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First time ever: Researchers rewrite an entire bacterial genome and add a healthy twist

First time ever: Researchers rewrite an entire bacterial genome and add a healthy twist | Technology & Business | Scoop.it

Scientists from Yale and Harvard have recoded the entire genome of an organism and improved a bacterium’s ability to resist viruses, a dramatic demonstration of the potential of rewriting an organism’s genetic code.

“This is the first time the genetic code has been fundamentally changed,” said Farren Isaacs, assistant professor of molecular, cellular, and developmental biology at Yale and co-senior author of the research published Oct. 18 in the journal Science. “Creating an organism with a new genetic code has allowed us to expand the scope of biological function in a number of powerful ways.”

 

The creation of a genomically recoded organism raises the possibility that researchers might be able to retool nature and create potent new forms of proteins to accomplish a myriad purposes — from combating disease to generating new classes of materials.

 

The research — headed by Isaacs and co-author George Church of Harvard Medical School — is a product of years of studies in the emerging field of synthetic biology, which seeks to re-design natural biological systems for useful purposes.

 

In this case, the researchers changed fundamental rules of biology.

Proteins, which are encoded by DNA’s instructional manual and are made up of 20 amino acids, carry out many important functional roles in the cell. Amino acids are encoded by the full set of 64 triplet combinations of the four nucleic acids that comprise the backbone of DNA. These triplets (sets of three nucleotides) are called codons and are the genetic alphabet of life.

 

Isaacs, Jesse Rinehart of Yale, and the Harvard researchers explored whether they could expand upon nature’s handywork by substituting different codons or letters throughout the genome and then reintroducing entirely new letters to create amino acids not found in nature. This work marks the first time that the genetic code has been completely changed across an organism’s genome.

 

In the new study, the researchers working with E. coli swapped a codon and eliminated its natural stop sign that terminates protein production. The new genome enabled the bacteria to resist viral infection by limiting production of natural proteins used by viruses to infect cells. Isaacs — working with Marc Lajoie of Harvard, Alexis Rovner of Yale, and colleagues — then converted the “stop” codon into one that encodes new amino acids and inserted it into the genome in a plug-and-play fashion. 

 

The work now sets the stage to convert the recoded bacterium into a living foundry, capable of biomanufacturing new classes of  “exotic” proteins and polymers. These new molecules could lay the foundation for a new generation of materials, nanostructures, therapeutics, and drug delivery vehicles, Isaacs said.

 

“Since the genetic code is universal, it raises the prospect of recoding genomes of other organisms,” Isaacs said. “This has tremendous implications in the biotechnology industry and could open entirely new avenues of research and applications.”


Via Dr. Stefan Gruenwald
odysseas spyroglou's insight:

The brave new world starts here. I hope we'll find our way to a less dystopian future.

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Dmitry Alexeev's curator insight, October 20, 2013 4:18 AM

thats a new generation biological tool although there has been already attempts to encode non-standard amino acids - but never before on a full genome scale - intrestingle how soon wilkl this be available as a conventional instrument? this is a novel scientific tool - which will among others help us to study life

Leire Tapia's curator insight, October 21, 2013 4:08 PM

He elegido esta noticia porque la relaciono con la libertad de investigación. Es un derecho vinculado al ser humano y es un derecho exigible. Es también importante comunicar los resultados y no caer en el peligro de la censura. No hay que esconder lo que la ciencia descubre pero si es importante establecer límites relacionados con la protección de la salud y con la dignidad humana.

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Rescooped by odysseas spyroglou from Quantified Self, Data Science, Digital Health, Personal Analytics, Big Data
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To Nail Your New Year's Resolutions, Quantify Your Self

To Nail Your New Year's Resolutions, Quantify Your Self | Technology & Business | Scoop.it
TO NAIL YOUR NEW YEAR'S RESOLUTIONS, QUANTIFY YOUR SELF

Via Tictrac
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You can't really improve if you can't measure it.

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This marketing platform helped Samsung beat Apple ... and predicts the future with 78% accuracy

This marketing platform helped Samsung beat Apple ... and predicts the future with 78% accuracy | Technology & Business | Scoop.it
Facebook wants to be the social layer for the web. Google wants to be the discovery layer, and PayPal wants to be the financial layer. Networked Insights, however, wants to be the consumer inten...
odysseas spyroglou's insight:
It's a very interesting article and a company to keep in mind. Maybe the future in business is not that uncertain (if you can afford the "oracle" that is).
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A European in San Francisco

A European in San Francisco | Technology & Business | Scoop.it
San Francisco is considered one of the most beautiful cities of the USA. It's picturesque, it's traditional, it's progressive, open to diversity, full of colour and images. It is said that it is on...
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#Launch me up

#Launch me up | Technology & Business | Scoop.it

REaIt's been a couple of days since we were in San Francisco, participating in an event that was both inspiring and awakening. How else can you describe the speed and abundance of information you are ...

