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Venter Supports DNA Printers

Venter Supports DNA Printers | Synthetic Biology | Scoop.it

The famed geneticist says his team is testing 3-D DNA printers that could churn out vaccines at home.

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Synthetic Biology
All about the growing field of synthetic biology
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iGEM Students Engineer Biological Tools for a Better World

iGEM Students Engineer Biological Tools for a Better World | Synthetic Biology | Scoop.it

The International Genetically Engineered Machine competition (iGEM) is the preeminent, multinational, undergraduate synthetic biology competition that takes place each year. The competition focuses on engineering aspects of synthetic biology as a foundation to develop research skills and foster collaboration among student participants. The duration of the competition is fairly short, with most of the work occurring over the summer months, when most students take time off from their studies. It is truly impressive the types of relevant world issues for which the teams are able to address and test solution in such a short time.

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Engineered Bacteria Stick To Cancer Cells

Engineered Bacteria Stick To Cancer Cells | Synthetic Biology | Scoop.it

Synthetic Biology: Researchers modified bacterial proteins called adhesins to target proteins expressed on human cells

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Rakesh Yashroy's curator insight, August 20, 5:53 AM

Host-pathogen interface shows how bacterial pathogens get virulent to attack the host cells @ https://www.academia.edu/7328964/YashRoy_R_C_1992_Salmonella_3_10_r_-_surface_interactions_with_intestinal_epithelial_microvilli.Indian_Journal_of_Animal_Sciences._Vol_62_No.6_pp_502-504. Bacterial surface can be artificially modified so that they attack unwanted cancer cells in host body.

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Bacterial Robotics building "bactobots" engineered to destroy skull-based tumors

Bacterial Robotics building "bactobots" engineered to destroy skull-based tumors | Synthetic Biology | Scoop.it

Cincinnati-based Bacterial Robotics is engineering a legion of so-called “bactobots” to do our bidding – in the fields of health care, industrial waste management and a litany of others.

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Engineered Bacteria Produce Aromatic Aldehydes

Engineered Bacteria Produce Aromatic Aldehydes | Synthetic Biology | Scoop.it

Synthetic Biology: The microbes use the aldehydes to synthesize a precursor to the pharmaceutical ephedrine, as well as the artificial flavorants benzaldehyde and vanillin

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Changing the world: Team FerriTALEs

With support from Alberta Innovates-Technology Futures, a group of young scientists out of the University of Calgary are working on a project that might help change the world. Team FerriTALEs have developed a DNA-based biosensor to detect the presence of E. coli in cattle. Using the cutting edge science of synthetic biology, hear how these young people are helping to solve the world's problems.

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Spinning a genetic web, 3-D-printer style

Spinning a genetic web, 3-D-printer style | Synthetic Biology | Scoop.it

Taking nature's cues to build self-assembly into the molecular structure

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New tools advance bio-logic

New tools advance bio-logic | Synthetic Biology | Scoop.it

Researchers at Rice University and the University of Kansas Medical Center are making modular genetic circuits that can perform more complex tasks by swapping protein building blocks.

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Tom Knight, Godfather Of Synthetic Biology, On How To Learn Something New

Tom Knight, Godfather Of Synthetic Biology, On How To Learn Something New | Synthetic Biology | Scoop.it

The MIT computing wiz and key player in the recent technological revolution talks about his path from AI to DNA.

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First ever biological amplifier created by Imperial scientists

First ever biological amplifier created by Imperial scientists | Synthetic Biology | Scoop.it

Scientists have made an amplifier to boost biological signals, using DNA and harmless E. coli bacteria.

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Using synthetic biology to make new antibiotics

Using synthetic biology to make new antibiotics | Synthetic Biology | Scoop.it

Research at Victoria University of Wellington could lead to a new generation of antibiotics, helping tackle the global issue of ‘superbugs’ that are resistant to modern medicine.

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Biohackers Are Growing Real Cheese In A Lab, No Cow Needed

Biohackers Are Growing Real Cheese In A Lab, No Cow Needed | Synthetic Biology | Scoop.it

Real vegan cheese. It's not an oxymoron, it's a miracle of synthetic biology.

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I'm homing in on the genetic essence of life

I'm homing in on the genetic essence of life | Synthetic Biology | Scoop.it

Synthetic biologist Hamilton Smith wants to find the smallest genome that will keep a bacterium alive – and tidy up evolution's sloppy work

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Color-changing petunias on their way

Color-changing petunias on their way | Synthetic Biology | Scoop.it

Petunias come in so many vibrant varieties; it’s hard to decide which color to buy. One day soon, you might not have to choose.

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Kitchen counter bio hacking

Kitchen counter bio hacking | Synthetic Biology | Scoop.it

I first heard about Synbiota at SXSWi this year, when they won an Accelerator Award. According to the announcement, “Synbiota is a virtual collaboration site that connects scientists, researchers, universities and others from around the world to solve complex problems using genetic engineering.” That week they announced the world’s first Massive Open Online Science (MOOS) event. Called #ScienceHack, hundreds of researchers from around the globe (some as clueless as us!) would use a new “wetware” kit to produce prohibitively expensive medicine at a fraction of the price.

