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What if we build a different genome?

What if we build a different genome? | Synthetic Biology | Scoop.it

As biologists continue the decadeslong race to map the genomes of living things, a group of forward-thinking BU engineers is asking the kind of questions that engineers can’t help but ask: what if we built a different genome?


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Synthetic Biology
All about the growing field of synthetic biology
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iGEM Students Engineer Biological Tools for a Better World

iGEM Students Engineer Biological Tools for a Better World | Synthetic Biology | Scoop.it

The International Genetically Engineered Machine competition (iGEM) is the preeminent, multinational, undergraduate synthetic biology competition that takes place each year. The competition focuses on engineering aspects of synthetic biology as a foundation to develop research skills and foster collaboration among student participants. The duration of the competition is fairly short, with most of the work occurring over the summer months, when most students take time off from their studies. It is truly impressive the types of relevant world issues for which the teams are able to address and test solution in such a short time.

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Designer viruses could be the new antibiotics

Designer viruses could be the new antibiotics | Synthetic Biology | Scoop.it
Bacterial infections remain a major threat to human and animal health. Worse still, the catalogue of useful antibiotics is shrinking as pathogens build up resistance to these drugs. There are few promising new drugs in the pipeline, but they may not prove to be enough. Multi-resistant organisms – also called “superbugs” – are on the rise and many predict a gloomy future if nothing is done to fight back.
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Cancer-Detecting Yogurt Could Replace Colonoscopies

Cancer-Detecting Yogurt Could Replace Colonoscopies | Synthetic Biology | Scoop.it

Engineered yogurt bacteria could make detecting colorectal cancer and other diseases as simple as a pregnancy test.

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A new study on how to engineer synthetic gene networks, recreates the stripe patterns found in animals, using bacteria

A new study on how to engineer synthetic gene networks, recreates the stripe patterns found in animals, using bacteria | Synthetic Biology | Scoop.it

Pattern formation is essential in the development of animals and plants. The central problem in pattern formation is how can genetic information be translated in a reliable manner to give specific spatial patterns of cellular differentiation.

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Timothy Lu - Accelerating the engineering of life for human health applications

Broad View: Timothy Lu - Accelerating the engineering of life for human health applications

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Turbo Tobacco Borrows Bacteria Genes for Faster Photosynthesis

Turbo Tobacco Borrows Bacteria Genes for Faster Photosynthesis | Synthetic Biology | Scoop.it

A team of British and American biologists has successfully infused tobacco plants with bacterial genes—paving the way for turbocharged crops that grow faster with less fertilizer.

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Macquarie University undergraduate science students to compete in world’s premier synthetic biology competition

Macquarie University undergraduate science students to compete in world’s premier synthetic biology competition | Synthetic Biology | Scoop.it

Twelve undergraduate biomolecular science students from Macquarie University are set to compete in the International Genetically Engineered Machine (iGEM) competition, which will draw students from around the world to a jamboree style event in Boston, Massachusetts, in late October.

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Scientists create renewable fossil fuel alternative using bacteria

Scientists create renewable fossil fuel alternative using bacteria | Synthetic Biology | Scoop.it

Researchers have engineered the harmless gut bacteria E.coli to generate renewable propane.

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Andrew Hessel: Biotechnology, Genetic Engineering and Future of Life Science

Andrew Hessel: Biotechnology, Genetic Engineering and Future of Life Science | Synthetic Biology | Scoop.it

Andrew Hessel is the Distinguished Researcher with Autodesk and co-chair of Bioinformatics and Biotechnology at the Singularity University.

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Microbial DNA, Biobricks and Body Odor, My Post Grad Year with iGEM Paris Bettencourt

Microbial DNA, Biobricks and Body Odor, My Post Grad Year with iGEM Paris Bettencourt | Synthetic Biology | Scoop.it

The iGEM, or International Genetically Engineered Machine, competition offers a platform for university students across the world interested in synthetic biology to work on creative projects centered around the foundation of synthetic biology: streamlining biology into an engineering science and building biological systems from standard parts that are operated in living cells.

