Tissue Engineering
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Skin regeneration is product of two types of stem cells

Skin regeneration is product of two types of stem cells | Tissue Engineering | Scoop.it
Stem cells are essential for tissue regeneration and, in a recent study, Cornell researchers have challenged a long-standing model regarding epidermal stem cells and their role in skin repair.
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New web lecture - Soft Tissue Esthetics e Health - 10 Key Factors in Soft Tissue Management

New web lecture - Soft Tissue Esthetics e Health - 10 Key Factors in Soft Tissue Management | Tissue Engineering | Scoop.it

Dr Sascha Jovanovic

There are 10 key criteria that are important in implant therapy to achieve optimal soft tissue outcomes. The criteria are divided into 2 areas. The first area involves the biomaterial elements in therapy, while the second involves procedural issues. The biomaterial elements of implant surface, the implant neck, abutment material, the sub gingival abutment design, and abutment reconnection will be discussed.


See on www.osteovision.it


Via Alessandro Dentoni
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Russian Scientists Recover Well-Preserved Woolly Mammoth Blood ...

Russian scientists have announced the recovery of well-preserved woolly mammoth blood and tissue from a 10,000-year-old female carcass found on the New Siberian Islands off the coast of Siberia. The Russian scientists ...
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Comparison of electrophysiological data from human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) to functional pre-clinical safety assays

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A Computational Model for Collective Cellular Motion in Three Dimensions: General Framework and Case Study for Cell Pair Dynamics

A Computational Model for Collective Cellular Motion in Three Dimensions: General Framework and Case Study for Cell Pair Dynamics | Tissue Engineering | Scoop.it

Cell migration in healthy and diseased systems is a combination of single and collective cell motion. While single cell motion has received considerable attention, our understanding of collective cell motion remains elusive. A new computational framework for the migration of groups of cells in three dimensions is presented, which focuses on the forces acting at the microscopic scale and the interactions between cells and their extracellular matrix (ECM) environment. Cell-cell adhesion, resistance due to the ECM and the factors regulating the propulsion of each cell through the matrix are considered. In particular, our approach emphasizes the role of receptors that mediate cell-cell and cell-matrix interactions, and examines how variation in their properties induces changes in cellular motion. As an important case study, we analyze two interacting cells. Our results show that the dynamics of cell pairs depends on the magnitude and the stochastic nature of the forces. Stronger intercellular stability is generally promoted by surface receptors that move. We also demonstrate that matrix resistance, cellular stiffness and intensity of adhesion contribute to migration behaviors in different ways, with memory effects present that can alter pair motility. If adhesion weakens with time, our findings show that cell pair break-up depends strongly on the way cells interact with the matrix. Finally, the motility for cells in a larger cluster (size 50 cells) is examined to illustrate the full capabilities of the model and to stress the role of cellular pairs in complex cellular structures. Overall, our framework shows how properties of cells and their environment influence the stability and motility of cellular assemblies. This is an important step in the advancement of the understanding of collective motility, and can contribute to knowledge of complex biological processes involving migration, aggregation and detachment of cells in healthy and diseased systems.


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3D Printer Builds Living Tissue – Printed Muscle!

3D Printer Builds Living Tissue – Printed Muscle! | Tissue Engineering | Scoop.it

Via Kalani Kirk Hausman
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Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice

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Humacyte Announces Significant Clinical Milestones in its Novel Bioengineered ... - PR Newswire (press release)

Humacyte Announces Significant Clinical Milestones in its Novel Bioengineered ...
PR Newswire (press release)
Bioengineered vessels are decellularized, thereby rendering them non-immunogenic and implantable into any patient.
Samantha Lipsky's insight:

Have been a fan of Laura E. Niklason's work for years.

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Texas 3-Step decellularization protocol: Lookin... [J Proteomics. 2013] - PubMed - NCBI

PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Vascularized and functional human liver from an iPSC-derived organ bud transplant

Vascularized and functional human liver from an iPSC-derived organ bud transplant | Tissue Engineering | Scoop.it

Via Carlos Garcia Pando
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Carlos Garcia Pando's curator insight, July 7, 2013 6:03 AM

The researchers found that a mixture of human liver precursor cells and two other cell types can spontaneously form three-dimensional structures dubbed “liver buds.” In the mice, these liver buds formed functional connections with natural blood vessels and perform some liver-specific functions such as breaking down drugs in the bloodstream.