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Read about #launch one of the biggest startup events. it's been almost a month but it's still like yesterday.

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Health Service In Crisis - March 2014 Gamification and Immersive Te...

Health Services in Crisis? Can Gamification Make a Difference? As I prepare to journey to Asia to speak at conference in Thailand, Malaysia and Korea, this m...
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This is quite interesting and it seems that gamification is here to stay. 

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What You Think You Know About the Web Is Wrong | TIME

What You Think You Know About the Web Is Wrong | TIME | Technology & Business | Scoop.it
If you’re an average reader, I’ve got your attention for 15 seconds, so here goes: We are getting a lot wrong about the web these days. We confuse what people have clicked on for what they’ve read. We mistake sharing for reading.
odysseas spyroglou's insight:

Not everything is as it seems. Pageviews and clicks and visitors are just metrics and it seems that they are more or less outdated. Attracting Attention is what matters.

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Lego Serious Play is not a game.

Lego Serious Play is not a game. | Technology & Business | Scoop.it
How Liquid is using Lego blocks to help clients find creative solutions to business and brand challenges. Lego Serious Play is a hands-on, experiential process designed to enhance innovation and
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How an iconic child's play can become a creativity tool.

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The Complete Quantitative Guide To Judging Your Startup | TechCrunch

The Complete Quantitative Guide To Judging Your Startup | TechCrunch | Technology & Business | Scoop.it
Raising capital from investors is often a frustrating experience. While part of that frustration will always be present when working on high-risk projects, a..
odysseas spyroglou's insight:

This one may be recommended for startups, but in fact I can see real value in these metrics even for more established companies.

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4 Benefits of Sales Gamification

4 Benefits of Sales Gamification | Technology & Business | Scoop.it
Although it has its share of critics, gamification can energize your sales team and foster a more collaborative office environment.
odysseas spyroglou's insight:

Everything should be fun. Gamification can be applied even to sectors that we never thought off. (Not that this is the case).

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The Entrepreneur Test - do you have the traits of an entrepreneur? - Enternships Resource Zone

The Entrepreneur Test - do you have the traits of an entrepreneur? - Enternships Resource Zone | Technology & Business | Scoop.it
We’ve been chatting rather a lot with our pals at the New Entrepreneur Foundation recently, as they open their cohort for the next year of entrepreneurial super-stardom. But how do you know whether you’re right for such a challenge? Sure it’s easy to look back at the glittering careers of Steve Jobs and Bill Gates …
odysseas spyroglou's insight:

Entrepreneur is surely not an easy profession and unfortunately the business culture in Europe is not that forgiving as the one in USA. But in any case it's an interesting and never boring choice. 

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18 Essential Hadoop Tools for Crunching Big Data

18 Essential Hadoop Tools for Crunching Big Data | Technology & Business | Scoop.it
Making the most of this powerful MapReduce platform means mastering a vibrant ecosystem of quickly evolving code.
odysseas spyroglou's insight:

Big data is everywhere now days. Hadoop was the beginning.

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odysseas spyroglou's curator insight, December 5, 2013 12:35 PM

Big data need their tools.

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Why video is the next big thing in big data

Why video is the next big thing in big data | Technology & Business | Scoop.it
One of the big themes at our Structure Data conference in March is the advent of new techniques to make sense of new data sources. One of the most-promising is video, which had value well beyond capturing crimes and making us laugh on YouTube.
odysseas spyroglou's insight:

Video comes to the big data domain.

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Such DFW. Very Orwell. So Doge. Wow. | TechCrunch

Such DFW. Very Orwell. So Doge. Wow. | TechCrunch | Technology & Business | Scoop.it
Let's talk about doge, but first let's talk about the late great David Foster Wallace, who thirteen years ago wrote a classic essay about modern English*..
odysseas spyroglou's insight:

Maybe it's time to bring plain and simple, elegant language to our everyday communications.

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Watch Your Figures: How to Use Numbers To Tell A Story | Klout Blog

Watch Your Figures: How to Use Numbers To Tell A Story | Klout Blog | Technology & Business | Scoop.it
In an age of 140-character limits and fierce competition for social feed mindshare, using numbers to craft short and powerful stories is a necessary skill.
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Some great advice about how numbers can boost the impact of a story.

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How to Make Sure There's a Market for Your Business Idea

How to Make Sure There's a Market for Your Business Idea | Technology & Business | Scoop.it
No matter how great your idea, if you don't have a solid market, you're wasting your time. Here are four ways to be more strategic about...
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Excellent advices when starting a new idea.
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There's no future in on-premises IT -- it's time to move to the cloud

There's no future in on-premises IT -- it's time to move to the cloud | Technology & Business | Scoop.it
If you think virtualization skills mean your future as an IT admin is secure, you're sadly mistaken
odysseas spyroglou's insight:

IT administration as we know it is changing. Older IT admins need to change asap and embrace new ideas and technologies.