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Yeast turned into morphine and opioid biofactories

Yeast turned into morphine and opioid biofactories | Synthetic Biology | Scoop.it

Scientists hope that biotech route could protect the drug supply chain from harvest failures and problems with illicit use

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Engineered Bacteria Stick To Cancer Cells

Engineered Bacteria Stick To Cancer Cells | Synthetic Biology | Scoop.it

Synthetic Biology: Researchers modified bacterial proteins called adhesins to target proteins expressed on human cells

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Rakesh Yashroy's curator insight, August 20, 8:53 AM

Host-pathogen interface shows how bacterial pathogens get virulent to attack the host cells @ https://www.academia.edu/7328964/YashRoy_R_C_1992_Salmonella_3_10_r_-_surface_interactions_with_intestinal_epithelial_microvilli.Indian_Journal_of_Animal_Sciences._Vol_62_No.6_pp_502-504. Bacterial surface can be artificially modified so that they attack unwanted cancer cells in host body.

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Building a Community of Builders: The Plan for PLOS SynBio

Building a Community of Builders: The Plan for PLOS SynBio | Synthetic Biology | Scoop.it

Synthetic Biology represents a unique opportunity for scientists to discover, engineer, build, and communicate. Here's what PLOS is doing to help.

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A protein approach to halve and to whole

A protein approach to halve and to whole | Synthetic Biology | Scoop.it

Rice University scientists have developed a plug-and-play approach to detect interactions between proteins they say could greatly improve understanding of basic biological functions. 

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Beyond GMOs: The Rise of Synthetic Biology

Beyond GMOs: The Rise of Synthetic Biology | Synthetic Biology | Scoop.it

Genetically modified organisms today usually have just one engineered gene. Scientists now want to create organisms with whole new gene clusters.

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Engineering parts and genetic devices

How a gene is regulated? How to create a genetic circuit?
Parts are DNA sequences that contain primitive elements of biological function (ex. protein coding sequences, promoter sequences). Parts engineering refers to engineering or optimizing these different biological primitives to generate new user-defined functions. Genetic Devices are collections of parts that encode for a user-defined function. For example, a simple genetic device would be a promoter, a RBS, a gene and a terminator. One can increase the complexity of devices and modulate genetic function.

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Drew Endy: The iGEM Revolution

Drew Endy: The iGEM Revolution | Synthetic Biology | Scoop.it

iGEM stands for the “International Genetically Engineered Machines” competition.

Thousands of student bioengineers from all over the world construct new life forms and race them every year at the Giant Jamboree in Boston. iGEM has been going on for ten years (2,500 competitors this year, over 32 countries, 20,000+ alumni) and gives a peerless window into the global grassroots synthetic-biology revolution, yet the phenomenon has been largely overlooked by the media, industry, and most governments.

iGEM began with college undergraduates and recently expanded to include high school teams. In making their genetic creations students get from and give back to a repository of over 10,000 genetic components called BioBricks parts. The organisms (mostly microbes) the students engineer range from frivolous (doing a stadium-style “wave”) to beneficial (detecting and eliminating water pollutants) to ingenious (increasing plant root structure to fix carbon while ensuring that no exotic genes can escape). iGEM teams "are also challenged to actively consider and address the safety, security and environmental implications of their work."

Drew Endy, a professor of Bioengineering at Stanford, was one of the creators of iGEM and is co-founder and president of the BioBricks Foundation, an organization whose mission is "to develop biotechnology in an open and ethical manner to benefit all people and the planet." He is a strong proponent of “open source” biotech and public discussion of the techniques, benefits, and potential hazards of synthetic biology.

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Creating 480 varieties of wheat is deserving of the World Food Prize

Creating 480 varieties of wheat is deserving of the World Food Prize | Synthetic Biology | Scoop.it

Improving wheat is a major challenge for agricultural scientists. The world’s population continues to grow – and so does its appetite. Sanjaya Rajaram, winner of the 2014 World Food Prize, used an innovative breeding technique to develop 480 new wheat varieties. Rajaram’s varieties are high-yielding yet resistant to diseases and stresses, which allows them to thrive in a range of environments. Across the world, scientists are currently exploring a range of strategies to increase wheat yield.