To demonstrate the therapeutic potential of the liver bud method, Takebe and colleagues transplanted a dozen liver buds into the abdomen of mice whose natural liver function was shut down with a drug. The liver bud transplants kept these mice alive for the month they were watched.

The liver buds did not achieve all the functions of a mature liver. For instance, the buds did not form a bile duct system. However, in ongoing research, the team has found that by transplanting the buds into an existing liver, the body seems to make use of the existing bile system,

 

 

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Scots scientists to trial synthetic human blood - Health - Scotsman.com

Scots scientists to trial synthetic human blood - Health - Scotsman.com | Tissue Engineering | Scoop.it
SCOTTISH scientists have been given the go-ahead for the world’s first trials in humans of synthetic blood, The Scotsman can reveal. (Go ahead for trials to make blood from stem cells. Well done those folks @RoslinCells, SCRM and SNBTS.

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The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices

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NYSCF scientists create personalized bone substitutes from skin cells

NYSCF scientists create personalized bone substitutes from skin cells | Tissue Engineering | Scoop.it
Daily Mail
NYSCF scientists create personalized bone substitutes from skin cells ...

Via Jacob Blumenthal, Carlos Garcia Pando
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Jacob Blumenthal's curator insight, May 7, 2013 6:51 AM

The researchers team generated bone constructs from iPS cells, characterized them in-vitro and transplanted them into animal models to examine their functionality, in-vivo.

 

Link: http://www.pnas.org/content/early/2013/05/07/1301190110

 

Carlos Garcia Pando's curator insight, May 8, 2013 2:31 AM

http://www.nyscf.org/news/nyscf-in-the-news/item/1525-nyscf-scientists-create-human-bone-from-skin-cells

In a step towards personalized bone grafts to treat traumatic injury or congenital defects, a study, led by Darja Marolt, PhD, and Giuseppe Maria de Peppo, PhD, and published in the Proceedings of the National Academy of Sciences, reports the generation of patient-specific bone substitutes from skin cells for repair of large bone defects. This advance will facilitate the development of customizable, three-dimensional bone grafts on-demand, matched to fit the exact needs and immune profile of a patient. Taking skin cells, the NYSCF scientists utilized an advanced technique called “reprogramming” to revert adult cells into an embryonic-like state. The researchers differentiated the resultant induced pluripotent stem (iPS) cells into bone-forming progenitors and then seeded these cells onto a three-dimensional scaffold, which was placed into an artificial, biologically active environment, a bioreactor. Analysis revealed that, even in vitro, bone formed; and, when implanted in mice, the bone matured into typical dense, mineral-rich tissue. Next steps for this proof-of-concept research include protocol optimization and long-term safety trials in animal models.

 

This is the press release from NYSCF Read a press release on this research

 

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Using Stem Cells to Cure Liver Disease

(Visit: http://www.uctv.tv/) There are too few donated livers for all the people who need them, and organ transplants come at significant risk of rejection. ...

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Novel biomimetic hydroxyapatite/alginate nanocomposite fibrous scaffolds for bone tissue regeneration - Online First - Springer

Novel biomimetic hydroxyapatite/alginate nanocomposite fibrous scaffolds for bone tissue regeneration - Online First - Springer | Tissue Engineering | Scoop.it
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ScienceDirect.com - Journal of Proteomics - Texas 3-Step decellularization protocol: Looking at the cardiac extracellular matrix

ScienceDirect.com - Journal of Proteomics - Texas 3-Step decellularization protocol: Looking at the cardiac extracellular matrix | Tissue Engineering | Scoop.it
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Girl Receives Engineered Trachea Treated With Her Own Stem Cells - Singularity Hub

Girl Receives Engineered Trachea Treated With Her Own Stem Cells - Singularity Hub | Tissue Engineering | Scoop.it
Singularity Hub
Girl Receives Engineered Trachea Treated With Her Own Stem Cells
Singularity Hub
In 2010 doctors implanted an emergency donor trachea when a metal stint used to keep his airway open caused major bleeding.
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Study Suggests New Source of Kidneys for Transplant - Renal Business Today

Study Suggests New Source of Kidneys for Transplant - Renal Business Today | Tissue Engineering | Scoop.it
Study Suggests New Source of Kidneys for Transplant
Renal Business Today
In fact, an analysis of the decellularized organs revealed that antigens likely to cause an immune response were removed in the cleaning process.
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