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Breast Cancer and Healing ~ The Pink Paper
Breast cancer prevention and healing news, information and inspiration for THRIVERS of strength & spirit. The Pink Paper is your online source of HOPE. Be empowered. Say "Yes" to Health, Happiness and Hope.
Curated by Natalie Palmer
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Chronic Inflammation Resulting from Typical Lifestyle Choices Promotes Cancer

Chronic Inflammation Resulting from Typical Lifestyle Choices Promotes Cancer | Breast Cancer and Healing ~ The Pink Paper | Scoop.it
Chronic inflammation has started to become a buzzword in the health world as research builds indicating that it may be the cause of many serious illnesses, from heart disease to cancer.

Via Graham Player Ph.D.
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Graham Player Ph.D.'s curator insight, April 25, 2014 2:52 AM

There is direct connection between chronic inflammation and the development of cancer, as well as many other disease states. Many factors can contribute to chronic inflammation including stress, toxins, genetic predisposition, lack of exercise and diet.

Many doctors today recommend people take daily anti-inflammatory medicine, such as aspirin, to reduce their chances of developing chronic long-term inflammation. While this may be the case, research indicates this practice may be causing more harm than good for some people.

One byproduct of inflammation is an increase in C-reactive protein in the body, and it is good practice to have this checked during routine medical checkups. Research indicates that foods high in magnesium (e.g. almonds, spinach, cashews, black beans, kelp, pumpkin seeds, etc.) can help reduce inflammation and elevated levels of C-reactive protein.

Maintaining a proper balance between omega-3 and omega-6 fatty acids can also help to reduce the risk of inflammation. The typical western diet is deficient in omega-3 fatty acids, and has excessive amounts of omega-6 fatty acids. Research has indicated that excessive amounts of omega-6 fatty acids and a very high omega-6/omega-3 ratio, as is found in today's Western diets, promotes many diseases, including cardiovascular disease, cancer, and inflammatory and autoimmune diseases.

One study found that a ratio of 2.5/1 (omega-6 / omega-3) reduced rectal cell proliferation in patients with colorectal cancer, whereas a ratio of 4/1 with the same amount of omega-3 had no such effect. Studies indicate that the optimal ratio may vary by disease.

The bottom line is that reducing the level of chronic inflammation, assisted by a diet with a lower ratio of omega-6/omega-3 fatty acids is desirable in reducing the risk of many of the chronic diseases including cancer. To learn more see here - http://www.ncbi.nlm.nih.gov/pubmed/12442909

Tambre Leighn's curator insight, April 28, 2014 5:49 PM

...and MORE data about the role of nutrition and physical activity in cancer prevention...

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Routes From Diagnosis Cancer Survivorship Report


Via Marie Ennis-O'Connor
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Teresa Levitch's curator insight, April 4, 2014 6:03 AM

Wonderful charts, in depth information about survivorship issues. It can be downloaded for reading offline.

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Trends in cancer care The power of the epatient

Trends in cancer care The power of the epatient | Breast Cancer and Healing ~ The Pink Paper | Scoop.it
Not all epatients are Internet savvy, but they are engaged, educated, equipped, and enabled to be experts and equal partners in their care.

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National Fertility Preservation Register: datatabase to help cancer patients with fertility issues

National Fertility Preservation Register: datatabase to help cancer patients with fertility issues | Breast Cancer and Healing ~ The Pink Paper | Scoop.it
DISCOVERING they have cancer is a big enough blow for a young person, but only half are getting access to services to preserve their fertility from the treatment.

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Treatment helps to destroy breast cancer cells

Treatment helps to destroy breast cancer cells | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

"SOUTH BEND, Ind.-- More than 232,000 women were diagnosed with breast cancer last year.

When treatments fail and the cancer comes back patients are often left with few options.

Now, a new therapy is heating up tumors.

Two years ago doctors told Lisa Ridgeway she had triple negative breast cancer, a very aggressive disease with no cure.

