.
New research found that a drug – RGFP966 – administered to rats made them more attuned to what they were hearing, able to retain and remember more information, and develop new connections that allowed these memories to be transmitted between brain cells.
Many women with early-stage breast cancer can skip chemotherapy without hurting their odds of beating the disease - good news from a major study that shows the value of a gene-activity test to gauge each patient's risk.
Using an animal model they developed, Saint Louis University and Utah State university researchers have identified a strategy that could keep a common group of viruses called adenoviruses from replicating and causing sickness in humans.
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