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Programmable DNA-Guided Artificial Restriction Enzymes

Programmable DNA-Guided Artificial Restriction Enzymes | Synthetic Biology-hacks | Scoop.it
Restriction enzymes are essential tools for recombinant DNA technology that have revolutionized modern biological research. However, they have limited sequence specificity and availability. Here we report a Pyrococcus furiosus Argonaute (PfAgo) based platform for generating artificial restriction enzymes (AREs) capable of recognizing and cleaving DNA sequences at virtually any arbitrary site and generating defined sticky ends of varying length. Short DNA guides are used to direct PfAgo to target sites for cleavage at high temperatures (>87 °C) followed by reannealing of the cleaved single stranded DNAs. We used this platform to generate over 18 AREs for DNA fingerprinting and molecular cloning of PCR-amplified or genomic DNAs. These AREs work as efficiently as their naturally occurring counterparts, and some of them even do not have any naturally occurring counterparts, demonstrating easy programmability, generality, versatility, and high efficiency for this new technology.

Via Gerd Moe-Behrens
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Microsoft Plans to Have a DNA-Based Computer by 2020

Microsoft Plans to Have a DNA-Based Computer by 2020 | Synthetic Biology-hacks | Scoop.it
It’s durable, exponentially scalable, and it’ll last millennia, if not millions of years.
 

Via Gerd Moe-Behrens
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Snowfall was recorded in the Sahara Desert for the first time in 37 years — and the satellite imagery is gorgeous

Snowfall was recorded in the Sahara Desert for the first time in 37 years — and the satellite imagery is gorgeous | Synthetic Biology-hacks | Scoop.it

It snowed on December 19 in the Sahara Desert, and NASA's Landsat 7 satellite was there (or rather, hundreds of miles overhead) to see it.


The photo comes from Landsat 7's Enhanced Thematic Mapper Plus visible-light camera, and depicts the first snowfall recorded in the massive African desert in 37 years.


The snow-covered area depicted in the photo lies on the northern end of the desert, near the Moroccan-Algerian border and the town of Ain Safra. Here's the full image, which you can click to enlarge:...


Via Jeff Domansky, massimo facchinetti
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Jeff Domansky's curator insight, December 23, 2016 2:08 AM

Wonderful NASA images of snow in the Sahara Desert.

Dorothy Retha Cook's curator insight, January 9, 6:18 AM

Man can't tell God what he can't do. Look at God snow in hot places . All things are possible thru and by Christ Jesus that strengthens us

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Bringing out the usual – and unusual – cancer genomics suspects | Broad Institute of MIT and Harvard

Bringing out the usual – and unusual – cancer genomics suspects | Broad Institute of MIT and Harvard | Synthetic Biology-hacks | Scoop.it
Bringing out the usual – and unusual – cancer genomics suspects: Context helps separate culprit genes from bystanders http://t.co/KsIn7DmGSa
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The eighth wonder: developments in synthetic biology - Science Omega

The eighth wonder: developments in synthetic biology - Science Omega | Synthetic Biology-hacks | Scoop.it
Science Omega
The eighth wonder: developments in synthetic biology
Science Omega
A number of key disciplines have garnered significant attention within the sector, particularly synthetic biology.
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Joule Patents Organism for Biofuels | Bio Pure Fuels

Here is an article about Joules patenting an organism for biofuels; a very interesting story regarding patenting an organism...


Via Marko Dolinar
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Life is Suite: A group of software apps helps synthetic biologists work faster and better » Systems Engineering | Blog Archive | Boston University

Life is Suite: A group of software apps helps synthetic biologists work faster and better » Systems Engineering | Blog Archive | Boston University | Synthetic Biology-hacks | Scoop.it

by

Art Jahnke

"As biologists continue the decades-long race to map the genomes of living things, a group of forward-thinking BU engineers is asking the kind of questions that engineers can’t help but ask: what if we built a different genome?

