Systemic Mastocytosis, Tinnitus etc

Dr Gotlib discusses the significance of the FDA approval of avapritinib in indolent systemic mastocytosis, key findings from the PIONEER trial, and the quality of life benefits that avapritinib provides for patients in this population.

Mastocytosis is a rare and heterogeneous group of diseases whose common element is the presence of dense mast-cell infiltrates in various tissues. The gastrointestinal (GI) tract is frequently affected with vague and subtle manifestations, making the ...

Pam discusses her systemic mastocytosis journey, the need for improved diagnostics, and her participation in What’s Your SMthing?

Degranulation of activated mast cells affects many conditions and can modulate physiological and pathological responses...

Skin manifestations of haematological diseases, Blood disorders. Authoritative facts from DermNet New Zealand.

The following is a summary of "Proteomic and transcriptomic screening demonstrates increased mast cell–derived CCL23 in systemic mastocytosis," published in the JULY 2023 issue of Allergy & Immunology by Söderlund, et al.

Avapritinib is used to treat a certain type of stomach, bowel, or esophagus cancer called gastrointestinal stromal tumor (GIST) that cannot be treated with surgery or that has spread to other parts of the body (metastatic), and that is caused by a certain platelet-derived growth factor receptor...

The Duke Blood Cancer Center has been recognized as a Center of Excellence by the American Initiative in Mast Cell Diseases Network.

This study evaluates the efficacy of avapritinib versus placebo in treating indolent systemic mastocytosis (ISM) through a randomized trial, revealing that avapritinib leads to substantial symptom reduction and mast-cell burden alleviation over a 24-week period.

Taxanes in the treatment of cancer are associated with a significant incidence of hypersensitivity reactions, which may preclude their use in patients in need of first line therapy. Drug desensitization induces transient immunological tolerance and has allowed the reintroduction of taxanes in...

Physiologic levels of basal serum tryptase vary among healthy individuals, depending on the numbers of mast cells, basal secretion rate, copy numbers of the TPSAB1 gene encoding alpha tryptase, and renal function.

Mastocytosis is a rare condition caused by an excess number of mast cells building up in your body. It can come with a wide range of symptoms. Learn more.

It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a quick response to the various stimulants, including—but not limited to—allergens, pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs).

The social Community for Global Healthcare Elites. Doctors, Medical Professionals & Pharmaceutical professionals. Medical Thesis Abstracts and Journals Library.

A new study by Jason Gotlib and team showed that in individuals with indolent systemic mastocytosis (ISM), avapritinib was more effective than a placebo at lowering uncontrolled symptoms and mast-cell...

Read our factsheets which have been developed to provide information on a wide range of anaesthetic related topics.

A study revealed that anesthesiologists must be familiar with SM and be diligent to recognize early signs and symptoms of mast cell degranulation.

Are you looking for the cause of Irritable Bowel Syndrome?Today, I will role of mast cell activation and dybiosis as cause of Irritable Bowel Syndrome.

In my world and my mind, if I wanted it, I could achieve it. Just when life couldn’t be better, systemic mastocytosis (SM) came into the picture.

Mast Cell Diseases: MCAS, Mastocytosis, Hereditary Alpha Tryptasemia & More...

This study demonstrates that the JAK1/JAK2 inhibitor ruxolitinib can inhibit MCactivity, possibly through prevention of STAT5 activation. This renders the JAK-STAT pathway as an interesting target for therapy to release symptom burden in mastocytosis and many other MC mediator-related diseases.

Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into three main presentations.

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthritis, and the complex interaction and activation of innate and adaptive immune cells are involved in RA pathogenesis. Mast cells (MCs) are one of the tissue-resident innate immune cells, ...

Autism spectrum disorders (ASDs) have been associated with brain inflammation as indicated by microglia activation, as well as brain expression and increased plasma levels of interleukin-6 (IL-6) and tumor necrosis factor (TNF).