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Limitless learning Universe
Nature and the universe are a wonder. Insufficiently explored...
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RiseEarth : 4 Medicinal #Mushrooms That Fight #Cancer

RiseEarth : 4 Medicinal #Mushrooms That Fight #Cancer | Limitless learning Universe | Scoop.it
Only together we can make a difference! The truth awaits to be known.
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This #Malaria #Drug Is Having an Amazing Effect on #Brain #Cancer Patients

This #Malaria #Drug Is Having an Amazing Effect on #Brain #Cancer Patients | Limitless learning Universe | Scoop.it

When cancer is resistant even to chemo.
DAVID NIELD 20 JAN 2017


There's new hope for improved brain cancer treatments after scientists noticed unexpectedly positive effects coming from an unlikely source – a drug normally used to treat malaria.

The anti-malaria drug chloroquine has now been used as a last resort on three brain cancer patients, and in each case, it seems to have overcome the cancer's resistance to traditional treatments.

Chloroquine appears to break down the defences that tumours develop in response to cancer-fighting drugs by effectively 'resetting' their vulnerability to treatment.

"We have treated three patients with the combination, and all three have had a clinical benefit," says paediatric oncologist Jean Mulcahy-Levy from the University of Colorado.

"It's really exciting - sometimes you don't see that kind of response with an experimental treatment."

One of the patients is 26-year-old Lisa Rosendahl, who was previously given just a few months to live. The aggressive glioblastoma in her brain had become resistant to chemotherapy and other targeted treatments.

Rosendahl was eventually put on a cancer inhibitor called vemurafenib, but as often happens with that particular drug, the tumour in her brain soon adapted to become resistant to it, too.

That led the staff working on Rosendahl's case to try a different approach - targeting a separate cellular process called autophagy.

Autophagy is a normal process inside the body whereby dead or damaged cells are removed and recycled to make way for fresh ones. Taken from Greek, the term literally means "to eat oneself", and it's an important way of detoxifying and repairing the body.

The trouble is, tumours sometimes use autophagy to stay healthy, leveraging cellular recycling to withstand the stress that drugs put them under. Rosendahl had a type of cancer that was especially dependent on the process, due in part to a genetic mutation called BRAFV600E.

Fortunately, chloroquine is known to inhibit autophagy, so with that in mind, Mulcahy-Levy and her team decided to give the drug a try as a last-ditch effort to combat the tumours - by combining it with vemurafenib.

"Miraculously, [Rosendahl] had a response to this combination," says Mulcahy-Levy. "Four weeks later, she could stand and had improved use of her arms, legs, and hands."

The chloroquine didn't remove the tumour, but it did weaken the cancer's defences enough to get the vemurafenib drug working again to do that on its own, and now Rosendahl's quality of life is improving.

Only three patients have been given the treatment so far, and not every type of cancer relies so much on autophagy, so until it's been tested on a much larger and diverse sample, it's too soon to tell if it will have similar effects on other patients.

But the team says a wider clinical test could be rolled out quickly, because chloroquine is already approved as a safe anti-malaria drug by the US FDA (Food and Drug Administration).

The researchers hope that future studies will reveal other cancers where this treatment could be effective. 

"It makes me feel really lucky to be a pioneer in this treatment," says Rosendahl. "I hope it helps and I hope it helps people down the road. I want it to help."

The latest findings have been published in eLife.


Via Kim Frye, talkingdrumnigeria, Evieira
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#Malware „Fruitfly“ späht #Macs per Screenshotfunktion aus | #Apple #Mac #CyberSecurity 

#Malware „Fruitfly“ späht #Macs per Screenshotfunktion aus | #Apple #Mac #CyberSecurity  | Limitless learning Universe | Scoop.it
Ein Malware spioniert offenbar seit Jahren Macs aus, aktiv war sie wohl vor allem in Forschungseinrichtungen.


Eine neue Mac-Malware haben die Forscher von Malwarebytes entdeckt und als OSX.Backdoor.Quimitchin benannt, Apple nennt sie „Fruitfly“. Sie besteht aus einer Perl-Skript-Datei und einem Launch-Agent namens com.client.client.plist. Letzterer sorgt für die Aktivierung des Skripts, der eigentlichen Malware.

