Rodent Models In Research
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Phenotyping human diseases in mice: an interview with Professor Carola Vinuesa - News-Medical.net

Phenotyping human diseases in mice: an interview with Professor Carola Vinuesa - News-Medical.net | Rodent Models In Research | Scoop.it
One of the main obstacles to finding effective therapies for human diseases has been our limited understanding of disease pathogenesis: we lack detailed knowledge of the cellular and molecular mechanisms that lead to the development of disease.
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Should We Trust Studies On Mice?

Over the last century, 95% of all medical experiments have been done on lab mice. But are they the perfect laboratory stand-in for humans? Some recent studies may suggest otherwise. Read...
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Mice discriminate partial sounds just as humans do with partial words - Phys.Org

Mice discriminate partial sounds just as humans do with partial words - Phys.Org | Rodent Models In Research | Scoop.it
Micheal L. Dent, a University at Buffalo psychologist, listens to what is inaudible to others. And what she's hearing might one day help us better understand human hearing loss.
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Diabetes reversed in mice by using stem cells - BioNews

Diabetes reversed in mice by using stem cells - BioNews | Rodent Models In Research | Scoop.it
Tech Times
Diabetes reversed in mice by using stem cells
BioNews
Stem cells have reversed the equivalent of type 1 diabetes in genetically modified mice.
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Brilliant blue G may shine in treating traumatic brain injuries - ECNmag.com

ECNmag.com Brilliant blue G may shine in treating traumatic brain injuries ECNmag.com They'll also be looking again at the efficacy of brilliant blue G at stopping the crescendo by giving it up to eight hours after the initial injury in their...
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Study finds liver tumors in mice exposed to low levels of BPA - Michigan Radio

Study finds liver tumors in mice exposed to low levels of BPA - Michigan Radio | Rodent Models In Research | Scoop.it
Study finds liver tumors in mice exposed to low levels of BPA
Michigan Radio
Dolinoy and her team found liver tumors in mice exposed to BPA from their mothers when they were fetuses, and through nursing.
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Cognition and behavior: Epilepsy drug alters rodent gut - SFARI News

Cognition and behavior: Epilepsy drug alters rodent gut - SFARI News | Rodent Models In Research | Scoop.it
Cognition and behavior: Epilepsy drug alters rodent gut
SFARI News
... composition of gut bacteria in rodents, according a study published 11 December in Brain Behavior and Immunity1.
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Shining a Light on Pain - MIT Technology Review

Shining a Light on Pain - MIT Technology Review | Rodent Models In Research | Scoop.it
Shining a Light on Pain
MIT Technology Review
In the Stanford group's latest work, published in the journal Nature Biotechnology, they first used gene therapy to install light-sensitive molecules into the nerve endings in the skin of mice.
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Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism ... - Science Careers Blog (subscription)

Medical Daily
Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism ...
Science Careers Blog (subscription)
In mammals, a class of neurons in the brain normally switches from excitatory to inhibitory functions at birth.
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Drug calms overly excitable brains in autism rodent models - SFARI News

Drug calms overly excitable brains in autism rodent models - SFARI News | Rodent Models In Research | Scoop.it
Medical Daily
Drug calms overly excitable brains in autism rodent models
SFARI News
The blood pressure drug bumetanide normalizes a deficit in brain activity in two rodent models of autism, according to a study published last week in Science1.
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Mice Study Links BPA, Cancer - Laboratory Equipment

Mice Study Links BPA, Cancer - Laboratory Equipment | Rodent Models In Research | Scoop.it
Financial Express
Mice Study Links BPA, Cancer
Laboratory Equipment
In one of the first studies to show a significant association between BPA and cancer development, Univ.
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Scientists identify memory-boosting molecule in mice - Apple Balla

Scientists identify memory-boosting molecule in mice - Apple Balla | Rodent Models In Research | Scoop.it

Los Angeles, June 15 — Scientists have identified a key memory-enhancing molecule in mice that could pave the way for boosting cognitive functions in humans, says a study.
Read more at http://www.appleballa.com/2013/06/95858/scientists-identify-memory-boosting-molecule-mice#f8yRdK3Mm2ACIyg4.99


Via Sheila Weeks
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BRAF Research in Mice Could Pave Way for Future Colorectal Cancer Treatments

BRAF Research in Mice Could Pave Way for Future Colorectal Cancer Treatments | Rodent Models In Research | Scoop.it

Researchers have been examining colorectal cancer tumors in mice with mutations in the BRAF gene to identify possible treatment options for humans with the same mutation. They replaced the normal BRAF gene with a mutated version identical to the one seen in human colorectal cancer cases, and noted that the mice soon developed polyps, abnormal growths in the intestine, that transformed from benign growths to malignant tumors. The researchers also discovered a step-driven pathway of mutations that drives this transformation. Mutations such as the one that activates the BRAF gene tell mutated cells to grow and divide, and other mutations disrupt and inhibit proteins like p53 that are designed to protect the body by suppressing cancer progression. This allows the cancer to grow at a steady pace, not precluded by the body’s natural defense mechanisms. Researchers tested the mice with combinations of different drugs, and found that mice had very similar responses to humans with the BRAF mutation.