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Endeavor Greece | Greek startup scene at a glance

Endeavor Greece | Greek startup scene at a glance | Technology & Business | Scoop.it

Endeavor Greece, a global non-profit organization supporting entrepreneurship, presents interesting numbers and results for startups in Greece, in the framework of the increased activity of the previous years and the intense discourse on the issue.
The number of startups has increased significantly in comparison to 2010. In particular, 16 startups were founded in 2010 and this number was ten times higher in 2013. There is a similar increase of funds invested in startups for the same period. In particular, investment in 2013 reached €42 million, 80 times higher versus 2010, raised by 30 companies when it was just €500.000.
The impact of Jeremie funds, invested to several startups through four companies, Elikonos, Odyssey, Open Fund and PJ Tech Catalyst, is of course very significant. The results are obvious in both Greece-based investments that were equal to the 72% of the total and seed investment (69% of total) in 2013, as well as the distribution of funds by sector. In particular, technology companies have raised 50% of the total investment in 2013.

odysseas spyroglou's insight:

This can only be a good thing. I hope the government will stay out of this.

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Silicon Valley’s Youth Problem

Silicon Valley’s Youth Problem | Technology & Business | Scoop.it
In start-up land, the young barely talk to the old (and vice versa). That makes for a lot of cool apps. But great technology? Not so much.
odysseas spyroglou's insight:
It's a long article, but it's worth reading it. It's true that what is hot and sexy in the startup world today does necessary solves the worlds problems. But hopefully will get there.
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Create infographics & online charts | infogr.am

Create infographics & online charts | infogr.am | Technology & Business | Scoop.it
Create infographics and interactive online charts. It's free and super-easy!
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EUROPA - PRESS RELEASES - Press release - Commission to pursue role as honest broker in future global negotiations on Internet Governance

EUROPA - PRESS RELEASES - Press release - Commission to pursue role as honest broker in future global negotiations on Internet Governance | Technology & Business | Scoop.it
European Commission - Press Release details page - European Press release Brussels, 12 February 2014 Commission In the wake of large-scale Internet surveillance and reduced trust in the internet, the European Commission today proposes a key reform to the way the Internet is managed and run. The proposal calls for more transparent, accountable and inclusive governance. Commission Vice-President
odysseas spyroglou's insight:

Internet governance. Internet needs management and somebody got to do it.

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Access to Information, Privacy Protection and Freedom of Speech | News | eEnviPer

Access to Information, Privacy Protection and Freedom of Speech | News | eEnviPer | Technology & Business | Scoop.it

In eEnviPer's fifth White Paper, Ivan Vučetić of Evrogeomatika explains how the governments can manage ethical and legal issues arising from the use of cloud computing software like eEnviPer.  - See more at: http://eenviper.eu/news/29#sthash.tjJEdCop.dpuf

odysseas spyroglou's insight:

The world is gradually getting an ever present and much alive online layer. We have to consider all implications.

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The World's Top 10 Most Innovative Companies in Retail

The World's Top 10 Most Innovative Companies in Retail | Technology & Business | Scoop.it
No industry has been more transfigured in the past year than retail. Stores now behave like websites, tracking customers as they browse. American...
odysseas spyroglou's insight:

Innovations does not should not stop in technology. Retail is an enormous market that affects each and everyone. And btw brick and mortar retail business is growing worldwide faster than the online one.

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Rescooped by odysseas spyroglou from Computer games
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The State Of Social Business - Schaefer Marketing Solutions: We Help Businesses {grow}

The State Of Social Business - Schaefer Marketing Solutions: We Help Businesses {grow} | Technology & Business | Scoop.it
New research shows companies investing heavily in social media but just 25 percent reporting a commensurate increase in revenues.

Via Jeremy Cooke
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Social business and growth.

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Jeremy Cooke's curator insight, February 4, 2014 9:58 AM

Social media requires digital creativity to be effective - game dev second nature ? 

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Design Does Matter

Design Does Matter | Technology & Business | Scoop.it
I bought my first computer back in 1984. It was one of the first models of, the iconic today, ZX Spectrum. A home computer that probably launched the revolution of personal computing in Europe (alo...
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The importance of design in technology and everyday life.

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A (Nearly) Complete Online Toolkit For Startups

A (Nearly) Complete Online Toolkit For Startups | Technology & Business | Scoop.it
Starting a company isn't just about product--it's also about project management finances payroll customer support and a bunch of other things that...
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A bunch of tools not only for startups but for every small (and even larger) company.

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