Wie sie auf  die  Rechner gelangen kann, ist allerdings bisher nicht bekannt. Ist sie im Hintergrund aktiv, kann die Malware über einen zentralen Server gesteuert werden, nimmt Bildschirmfotos auf und protokolliert die Laufzeit des Macs. Zugriff auf die Mac-Kamera ist ebenfalls möglich, ein zweites Skript und ein Java-Tool sind enthalten.

 

Durch ein Sicherheitsupdate von Apple sollen Macs zukünftig gegen die Malware geschützt sein, die kostenlose Software Anti-Malware von Malwarebytes kann die Malware  erkennen und entfernen.

 

Learn more / En savoir plus / Mehr erfahren:

 

http://www.scoop.it/t/apple-mac-ios4-ipad-iphone-and-in-security/?tag=Fruitfly

 

http://www.scoop.it/t/apple-mac-ios4-ipad-iphone-and-in-security

 


Via Gust MEES
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Gust MEES's curator insight, January 19, 9:59 AM
Ein Malware spioniert offenbar seit Jahren Macs aus, aktiv war sie wohl vor allem in Forschungseinrichtungen.


Eine neue Mac-Malware haben die Forscher von Malwarebytes entdeckt und als OSX.Backdoor.Quimitchin benannt, Apple nennt sie „Fruitfly“. Sie besteht aus einer Perl-Skript-Datei und einem Launch-Agent namens com.client.client.plist. Letzterer sorgt für die Aktivierung des Skripts, der eigentlichen Malware.

Wie sie auf  die  Rechner gelangen kann, ist allerdings bisher nicht bekannt. Ist sie im Hintergrund aktiv, kann die Malware über einen zentralen Server gesteuert werden, nimmt Bildschirmfotos auf und protokolliert die Laufzeit des Macs. Zugriff auf die Mac-Kamera ist ebenfalls möglich, ein zweites Skript und ein Java-Tool sind enthalten.

 

Durch ein Sicherheitsupdate von Apple sollen Macs zukünftig gegen die Malware geschützt sein, die kostenlose Software Anti-Malware von Malwarebytes kann die Malware  erkennen und entfernen.

 

Learn more / En savoir plus / Mehr erfahren:

 

http://www.scoop.it/t/apple-mac-ios4-ipad-iphone-and-in-security/?tag=Fruitfly

 

http://www.scoop.it/t/apple-mac-ios4-ipad-iphone-and-in-security

 

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Persistent infection keeps immune memory sharp, leading to long-term protection #immunity #biology

Persistent infection keeps immune memory sharp, leading to long-term protection #immunity #biology | Limitless learning Universe | Scoop.it
For many infectious diseases, a single bout of the illness protects a person against contracting it again. Sometimes, the infecting microbe persists in the body long after symptoms resolve. Now, researchers studying the tropical parasite Leishmania have found a clue to explain the link between long-term immunity and long-term infection: The parasite is constantly multiplying and being killed by immune cells, keeping the immune system alert and prepared for any new encounters with the parasite.

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50 years ago, Martin Luther King Jr. turned his #activism against the #Vietnam War, and lost allies as a result

50 years ago, Martin Luther King Jr. turned his #activism against the #Vietnam War, and lost allies as a result | Limitless learning Universe | Scoop.it
It's not remembered like "I have a dream," but Martin Luther King's "Beyond Vietnam" speech captures the man and his desire to promote peace.
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Two New #Bug Species Have All-Pink Females

Two New #Bug Species Have All-Pink Females | Limitless learning Universe | Scoop.it
The leaf-like katydids, native to northern Borneo, sport dramatically different color differences between sexes.

