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Cheap, Paper-Based Blood Test Costs Only Pennies, No Lab Equipment Needed

Cheap, Paper-Based Blood Test Costs Only Pennies, No Lab Equipment Needed | The future of medicine and health |
An inexpensive diagnostic test made from paper has been developed that can assess liver health in only 15 minutes and for only pennies a test.


An inexpensive diagnostic test made from paper has been developed that can assess liver health in only 15 minutes and for only pennies a test. The test uses a single drop of blood from a fingerprick to measure the presence of liver enzymes, and doesn’t require the presence of a laboratory, instrumentation, or syringes. If liver enzymes are present in the blood, wells within the paper will show a color change, which can be color matched to a scale to determine approximate degree of concentration.

Liver damage can be a consequence of taking antiretroviral drugs, which are prescribed to HIV patients. Because of the high HIV-infection rates in poor countries, liver problems are on the rise, so the ability to cheaply monitor blood is important to prevent potentially fatal side effects of the drugs meant to save people’s lives.

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The human brain makes fructose, researchers discover – here's why that might be a big deal

The human brain makes fructose, researchers discover – here's why that might be a big deal | The future of medicine and health |
Researchers at Yale University have discovered that the brain is capable of making fructose – a simple sugar, usually found in fruit, vegetables and honey.

Not all sugars are equal. Glucose is a simple sugar that provides energy for the cells in your body. Fructose has a less important physiological role and has been repeatedly linked to the development of obesity and type 2 diabetes. When there is excess glucose the processes that break it down can become saturated, so the body converts glucose into fructose instead, using a process known as the “polyol pathway”, a chemical reaction involved in diabetic complications. The researchers at Yale reported in the journal, JCI Insight, that the brain uses the polyol pathway to produce fructose in the brain.

Unlike glucose, which can be metabolised throughout the body, fructose is normally metabolised almost completely in the liver and also in semen where it produces energy for sperm. Most fructose produced by this pathway is thought to stay inside the cells that make it, as fructose levels in the blood are usually extremely low. These low circulating levels make it unlikely that fructose made in this way reaches the brain in significant amounts, and yet some studies have previously identified very high levels of fructose in the central nervous system (the brain and spinal cord).

Importantly, research has shown that exposure to fructose can significantly alter the expression of hundreds of genes in the brain, including genes that control metabolism, cell communication, inflammation and brain function. This suggests that fructose is likely to alter brain function.
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Life expectancy to break 90 barrier by 2030 - BBC News

Life expectancy to break 90 barrier by 2030 - BBC News | The future of medicine and health |
South Korean women will be the first in the world to have an average life expectancy above 90, a study suggests.

Imperial College London and the World Health Organization analysed lifespans in 35 industrialised countries.

It predicted all would see people living longer in 2030 and the gap between men and women would start to close in most countries.

The researchers said the findings posed big challenges for pensions and care for elderly people.

"South Korea has gotten a lot of things right," Prof Majid Ezzati told the BBC News website.

"They seem to have been a more equal place and things that have benefited people - education, nutrition - have benefited most people.

"And so far, they are better at dealing with hypertension and have some of the lowest obesity rates in the world."

The data also forecasts that Japan, once the picture of longevity, will tumble down the global rankings.

It currently has the highest life expectancy for women, but will be overtaken by both South Korea and France, the study suggests. Meanwhile, male life expectancy will go from the fourth highest to eleventh out of the countries studied.
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Obese does not necessarily mean unhealthy

Obese does not necessarily mean unhealthy | The future of medicine and health |
Self-proclaimed “weight loss hypnosis master” Steve Miller has announced a campaign to see all overweight NHS staff wearing badges that read “I’m fat, but I’m losing it”. He also wants all restaurant menus to carry the warning that “if you’re fat, think before ordering”.

It would be easy to discount Miller’s campaign as a publicity stunt, but doing so would ignore the damaging consequences it is likely to have. Scientific evidence overwhelmingly demonstrates that this sort of obesity stigma is an ineffective way to reduce the incidence of obesity, and in fact perpetuates it. If this strategy supported losing weight, the obesity “epidemic” would already be over, because obese people are frequently framed as lazy, gluttonous and targets for ridicule as it is.
Body shaming

Obesity stigma, guilt, and shame reinforce high body weights and can even promote weight gain. Experiencing obesity stigma often leads people to adopt coping strategies that undermine physical health – such as comfort eating, or avoiding exercise in case they are made to feel embarrassed about their bodies. Obesity stigma has also been strongly linked with depression and compromised mental health .
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Scientists Have Figured Out How to Make Wounds Heal Without Scars

Scientists Have Figured Out How to Make Wounds Heal Without Scars | The future of medicine and health |
Whether it’s from a surgical procedure, clumsy shaving, or that traumatic biking incident that happened when you were five, just about everyone has a scar they wish would just fade away.

