Mapping a genetic world beyond genes | this curious life |
Most of the DNA alterations that are tied to disease do not alter protein-coding genes, but rather the “switches” that control them. Characterizing these switches is one of many goals of the Encyclopedia of DNA Elements (ENCODE) project.


'[This work] has revealed elements that act like dimmer switches, subtly turning up or down a gene’s activity and influencing what parts of the genome are utilized in different kinds of cells. The team characterized and mapped out the locations of thousands of these switches and signals.'