Known as synthetic biologists, they believe that with some skillful genomic tweaks, living organisms, such as cells and microbes, can be put to work doing things that are too dangerous or not even possible for higher life-forms like ourselves.

“There are so many possibilities,” says Douglas Densmore, the Richard and Minda Reidy Family Career Development Assistant Professor in the College of Engineering electrical and computer engineering department. “Some are biotherapeutic. For example, we use chemotherapy to kill cancer cells, which is horribly damaging to the body. We may be able to noninvasively use bacteria that are already in your body to kill cancer cells. Or we can use bacteria to make clean energy.”

In the last few years, as computing power has multiplied and the cost of decoding and synthesizing DNA has nose-dived, synthetic biological possibilities have started to look more like probabilities. Oil spill cleanup is also high on the things-to-do list for customized microbes. So is weapons detection, which may explain why the Office of Naval Research is funding a $7.5 million project called Utilizing Synthetic Biology to Create Programmable Micro-Bio-Robots. The project, which involves Densmore and two other BU engineers as well as researchers from Harvard, MIT, Northeastern, and the University of Pennsylvania, intends to create a dynamic trio of humans, robots, and genetically engineered bacteria, all of which will work together to detect whatever the bacteria are programmed to detect. That could be explosives or toxins or heat or light. The customized bacteria will talk to one another, and they will report to miniature “chaperone robots,” a mere 10 to 100 centimeters long, that will each control thousands of microbes. Finally, the chaperone robots will wirelessly report back to humans.
......."
http://bit.ly/WqKa13


Via Gerd Moe-Behrens
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Genomics and African Queens: Diversity Within Ethiopian Genomes ... - Science Daily (press release)

Genomics and African Queens: Diversity Within Ethiopian Genomes ... - Science Daily (press release) | Synthetic Biology-hacks | Scoop.it
Genomics and African Queens: Diversity Within Ethiopian Genomes ...Science Daily (press release)Researchers have started to unveil the genetic heritage of Ethiopian populations, who are among the most diverse in the world, and lie at the gateway from...
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BMC Genomics | Abstract | Whole genome sequencing analysis of Plasmodium vivax using whole genome capture

Malaria caused by Plasmodium vivax is an experimentally neglected severe disease with a substantial burden on human health. Because of technical limitations, little is known about the biology of this important human pathogen.
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A check-in at NYU Center For Genomics & System Biology

A check-in at NYU Center For Genomics & System Biology | Synthetic Biology-hacks | Scoop.it
College Science Building in New York, NY (I'm at NYU Center For Genomics & System Biology (New York, NY) http://t.co/DqdVQpRm...)...
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From Chemtrails to Pseudo-Life: The Dark Agenda of Synthetic Biology

As the natural world dies around us, what will take its place? Planetary engineering includes bioremediation measures to bring us genetically engineered tree... (RT @J4LYN: #Trueconfessions of the serial killers.
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Will Genetic Engineering Bring Killer Tomatoes to Grocery Stores ...

Will Genetic Engineering Bring Killer Tomatoes to Grocery Stores ... | Synthetic Biology-hacks | Scoop.it
Crop genetics conjures fears of Frankenstein in some minds and hopes for technological advancements in others. Biologists have recently decoded and published the entire tomato genome. What does that mean for us, the ...
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Postdoc R&D position in Bioinformatics Genome Computing at ...