Via Neelima Sinha
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Taking graphics cards beyond gaming #ATI #Nvidia #AMD has the better cards

Taking graphics cards beyond gaming #ATI #Nvidia #AMD has the better cards | Limitless learning Universe | Scoop.it
The graphics cards found in powerful gaming computers are now capable of solving computationally intensive mathematical problems common in science and engineering applications, thanks to a new solver developed by researcher
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#Retroviruses 'almost half a billion years old' #HIV #biology #history

#Retroviruses 'almost half a billion years old' #HIV #biology #history | Limitless learning Universe | Scoop.it

Retroviruses – the family of viruses that includes HIV – are almost half a billion years old, according to new research by scientists at Oxford University. That's several hundred million years older than previously thought and suggests retroviruses have ancient marine origins, having been with their animal hosts through the evolutionary transition from sea to land.


Via Integrated DNA Technologies
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The case for taking a very little bit of #LSD everyday #microdosing

The case for taking a very little bit of #LSD everyday #microdosing | Limitless learning Universe | Scoop.it
Writer and former public defender Ayelet Waldman experiments with microdosing.
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#Physicists make first-ever direct observation of collisional plasmoid instability during magnetic reconnection #Princeton

#Physicists make first-ever direct observation of collisional plasmoid instability during magnetic reconnection #Princeton | Limitless learning Universe | Scoop.it
Physicists at the U.S. Department of Energy's (DOE) Princeton Plasma Physics Laboratory (PPPL) have for the first time directly observed a phenomenon that had previously only been hypothesized to exist. The phenomenon, plasmoid instabilities that occur during collisional magnetic reconnection, had until this year only been observed indirectly using remote-sensing technology. In a paper published in the August 2016 issue of Physical Review Letters, PPPL physicists report that they created the phenomenon in a laboratory setting where they could measure it directly and confirm its existence on the electron scale, which describes the range of motion of electrons and how quickly they move. This research was funded both by the DOE's Office of Science and NASA's Heliophysics Division.

Plasmoid instabilities create magnetic bubbles within plasma, superhot gas whose atoms have separated into electrons and atomic nuclei. The magnetic bubbles then cause fast magnetic reconnection, when a plasma's magnetic field lines break apart and join together again, releasing large amounts of energy. Before now, physicists at NASA and other institutions had only been able to directly confirm the existence of these instabilities in collisionless plasmas, like those surrounding Earth in the upper atmosphere, in which the plasma particles do not collide often.

Scientists had not been able to confirm the existence of plasmoid instabilities in collisional plasmas, in which the particles frequently collide, because such plasmas occur in outer space, far from Earth. Collisional plasmas like those on the surfaces of stars are so far away that scientists have difficulty measuring them directly. But physicists at the Massachusetts Institute of Technology and elsewhere had predicted their existence years ago.

Via Mariaschnee
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Death and #Rebirth: Startling New Information Emerges About #Ancient Egyptian Pot Burials #Science #Tech #history

Death and #Rebirth: Startling New Information Emerges About #Ancient Egyptian Pot Burials #Science #Tech #history | Limitless learning Universe | Scoop.it
Ancient Egyptian funerary practices were not just about making mummies. Surprising new information reveals that pot burials were not just for poor children in ancient Egypt either. Instead, it seems that citizens of any age and socio-economi
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The Greatest #Civilisation Ever Forgotten? | #History Today

The Greatest #Civilisation Ever Forgotten? | #History Today | Limitless learning Universe | Scoop.it
Perhaps the most famous statement about the Indus civilisation is the opening paragraph of an article in the Illustrated London News published in 1924 by John Marshall, director general of the Archaeological Survey of India: ‘Not often has it been given to archaeologists, as it was given to [Heinrich] Schliemann at Tiryns and Mycenae, or to [Aurel] Stein in the deserts of Turkestan, to light upon the remains of a long-forgotten civilisation. It looks, however, at this moment, as if we are on the threshold of such a discovery in the plains of the Indus.’ Subsequent Indus excavations certainly made an impression on the young Kenneth Clark. In Civilisation, Clark, while pondering the non-western beginnings of civilisation two-and-a-half millennia before the classical Greeks, observed in 1969: Three or four times in history man has made a leap forward that would have been unthinkable under ordinary evolutionary conditions. One such time was about the year 3000 BC, when quite suddenly civilisation appeared, not only in Egypt and Mesopotamia but also in the Indus Valley; another was in the sixth century BC, when there was not only the miracle of Ionia and Greece … but also in India a spiritual enlightenment that has perhaps never been equalled.
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#Google reveals secret test of #AI bot to beat top #Go players

#Google reveals secret test of #AI bot to beat top #Go players | Limitless learning Universe | Scoop.it
Updated version of DeepMind's AlphaGo program behind mystery online competitor.

