It was the stuff of nightmares. Six men volunteered for a clinical trial to test a new drug and within minutes were fighting for their lives. Robin McKie and Jo Revill report on the race to develop life-saving medicines ... and the grave risks that can be involved.
Originally intended for the treatment of B cell chronic lymphocytic leukemia (B-CLL) and rheumatoid arthritis, TGN1412 is a humanised monoclonal antibody that not only binds to, but is a strong agonist for, the CD28 receptor of the immune system's T cells.
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