Postdoc R&D position in Bioinformatics Genome Computing at ... | Synthetic Biology-hacks | Scoop.it
The Genome Computing project focuses on big data analysis and Web technology for genomic data, and use next generation sequencing technology, which opens up to radical innovation in biological and medical research.
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Metabolic engineering and synthetic biology approaches driving isoprenoid production in Escherichia coli

Isoprenoids comprise the largest family of natural organic compounds with many useful applications in the pharmaceutical, nutraceutical, and industrial fields. Rapid developments in metabolic engineering and synthetic biology have facilitated the engineering of isoprenoid biosynthetic pathways in Escherichia coli to induce high levels of production of many different isoprenoids. In this review, the stem pathways for synthesizing isoprene units as well as the branch pathways deriving diverse isoprenoids from the isoprene units have been summarized. The review also highlights the metabolic engineering efforts made for the biosynthesis of hemiterpenoids, monoterpenoids, sesquiterpenoids, diterpenoids, carotenoids, retinoids, and coenzyme Q10 in E. coli. Perspectives and future directions for the synthesis of novel isoprenoids, decoration of isoprenoids using cytochrome P450 enzymes, and secretion or storage of isoprenoids in E. coli have also been included.

Via Gerd Moe-Behrens
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Biohacking & the Rise of Digital Biology

Biohacking & the Rise of Digital Biology | Synthetic Biology-hacks | Scoop.it
Biohacking and digital biology are taking off with huge promise of positively impacting a wide variety of industries.

Via Gerd Moe-Behrens
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2017 shaping up to be pivotal year for CAR-T and CRISPR therapies | FierceBiotech

2017 shaping up to be pivotal year for CAR-T and CRISPR therapies | FierceBiotech | Synthetic Biology-hacks | Scoop.it
2017 is promising to be a pivotal year for synthetic biology as two landmark technologies—CRISPR/Cas9 and CAR-T—head toward critical milestones.

Via Gerd Moe-Behrens
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Patent ruling won't alter Empire Genomics approach - Business First of Buffalo

Patent ruling won't alter Empire Genomics approach - Business First of Buffalo | Synthetic Biology-hacks | Scoop.it
Patent ruling won't alter Empire Genomics approach
Business First of Buffalo
A Buffalo biotech firm says the U.S.
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Court: Nobody Can Patent Your Genes … What Does That Mean? - AARP News (blog)

Court: Nobody Can Patent Your Genes … What Does That Mean? - AARP News (blog) | Synthetic Biology-hacks | Scoop.it
AARP News (blog)
Court: Nobody Can Patent Your Genes … What Does That Mean?
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Proteins made to order

Proteins made to order | Synthetic Biology-hacks | Scoop.it
Researchers design proteins from scratch with predictable structures.

Via Gerd Moe-Behrens
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Your Laptop Can Now Analyze Big Data - Technology Review

Your Laptop Can Now Analyze Big Data - Technology Review | Synthetic Biology-hacks | Scoop.it
New software makes it possible to do in minutes on a small computer what used to be done by large clusters of computers.

Via Gerd Moe-Behrens
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Top scientists to attend Doha symposium - Gulf Times

Top scientists to attend Doha symposium - Gulf Times | Synthetic Biology-hacks | Scoop.it
Gulf TimesTop scientists to attend Doha symposiumGulf Times“This is the first time in Qatar that international bioinformaticians and scientists who use bioinformatics platforms in the country are coming together to discuss the ...QBRI and QCRI Co-Sponsor...
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Biotechnology revolution unlocks riches

Biotechnology revolution unlocks riches | Synthetic Biology-hacks | Scoop.it
The U.S. government spent $3.8 billion on the human genome project but it has helped drive $796 billion in economic activity.
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Cancer, Data and the Fallacy of the $1000 Genome - Forbes

Cancer, Data and the Fallacy of the $1000 Genome - Forbes | Synthetic Biology-hacks | Scoop.it
I wish I could take credit for the title of today’s blog post, but it actually derives from a talk given by Mark Boguski of Harvard Medical School at a recent healthcare conference in Boston.  Before you read any further, you should look up Mark’s...
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Versatile Genetic Tool Box for the Crenarcha... [Front Microbiol. 2012] - PubMed - NCBI

PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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smarterplanet: Synthetic Biology Explained  ...

smarterplanet: “ Synthetic Biology Explained From selective breeding to genetic modification, our understanding of biology is now merging with the principles of engineering to bring us synthetic...
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