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Hallmarks of Cancer: Where do Parasites fit in? - PLoS Blogs

Hallmarks of Cancer: Where do Parasites fit in? - PLoS Blogs | Tropical diseases | Scoop.it
PLoS Blogs (blog)
Hallmarks of Cancer: Where do Parasites fit in?
PLoS Blogs (blog)
I investigate how parasites modulate the human innate immune system to cause diseases like leishmaniasis and lymphatic filariasis.
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Tropical diseases
My personal pick of news focusing mainly on insect transmitted diseases. I highlight the 'neglected tropical diseases*'. The term 'tropical diseases' is not strictly accurate as some of the diseases also occur in cooler climes but it is a convenient header that most people understand. * http://www.who.int/neglected_diseases/about/en/
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Genetically Modified Mosquitoes Will Guard the World Cup Against Dengue | VICE News

Genetically Modified Mosquitoes Will Guard the World Cup Against Dengue | VICE News | Tropical diseases | Scoop.it
The future of public health is here at last, and it’s just in time for the world's biggest sporting event.
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World cup fans to face dengue mosquito in Brazil

World cup fans to face dengue mosquito in Brazil | Tropical diseases | Scoop.it
Samba, football and ... a dangerous mosquito. That’s Brazil. At the World Cup 2014, supporters should worry not only about their national team, as their opponent i...
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Internal Displaced People in South Sudan are at great risk of disease outbreaks

The humanitarian situation in South Sudan has further deteriorated in the past two weeks. Poor water, hygiene and sanitation conditions in Internally Displaced Persons camps, a looming risk of disease outbreaks.
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The Effects of Weather and Climate Change on Dengue

The Effects of Weather and Climate Change on Dengue | Tropical diseases | Scoop.it
by Felipe J. Colón-González, Carlo Fezzi, Iain R. Lake, Paul R. Hunter
Background There is much uncertainty about the future impact of climate change on vector-borne diseases.
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Relative Risk of Visceral Leishmaniasis in Brazil: A Spatial Analysis in Belo Horizonte

Relative Risk of Visceral Leishmaniasis in Brazil: A Spatial Analysis in Belo Horizonte | Tropical diseases | Scoop.it
by Valdelaine Etelvina Miranda de Araújo, Letícia Cavalari Pinheiro, Maria Cristina de Mattos Almeida, Fernanda Carvalho de Menezes, Maria Helena Franco Morais, Ilka Afonso Reis, Renato Martins Assunção, Mariângela Carneiro Background Visceral...
Sandflyman's insight:

Dgos are a resrvoir for Leishmania in Brazil. I was impressed to read that  they test >150,000 dogs/year for leishmania infection, which was equivalent to more than half the dog population in the city. There  is also an information system to record control activities of the canine reservoir.

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Developing Eradication Investment Cases for Onchocerciasis, Lymphatic Filariasis, and Human African Trypanosomiasis: Rationale and Main Challenges

Developing Eradication Investment Cases for Onchocerciasis, Lymphatic Filariasis, and Human African Trypanosomiasis: Rationale and Main Challenges | Tropical diseases | Scoop.it
by Fabrizio Tediosi, Peter Steinmann, Don de Savigny, Marcel Tanner
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A twenty-year follow-up of canine leishmaniasis in three military kennels in southeastern France

A twenty-year follow-up of canine leishmaniosis in three military kennels in ...
7thSpace Interactive (press release)
This result is also of interest to public health, as dogs are reservoirs for Leishmania infantum.
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Use of deltamethrin dog collars to control leishmania in dogs...

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Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs used for visceral leishmaniasis treatment.

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This is a bit shocking. Arsenic and antimony have similar chemistry. The antimonials are still used as  drugs (with toxic side effects) for treating leishmaniais. The authors  used a mouse model and concluded that the increased resistance to Pentostam in patients living in Bihar may have been due to environmental arsenic exposure.

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Deadly gaps persist in new drug development for neglected diseases

Deadly gaps persist in new drug development for neglected diseases | Tropical diseases | Scoop.it
Researchers report a persistent deficiency in truly new therapeutics for neglected diseases, despite nominal progress and an acceleration in research and development (R&D) efforts.
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Newly accessible Japanese encephalitis vaccine will make saving children easier in developing countries

Newly accessible Japanese encephalitis vaccine will make saving children easier in developing countries | Tropical diseases | Scoop.it

A newly accessible vaccine against Japanese encephalitis is going to make the protection of more children in developing countries easier. The vaccine, manufactured in China, only needs to be given in one dose, it can be used for infants, and it is less expensive than other Japanese encephalitis vaccines.

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Chinese/WHO collaborations on vaccine production.

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Innovative approach could ultimately end deadly disease of sleeping sickness

Innovative approach could ultimately end deadly disease of sleeping sickness | Tropical diseases | Scoop.it
A tag team of two bacteria, one of them genetically modified, has a good chance to reduce or even eliminate the deadly disease African trypanosomiasis, or sleeping sickness, researchers conclude in a recent mathematical modeling study.
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Iran Unveils 2 New Nano Drugs for Curing Leishmaniasis, Inflammatory Diseases

Iran Unveils 2 New Nano Drugs for Curing Leishmaniasis, Inflammatory Diseases | Tropical diseases | Scoop.it
Iran Unveils 2 New Nano Drugs for Curing Leishmaniasis, Inflammatory Diseases
Sandflyman's insight:

Iranian-made medicines for the treatment of leishmaniasis and inflammatory and other skin diseases, which have been produced through the application of nanotechnology.

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Japan's Eisia donates Filariasis vaccines for 6 years - Mizzima News

Japan's Eisia donates Filariasis vaccines for 6 years
Mizzima News
U Myo Myint, Technical Officer of the World Health Organization (WHO), announced that Japanese company Eisia will donate Filariasis vaccine for 6 consecutive years.
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Down to zero: Nigeria stops guinea-worm disease in its tracks!