And while there’s not a whole lot that can be done for scars that are already there, researchers have figured out how to make fresh wounds heal as normal, regenerated skin, instead of the usual scar tissue - something that was previously thought to be impossible in mammals.

"Essentially, we can manipulate wound healing so that it leads to skin regeneration rather than scarring," said one of the team, George Cotsarelis, chair of the Department of Dermatology at the University of Pennsylvania.

"The secret is to regenerate hair follicles first. After that, the fat will regenerate in response to the signals from those follicles."

If you've ever wondered why scar tissue looks so different from regular skin, it's because scar tissue doesn't contain any fat cells or hair follicles.

The type of skin that regenerates over a small, superficial cut is filled with fat cells called adipocytes, just like the skin you were born with, which means the two will eventually blend into each other once the wound has healed.

But scar tissue is made up almost entirely of cells called myofibroblasts, and doesn't contain any fat cells at all. So instead of blending into the surrounding skin once the wound has fully healed, it looks completely different - permanently.

The same goes for ageing skin - as we age, we lose our adipocytes, which leads to discolouration and deep, irreversible wrinkles.

But scientists have discovered that existing myofibroblasts can actually be converted into adipocytes, which suggests that as a wound is healing, scar tissue could be converted to regenerated skin instead - something that scientists thought could only be possible in fish and amphibians.
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More evidence backs transposon theory of aging - Futurity

More evidence backs transposon theory of aging - Futurity | The future of medicine and health |
A new study increases and strengthens the links that have led scientists to propose the “transposon theory of aging.”

Transposons are rogue elements of DNA that break free in aging cells and rewrite themselves elsewhere in the genome, potentially creating lifespan-shortening chaos in the genetic makeups of tissues.

As cells get older, prior studies have shown, tightly wound heterochromatin wrapping that typically imprisons transposons becomes looser, allowing them to slip out of their positions in chromosomes and move to new ones, disrupting normal cell function. Meanwhile, scientists have shown that potentially related interventions, such as restricting calories or manipulating certain genes, can demonstrably lengthen lifespans in laboratory animals.
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Aging Is Reversible--at Least in Human Cells and Live Mice

Aging Is Reversible--at Least in Human Cells and Live Mice | The future of medicine and health |
New research suggests it is possible to slow or even reverse aging, at least in mice, by undoing changes in gene activity—the same kinds of changes that are caused by decades of life in humans.

By tweaking genes that turn adult cells back into embryoniclike ones, researchers at the Salk Institute for Biological Studies reversed the aging of mouse and human cells in vitro, extended the life of a mouse with an accelerated-aging condition and successfully promoted recovery from an injury in a middle-aged mouse, according to a study published Thursday in Cell.

The study adds weight to the scientific argument that aging is largely a process of so-called epigenetic changes, alterations that make genes more active or less so. Over the course of life cell-activity regulators get added to or removed from genes. In humans those changes can be caused by smoking, pollution or other environmental factors—which dial the genes’ activities up or down. As these changes accumulate, our muscles weaken, our minds slow down and we become more vulnerable to diseases.

The new study suggests the possibility of reversing at least some of these changes, a process researchers think they may eventually get to work in living humans. “Aging is something plastic that we can manipulate,” says Juan Carlos Izpisua Belmonte, the study’s senior author and an expert in gene expression at Salk. In their study Belmonte and his colleagues rejuvenated cells by turning on, for a short period of time, four genes that have the capacity to convert adult cells back into an embryoniclike state.

In living mice they activated the four genes (known as “Yamanaka factors,” for researcher Shinya Yamanaka, the Nobelist who discovered their combined potential in 2006). This approach rejuvenated damaged muscles and the pancreas in a middle-aged mouse, and extended by 30 percent the life span of a mouse with a genetic mutation responsible for Hutchinson–Gilford progeria syndrome, which causes rapid aging in children.
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Psilocybin: A Journey beyond the Fear of Death?

