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Bioteeth From Stemcells Will Regrow Complete Tooth, Superior to Implants

Bioteeth From Stemcells Will Regrow Complete Tooth, Superior to Implants | Tecnologia médica | Scoop.it

Replacing missing teeth with new bioengineered teeth, grown from stem cells generated from a person's own gum cells, is a new method that will be vastly superior to the currently used implant technology.

 

New research, published in the Journal of Dental Research and led by Professor Paul Sharpe, an expert in craniofacial development and stem cell biology at King's College London's Dental Institute, describes advances in the development of this method by sourcing the required cells from a patient's own gum.

 

Research towards producing bioengineered teeth, also called bioteeth, aims to grow new and natural teeth by employing stem cell technology which generates immature teeth (teeth primordia) that mimic those in the embryo. These can be transplanted as small cell pellets into the adult jaw to develop into functional teeth, the researchers say.

 

Remarkably, despite the very different environments, embryonic teeth primordia can develop normally in the adult mouth. Embryonic tooth primordia cells can readily form immature teeth following dissociation into single cell populations and subsequent recombination, but such cell sources are impractical to use in a general therapy.

 

"What is required is the identification of adult sources of human epithelialand mesenchymal [stem] cells that can be obtained in sufficient numbers to make biotooth formation a viable alternative to dental implants," said Sharpe.

 

This challenge was now solved by the researchers, who sucessfully isolated adult human gum (gingival) tissue from patients at the Dental Institute at King's College London, grew more of it in the lab, and then combined it with the cells of mice that form teeth (mesenchyme cells). By transplanting this combination of cells into mice, the researchers were able to grow hybrid human/mouse teeth containing dentine and enamel, as well as viable roots.

 

"Epithelial cells derived from adult human gum tissue are capable of responding to tooth inducing signals from embryonic tooth mesenchyme in an appropriate way to contribute to tooth crown and root formation and give rise to relevant differentiated cell types, following in vitro culture," said Sharpe.

 

"These easily accessible epithelial cells are thus a realistic source for consideration in human biotooth formation. The next major challenge is to identify a way to culture adult human mesenchymal cells to be tooth-inducing, as at the moment we can only make embryonic mesenchymal cells do this."

 

Current implant-based methods of whole tooth replacement fail to reproduce a natural root structure and as a consequence of the friction from eating and other jaw movement, loss of jaw bone can occur around the implant.


Via Dr. Stefan Gruenwald
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Jennifer Frezza 's curator insight, December 8, 2013 6:28 PM

Isn't science amazing?

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Pissenlit vertus thérapeutiques | Bienfaits, Vertus, Posologie, Danger

Pissenlit vertus thérapeutiques | Bienfaits, Vertus, Posologie, Danger | Tecnologia médica | Scoop.it
Muitas vezes, atravessa o dente de leão em pé país. É facilmente identificável por suas folhas, característica [...]

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La medicina en los dispositivos móviles - hi-tech

En esta sala, se encuentra el futuro de las consultas médicas. ... Euronews, el canal de noticias mas visto en Europa. Abónese a su dosis diaria de noticias ...
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Le piment rouge et Capsicum | Bienfaits, Vertus, Posologie, Danger

Le piment rouge et Capsicum | Bienfaits, Vertus, Posologie, Danger | Tecnologia médica | Scoop.it
Le piment a du piquant ! Et vous, quelles sont vos recettes pimentées préférées[…]

Via Rafaele Sgrillo
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