Via Mariaschnee
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Ground-Penetrating Radar Helps #Archaeologists Find #Viking Age Manor | #Archaeology | Sci-News.com

Ground-Penetrating Radar Helps #Archaeologists Find #Viking Age Manor | #Archaeology | Sci-News.com | Limitless learning Universe | Scoop.it
A large manor has been found at the archaeological site of Korshamn near the Viking Age proto-town of Birka in Sweden.
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#RNA hitches a ride on ultrasound waves to enter colon cells #biology #medicine #FF

#RNA hitches a ride on ultrasound waves to enter colon cells #biology #medicine #FF | Limitless learning Universe | Scoop.it

MIT researchers have demonstrated that they can deliver strands of unformulated RNA very efficiently to colon cells, using bursts of ultrasound waves that propel the RNA into the cells.


Via Integrated DNA Technologies
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Global Warming Is Changing How the #Ocean Carries #Sound | Hakai Magazine

Global Warming Is Changing How the #Ocean Carries #Sound | Hakai Magazine | Limitless learning Universe | Scoop.it
Scientists are using an underwater drone to study a mysterious new sound channel in the Beaufort Sea.

Via Mariaschnee
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#Europe in the beginning of the 14th century #history

#Europe in the beginning of the 14th century #history | Limitless learning Universe | Scoop.it
Maps that explain the World.

Via Fernando Gil
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#Video: #Huygens' descent to #Titan

#Video: #Huygens' descent to #Titan | Limitless learning Universe | Scoop.it
On December 25, 2004, the piggybacking Huygens probe was released from the 'mothership' Cassini spacecraft and it arrived at Titan on January 14, 2005. The probe began transmitting data to Cassini four minutes into its descen
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Video: #Blind mouse navigates like a bat, adjustment in #Nature #biology

Video: #Blind mouse navigates like a bat, adjustment in #Nature #biology | Limitless learning Universe | Scoop.it
Vietnamese pygmy dormouse uses ultrasonic signals to get around
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A hidden #code in our #DNA explains how new pieces of genes are made #biology #science

A hidden #code in our #DNA explains how new pieces of genes are made #biology #science | Limitless learning Universe | Scoop.it
We're all here because of mutations. Random changes in genes are what creates variety in a species, and this is what allows it to adapt to new environments and eventually evolve into completely new species. But most rando
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Northern Lights could reach millions across the world this evening #Aurora Borealis

Northern Lights could reach millions across the world this evening #Aurora Borealis | Limitless learning Universe | Scoop.it
An increase in solar activity means the chances of seeing the Northern Lights tonight in places like Canada, Scandinavia, Scotland and even England and are greater than usual.
Via Poppen Report
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Mysterious cosmic radio blasts traced to surprising source #astronomy #science

Mysterious cosmic radio blasts traced to surprising source #astronomy #science | Limitless learning Universe | Scoop.it
Repeating bursts come from a faint, distant dwarf galaxy.
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Spectacular collision of suns will create new star in night sky in 2022

Spectacular collision of suns will create new star in night sky in 2022 | Limitless learning Universe | Scoop.it
At the beginning of the 3rd century civil war raged in Britain as the Roman emperor Septimius Severus sought to quell unrest in the north.
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#Physicists solve decades-old scientific mystery of negative differential resistance #science #physics

#Physicists solve decades-old scientific mystery of negative differential resistance #science #physics | Limitless learning Universe | Scoop.it
With a storied history that includes more than a half-century of research, a Nobel Prize, and multiple attempts at practical applications, the story of negative differential resistance—or NDR—reads like a scientific mystery
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