Psilocybin: A Journey beyond the Fear of Death? | The future of medicine and health |
In one of the largest and most rigorous clinical investigations of psychedelic drugs to date, researchers at Johns Hopkins University and New York University have found that a single dose of psilocybin—the psychoactive compound in “magic” mushrooms—substantially diminished depression and anxiety in patients with advanced cancer.

Psychedelics were the subject of a flurry of serious medical research in the 1960s, when many scientists believed some of the mind-bending compounds held tremendous therapeutic promise for treating a number of conditions including severe mental health problems and alcohol addiction. But flamboyant Harvard psychology professor Timothy Leary—one of the top scientists involved—started aggressively promoting LSD as a consciousness expansion tool for the masses, and the youth counterculture movement answered the call in a big way. Leary lost his job and eventually became an international fugitive. Virtually all legal research on psychedelics shuddered to a halt when federal drug policies hardened in the 1970s.

The decades-long research blackout ended in 1999 when Roland Griffiths of Johns Hopkins was among the first to initiate a new series of studies on psilocybin. Griffiths has been called the grandfather of the current psychedelics research renaissance, and a 21st-century pioneer in the field—but the soft-spoken investigator is no activist or shaman/showman in the mold of Leary. He’s a scientifically cautious clinical pharmacologist and author of more than 300 studies on mood-altering substances from coffee to ketamine.

Much of Griffiths’ fascination with psychedelics stems from his own mindfulness meditation practice, which he says sparked his interest in altered states of consciousness. When he started administering psilocybin to volunteers for his research, he was stunned that more than two-thirds of the participants rated their psychedelic journey one of the most important experiences of their lives.

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New Evidence Suggests Parkinson's Might Start in the Gut, Not the Brain

New Evidence Suggests Parkinson's Might Start in the Gut, Not the Brain | The future of medicine and health |
A new study adds to a growing body of research that suggests we might have been thinking about Parkinson's disease wrong this whole time.

Instead of being isolated to the brain, new evidence in mice suggests that the condition might actually start in the gut. And it could explain some of the strange coincidences seen in the disease, such as why most Parkinson's patients complain of constipation up to a decade before other symptoms arise.

Parkinson's disease is most commonly associated with tremors, stiffness, and difficulty moving, caused by neurons deep in the brain being killed off.

Although there are treatments to slow the progress of the condition, there's no way to prevent or cure it, and researchers still don't really understand what causes it and how it progresses.

For years, scientists have limited the search for the cause of Parkinson's to the brain, but a growing body of evidence suggests that might be the wrong approach.

Parkinson's might actually originate in the gut before spreading to the brain, it could explain some of the strange links researchers have seen with Parkinson's patients.

Researchers have noticed that people with Parkinson's often report constipation, as well as other digestive problems, up to 10 years before they notice tremors. There's also evidence that people with Parkinson's disease have different gut bacteria to other healthy adults.

Now a new study in mice has shown that the toxic fibres that build up around the nerve cells of Parkinson's patients can influence the nerves in the brain in a matter of weeks.

"We have discovered for the first time a biological link between the gut microbiome and Parkinson's disease," said lead researcher Sarkis Mazmanian from the Californian Institute of Technology (Caltech).
Daniel Jimenez Zulic's curator insight, January 19, 9:11 PM
ultimamente todo esta en la microbiota... sorprendente!!!
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A handful of nuts a day cuts the risk of a wide range of diseases

A handful of nuts a day cuts the risk of a wide range of diseases | The future of medicine and health |
A large analysis of current research shows that people who eat at least 20g of nuts a day have a lower risk of heart disease, cancer and other diseases.

The analysis of all current studies on nut consumption and disease risk has revealed that 20g a day - equivalent to a handful - can cut people's risk of coronary heart disease by nearly 30 percent, their risk of cancer by 15 percent, and their risk of premature death by 22 percent.

An average of at least 20g of nut consumption was also associated with a reduced risk of dying from respiratory disease by about a half, and diabetes by nearly 40 percent, although the researchers note that there is less data about these diseases in relation to nut consumption.

The study, led by researchers from Imperial College London and the Norwegian University of Science and Technology, is published in the journal BMC Medicine.

The research team analysed 29 published studies from around the world that involved up to 819,000 participants, including more than 12,000 cases of coronary heart disease, 9,000 cases of stroke, 18,000 cases of cardiovascular disease and cancer, and more than 85,000 deaths.

