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Interesting YouTube video! CytoComp is going to reinvent how we do medical treatment - A revolutionary biological computer

Interesting YouTube video! CytoComp is going to reinvent how we do medical treatment - A revolutionary biological computer | SynBioFromLeukipposInstitute | Scoop.it

http://youtu.be/BMRqKVktvhs

From the description:
"A Our Vision
This I have been waiting for for a long time. Every once in a while a revolutionary product comes along that changes everything. You are very fortunate, if you can work at least on one of these products during your career. The product I will present today will not only change our company, it will not just change how we will treat a single disease, it will change the whole medical industry. We have had several major breakthrough in medicine such as insulin and DNA. Well today, I will introduce one novel, revolutionary product of this group. This is one game changing device, and we are calling it CytoComp. Today CytoComp is going to reinvent how we do medical treatment. Before we get into it let me say a few words about biological computers. Actually not all computers are made of silicon. CytoComp is a biological computer. Biological computers make life perform work, which in traditional computers are done by chips and circuit boards. At CytoComp we are trying to find medical applications for biological computers So CytoComp reinvents medical treatment. So much about our vision. Lets move on to the problem we wish to solve with CytoComp.

B The Problem
Alone in the US 16 million people suffer from a endocrine disorder. CytoComp is applicable to many of them. Our first focus will be on the type 1 diabetic. So many as 17 to 34 million people worldwide suffer from this disease. The type 1 diabetic wants: No daily finger sticking, no insulin injections, no external devices to carry around. In summery: The type 1 diabetic wants a carefree life. Let us now move on to our solution.

C The Solution
CytoComp is an implantable biological computer that automatically takes care of the blood sugar and insulin for the type 1 diabetic. Moreover, you have the option to monitor this on a mobile device. CytoComp is really reinventing medical treatment. It will be useful for for the treatment of a wide range of diseases. Thus, the impact of CytoComp will dramatically increase over the years to come. We believe that CytoComp will change the life of millions of people to the better. We are sure, after you get hand on CytoComp you will never look at medicine in the same way."

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*Bio-electrospraying and Cell Electrospinning: Progress and Opportunities for Basic Biology and Clinical Sciences*

by

Poncelet D, de Vos P, Suter N, Jayasinghe SN.

"Engineering of functional tissues is a fascinating and fertile arena of research and development. This flourishing enterprise weaves together many areas of research to tackle the most complex question faced to date, namely how to design and reconstruct a synthetic three-dimensional fully functional tissue on demand. At present our healthcare is under threat by several social and economical issues together with those of a more scientific and clinical nature. One such issue arises from our increasing life expectancy, resulting in an ageing society. This steeply growing ageing society requires functional organotypic tissues on demand for repair, replacement, and rejuvenation (R(3) ). Several approaches are pioneered and developed to assist conventional tissue/organ transplantation. In this Progress Report, "non-contact jet-based" approaches for engineering functional tissues are introduced and bio-electrosprays and cell electrospinning, i.e., biotechniques that have demonstrated as being benign for directly handling living cells and whole organisms, are highlighted. These biotechniques possess the ability to directly handle heterogeneous cell populations as suspensions with a biopolymer and/or other micro/nanomaterials for directly forming three-dimensional functional living reconstructs. These discoveries and developments have provided a promising biotechnology platform with far-reaching ramifications for a wide range of applications in basic biological laboratories to their utility in the clinic."

http://1.usa.gov/UZkTHM

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Synthetic Biology, A New Frontier: Christopher Bradley at TEDxNYU

Synthetic Biology, A New Frontier: Christopher Bradley at TEDxNYU | SynBioFromLeukipposInstitute | Scoop.it

Synthetic Biology: A New Frontier
In this fascinating talk Christopher Bradley shows us that our world is about to change radically thanks to the promise of Synthetic Biology.

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Biologically inspired innovation

Biologically inspired innovation | SynBioFromLeukipposInstitute | Scoop.it

The Wyss Institute’s pursuit of alternatives is gaining momentum

By Connor Bamford

"At lab benches and computer desks throughout the Wyss Institute for Biologically Inspired Engineering in Boston, researchers are attempting to solve some of humanity’s most pressing problems. The questions its scientists are asking are not uncommon: How can we discover more effective drugs? How can we solve the global energy crisis? But the possible answers they’re developing are atypical, such as using autonomous microrobots to diagnose and treat diseases.

