The CBR is a multidisciplinary unit with an emphasis on genetics, molecular biology, and biotechnology. The centre was created to promote interdisciplinary basic and translational biomedical research. Our members span several UVic departments, the UVic Division of Medical Sciences, the Vancouver Island Health Authority and the BC Cancer Agency.
This topic will provide general info on a variety health and science related subjects, mirroring the interests of the CBR members.
Wild aquatic bird populations have long been considered the natural reservoir for influenza A viruses with virus transmission from these birds seeding other avian and mammalian hosts. While most evidence still supports this dogma, recent studies in bats have suggested other reservoir species may also exist. Extensive surveillance studies coupled with an enhanced awareness in response to H5N1 and pandemic 2009 H1N1 outbreaks is also revealing a growing list of animals susceptible to infection with influenza A viruses. Although in a relatively stable host-pathogen interaction in aquatic birds, antigenic, and genetic evolution of influenza A viruses often accompanies interspecies transmission as the virus adapts to a new host. The evolutionary changes in the new hosts result from a number of processes including mutation, reassortment, and recombination. Depending on host and virus these changes can be accompanied by disease outbreaks impacting wildlife, veterinary, and public health.
Here's our 60 look at why Ebola is so deadly. The World Health Organization (WHO) has called for "drastic action" to contain an Ebola outbreak in West Africa that has killed nearly 500 people. It is the world's largest outbreak in terms of cases, deaths and geographical spread.
Scientists have found that eating almonds in your diet can reduce the risk of heart disease by keeping blood vessels healthy and significantly increasing the amount of antioxidants in the blood stream.
PARV4 was first reported in 2005 in a hepatitis B virus–infected injecting drug user (IDU) . It was detected by a screening process that aimed to identify new DNA viruses in subjects reporting risk factors for HIV combined with nonspecific symptoms of “viral infection syndrome”, including fatigue, malaise, and headache .
This is an excellent piece on that quack, Dr Oz, by John Oliver. The first 5 minutes is spent mocking the fraud, but then, the last ten minutes are all about the real problem: the evisceration of the FDA’s regulatory power over supplements, thanks to Senators Hatch and Harkin. OK, there is a silly bit…
A new theory about disorders that attack the brain and spinal column has received a significant boost from scientists. The theory attributes these disorders to proteins that act like prions, which are copies of a normal protein that have been corrupted in ways that cause diseases.
The spread of the antibiotic-resistant pathogen MRSA (methicillin-resistant Staphylococcus aureus) remains a concerning public health problem, especially among doctors trying to determine appropriate treatment options for infected patients. Bacterial pathogens, such as MRSA, cause disease in part due to toxicity, or the bacterium's ability to damage a host's tissue.
On July 1, 2014, the National Institutes of Health (NIH) notified the appropriate regulatory agency, the Division of Select Agents and Toxins (DSAT) of the Centers for Disease Control and Prevention (CDC), that employees discovered vials labeled ”variola,” commonly known as smallpox, in an unused portion of a storage room in a Food and Drug Administration (FDA) laboratory located on the NIH Bethesda campus.
Since the first pandemic outbreak of avian influenza A virus (H5N1 subtype) in 1997, the National Center for Biotechnology Information (NCBI) has provided a large number of influenza virus sequences with well-organized annotations. Using the time-series sequences of influenza A viruses, we developed a simulation tool for influenza virus, named SimFlu, to predict possible future variants of influenza viruses. SimFlu can create variants from a seed nucleotide sequence of influenza A virus using the codon variation parameters included in the SimFlu package. The SimFlu library provides pre-calculated codon variation parameters for the H1N1, H3N2, and H5N1 subtypes of influenza A virus isolated from 2000 to 2011, allowing the users to simulate their own nucleotide sequences by selecting their preferred parameter options. SimFlu supports three operating systems - Windows, Linux, and Mac OS X. SimFlu is publicly available at http://lcbb.snu.ac.kr/simflu.
The immune system includes natural killer cells (NK cells), which recognize and eliminate tumor or virus-infected cells. NK cells combat the body’s own stressed cells to prevent them from becoming a potential hazard. However, this bears its risks.
1– Herpes viruses are old. They are ooooooold. Like, hundreds of millions of years old. Specifically, about 400 million years old. 2– Herpes viruses are everywhere. Fish, reptiles, birds, cows, humans, everywhere. And there are lots of different kinds that humans have to deal with– CMV, EBV, HHV-8, VZV, HSV… 3– And, though herpes viruses should…
Chris Upton + helpers's insight:
If herpes is that old, then what does that tell us about the other Large DNA viruses?
Cytomegalovirus, or CMV, is perhaps one of the biggest pathogens you’ve never heard of—big, both proportionately and epidemiologically. If you’re healthy, it’s harmless, but if you have an impaired immune system, the virus can assert itself with a vengeance. Now, researchers have discovered a menu of tactical secrets CMV employs.
In a discovery at the Children’s Medical Center Research Institute at UT Southwestern (CRI), a research team has taken a significant step in cracking the code of an atypical metabolic pathway that allows certain cancerous tumors to thrive, providing a possible roadmap for defeating such cancers.
A new study revealed how T cells, the immune system's foot soldiers, respond to an enormous number of potential health threats and found surprising similarities in the way immune system defenders bind to disease-causing invaders.
The quest to improve survival of children with a high-risk brain tumor has investigators to two drugs already used to treat adults with breast, pancreatic, lung and other cancers. Researchers demonstrated that the drugs pemetrexed and gemcitabine killed cells from mouse and human brain tumors, called group 3 medulloblastoma, growing in the laboratory. Medulloblastoma is diagnosed in about 400 children annually in the U.S., making it the most common pediatric brain tumor.
A newborn baby, for all its cooing cuddliness, is a data acquisition machine, absorbing information to finish honing the job of brain wiring that started before birth. This is true nowhere more so than the eyes, which start life peering at a blurry world and within months can make out a crisp, three-dimensional image of a mobile dangling overhead.