While there was some variation between the populations that were studied, such as between men and women, people living in different regions, or people with different risk factors, the researchers found that nut consumption was associated with a reduction in disease risk across most of them.

Study co-author Dagfinn Aune from the School of Public Health at Imperial said: "In nutritional studies, so far much of the research has been on the big killers such as heart diseases, stroke and cancer, but now we're starting to see data for other diseases.
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New AI Mental Health Tools Beat Human Doctors at Assessing Patients

New AI Mental Health Tools Beat Human Doctors at Assessing Patients | The future of medicine and health |
About 20 percent of youth in the United States live with a mental health condition, according to the National Institute of Mental Health.

That’s the bad news.

The good news is that mental health professionals have smarter tools than ever before, with artificial intelligence-related technology coming to the forefront to help diagnose patients, often with much greater accuracy than humans.

A new study published in the journal Suicide and Life-Threatening Behavior, for example, showed that machine learning is up to 93 percent accurate in identifying a suicidal person. The research, led by John Pestian, a professor at Cincinnati Children's Hospital Medical Center, involved 379 teenage patients from three area hospitals.

Each patient completed standardized behavioral rating scales and participated in a semi-structured interview, answering five open-ended questions such as "Are you angry?" to stimulate conversation, according to a press release from the university.

The researchers analyzed both verbal and non-verbal language from the data, then sent the information through a machine-learning algorithm that was able to determine with remarkable accuracy whether the person was suicidal, mentally ill but not suicidal, or neither.

“These computational approaches provide novel opportunities to apply technological innovations in suicide care and prevention, and it surely is needed,” Pentian says in the press release.
IT's curator insight, December 13, 2016 10:26 PM
I think that is it the same as tip on a result of game. If you wanna try this method, do it. 
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Bioprinting Is One Step Closer to Making a Human Kidney

Bioprinting Is One Step Closer to Making a Human Kidney | The future of medicine and health |
Bioprinting has been all over the news in the past several years with headline-worthy breakthroughs like printed human skin, synthetic bones, and even a fully functional mouse thyroid gland.

3D printing paved the way for bioprinting thanks to the printers’ unique ability to recreate human tissue structures; their software can be written to ‘stack’ cells in precise patterns as directed by a digital model, and they can produce tissue in just hours and make numerous identical samples.

Despite the progress in bioprinting, however, more complex human organs continue to elude scientists, and resting near the top of the ‘more complex’ list are the kidneys.
Kidney basics

The kidneys, bean-shaped and fist-sized, are located below the rib cage on either side of the spine and play a critical role in our day-to-day health. Each kidney cleans the blood by passing fluid and waste products through a biological filter called a nephron that blocks blood cells and important molecules like proteins. Necessary minerals are passed back to the blood, and waste exits the body in urine.

Our kidneys filter 120 to 150 quarts of blood every day, keeping the blood’s composition stable and our bodies functioning properly. Our kidneys prevent waste buildup in the body, stabilize our electrolyte levels, and produce hormones to regulate blood pressure and make red blood cells.
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Why frequent dieting makes you put on weight – and what to do about it

Why frequent dieting makes you put on weight – and what to do about it | The future of medicine and health |
People who regularly go on diets tend to lose weight initially but bounce back and even gain weight after stopping the regime. This phenomenon – dubbed yo-yo dieting – is associated with changes in metabolism and is one reason why the vast majority of calorie-based diets fail. But exactly what causes these metabolic changes has remained a mystery – until now.

Previous studies in identical twins who differed in dieting patterns have shown that non-genetic factors are largely responsible. The working hypothesis was that when you gain weight you somehow “reset” your internal thermostat corresponding to the higher weight level and so when you lose weight – your body does all it can to return to that new higher set point. Now new research, published in Nature, explains why this happens to some people more than others and, importantly, how it could be reversed.

The study, by an Israeli group of scientists, mimicked human yo-yo dieters in lab mice. The researchers fed the mice in several cycles of alternating weight gaining and losing diets. They started with big, high-fat portions to fatten them up then slimmed them down with a diet of normal, light meals, then repeated the regime. Like humans, the mice slowly gained weight compared to other mice on steady diets of similar calories – even those on continuous high-fat diets.

