There are 10 key criteria that are important in implant therapy to achieve optimal soft tissue outcomes. The criteria are divided into 2 areas. The first area involves the biomaterial elements in therapy, while the second involves procedural issues. The biomaterial elements of implant surface, the implant neck, abutment material, the sub gingival abutment design, and abutment reconnection will be discussed.
Russian scientists have announced the recovery of well-preserved woolly mammoth blood and tissue from a 10,000-year-old female carcass found on the New Siberian Islands off the coast of Siberia. The Russian scientists ...
Cell migration in healthy and diseased systems is a combination of single and collective cell motion. While single cell motion has received considerable attention, our understanding of collective cell motion remains elusive. A new computational framework for the migration of groups of cells in three dimensions is presented, which focuses on the forces acting at the microscopic scale and the interactions between cells and their extracellular matrix (ECM) environment. Cell-cell adhesion, resistance due to the ECM and the factors regulating the propulsion of each cell through the matrix are considered. In particular, our approach emphasizes the role of receptors that mediate cell-cell and cell-matrix interactions, and examines how variation in their properties induces changes in cellular motion. As an important case study, we analyze two interacting cells. Our results show that the dynamics of cell pairs depends on the magnitude and the stochastic nature of the forces. Stronger intercellular stability is generally promoted by surface receptors that move. We also demonstrate that matrix resistance, cellular stiffness and intensity of adhesion contribute to migration behaviors in different ways, with memory effects present that can alter pair motility. If adhesion weakens with time, our findings show that cell pair break-up depends strongly on the way cells interact with the matrix. Finally, the motility for cells in a larger cluster (size 50 cells) is examined to illustrate the full capabilities of the model and to stress the role of cellular pairs in complex cellular structures. Overall, our framework shows how properties of cells and their environment influence the stability and motility of cellular assemblies. This is an important step in the advancement of the understanding of collective motility, and can contribute to knowledge of complex biological processes involving migration, aggregation and detachment of cells in healthy and diseased systems.
Humacyte Announces Significant Clinical Milestones in its Novel Bioengineered ... PR Newswire (press release) Bioengineered vessels are decellularized, thereby rendering them non-immunogenic and implantable into any patient.
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Have been a fan of Laura E. Niklason's work for years.
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SCOTTISH scientists have been given the go-ahead for the world’s first trials in humans of synthetic blood, The Scotsman can reveal. (Go ahead for trials to make blood from stem cells. Well done those folks @RoslinCells, SCRM and SNBTS.
Singularity Hub Girl Receives Engineered Trachea Treated With Her Own Stem Cells Singularity Hub In 2010 doctors implanted an emergency donor trachea when a metal stint used to keep his airway open caused major bleeding.
Study Suggests New Source of Kidneys for Transplant Renal Business Today In fact, an analysis of the decellularized organs revealed that antigens likely to cause an immune response were removed in the cleaning process.
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