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Cancer Commons's curator insight, July 11, 2013 3:59 PM

Medical Xpress | Jul 8, 2013

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Of mice and men: Comparing genetics raises new questions about reliability of ... - Genetic Literacy Project

The laboratory mouse really lies at the foundation of numerous life science studies, but is it an appropriate model in all cases?
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A derivative of vitamin B3 found to prevent liver cancer in mice

A derivative of vitamin B3 found to prevent liver cancer in mice | Rodent Models In Research | Scoop.it
Liver cancer is one of the most frequent cancers in the world, and with the worst prognosis; according to the World Health Organisation (WHO), in 2012, 745,000 deaths were registered worldwide...
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Hybrid chemical / genetic therapy restores light sensitivity to retina in ... - Medical Xpress

Hybrid chemical / genetic therapy restores light sensitivity to retina in ... - Medical Xpress | Rodent Models In Research | Scoop.it
A new genetic therapy helped blind mice and dogs regain some sensitivity to light - enough for the mice to distinguish flashing from non-flashing lights - setting the stage for future clinical trials in humans.
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Autism Cure By Lowering Chloride: New Drug Prevents Autism In Mouse Model ... - Medical Daily

Medical Daily
Autism Cure By Lowering Chloride: New Drug Prevents Autism In Mouse Model ...
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NIH-funded researchers use antibody treatment to protect humanized mice from ... - EurekAlert (press release)

UPI.com (blog)
NIH-funded researchers use antibody treatment to protect humanized mice from ...
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To fight muscular dystrophy, nanoparticles target cells that choke themselves ... - FierceDrugDelivery

To fight muscular dystrophy, nanoparticles target cells that choke themselves ... - FierceDrugDelivery | Rodent Models In Research | Scoop.it
To fight muscular dystrophy, nanoparticles target cells that choke themselves ...
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Molecular Brain | Abstract | Deep-brain magnetic stimulation ...

Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders. Yan Zhang, Rong-Rong Mao, Zhi-Fang Chen, Meng Tian, ...
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Researchers rejuvenate stem cell population from elderly mice, enabling muscle ... - Science Codex

Researchers rejuvenate stem cell population from elderly mice, enabling muscle ... - Science Codex | Rodent Models In Research | Scoop.it
DigitalJournal.com
Researchers rejuvenate stem cell population from elderly mice, enabling muscle ...
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Yogurt-eating mice found to have larger testicles

Yogurt-eating mice found to have larger testicles | Rodent Models In Research | Scoop.it
Research suggests certain probiotic bacterium causes elderly mice to experience increased testosterone levels (And in other news "@ElementsMatter Yogurt-eating mice found to have larger testicles - http://t.co/ztOmimRORO)...
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NASA Chief Scientist Ellen Stofan '83 touches down in her old department - William and Mary News

NASA Chief Scientist Ellen Stofan '83 touches down in her old department - William and Mary News | Rodent Models In Research | Scoop.it
William and Mary News NASA Chief Scientist Ellen Stofan '83 touches down in her old department William and Mary News In two months, we're sending up our first rodent lab to do all kinds of cool genetics research.” She explained that NASA's science...
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Antioxidants speed cancer in mice - Nature.com

Antioxidants speed cancer in mice - Nature.com | Rodent Models In Research | Scoop.it
Nature.com
Antioxidants speed cancer in mice
Nature.com
A study in mice has found that two commonly used antioxidants — vitamin E and a compound called N-acetylcysteine (NAC) — speed the growth of lung cancer rather than curb it.
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Virus-associated activation of innate immunity induces rapid disruption of Peyer's patches in mice

Virus-associated activation of innate immunity induces rapid disruption of Peyer's patches in mice | Rodent Models In Research | Scoop.it
Here we investigate the influence of virus-associated innate immune activation on lymphocyte distribution in secondary lymphoid organs. We show for the first time that virus infection of mice induces rapid disruption of the ...

Via Gilbert C FAURE
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