"There's not a lot of drugs that work, or work for a long period of time," said Ridgeway

The mom of two was facing a typical life expectancy of just three years.

"That's a mom's horror story, knowing that you aren't going to be here," said Ridgeway

Lisa had surgery, radiation and chemo, but her cancer came back two more times.

Now she's trying something new. Doctors at the Cleveland Clinic are offering patients hyperthermia treatment.

"Hyperthermia is heat therapy. It's actually been around since the time of the Egyptians," said Dr. Jennifer Yu, a Radiation Oncologist at the Cleveland Clinic.

A hot bag is placed on top of the skin and a microwave unit heats the bag and the tissue under it to about 110 degrees. The heat increases blood flow and makes tumors more sensitive to radiation.

“It improves cell kill," said Dr. Yu

Typically, treatments last one hour and are performed one to two times a week.

Hyperthermia is also used in other cancers such as melanomas, gynecologic cancers, and head and neck cancers."


Via Susan Zager
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Susan Zager's curator insight, April 18, 2014 3:31 PM

For more information on hyperthermia treatment.for cancer go to: http://www.cancer.gov/cancertopics/factsheet/Therapy/hyperthermia


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Breast cancer procedue allows quicker recovery

Breast cancer procedue allows quicker recovery | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

"ARASOTA, Fla. – According to the American Cancer Society, more than 230,000 new cases of invasive breast cancer will affect women in the U.S. this year. Now Suncoast surgeons are using a new procedure with a quicker recovery.

Women on the Suncoast undergoing mastectomy and reconstruction may now be candidates for nipple sparing surgery, thanks to the skilled hands of a handful of specially trained surgeons using an instrument called the PlasmaBlade.

Tanya Kukrecht knows how physically and emotionally devastating cancer treatment and surgery is. She helps women with prosthetics following mastectomy, designs and sends wigs to women in the U.S. who've lost their hair to chemotherapy. She says we've come a long way. “With new instruments, and new ways of doing and new chemo, and new way of doing surgery, it is much less devastating.”

Now, a new surgical device with the precision of a scalpel uses radio frequency energy to perform the most delicate of surgeries. “The PlasmaBlade has caused a lot less thermal and tissue damage, which has allowed us to look more into nipple sparing mastectomy and straight to implant reconstruction.”

It’s a huge revolution in breast cancer and preventative breast cancer care, says plastic surgeon Dr. Alissa Shulman, who performs the nipple sparing surgery. “This allows us to remove the breast tissue and leave the entire envelop of the breast, which includes the nipple, the areola and all the surrounding skin, which really preserves not only the shape and color of your breast, but can even occasionally preserve the feeling of the nipple.”


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Breast cancer replicates brain development process

Breast cancer replicates brain development process | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

 

"New research led by a scientist at the University of York reveals that a process that forms a key element in the development of the nervous system may also play a pivotal role in the spread of breast cancer.

A research team, led by Dr Will Brackenbury, a Medical Research Council Fellow in the Department of Biology at York, has studied how voltage-gated sodium channels assist in the metastasis of cancerous tumours. These channels are found in the membranes of excitable cells, such as neurons, where they are involved in transmission of electrical impulses. However, the channels have also been found in metastatic cancer cells.

Using clinical breast cancer specimens from the Breast Cancer Campaign Tissue Bank and preclinical laboratory modelling, the researchers, including Dr Rebecca Millican-Slater, a consultant pathologist at St James University Hospital, Leeds, discovered that a sodium channel protein called Beta-one is present at high levels in breast cancer samples compared with normal tissue.

In research published in the International Journal of Cancer, they show for the first time that the increase in beta-one protein levels make tumours grow faster. They also discovered that Beta-one proteins play a significant role in enabling the cells to change shape and move, and consequently metastasise.

