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What if we build a different genome?

What if we build a different genome? | Synthetic Biology | Scoop.it

As biologists continue the decadeslong race to map the genomes of living things, a group of forward-thinking BU engineers is asking the kind of questions that engineers can’t help but ask: what if we built a different genome?


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Synthetic Biology
All about the growing field of synthetic biology
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Modified bacteria become a multicellular circuit

Modified bacteria become a multicellular circuit | Synthetic Biology | Scoop.it

Rice scientists create a biological circuit by programming bacteria to alter gene expression in an entire population.

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iGEM: Catalyzing Entrepreneurs and Startups in Synthetic Biology

iGEM: Catalyzing Entrepreneurs and Startups in Synthetic Biology | Synthetic Biology | Scoop.it

The “e” in iGEM stands for “engineered”. Everyone knows that. But there’s another e-word iGEM headquarters wants teams to consider: entrepreneurship.

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Stanford researchers genetically engineer yeast to produce opioids

Stanford researchers genetically engineer yeast to produce opioids | Synthetic Biology | Scoop.it

It typically takes a year to produce hydrocodone from plants, but Christina Smolke and colleagues have genetically modified yeast to make it in just a few days. The technique could improve access to medicines in impoverished nations, and later be used to develop treatments for other diseases.

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Engineering A New Chemical Communication System Into Bacteria

Engineering A New Chemical Communication System Into Bacteria | Synthetic Biology | Scoop.it

Synthetic Biology: Putting a synthetic quorum-sensing system into gram-positive bacteria could help improve industrial enzyme production

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How new biosensors turn E. coli into something valuable

How new biosensors turn E. coli into something valuable | Synthetic Biology | Scoop.it
Wyss reprograms engineered bacteria into source of natural energy for pharmaceuticals, plastics, fuel
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Virginia Tech scientist develops model for robots with bacterial brains

Virginia Tech scientist develops model for robots with bacterial brains | Synthetic Biology | Scoop.it

Forget the Vulcan mind-meld of the Star Trek generation — as far as mind control techniques go, bacteria is the next frontier.

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Denis Malyshev, The DNA Amplifier

Denis Malyshev, The DNA Amplifier | Synthetic Biology | Scoop.it

Synthetic biologist is expanding the genetic alphabet to create unnatural proteins

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Scientists use molecular ‘lock and key’ for potential control of GMOs

Scientists use molecular ‘lock and key’ for potential control of GMOs | Synthetic Biology | Scoop.it

UC Berkeley researchers have developed an easy way to put bacteria under a molecular lock and key in order to contain its accidental spread. The method involves a series of genetic mutations that render the microbe inactive unless the right molecule is added to enable its viability.

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A Bay Area Startup Spins Lab-Grown Silk

A Bay Area Startup Spins Lab-Grown Silk | Synthetic Biology | Scoop.it

Five years ago, the graduate students behind a secretive startup called Bolt Threads set out to replicate the unique chemical properties of spider silk, an almost magically flexible and durable material that’s in some ways as strong as steel. One of the first things they did was buy a batch of Nephila spiders—the common golden silk orb-weavers—from an insect dealer in Florida. Then they let the spiders spin their webs all over the company’s first office at the University of California at San Francisco. One day a well-known UCSF molecular biologist walked in, saw a spider hanging in a doorway, and ran away screaming.

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Intelligent bacteria for detecting disease

Intelligent bacteria for detecting disease | Synthetic Biology | Scoop.it

Another step forward has just been taken in the area of synthetic biology. Research teams from Inserm and CNRS (French National Centre for Scientific Research) Montpellier, in association with Montpellier Regional University Hospital and Stanford University, have transformed bacteria into “secret agents” that can give warning of a disease based solely on the presence of characteristic molecules in the urine or blood. To perform this feat, the researchers inserted the equivalent of a computer programme into the DNA of the bacterial cells. The bacteria thus programmed detect the abnormal presence of glucose in the urine of diabetic patients. This work, published in the journal Science TranslationalMedicine, is the first step in the use of programmable cells for medical diagnosis

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Microdomains set the stage for breakthroughs in study of human disease

Microdomains set the stage for breakthroughs in study of human disease | Synthetic Biology | Scoop.it

J. Andrew MacKay builds on his team’s attempt to control polypeptide-based structures.

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Empowering citizen scientists

A scientifically literate general public ranks high on the wish list of biological researchers. According to a poll taken at a recent synthetic biology conference, scientists see a public uninformed about biotechnology as a threat to their work. Instead they want the 'man on the street' to understand and support what goes on in the lab. In our June Editorial we discussed different routes used to disseminate scientific information. We now want to encourage our readers to get involved in venues that give lay people a chance to get hands-on experience in biology: DIYbio labs.