Part engineer, part biologist, researchers at Wyss (pronounced “Vees”) are combining the power of synthetic biology, microfabrication technology and ..."

http://bit.ly/TrG2es

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Hybrid 3-D Printer Used to Create Cartilage Implants | Wired Design | Wired.com

Hybrid 3-D Printer Used to Create Cartilage Implants | Wired Design | Wired.com | SynBioFromLeukipposInstitute | Scoop.it
Scientists at the Wake Forest Institute of Regenerative Medicine have pioneered an approach to replace damaged cartilage, combining two low-cost techniques: electrospinning and inkjet printing. That's right.
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Engineered, harnessed, and hijacked: synthetic uses for cytoskeletal systems

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Brian S. Goodman, Nathan D. Derr, Samara L. Reck-Peterson

"Synthetic biology re-imagines existing biological systems by designing and constructing new biological parts, devices, and systems. In the arena of cytoskeleton-based transport, synthetic approaches are currently used in two broad ways. First, molecular motors are harnessed for non-physiological functions in cells. Second, transport systems are engineered in vitro to determine the biophysical rules that govern motility. These rules are then applied to synthetic nanotechnological systems. We review recent advances in both of these areas and conclude by discussing future directions in engineering the cytoskeleton and its motors for transport."

http://bit.ly/UHmEJs

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Wired Health Conference Highlights: Synthetic Biology

Highlights: Craig Venter, CEO & President, Synthetic Genomics, shares the latest advancements in synthetic genomic research and technology. According to Vent...
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Synthetic biology postdoctoral position,

Karmella Haynes
Synthetic biology postdoctoral position, Washington University in St. Louis

We are seeking an enthusiastic Postdoctoral Researcher to start Synthetic Biology projects in the Moon lab. We aim to engineer microbes for addressing energy, environmental, and health issues. Specifically, we are interested in developing synthetic biology tools, constructing genetic circuits, and refactoring cellular pathways. For more information, please visit our website
http://moon.eece.wustl.edu/

REQUIREMENTS:
1. PhD degree in chemical engineering, bioengineering, chemistry, physics, microbiology, molecular biology or related areas
2. Experience in molecular biology techniques is essential.
3. The Postdoctoral Researcher is expected to work independently, supervise PhD students, and collaborate with other labs.

Please send the application to:

Tae Seok Moon
Department of Energy, Environmental & Chemical Engineering Washington University in St. Louis
One Brookings Dr. Box 1180
St. Louis, MO 63130
tsmoon@seas.wustl.edu
Please include the following:

- Cover letter, including research and career interests
- CV
- Preprints of publications (if listed on your CV, but not yet available)
- Please have your PhD advisor send a letter of recommendation at the same time.

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Life performs computation much more than you’ve ever thought

Life performs computation much more than you’ve ever thought | SynBioFromLeukipposInstitute | Scoop.it

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Rayna Stamboliyska

"“The level of intelligence has been tremendously increased, because people are thinking and communicating in terms of screens, and not in lettered books. Much of the real action is taking place in what is called cyberspace. People have learned how to boot up, activate, and transmit their brains.

Essentially, there’s a universe inside your brain. The number of connections possible inside your brain is limitless. And as people have learned to have more managerial and direct creative access to their brains, they have also developed matrices or networks of people that communicate electronically. There are direct brain/computer link-ups. You can just jack yourself in and pilot your brain around in cyberspace-electronic space.” ― Timothy Leary, Chaos & Cyber Culture

This quote brings up thoroughly discussed concepts of “wired human interactions” and “globalized self,” all describing our relationship to the internet. The quote also highlights another perspective: the ultimate connection as showcased in cyberpunk culture through the “console cowboy” Case in the Neuromancer or the “game pods”, these outlets plugged through bio-ports in Cronenberg’s movie, Existenz. But if this sounded as daring science fiction 10 years ago, achieving this ‘ultimate connection’ now looks feasible in the near future. Research unveiling the hidden potential of DNA in terms of molecular computation has been ongoing for years, and its outcomes are more promising and mind-blowing than one might have imagined. I kindly invite you to join me in a dive into the exciting waters of DNA-based computers."
http://bit.ly/10q298f

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Pioneering innovation - NOW - Concordia University

Pioneering innovation - NOW - Concordia University | SynBioFromLeukipposInstitute | Scoop.it
New Centre for Applied Synthetic Biology focuses on problem-solving...
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How Does Plant Cell Wall Nanoscale Architecture Correlate with Enzymatic Digestibility?