 


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USU-HJF Effort to License Promising Breast Cancer Vaccine Wins Award

USU-HJF Effort to License Promising Breast Cancer Vaccine Wins Award | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

"BETHESDA, Md. -- (BUSINESS WIRE) -- A joint effort by The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) and the Uniformed Services University of the Health Sciences (USU) to license a promising breast cancer vaccine to reduce breast cancer recurrence rates has received the 2014 Award for Excellence in Technology Transfer. This marks the second consecutive award for the University, which is aided in its technology transfer efforts by HJF through the USU-HJF Joint Office of Technology Transfer.

The award is for work by Army Colonel George Peoples, M.D., chief of surgical oncology at the San Antonio Military Medical Center, and his colleagues on a breast cancer vaccine to reduce recurrence rates. The vaccine, called E75, is a peptide of human epidermal growth factor receptor 2 (HER2/neu). The vaccine, commercially known as NeuVax™ (nelipepimut-S), stimulates a patient’s cytotoxic T-cells, or “killer T-cells,” to target and eradicate cells that express any level of HER2. Researchers at the University of Texas M.D. Anderson Cancer Center in Houston discovered the E75 peptide.

USU supported successful Phase I and Phase II clinical trials of the E75 vaccine, showing breast cancer recurrence rates that were reduced by half after five years of follow-up. Based on the Phase II clinical trial results, the U.S. Food and Drug Administration granted NeuVax™ a special protocol assessment for the Phase III clinical trial, which is being conducted by the technology transfer recipient and commercial partner, Galena Biopharma of Portland, Ore. The Phase III clinical trial began in 2012. "   


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Eating a High-Fat Diet May Boost Breast Cancer Risk - Health News ...

Eating a High-Fat Diet May Boost Breast Cancer Risk - Health News ... | Breast Cancer and Healing ~ The Pink Paper | Scoop.it
WEDNESDAY, April 10, 2014 (HealthDay News) — For more than three decades, experts have debated whether eating a high-fat diet increases breast cancer risk. Now, new research suggests it might boost the chances of ...
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'I Touch Myself' Breast Cancer Anthem #itouchmyselfproject

You can help keep Chrissy's dream alive by spreading her message. Visit http://itouchmyself.org 'I Touch Myself' was the Divinyls' biggest hit and touched mi...
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What is Wellness? It's dimensions and its relation with stress.

What is Wellness? It's dimensions and its relation with stress. | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

What is Wellness ?

                            - http://www.wellness.com/what-is-wellness -

Wellness is the result of personal initiative seeking a more optimal, holistic and balanced state of health.

 

Wellness is an active process of becoming aware of and making choices toward a healthy and fulfilling life.a state of optimal well-being that is oriented toward maximizing an individual's potential.It takes more than physical exercise to maintain good health.

 

Wellness is generally used to mean a healthy balance of the mind, body and spirit that results in an overall feeling of well-being.is a state of being well, a way of life, a choice, and a lifestyle designed to achieve a person's highest potential for well-being.

 

Wellness is much more than merely physical health, exercise or nutrition. It is the full integration of states of physical, mental, and spiritual ...

Wellness is first and foremost a choice to assume responsibility for the quality of your life. It begins with a conscious decision to shape a healthy lifestyle........Read more: http://www.wellness.com/what-is-wellness

 


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lissacoffey's comment, April 22, 2014 4:24 AM
Thanks for rescoop....
Kimberly Ward's curator insight, June 20, 2014 9:44 AM

Definitely worth the read!

Richard Haddad's curator insight, July 5, 2014 3:17 PM

le régime équilibre  est la base  d'une santé  certaine ,mais cela n'a l'air suffisant  et il est nécessaire d'avoir un mental tout aussi solide ,et une situation financière  positive  etc etc  . Pour ma part. J'ajouterai  l'équilibre  Microbiotique.  Qui a son tour équilibrera cœur cerveau pancréas. Etc . Dans le site "regimeefficace un document entier vous sera offerte   À noter. Jour après jour  pour vous permettre de suivre  votre évolution      

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Experimental Breast Cancer Drug Seems Safe, Effective for Advanced Disease

Experimental Breast Cancer Drug Seems Safe, Effective  for Advanced Disease | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

"SUNDAY, April 6, 2014 (HealthDay News) -- In an early trial, an experimental breast cancer drug stopped disease growth and shrank tumors by more than 30 percent in some patients.