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iGEM Paris-Bettencourt

This is the promotional video of iGEM Paris-Bettencourt team 2014 Twitter: @iGEM_Paris Facebook: iGEM Paris Bettencourt

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Life-Saving Dividends for Synthetic Biology Research: Microbial-Based Antimalarial Drug Shipped to Africa

Life-Saving Dividends for Synthetic Biology Research: Microbial-Based Antimalarial Drug Shipped to Africa | Synthetic Biology | Scoop.it

A project begun some 13 years ago by Jay Keasling, the Associate Laboratory Director for Biosciences at Berkeley Lab and the CEO of the Joint BioEnergy Institute (JBEI), was culminated with an announcement on August 12 from the partnership of Sanofi, the multinational pharmaceutical company, and PATH, the nonprofit global health organization. Sanofi/PATH announced the shipment of 1.7 million treatments of semi-synthetic artemisinin to malaria-endemic countries in Africa. Unlike conventional artemisinin, which is derived from the bark of the sweet wormwood plant, this synthetic version of the World Health Organization’s frontline antimalarial drug is derived from yeast. The addition of a microbial-based source of artemisinin to the botanical source provides a stable new option for treating the millions of victims who are stricken with malaria each year, most of them children.

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Unique nucleotide sequence–guided assembly of repetitive DNA parts for synthetic biology applications

Unique nucleotide sequence–guided assembly of repetitive DNA parts for synthetic biology applications | Synthetic Biology | Scoop.it

Recombination-based DNA construction methods, such as Gibson assembly, have made it possible to easily and simultaneously assemble multiple DNA parts, and they hold promise for the development and optimization of metabolic pathways and functional genetic circuits. Over time, however, these pathways and circuits have become more complex, and the increasing need for standardization and insulation of genetic parts has resulted in sequence redundancies—for example, repeated terminator and insulator sequences—that complicate recombination-based assembly. We and others have recently developed DNA assembly methods, which we refer to collectively as unique nucleotide sequence (UNS)–guided assembly, in which individual DNA parts are flanked with UNSs to facilitate the ordered, recombination-based assembly of repetitive sequences. Here we present a detailed protocol for UNS-guided assembly that enables researchers to convert multiple DNA parts into sequenced, correctly assembled constructs, or into high-quality combinatorial libraries in only 2–3 d. If the DNA parts must be generated from scratch, an additional 2–5 d are necessary. This protocol requires no specialized equipment and can easily be implemented by a student with experience in basic cloning techniques.

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Preparing synthetic biology for the world

Synthetic Biology promises low-cost, exponentially scalable products and global health solutions in the form of self-replicating organisms, or “living devices.” As these promises are realized, proof-of-concept systems will gradually migrate from tightly regulated laboratory or industrial environments into private spaces as, for instance, probiotic health products, food, and even do-it-yourself bioengineered systems. What additional steps, if any, should be taken before releasing engineered self-replicating organisms into a broader user space? In this review, we explain how studies of genetically modified organisms lay groundwork for the future landscape of biosafety. Early in the design process, biological engineers are anticipating potential hazards and developing innovative tools to mitigate risk. Here, we survey lessons learned, ongoing efforts to engineer intrinsic biocontainment, and how different stakeholders in synthetic biology can act to accomplish best practices for biosafety.

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Morph Bioinformatics: Cloning on Your Smartphone

Morph Bioinformatics: Cloning on Your Smartphone | Synthetic Biology | Scoop.it

As novel the aims of the researchers and beautiful the products of genetic engineering might be, the molecular cloning procedures are long-drawn and frustratingly boring. While more than 600 restriction enzymes (called molecular scissors since they cut DNA at specific sites) are commercially available to cut genes from different sources at different sites, each combination of restriction enzymes requires a different buffer composition. Meanwhile, codon optimization is a task that researchers must perform while keeping in mind the gene source and the protocol. In the end, if the target gene or genes don’t get expressed, it is usually very difficult for most labs to figure out what went wrong. Available bioinformatics tools are complex and not very user-friendly.

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Synthetic Biology: A common language makes for a stronger community

New standards within the synthetic biology community may help lift the field from pure research to practical applications, according to an international group of researchers, including a computational synthetic biologist at Virginia Tech.

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The "first man-made biological leaf" could enable humans to colonise space

RCA graduate Julian Melchiorri says the synthetic biological leaf he developed, which absorbs water and carbon dioxide to produce oxygen just like a plant, could enable long-distance space travel.

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The Gene Construction Revolution

The Gene Construction Revolution | Synthetic Biology | Scoop.it
How Custom, Double-Stranded DNA is Replacing High Quality Long Oligos
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Synthetic biology, indigo is your color.

Synthetic biology, indigo is your color. | Synthetic Biology | Scoop.it

Color is at the heart of our project here at Revolution Bio. Color makes things brighter, more fun, and more engaging. Color can also become a rallying point for people interested in building a common cause.

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Genetically-engineered moths make spider silk for flameproof pants

Genetically-engineered moths make spider silk for flameproof pants | Synthetic Biology | Scoop.it

Spider silk is widely considered a superfibre, a near magical material with potential medical and military applications. The problem is that cost-effective mass production has eluded scientists for years. Until now, it seems. A Michigan firm has brought us one step closer thanks to a genetically engineered silkworm, modified to produce spider silk.

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Interview: Designing DNA Sequences in Synthetic Biology with HPC

Interview: Designing DNA Sequences in Synthetic Biology with HPC | Synthetic Biology | Scoop.it

Unfolding the mystery behind DNA sequences is key to designing synthetic microorganisms for alternate fuel sources. Penn State University Assistant Professor, Howard Salis Ph.D., leveraged Amazon Web Services (AWS) to offer an online HPC portal to bring supercomputing resources to scientists the world over for this project. We sat down with Dr. Salis to learn more about this fascinating topic.

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