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Scooped by idtdna onto syntheticbio |
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One of the major goals of the emerging area of synthetic biology is to design and build engineered biological systems in a reliable way, as engineers today design integrated circuits based on the known physical properties of their materials. It is foreseeable, thereby, that the last two steps in such a workflow would be to convert a large digitized sequence stored in a computer into a real DNA molecule (as large as a chromosome) and then to install it in the right contextual host.
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gBlocks™ Gene Fragments are double-stranded, sequence-verified genomic blocks up to 500 bp in length that can be shipped in 4–6 working days for affordable and easy gene construction or modification. With gBlocks Gene Fragments, IDT has developed a new tool that makes Synthetic Biology easier and more accessible than ever for any lab. Delete the scoop?
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If a new and deadly strain of influenza were to arise, putting together a vaccine against it in the least possible time would be a priority. To test how quickly that could be done a group of researchers have just had a race with themselves. They have not quite matched the show sometimes given by workers at the Venetian arsenal, who would assemble a galley in a single day in order to overawe visiting foreign dignitaries. But Philip Dormitzer, Craig Venter and their colleagues did create the crucial component of a flu jab in four days and four hours. Delete the scoop?
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Advanced genetic engineering is already changing vaccine development and could make inroads into other branches of medicine. Delete the scoop?
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The Biotechnology and Biological Sciences Research Council (BBSRC) is contributing €3M as a major partner in a new Europe-wide call for research projects in Synthetic Biology. The call is the first from the Synthetic Biology ERA-NET (ERASynBio) - a project designed to enhance European Synthetic Biology research through joint policy making, community building and training, and transnational funding. Delete the scoop?
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Venue: Stata Center, MIT, Cambridge, Massachusetts, USADate: Saturday morning, May 11 to Sunday noon May 12, 2013 Recognizing the fast emergence and potential significance of this field, the aim of this workshop is to bring together practitioners of mammalian synthetic biology together with experts from other relevant fields. The general goals of the workshop are to nucleate the nascent mammalian synthetic biology community, reach out to experts from other fields that can benefit from and contribute to this field, and define the important challenges and future directions. The workshop format will provide a forum for exposition of the latest developments in the field and discussions of how experts from other fields can benefit from and contribute to mammalian synthetic biology. Perhaps more importantly, the workshop will also include breakout sessions that will identify the main challenges and opportunities. Findings from the breakout sessions will be assembled into a written report that will be distributed to all workshop participants and to relevant government and funding agencies. The agenda on Saturday will include several 30 minute talks about mammalian synthetic biology tools and capabilities, talks about industrial and clinical applications, and two sets of breakout sessions. Delete the scoop?
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Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, served as one of the key sponsors for the 2012 International Genetically Engineered Machine Competition (iGEM). The competition, which encourages innovative research for the design and build of functional biological systems within living cells, saw 191 undergraduate teams from different nationalities register for the 2012 event. IDT provided the young research teams with access to their high-quality oligo products, including primers and synthetic genes, and was delighted to have 3 of their sponsored teams placed in the top 4 positions, with some impressive, novel bio-engineering models—an exciting prospect for future biological applications of the IDT product range. Via Socrates Logos Delete the scoop?
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Interview with George Church, Professor of Genetics at Harvard Medical School, where he discusses the Glowing Plant project and the potential of Synthetic Biology and DIY Bio. Delete the scoop?
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Create GLOWING PLANTS using synthetic biology and Genome Compiler's software - the first step in creating sustainable natural lighting. Delete the scoop?
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A team of Yale undergraduates has discovered the structure of of the most powerful known antifreeze to date. Delete the scoop?
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It sounds like science fiction but a team from the University of Exeter, with support from Shell, has developed a method to make bacteria produce diesel on demand. While the technology still faces many significant commercialisation challenges, the diesel, produced by special strains of E. coli bacteria, is almost identical to conventional diesel fuel. Delete the scoop?
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Could synthetic biology be used to develop heat-resistant coral? Could it bring back over-exploited fish stocks? If the answer is yes...should we? Delete the scoop?
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But worries persist about unintended consequences of tinkering with nature. Delete the scoop?
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Arizona State University is beginning to establish its place on the map in the burgeoning field of synthetic biology. Delete the scoop?
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MIT engineers have created synthetic biology circuits that can perform analog computations such as taking logarithms and square roots in living cells. Delete the scoop?
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“It’s undergraduate research, but we’re not treated like undergraduates,” said 19-year-old Josh Leehan, a second-year biology student. Delete the scoop?
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Full video of the March 25, 2013, event co-sponsored by Synberc and DISCOVER Magazine. Delete the scoop?
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Hoping to give new meaning to the term “natural light,” a small group of biotechnology hobbyists and entrepreneurs has started a project to develop plants that glow, potentially leading the way for trees that can replace electric streetlamps and potted flowers luminous enough to read by. Delete the scoop?
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Following the announcement of £600M capital investment for Research Councils in the autumn 2012 statement, a joint call will shortly be launched for multidisciplinary research centres in synthetic biology. The call has been developed by the RCUK Synthetic Biology Working Group, and will be supported by BBSRC and EPSRC, with BBSRC administering the call. Delete the scoop?
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As research into synthetic biology increases, this map identifies companies, universities, research institutions, laboratories and other centers across the globe that are active in this emerging field. Delete the scoop?
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Both bizarre and beneficial, the following article highlights some truly fascinating and pragmatic examples of modern genetic engineering. Delete the scoop?
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An interview with the synthetic biologist Christina Agapakis Delete the scoop?
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Kickstarter might be better known for funding films and hardware projects, but it’s now getting its first synthetic biology proposal. A Singularity University alum, a Stanford post-doc and a Stanford Ph.D. are looking to use synthetic biology and software from startup Genome Compiler to creating plants that glow. Delete the scoop?
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Synthetic biology is often referred to as “the field of the future,” the foundation of fuels, materials, medicines, as well as the way we produce knowledge of biological systems. But while the self-consciously revolutionary language of synthetic biology declares a change of the industrial status quo, the metaphors we rely on are explicit references to the successful revolutions of past industrial technologies. The term synthetic biology echoes the successes of synthetic chemistry, while the guiding concept of standardization in genetic components is modeled on 19th century standardization of interchangeable parts. Industrial metaphors mix further as we climb the abstraction hierarchy; genetic parts are assembled to fit into a cellular chassis, creating logic gates and circuits that can compute biological information, leading to the control of cellular factories, rapidly designed, built, and commercialized on an “Ikea”-like scale. Delete the scoop?
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Scientists have developed a new type of nanoparticle with potential applications in chemistry, biology and medicine. Delete the scoop?
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Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use short RNA to direct degradation of foreign nucleic acids. Here, we engineer the type II bacterial CRISPR system to function with custom guide RNA (gRNA) in human cells. For the endogenous AAVS1 locus, we obtained targeting rates of 10 to 25% in 293T cells, 13 to 8% in K562 cells, and 2 to 4% in induced pluripotent stem cells. We show that this process relies on CRISPR components; is sequence-specific; and, upon simultaneous introduction of multiple gRNAs, can effect multiplex editing of target loci. We also compute a genome-wide resource of ~190 K unique gRNAs targeting ~40.5% of human exons. Our results establish an RNA-guided editing tool for facile, robust, and multiplexable human genome engineering. Delete the scoop?
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