The pill, bemaciclib, was safe and well-tolerated by women with breast cancer that had spread, or metastasized, to other parts of the body, according to the results of this phase 1 trial.

"This is a novel oral treatment for patients with metastatic breast cancer," said lead researcher Dr. Amita Patnaik, the associate director of clinical research at South Texas Accelerated Research Therapeutics in San Antonio.

If these results are replicated in future trials, it's conceivable that the pill might extend survival for women with terminal breast cancer, experts suggested.

The drug was particularly effective for the most common type of breast cancer, called hormone receptor-positive breast cancer. In this type of cancer, cancer cells grow in response to signals from the hormones estrogen and/or progesterone.

The study included more than 130 women. Overall, Patnaik said half of them had cancer growth controlled and 25 percent had shrinkage of their tumors.

Unlike standard cancer drugs, this is a twice-daily pill that allows women to go on with their daily lives. In contrast, other cancer drugs are given intravenously at a hospital or doctor's office. Another difference, Patnaik said, is that bemaciclib is a targeted therapy, a newer type of drug that is better able to identify and attack specific cells."


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Radiotherapy after mastectomy improves outcomes for patients with up to three positive lymph nodes

Radiotherapy after mastectomy improves outcomes for patients with up to three positive lymph nodes | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

"Women whose breast cancer has spread to just a few axial lymph nodes are less likely to have their disease recur or to die from it if they have radiotherapy after mastectomy, according to new research. This study was presented at the European Breast Cancer Conference in Glasgow, Scotland, and was published in The Lancet (2014; doi:10.1016/S0140-6736(14)60488-8).

Until now, there has been uncertainty over whether women with early breast cancer that has spread to just one, two, or three lymph nodes under the arm gain any benefit from radiotherapy after surgery, explained Paul McGale, PhD, of the Early Breast Cancer Trialists' Collaborative Group at the Clinical Trial Services Unit in Oxford, United Kingdom.

"Another result from our study is that the proportional benefits of radiotherapy were similar in women regardless of whether or not they had also received chemotherapy or hormonal therapy. This is important because most women today receive these therapies. Our results suggest that women being treated today are likely to also benefit from radiotherapy if they have any positive lymph nodes," said McGale.

The research team analyzed results from 3,786 women in 14 randomized trials starting between 1964 and 1982. The women had underwent mastectomy along with the surgical removal of lymph nodes under the arm (axillary dissection) and were then randomized to either radiotherapy to the chest wall and surrounding regions or no radiotherapy. The women fell into three categories: those with no cancer in the lymph nodes; those with cancer in one, two, or three lymph nodes; and those with cancer in four or more lymph nodes. The women were followed for an average of a little more than 11 years, and data on the number of recurrences and deaths were available up to 2009."


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Fish and Mammals Found Contaminated with Tumors and Lesions

Fish and Mammals Found Contaminated with Tumors and Lesions | Breast Cancer and Healing ~ The Pink Paper | Scoop.it
Turner Radio Network - Providing the facts the mass-media won't.

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Graham Player Ph.D.'s curator insight, May 1, 2014 3:43 AM

Evidence of tumor growth and diseased tissue has been found in fish and other species from the sea and river estuaries. This report shows many photographs of salmon the mouth of the Hydaburg River, Alaska with strange growths, fish from Nigliq Channel and upstream from Nigliq Channel to the Colville River, Alaska with bloody lesions and tumors on them, and many other fish showing classic signs of radiation-caused cancerous tumors.

There is no way to tell exactly where in the Pacific Ocean these fish have been. One thing is for certain: they're ALL from the Pacific Ocean.

If the strange lesions and cancerous tumors were only affecting Salmon, one might theorize that a particular disease had struck a particular species. That's not the case. Fresh water Pike  are also being caught with grotesque cancerous tumors protruding outside their bodies. Tumors are also affecting other species of fish like the Canadian Whitefish. Vancouver Island area Herring are also being found to be bleeding from their gills, eyes, mouths and bellies.