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iGEM teams engineer success with gBlocks® Gene Fragments

iGEM teams engineer success with gBlocks® Gene Fragments | Synthetic Biology | Scoop.it

The 2015 iGEM teams have made significant progress on their projects. We spoke with some of the teams to find out how the competition is going, and how they are using gBlocks Gene Fragments.

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At Synthorx, Synthetic Biologists Put Artificial Life Forms to Work

At Synthorx, Synthetic Biologists Put Artificial Life Forms to Work | Synthetic Biology | Scoop.it

A startup company says it is expanding the language of DNA to create new tools for drug discovery.

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Contest - a hub for future scientists

Contest - a hub for future scientists | Synthetic Biology | Scoop.it

Set up a lab, deal with finances, plan, execute and analyze science and in an interesting way communicate the results. This is what students from Karolinska Institutet are dealing with this summer. The International Genetically Engineered Machines (iGEM) is a contest that will prepare the participants early on for a future career in science.

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Synthetic Biology Students Compete in iGEM 2015 Giant Jamboree

12th annual conference and competition to showcase student innovations in genetically engineered biological systems

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New biosensors for managing microbial ‘workers’

New biosensors for managing microbial ‘workers’ | Synthetic Biology | Scoop.it

Researchers at Harvard’s Wyss Institute have unveiled new biosensors that enable scientists to more effectively control and 'communicate with' engineered bacteria

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Programming an Abundant Human Gut Microbe

Programming an Abundant Human Gut Microbe | Synthetic Biology | Scoop.it

If you grew up playing with plug-and-play electronics kits (or, these days, the magical redstone in Minecraft), you’ll be familiar with the brunt literal-mindedness of circuit boards. Whatever elaborate construct of LEDs, buzzers, and motors you come up with has to rely on just two input conditions: is there electricity, or no?

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Nicola Patron leads standard for the assembly of DNA parts for plant synthetic biology.

Nicola Patron leads standard for the assembly of DNA parts for plant synthetic biology. | Synthetic Biology | Scoop.it

Dr Nicola Patron has led development of the first common standard for the assembly of DNA parts for plant synthetic biology.

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Microfluidic Device Mixes And Matches DNA For Synthetic Biology

Microfluidic Device Mixes And Matches DNA For Synthetic Biology | Synthetic Biology | Scoop.it

Device assembles rings of DNA and plugs them into cells

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Harvard synthetic biology researchers built a transplantable circadian clock

Harvard synthetic biology researchers built a transplantable circadian clock | Synthetic Biology | Scoop.it

NON-SCIENTISTS GENERALLY think of “circadian clock” as a metaphoric term. There’s nothing literally ticking away inside the human body, helping align it to the regular cycle of day and night. But synthetic biologists from Harvard Medical School (HMS) and the Wyss Institute for Biologically Inspired Engineering have created something just that tangible: a transplantable, bioengineered 24-hour clock, which functioned by itself after being inserted into a bacterium that doesn’t typically have a circadian rhythm.   

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Training for synthetic biology jobs in the new bioeconomy

Training for synthetic biology jobs in the new bioeconomy | Synthetic Biology | Scoop.it

Over the past decade, the development of fast and affordable technologies for DNA sequencing and synthesis and a growing understanding of complex biological systems have opened the door to a new approach to biology. It has become possible, at least in principle, to standardize, design, and build from scratch biological parts—and assemble them into systems that perform specific functions in a predictable and reliable way. This new field is synthetic biology,defined by the European Commission as “the application of science, technology and engineering to facilitate and accelerate the design, manufacture and/or modification of genetic materials in living organisms.”

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Find the Right DNA Tool for the Job – Accelerate Synthetic Biology with IDT at ASM 2015

Find the Right DNA Tool for the Job – Accelerate Synthetic Biology with IDT at ASM 2015 | Synthetic Biology | Scoop.it

IDT demonstrates how to enhance research methods with innovative new DNA tools 

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