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Stanford bioengineers develop a toolkit for designing more successful synthetic molecules

Stanford bioengineers develop a toolkit for designing more successful synthetic molecules | Synthetic Biology | Scoop.it

Synthetic molecules hold great potential for revealing key processes that occur in cells, but the trial-and-error approach to their design has limited their effectiveness. Christina Smolke introduces a computer model that could provide better blueprints for building synthetic genetic tools.

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Teachers Learn and Share the Love for Synthetic Biology

Teachers Learn and Share the Love for Synthetic Biology | Synthetic Biology | Scoop.it

Putting current synthetic biology science and engineering research into the hands of teachers to increase understanding and engagement with these exciting new fields is the job of BioBuilder.org, a program sponsored by the Synthetic Biology Engineering Research Center (SynBERC), an NSF-funded center headquartered at the University of California (UC) at Berkeley. In 2013, 125 teachers received training in one- to five-day workshops, returning to the classroom with new knowledge and teaching materials. Adding in the 75 trainees from 2012, the BioBuilder curriculum has now been brought to over 200 classrooms around the country.

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Crowdsourcing Synthetic Biology

Crowdsourcing Synthetic Biology | Synthetic Biology | Scoop.it

At first glance, the terms ‘synthetic’ and ‘biology’ seem like parts that wouldn’t quite fit with each other. Ironically though, not only do they fit together, but creating and putting parts together is what synthetic biology is all about. Except in this case, the parts aren’t made out of steel or plastic that are manufactured in a factory. The parts are made out of DNA, RNA and proteins. Building blocks that make up living things. Synthetic biology, as defined by the Synthetic Biology Engineering Research Center (Synberc) consortium “is the design and construction of new biological entities such as enzymes, genetic circuits, and cells or the redesign of existing biological systems.” Synthetic biology, which is equal parts biology and engineering, is emerging as one of the hottest fields in basic and applied research around the world. The applications of synthetic biology are far and wide, ranging from engineering bacteria that can clean up waste to creating more effective vaccines and delivering drugs with precision.

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DNA From This Ugly Fish Is Being Used to Synthesize Bulletproof Slime

DNA From This Ugly Fish Is Being Used to Synthesize Bulletproof Slime | Synthetic Biology | Scoop.it
If you have ever seen a picture or a video of a hagfish, it's probably been on some roundup of the ocean's most horrifying creatures. But the DNA within that very creature, often known as a "slime eel," just might be the key to creating sustainable, biodegradable plastic.
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Synthetic Biology Gone Wild? Probably Not. An interview with Tom Ellis.

Synthetic Biology Gone Wild? Probably Not. An interview with Tom Ellis. | Synthetic Biology | Scoop.it

The first annual Synthetic Biology: Engineering, Evolution & Design (SEED) conference was held last month in Manhattan Beach, CA. Both new and veteran star-studded synthetic biologists shared the podium for four days to showcase cutting-edge technologies being developed in their respective labs. Talks covering metabolic engineering, sensors, genetic circuits, and nanotechnology highlighted the diverse and interdisciplinary nature of SynBio research. In particular, a common theme involved research addressing issues of bio-safety and the potential ecological ramifications of synthetic biology. On the first day of SEED, I interviewed presenter Dr. Tom Ellis, to talk about his research and his views concerning SynBio research.

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Kitchen counter bio hacking

Kitchen counter bio hacking | Synthetic Biology | Scoop.it

I first heard about Synbiota at SXSWi this year, when they won an Accelerator Award. According to the announcement, “Synbiota is a virtual collaboration site that connects scientists, researchers, universities and others from around the world to solve complex problems using genetic engineering.” That week they announced the world’s first Massive Open Online Science (MOOS) event. Called #ScienceHack, hundreds of researchers from around the globe (some as clueless as us!) would use a new “wetware” kit to produce prohibitively expensive medicine at a fraction of the price.

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iGEM Paris-Bettencourt

This is the promotional video of iGEM Paris-Bettencourt team 2014 Twitter: @iGEM_Paris Facebook: iGEM Paris Bettencourt

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