Researchers in Australia noticed a large tumor protruding from the mouth of a great white shark, as well as another mass on the head of a bronze whaler shark. The great white's tumor measured 1 foot (30 centimeters) long and 1 foot wide, according to a study describing the tumors published online in November in the Journal of Fish Diseases. Yet sharks have not been known to get cancer.

Mammals as well as fish are being affected, including various types of Seals, Walruses and even Polar Bears. They have been found suffering from bloody lesions, some are suffering external tumors and others are losing their fur - hair loss is one of the first signs of radiation poisoning, even in humans.

We all need to consider this situation and what it means to ourselves in terms of food and lifestyle choices. There are many possibilities to the likely cause. The most obvious being the Fukushima incident pouring radioactive waste into the ocean. It is expected that Governments and officials will deny any possibility. The bottom line is that something is in the oceans that is causing the fish and mammals to become ill. If we eat those diseased fish it is possible that it could increase our risk of becoming ill.

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ASCO Releases Adapted Guideline on Screening, Assessment, and Management of Fatigue in Adult Survivors of Cancer

ASCO Releases Adapted Guideline on Screening, Assessment, and Management of Fatigue in Adult Survivors of Cancer | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

A majority of cancer patients experience some level of fatigue during their course of treatment, and approximately 30% contend with persistent fatigue for years after treatment. Fatigue is among the most common and distressing long-term effects of cancer treatment and significantly affects patient quality of life. ASCO has adapted a pan-Canadian guideline on screening, assessment, and care of cancer-related fatigue in adults with cancer, the National Comprehensive Cancer Network (NCCN) Guideline for Cancer-Related Fatigue, and the NCCN Guidelines for Survivorship for use in the screening, assessment, and management of fatigue in adult survivors of cancer.


Via Marie Ennis-O'Connor
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Teresa Levitch's curator insight, April 15, 2014 4:38 PM

 Fatigue is among the most common and distressing long-term effects of cancer treatment and significantly affects patient quality of life.

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10 Ways to Talk With Your Child About Cancer

10 Ways to Talk With Your Child About Cancer | Breast Cancer and Healing ~ The Pink Paper | Scoop.it
Having to tell others about your cancer diagnosis can be very challenging and uncomfortable. Sharing the news with a young child or teenager can be even more difficult. Many patients I talk with are hesitant to tell their children about their diagnosis...

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Chronic Inflammation Resulting from Typical Lifestyle Choices Promotes Cancer

Chronic Inflammation Resulting from Typical Lifestyle Choices Promotes Cancer | Breast Cancer and Healing ~ The Pink Paper | Scoop.it
Chronic inflammation has started to become a buzzword in the health world as research builds indicating that it may be the cause of many serious illnesses, from heart disease to cancer.

Via Graham Player Ph.D.
more...
Graham Player Ph.D.'s curator insight, April 25, 2014 2:52 AM

There is direct connection between chronic inflammation and the development of cancer, as well as many other disease states. Many factors can contribute to chronic inflammation including stress, toxins, genetic predisposition, lack of exercise and diet.

Many doctors today recommend people take daily anti-inflammatory medicine, such as aspirin, to reduce their chances of developing chronic long-term inflammation. While this may be the case, research indicates this practice may be causing more harm than good for some people.

One byproduct of inflammation is an increase in C-reactive protein in the body, and it is good practice to have this checked during routine medical checkups. Research indicates that foods high in magnesium (e.g. almonds, spinach, cashews, black beans, kelp, pumpkin seeds, etc.) can help reduce inflammation and elevated levels of C-reactive protein.

Maintaining a proper balance between omega-3 and omega-6 fatty acids can also help to reduce the risk of inflammation. The typical western diet is deficient in omega-3 fatty acids, and has excessive amounts of omega-6 fatty acids. Research has indicated that excessive amounts of omega-6 fatty acids and a very high omega-6/omega-3 ratio, as is found in today's Western diets, promotes many diseases, including cardiovascular disease, cancer, and inflammatory and autoimmune diseases.