Mice who bounced back and had increased weight regain after dieting had a lower energy expenditure than those on steady diets but still ate the same amount of food. We know this change in body metabolism occurs in yo-yo dieters. But the new study managed to figure out why – by looking at a forgotten organ of the body.

In humans, this organ weighs nearly as much as the liver and is located in our lower intestines. It is the microbiome – the community of microbes that outnumber our cells and have a hundred-fold more genes and enzymes capable of digesting food and regulating our metabolism and immune systems. It turns out that changes to the gut microbes were responsible.
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Deleting fears from the brain means you might never need to face them

Deleting fears from the brain means you might never need to face them | The future of medicine and health |
Conventional wisdom suggest that facing your fears is a good way to overcome them, indeed various forms of therapy for fear-related conditions are based on this premise. But by using a combination of artificial intelligence (AI) and neuroscience, an international team of researchers have come up with a way to eliminate specific fears from the brain without the subject actually needing to confront them, an approach that could offer more comfortable ways of treating phobias and post-traumatic stress disorders.

According to the National Institute of Mental Health, 18 percent of US adults are diagnosed with a fear or anxiety disorder each year. A typical approach to treating such fear-related conditions is what is known as exposure therapy, where subjects are made to face their fears in a safe environment, conditioning the brain to embrace the low level or entire absence of any real danger. So somebody with a fear of flying may be shown photo after photo of airplanes, or somebody with arachnophobia may be shown images of spiders. The idea is that through repetition, the anxious response to these cues is gradually erased from the brain.

But the approach does have its flaws. By nature, this type of therapy is not exactly pleasant, and its effects are not permanent so some patients will experience relapses down the road. This has lead scientists to explore different ways to enhance the effectiveness of treatment, or take different approaches altogether.
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The Hunger Gains: Extreme Calorie-Restriction Diet Shows Anti-Aging Results

The Hunger Gains: Extreme Calorie-Restriction Diet Shows Anti-Aging Results | The future of medicine and health |
The idea that organisms can live longer, healthier lives by sharply reducing their calorie intake is not exactly new. Laboratory research has repeatedly demonstrated the anti-aging value of calorie restriction, often called CR, in animals from nematodes to rats—with the implication that the same might be true for humans.

In practice though, permanently reducing calorie intake by 25 to 50 percent or more sounds to many like a way to extend life by making it not worth living. Researchers have also warned that what works for nematodes or rats may not work—and could even prove dangerous—in humans, by causing muscle or bone density loss, for example.

But now two new studies appear to move calorie restriction from the realm of wishful thinking to the brink of practical, and perhaps even tolerable, reality. Writing in Nature Communications, researchers at the University of Wisconsin–Madison and the National Institute on Aging reported last month chronic calorie restriction produces significant health benefits in rhesus monkeys—a primate with humanlike aging patterns—indicating “that CR mechanisms are likely translatable to human health.” The researchers describe one monkey they started on a 30 percent calorie restriction diet when he was 16 years old, late middle age for this type of animal. He is now 43, a longevity record for the species, according to the study, and the equivalent of a human living to 130.

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The very microbes that helped us evolve now make us sick – Asu Erden | Aeon Ideas

Between the mid-1990s and the mid-2000s alone, the likelihood of having a classmate with a food allergy increased by 20 per cent in the United States. In fact, over the past five decades, the incidence of all allergies and autoimmune diseases – caused by your body attacking itself – has skyrocketed. What could explain our sudden hypersensitivity to our surroundings and ourselves? Since evolution operates on the timescale of millennia, the culprits lie not in our genes but somewhere within our environment.

One thing that has changed in public health is our awareness of germs and how they spread. In response to that insight, over the past half-century our implementation of hygiene practices has spared us from debilitating infections and enormous human misery. But the new vigilance might have altered the development of our immune system, the collection of organs that fight infections and internal threats to our health.