Down to zero: Nigeria stops guinea-worm disease in its tracks! | Tropical diseases | Scoop.it
From more than 650 000 cases in 1988 to zero today, Nigeria has successfully stopped transmission of guinea-worm disease, also known as dracunculiasis. Thousands of volunteer polio vaccinators helped to check every household nationwide to ensure that there were no remaining cases before the country could be certified free of guinea-worm disease in December 2013.
Sandflyman's insight:

Wow a great positive story, we need more of this.

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Experts abuzz over latest mozzie trial

Experts abuzz over latest mozzie trial | Tropical diseases | Scoop.it
TOWNSVILLE’S dengue risk will be swatted down with the field trial of a revolutionary biological control measure. (Townsvilles #dengue risk will be swatted down with the field trial of a revolutionary biological control measure.
Sandflyman's insight:

Trials are continuing for this revolutionary approach; release of mosquitoes containing a symbiotic bacterium that arrests dengue transmission. I am told that the local population are quite keen on the idea.

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In 1792 they set off to undo slavery but ended up sending yellow fever across continents.

In 1792 they set off to undo slavery but ended up sending yellow fever across ...
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The Improbable Transmission of Trypanosoma cruzi to Human: The Missing Link in the Dynamics and Control of Chagas Disease

The Improbable Transmission of Trypanosoma cruzi to Human: The Missing Link in the Dynamics and Control of Chagas Disease | Tropical diseases | Scoop.it
by Pierre Nouvellet, Eric Dumonteil, Sébastien Gourbière
Chagas disease has a major impact on human health in Latin America and is becoming of global concern due to international migrations.
Sandflyman's insight:

This parasite is transmitted via the faeces of the bug shed whilst it is feeding on the host skin. Seems a very inefficient process, this study seeks to develop a predictive model to estimate the number of infections.

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An Unfolding Tragedy of Chagas Disease in North America

An Unfolding Tragedy of Chagas Disease in North America | Tropical diseases | Scoop.it
by Peter J. Hotez, Eric Dumonteil, Miguel Betancourt Cravioto, Maria Elena Bottazzi, Roberto Tapia-Conyer, Sheba Meymandi, Unni Karunakara, Isabela Ribeiro, Rachel M. Cohen, Bernard Pecoul
Sandflyman's insight:

"poorest people living in the Mexico and the U.S. are silently suffering under a heavy burden of Chagas disease, with pregnant women disproportionately affected"

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Understanding the Persistence of Plague Foci in Madagascar

Understanding the Persistence of Plague Foci in Madagascar | Tropical diseases | Scoop.it
by Voahangy Andrianaivoarimanana, Katharina Kreppel, Nohal Elissa, Jean-Marc Duplantier, Elisabeth Carniel, Minoarisoa Rajerison, Ronan Jambou
Plague, a zoonosis caused by Yersinia pestis, is still found in Africa, Asia, and the Americas.
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Hallmarks of Cancer: Where do Parasites fit in? - PLoS Blogs

Hallmarks of Cancer: Where do Parasites fit in? - PLoS Blogs | Tropical diseases | Scoop.it
PLoS Blogs (blog)
Hallmarks of Cancer: Where do Parasites fit in?
PLoS Blogs (blog)
I investigate how parasites modulate the human innate immune system to cause diseases like leishmaniasis and lymphatic filariasis.
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New York Times: "Neglected Diseases Still Are, Well, Neglected"

New York Times      [28 October, 2013]
"Neglected Diseases Still Are, Well, Neglected"
Click here to read the article
Sandflyman's insight:

Too true. Try getting research grant money to work on these diseases, it is too difficult and frustrating.

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PLOS Pathogens: The Cell Biology of Leishmania: How to Teach Using Animations

PLOS Pathogens: The Cell Biology of Leishmania: How to Teach Using Animations | Tropical diseases | Scoop.it
From molecules to physiology
Sandflyman's insight:

This is a great article discussing the production of 3D animations as teaching aids to help students visualise the life cycle of an insect borne parasitic  disease. It also happens to be my 'favourite'..the Leishmania. There are also links to film animations in the text.

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Leishmania parasites with greater infectivity associated with treatment failure

Leishmania parasites with greater infectivity associated with treatment failure | Tropical diseases | Scoop.it

Leishmania parasites with greater infectivity associated with treatment failure. Relapses after treatment for Leishmania infection may be due to a greater infectivity of the parasite rather than drug resistance, as has been previously...

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Lingual Leishmaniasis Presenting to Maxillofacial Surgery in UK ...

Lingual Leishmaniasis Presenting to Maxillofacial Surgery in UK ... | Tropical diseases | Scoop.it
Abstract. Leishmaniasis is a disease that is caused by protozoa of the genus Leishmania, which is prevalent in tropical and subtropical areas. Clinical forms of leishmaniasis are particularly diverse representing a complex of diseases.
Sandflyman's insight:

Unusual case in UK  lingual Leishmaniasis in an immunocompetent man ; Leishmania lesion in his tongue. Doesnt seem to be linked to travel abroad.

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Experimental leishmaniasis vaccine could overcome challenge of multiple species : Spoonful of Medicine

Experimental leishmaniasis vaccine could overcome challenge of multiple species : Spoonful of Medicine | Tropical diseases | Scoop.it

" Science Translational Medicine offers hope: immunologist Amitabha Mukhopadhyay of the India National Institute of Immunology in New Delhi and his colleagues describe a new vaccine that completely blocks the parasite from causing visceral leishmaniasis in mice and hamsters by targeting a receptor that they say is common to many forms of the parasite."

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