One study found that a ratio of 2.5/1 (omega-6 / omega-3) reduced rectal cell proliferation in patients with colorectal cancer, whereas a ratio of 4/1 with the same amount of omega-3 had no such effect. Studies indicate that the optimal ratio may vary by disease.

The bottom line is that reducing the level of chronic inflammation, assisted by a diet with a lower ratio of omega-6/omega-3 fatty acids is desirable in reducing the risk of many of the chronic diseases including cancer. To learn more see here - http://www.ncbi.nlm.nih.gov/pubmed/12442909

Tambre Leighn's curator insight, April 28, 2014 5:49 PM

...and MORE data about the role of nutrition and physical activity in cancer prevention...

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First genetic link discovered to difficult-to-diagnose breast cancer sub-type

First genetic link discovered to difficult-to-diagnose breast cancer sub-type | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

"Scientists have identified the first genetic variant specifically associated with the risk of a difficult-to-diagnose cancer sub-type accounting for around 10-15 per cent of all breast cancer cases.

The largest ever study of the breast cancer sub-type, called invasive lobular carcinoma, gives researchers important clues to the genetic causes of this particular kind of breast cancer, which can be missed through screening.

The research, published today in the journal PloS Genetics, was co-led by The Institute of Cancer Research, London, King’s College London, and Queen Mary University of London. It used gene chip technology and complex statistical analysis to compare the DNA of more than 6,500 women with invasive lobular cancer with the DNA of more than 35,000 women without the disease.

The study involved more than 100 research institutions from around the world and was funded by several organisations in the UK including Breast Cancer Campaign, Cancer Research UK, Breakthrough Breast Cancer and the ICR.

A woman with the genetic variant, called rs11977670, was found to have a 13 per cent higher chance of developing invasive lobular cancer than a woman without it. The variant is close to two genes on chromosome 7: BRAF, a known cancer-causing gene, and JHDM1D, which is involved in the activation and deactivation of other genes.

The discovery of the genetic variant, in conjunction with other markers, could help in the development of future genetic screening tools to assess women’s risk of developing invasive lobular cancer, and also gives researchers important new clues about the genetic causes of the disease and a related precursor to cancer called lobular carcinoma in situ.

Invasive lobular carcinoma develops in the lobes of the breast that produce milk and can be particularly difficult to diagnose, because the cancer often does not form a definite lump and may not show up on mammograms. As a result, women with this type of cancer tend to be diagnosed when the cancer is more advanced and more difficult to treat."

 

 


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Blocking Breast Cancer Drug A 'Major Blow'

Blocking Breast Cancer Drug A 'Major Blow' | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

"Moves to block a new breast cancer drug which extends women's lives by almost six months have been described as a "major blow".

Clinical trial results have shown that women on Kadcyla survived 30.9 months compared with 25.1 months on similar treatments.

However, the National Institute for Health and Care Excellence (Nice) said in its draft guidance the drug is not effective enough to justify the price the NHS is being asked to pay.

It is estimated that Kadcyla, manufactured by Roche, will cost around £90,000 per patient.

Nice chief executive Sir Andrew Dillon said: "We had hoped that Roche would have recognised the challenge the NHS faces in managing the adoption of expensive new treatments by reducing the cost of Kadcyla to the NHS.

"We apply as much flexibility as we can in approving new treatments, but the reality is that given its price and what it offers to patients, it will displace more health benefit which the NHS could achieve in other ways than it will offer to patients with breast cancer."

Professor Paul Ellis, a consultant oncologist at King's College, London and lead triallist for the drug in the UK, said: "Kadcyla represents a significant advance in HER2-positive breast cancer, so for Nice to issue negative preliminary guidance is a huge blow.