The idea that too clean an environment might be harmful has been dubbed ‘the hygiene hypothesis’. The concept has been perverted by some to suggest that the less clean the environment, the better. But its meaning is different: it is not dirt that we are missing but exposure to certain microbes that normally contribute to the development of our immune system. ‘It’s not that we aren’t exposed enough to microbes but that we’re not exposed to the right types of microbes,’ says the immunobiologist Ruslan Medzhitov at the Yale School of Medicine, also head of the Food Allergy Science Initiative at the Broad Institute.
So what has changed? In short, it’s the standard for what constitutes a good microbe versus a bad one. ‘Take bacterial species that increase nutrient absorption from food,’ Medzhitov says. These were immensely beneficial at a time where you had to go days without eating. Today in the parts of the world with an overabundance of food, having such bacteria in your intestine contributes to obesity. ‘Microbes that cause intestinal inflammation are another example of what we call bad microbes because they induce [detrimental immune] responses. But in the past, these microbes could have protected you from intestinal pathogens,’ he adds.
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This cancer-spotting algorithm rivals dermatologists - Futurity

This cancer-spotting algorithm rivals dermatologists - Futurity | The future of medicine and health |
The option of receiving a skin-cancer diagnosis by smartphone could save lives, say researchers.

It’s scary enough making a doctor’s appointment to see if a strange mole could be cancerous. Imagine, for example, that you were in that situation while also living far away from the nearest doctor, unable to take time off work, and not sure if you had the money to cover the cost of the visit.

Universal access to health care was on the minds of computer scientists when they set out to create an artificially intelligent diagnosis algorithm for skin cancer, making a database of nearly 130,000 skin disease images and training their algorithm to visually diagnose potential cancer. From the very first test, it performed with inspiring accuracy.
“We realized it was feasible, not just to do something well, but as well as a human dermatologist,” says Sebastian Thrun, an adjunct professor in the Stanford Artificial Intelligence Laboratory. “That’s when our thinking changed. That’s when we said, ‘Look, this is not just a class project for students, this is an opportunity to do something great for humanity.'”
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The Wrong Eating Habits Can Hurt Your Brain, Not Just Your Waistline

The Wrong Eating Habits Can Hurt Your Brain, Not Just Your Waistline | The future of medicine and health |
Being overweight can raise your blood pressure, cholesterol and risk for developing diabetes. It could be bad for your brain, too.

A diet high in saturated fats and sugars, the so-called Western diet, actually affects the parts of the brain that are important to memory and make people more likely to crave the unhealthful food, says psychologist Terry Davidson, director of the Center for Behavioral Neuroscience at American University in Washington, D.C.

He didn't start out studying what people ate. Instead, he was interested in learning more about the hippocampus, a part of the brain that's heavily involved in memory.

He was trying to figure out which parts of the hippocampus do what. He did that by studying rats that had very specific types of hippocampal damage and seeing what happened to them.

In the process, Davidson noticed something strange. The rats with the hippocampal damage would go to pick up food more often than the other rats, but they would eat a little bit, then drop it.

Davidson realized these rats didn't know they were full. He says something similar may happen in human brains when people eat a diet high in fat and sugar. Davidson says there's a vicious cycle of bad diets and brain changes. He points to a 2015 study in the Journal of Pediatrics that found obese children performed more poorly on memory tasks that test the hippocampus compared with kids who weren't overweight.

He says if our brain system is impaired by that kind of diet, "that makes it more difficult for us to stop eating that diet. ... I think the evidence is fairly substantial that you have an effect of these diets and obesity on brain function and cognitive function."

The evidence is growing. Research from the Cambridge Centre for Ageing and Neuroscience published in July found that obese people have less white matter in their brains than their lean peers — as if their brains were 10 years older. A more recent study from researchers at the University of Arizona supports one of the leading theories, that high body mass is linked to inflammation, which affects the brain.
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Ten people to get NHS bionic eyes - BBC News

Ten people to get NHS bionic eyes - BBC News | The future of medicine and health |
The NHS will pay for 10 blind patients to have "bionic eyes" to help treat an inherited form of blindness.

The bionic eye is a retinal implant which interprets images captured by a miniature video camera worn on a pair of glasses.

Five patients will be treated at Manchester Royal Eye Hospital and five at Moorfields Eye Hospital in 2017.

They will be monitored for a year afterwards to see how they get on in everyday life.

"I'm delighted," said Prof Paulo Stanga from the Manchester hospital.

He has been involved in earlier trials of the Argus II Bionic Eye, made by the company Second Sight, in retinitis pigmentosa.

He added: "It surpassed all of our expectations when we realised that one of the retinitis pigmentosa patients using the bionic eye could identify large letters for the first time in his adult life."

This disease, which is often passed down through families, destroys the light-sensing cells in the retina. It leads to vision loss and eventually blindness.
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Frequent sauna sessions may lower dementia risk

Frequent sauna sessions may lower dementia risk | The future of medicine and health |
We've already heard that things like special enzymes and fresh produce may help ward off Alzheimer's disease and other forms of dementia. According to new research from the University of Eastern Finland, however, you can now add "taking saunas" to that list – and the more often you take them, the better.

The university's Kuopio Ischaemic Heart Disease Risk Factor Study involved over 2,000 healthy men aged between 42 and 60, living in eastern Finland. At the start of the study period, the men were divided into three groups: those taking a sauna once a week, those taking a sauna two to three times a week, and those taking a sauna four to seven times a week.

After approximately 20 years the scientists checked back on them, to see how many test subjects from each group had developed Alzheimer's or other types of dementia. According to the university, "Among those taking a sauna four to seven times a week, the risk of any form of dementia was 66 percent lower and the risk of Alzheimer's disease 65 percent lower than among those taking a sauna just once a week."
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Human evolution 'not over yet' - BBC News

Human evolution 'not over yet' - BBC News | The future of medicine and health |
The regular use of Caesarean sections is having an impact on human evolution, say scientists.

More mothers now need surgery to deliver a baby due to their narrow pelvis size, according to a study.

Researchers estimate cases where the baby cannot fit down the birth canal have increased from 30 in 1,000 in the 1960s to 36 in 1,000 births today.

Historically, these genes would not have been passed from mother to child as both would have died in labour.

Researchers in Austria say the trend is likely to continue, but not to the extent that non-surgical births will become obsolete.

Dr Philipp Mitteroecker, of the department of theoretical biology at the University of Vienna, said there was a long standing question in the understanding of human evolution.

"Why is the rate of birth problems, in particular what we call fetopelvic disproportion - basically that the baby doesn't fit through the maternal birth canal - why is this rate so high?" he said.

"Without modern medical intervention such problems often were lethal and this is, from an evolutionary perspective, selection.

"Women with a very narrow pelvis would not have survived birth 100 years ago. They do now and pass on their genes encoding for a narrow pelvis to their daughters."
Opposing forces

It has been a long standing evolutionary question why the human pelvis has not grown wider over the years.

The head of a human baby is large compared with other primates, meaning animals such as chimps can give birth relatively easily.

The researchers devised a mathematical model using data from the World Health Organization and other large birth studies.

They found opposing evolutionary forces.

One is a trend towards larger newborns, which are more healthy.

However, if they grow too large, they get stuck during labour, which historically would have proved disastrous for mother and baby, and their genes would not be passed on.

"One side of this selective force - namely the trend towards smaller babies - has vanished due to Caesarean sections," said Dr Mitteroecker.

"Our intent is not to criticise medical intervention," he said. "But it's had an evolutionary effect. "
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Scientists Have Figured Out Why Human Skin Doesn’t Leak

Scientists Have Figured Out Why Human Skin Doesn’t Leak | The future of medicine and health |
Our skin might give us grief sometimes, but one thing we can always depend on it to do is not start indiscriminately leaking blood and sweat everywhere - despite the fact that we’re shedding roughly 500 million cells every 24 hours.

Yep, somehow we replace our entire outer layer of skin every two to four weeks, but it never leaks, and now scientists say they’ve figured out why - it’s made of a unique arrangement of shapes called tetrakaidecahedrons, which never leave a gap, even as individual cells are sloughed away.

"Our study is also helping us to see how the cells that make up our skin can switch on a mechanism to make a kind of glue, which binds the cells together, ensuring that our skin maintains its integrity," says one of the team, Reiko Tanaka, from the Imperial College London.

Tanaka and her team decided to investigate the various layers that make up the mammalian epidermis - our protective barrier of skin.

Previous studies have found that the mammalian epidermis has two main physical barriers in the top two layers of the epidermis.

Near the surface is an air-liquid interface barrier formed by the outermost layer of the skin, called the stratum corneum, and below that is a liquid-liquid interface barrier formed by tight junctions - incredibly narrow areas between tessellating skin cells that are virtually impermeable to fluid.
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Brain-fade? Your neurons might be taking a powernap

Brain-fade? Your neurons might be taking a powernap | The future of medicine and health |
We all live our lives in a daily cycle of alertness and tiredness, but the brain functions that drive this are still mostly a mystery. Stanford scientists have now uncovered a strange new finding: different sections of the brain cycle in and out of sleep all day, while you're awake, suggesting that the ability (or inability) to pay attention may be linked to brain wave cycles while asleep.