Jayson Dallas, general manager of Roche Products Limited, said: "Roche is extremely disappointed that Nice has failed to safeguard the interests of patients with this advanced stage of aggressive disease."


Via Susan Zager
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Susan Zager's curator insight, April 23, 2014 2:24 PM

It's a shame that NICE ( National Institute for Health and Care Excellence) in the UK did not approve Kadcyla for Her2-positive breast cancer. At the same time, there has to be a way to make this drug affordable. According to the article In the UK, "the decision by Nice is now up for public consultation and during this time patients will be able to apply to their local NHS and to the Cancer Drugs Fund (CDF) for the drug."

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In lab tests, the antimicrobial ingredient triclosan spurs growth of breast cancer cells

In lab tests, the antimicrobial ingredient triclosan spurs growth of breast cancer cells | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

"Some manufacturers are turning away from using triclosan as an antimicrobial ingredient in soaps, toothpastes and other products over health concerns. And now scientists are reporting new evidence that appears to support these worries. Their study, published in the ACS journal Chemical Research in Toxicology, found that triclosan, as well as another commercial substance called octylphenol, promoted the growth of human breast cancer cells in lab dishes and breast cancer tumors in mice.

Kyung-Chul Choi and colleagues note that hormonal imbalances seem to play a role in the development of breast cancer. Given that link, researchers are investigating whether endocrine-disrupting chemicals (EDCs), which are compounds that act like hormones, might spur cancer cell growth. EDCs have become ubiquitous in products, in the environment and even in our bodies. Research has found that two EDCs — triclosan, an antimicrobial ingredient in many products, including soaps, cosmetics and cutting boards; and octylphenol, which is in some paints, pesticides and plastics — have accumulated in the environment. Additionally, triclosan is reportedly in the urine of an estimated 75 percent of Americans. Choi’s team wanted to see what effect the two compounds have on breast cancer cells.

 


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Susan Zager's curator insight, April 24, 2014 3:03 PM

This study of EDCs  (triclosan,and octylphenol) was done in human breast cancer cells and mice. These EDC's are found in soaps, cosmetics, paints, pesticides and plastics and reported to be in the urine of 75% of Americans. 


To see the study go to: http://pubs.acs.org/doi/abs/10.1021/tx5000156


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Generex Announces Antigen Express AE37 Breast Cancer Vaccine Abstract Presentations at ASCO 2014 Meeting

Generex Announces Antigen Express AE37 Breast Cancer Vaccine Abstract Presentations at ASCO 2014 Meeting | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

"WORCESTER, Mass. and TORONTO, April 23, 2014 /PRNewswire/ -- Generex Biotechnology Corporation (www.generex.com) (OTCBB:GNBT) today announced that two abstracts in respect of results of the on-going Phase II study of a novel cancer vaccine designed to prevent relapse in patients who have had breast cancer will be presented at this year's American Society of Clinical Oncology (ASCO) Annual Meeting to be held in Chicago from May 30 to June 3, 2014.  The ASCO Annual Meeting is the premier annual oncology symposium, bringing together more than 25,000 oncology professionals from a broad range of specialties.

The abstracts, entitled "Primary analysis of prospective, randomized, single-blinded phase II trial of AE37 vaccine vs GM-CSF along administered in the adjuvant setting to high risk breast cancer patients" and "Immunogenic Comparison of Recurrent and Non-Recurrent Breast Cancer Patients Undergoing AE37 Peptide Vaccine Therapy", will be poster presentations on Monday, June 2 from 8:00 am CDT to 11:45 am CDT.

The AE37 cancer vaccine is being developed by the Company's wholly-owned subsidiary, Antigen Express, Inc. (www.antigenexpress.com).  The vaccine is designed to stimulate an immune response against the patient's cancer cells, preventing relapse in patients who have been treated for early stage breast cancer.

The recent analysis is based on data from nearly 300 patients, making this the largest controlled and randomized trial of a breast cancer vaccine trial conducted to date.  The data corroborate qualitatively the data reported after an interim analysis conducted two years ago.  Specifically, the more prevalent population of breast cancer patients ineligible to receive the drug Herceptin, and particularly those in high-risk groups (e.g., triple negative breast cancer), appear to benefit most from AE37.  Both of these patient populations represent areas of significant unmet need."