While much research has focussed on mechanisms that guide us in and out of sleep, this new study recorded the activity of columns of neurons in the brain, and noticed, for the first time, that all the neurons in each column would cycle together between phases of high and low activity.

"During an on state the neurons all start firing rapidly," says Kwabena Boahen, a senior author on the paper. "Then all of a sudden they just switch to a low firing rate. This on and off switching is happening all the time, as if the neurons are flipping a coin to decide if they are going to be on or off."

These cycles are similar to those that occur during sleep, suggesting that bits of the brain are regularly falling asleep and waking back up – a phenomenon that's been seen in birds that rest with microsleeps during long-haul flights. We may not have observed these cycles in humans before because they're hard to detect, on account of occurring in a matter of seconds or less, and the brain waves don't spread out much beyond that column of neurons.
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Now your smartphone can even analyze sperm

Now your smartphone can even analyze sperm | The future of medicine and health |
If a couple is having difficulty conceiving a child, it's important that the man get a motility test done – it shows how active his sperm are. The problem is, a lot of guys feel awkward about going to a clinic and "providing a sample" on-site. That's where Medical Electronic Systems' YO system comes in. It lets users check their motility at home (or wherever else they feel inclined to do so) using their iPhone or Galaxy smartphone.

First of all, there are indeed other male fertility tests already on the market.

According to Medical Electronic Systems, however, these typically just measure the concentration of sperm in a semen sample. If all those sperm are poor swimmers, they're not going to do much good. YO goes a step farther, by indicating what percentage of them are actually moving, and doing so in a correct manner.

The hardware end of the system consists mainly of the YO Clip, a miniature microscope which is placed over the phone's camera lens. A semen sample is subsequently put on an accompanying slide via an included pipette, then inserted into the Clip. A free iOS/Android app on the phone analyzes that sample, providing an on-screen rating of its Motile Sperm Concentration – it also shows actual video of the sperm, so users can see for themselves just how motivated they are.

YO is available now for preorder, with delivery scheduled to begin in January. It's priced at US$49.95, which includes the Clip and two slides.

Source: YO
Ziggi Ivan Santini's curator insight, December 2, 2016 3:19 AM

Smartphones can do anything these days.

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For the First Time, Living Cells Have Formed Carbon-Silicon Bonds

For the First Time, Living Cells Have Formed Carbon-Silicon Bonds | The future of medicine and health |
Scientists have managed to coax living cells into making carbon-silicon bonds, demonstrating for the first time that nature can incorporate silicon - one of the most abundant elements on Earth - into the building blocks of life.

While chemists have achieved carbon-silicon bonds before - they’re found in everything from paints and semiconductors to computer and TV screens - they’ve so far never been found in nature, and these new cells could help us understand more about the possibility of silicon-based life elsewhere in the Universe.

After oxygen, silicon is the second most abundant element in Earth’s crust, and yet it has nothing to do with biological life.

Why silicon has never be incorporated into any kind of biochemistry on Earth has been a long-standing puzzle for scientists, because, in theory, it would have been just as easy for silicon-based lifeforms to have evolved on our planet as the carbon-based ones we know and love.

Not only are carbon and silicon both extremely abundant in Earth’s crust - they’re also very similar in their chemical make-up.
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This Is How Teenage Depression and Anxiety Could Affect Your Body

This Is How Teenage Depression and Anxiety Could Affect Your Body | The future of medicine and health |
Research over the past decade has definitively shown that mental disorders such as depression aren't just in our heads - they affect our entire bodies.

And now, for the first time, scientists have mapped out which physical disorders are linked to which mental disorders in teenagers - and the results suggest that depression, anxiety, and eating disorders all leave their own physical signature marks on the body.

A new study has found that digestive system diseases and arthritis are more common after depression, and teenagers who've suffered from anxiety are more likely to go on to have skin disorders.

Now, let's be clear - this study only shows a correlation between these disorders, and no one is saying for sure that these mental disorders cause these physical issues.

But the researchers have found a link between them, which is enough to suggest that there's some kind of relationship here that's worth investigating - particularly since one in five young people in the US experience mental health issues.

To figure this out, a team from the University of Basel in Switzerland and Ruhr University Bochum in Germany looked at data on 6,483 teenagers aged between 13 and 18 in the US.
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