 

 


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Tissue testing during breast cancer lumpectomies prevents need for ...

Tissue testing during breast cancer lumpectomies prevents need for ... | Breast Cancer and Healing ~ The Pink Paper | Scoop.it
ROCHESTER, Minn. — Unique laboratory testing during breast cancer lumpectomies to make sure surgeons remove all cancerous tissue spares patients the need for a repeat lumpectomy in roughly 96 percent of cases at ...
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Pfizer Vs. Eli Lilly, Novartis In Breast Cancer Race - Seeking Alpha

Pfizer Vs. Eli Lilly, Novartis In Breast Cancer Race
Seeking Alpha
At the annual meeting of the American Association for Cancer Research in San Diego, Pfizer (PFE) presented details of the Phase 2 study.
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New Drug Demonstrates Early Promise in Metastatic Breast Cancer

New Drug Demonstrates Early Promise in Metastatic Breast Cancer | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

SAN DIEGO — The new oral drug LY2835219, an inhibitor of cyclin-dependent kinases (CDK) 4 and 6, showed early promise as monotherapy for patients with metastatic breast cancer, particularly for those with hormone receptor (HR)-positive disease, according to results of a phase I study presented here at the AACR Annual Meeting 2014, April 5-9.“Preclinical evaluation indicated that LY2835219 may have a potential therapeutic application for the treatment of human cancers in which aberrant CDK-4/6 pathway enhances cancer cell growth,” said Amita Patnaik, M.D., associate director of clinical research at South Texas Accelerated Research Therapeutics in San Antonio, Texas. “When tested on various breast cancer types in preclinical studies, HR-positive cells were found to be highly sensitive to this drug.“Approximately 80 percent of breast cancers are HR-positive,” added Patnaik. “Although our study was not designed to compare patient outcomes based on HR status, the clinical benefit rate was 61 percent in our patients with HR-positive breast cancer, which means patients had disease control for longer than 24 weeks or had their tumors reduce in size by more than 30 percent. This is very encouraging, and warrants the initiation of future clinical trials in this setting where treatments are needed.”In this phase I trial, Patnaik and colleagues tested LY2835219 as a single-agent treatment for five different types of tumors."


Via Susan Zager
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Financial burden of breast cancer greater for minorities

Financial burden of breast cancer greater for minorities | Breast Cancer and Healing ~ The Pink Paper | Scoop.it

"(HealthDay News) -- Racial and ethnic minority patients seem to be more vulnerable to breast cancer-related privations and financial decline, according to a study published online March 24 in the Journal of Clinical Oncology.

Reshma Jagsi, M.D., from the University of Michigan in Ann Arbor, and colleagues examined the financial experiences of a racially and ethnically diverse cohort of women diagnosed with nonmetastatic breast cancer from 2005 to 2007. Surveys were conducted about nine months after diagnosis and four years later among 1,502 women.

The researchers found that the median out-of-pocket expenses were ≤$2,000, with 17 percent reporting spending >$5,000. At four years after diagnosis, 12 percent of respondents reported medical debt, with significant variation by race: 9 percent for whites; 15 percent for blacks; 17 percent for English-speaking Latinas; and 10 percent for Spanish-speaking Latinas (P = 0.03). One-quarter of women experienced financial decline that was at least partly due to breast cancer, with increased odds of decline for Spanish-speaking Latinas versus whites (odds ratio [OR], 2.76; P = 0.006). Eighteen percent of the sample reported at least one privation, with privation significantly more likely for blacks (OR, 2.6; P < 0.001) and English-speaking Latinas (OR, 2.2; P = 0.02) versus whites.

"Racial and ethnic minority patients appear most vulnerable to privations and financial decline attributable to breast cancer, even after adjustment for income, education, and employment," the authors write."


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