BREAKING DOWN WALLS FOR BIOFUEL

How Does Plant Cell Wall Nanoscale Architecture Correlate with Enzymatic Digestibility?

by
Shi-You Ding, Yu-San Liu, Yining Zeng, Michael E. Himmel, John O. Baker, Edward A. Bayer

"Greater understanding of the mechanisms contributing to chemical and enzymatic solubilization of plant cell walls is critical for enabling cost-effective industrial conversion of cellulosic biomass to biofuels. Here, we report the use of correlative imaging in real time to assess the impact of pretreatment, as well as the resulting nanometer-scale changes in cell wall structure, upon subsequent digestion by two commercially relevant cellulase systems. We demonstrate that the small, noncomplexed fungal cellulases deconstruct cell walls using mechanisms that differ considerably from those of the larger, multienzyme complexes (cellulosomes). Furthermore, high-resolution measurement of the microfibrillar architecture of cell walls suggests that digestion is primarily facilitated by enabling enzyme access to the hydrophobic cellulose face. The data support the conclusion that ideal pretreatments should maximize lignin removal and minimize polysaccharide modification, thereby retaining the essentially native microfibrillar structure...."

http://bit.ly/QzlnXB

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Physics: Make nanotechnology research open-source : Nature : Nature Publishing Group

Physics: Make nanotechnology research open-source : Nature : Nature Publishing Group | SynBioFromLeukipposInstitute | Scoop.it
An important discussion. In SynBio we had this discussion too. All research and development might need to be open source. How do we finance it?

Physics: Make nanotechnology research open-source

http://bit.ly/QzcgpM

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A cell for a cell | Chemistry World

A cell for a cell | Chemistry World | SynBioFromLeukipposInstitute | Scoop.it
A tiny jail that can hold a single biological cell could be a useful tool for studying rare cells...
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Biomaterials-Based Electronics: Polymers and Interfaces for Biology and Medicine - Muskovich - 2012 - Advanced Healthcare Materials - Wiley Online Library

Human computer interface:

Biomaterials-Based Electronics: Polymers and Interfaces for Biology and Medicine

by
Muskovich M, Bettinger CJ.

"Advanced polymeric biomaterials continue to serve as a cornerstone for new medical technologies and therapies. The vast majority of these materials, both natural and synthetic, interact with biological matter in the absence of direct electronic communication. However, biological systems have evolved to synthesize and utilize naturally-derived materials for the generation and modulation of electrical potentials, voltage gradients, and ion flows. Bioelectric phenomena can be translated into potent signaling cues for intra- and inter-cellular communication. These cues can serve as a gateway to link synthetic devices with biological systems. This progress report will provide an update on advances in the application of electronically active biomaterials for use in organic electronics and bio-interfaces. Specific focus will be granted to covering technologies where natural and synthetic biological materials serve as integral components such as thin film electronics, in vitro cell culture models, and implantable medical devices. Future perspectives and emerging challenges will also be highlighted."

http://bit.ly/WuYvFA

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Divya B.'s curator insight, March 13, 2013 9:44 AM

We could certainly use something like this. The medicine industry needs all the help it can get when it comes to fighting disease and such, and this is just perfect!

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Synthetic biology team makes big strides

Synthetic biology team makes big strides | SynBioFromLeukipposInstitute | Scoop.it
Engineering students helped make an ASU team a leading contender in one of the most prominent international student engineering and science competitions.
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Meta-DNA: A DNA-Based Approach to Synthetic Biology

Meta-DNA: A DNA-Based Approach to Synthetic Biology | SynBioFromLeukipposInstitute | Scoop.it

by

Harish Chandran, Nikhil Gopalkrishnan, Bernard Yurke, John Reif

"The goal of synthetic biology is to design and assemble synthetic systems that mimic bio- logical systems. One of the most fundamental challenges in synthetic biology is to synthesize artificial biochemical systems, which we will call meta-biochemical systems, that provide the same functionality as biological nucleic acids-enzyme systems, but that use a very limited num- ber of types of molecules. The motivation for developing such synthetic biology systems is to enable a better understanding of the basic processes of natural biology, and also to enable re-engineering and programmability of synthetic versions of biological systems.
One of the key aspects of modern nucleic acid biochemistry is its extensive use of protein enzymes that were originally evolved in cells to manipulate nucleic acids, and then later adapted by man for laboratory use. This practice provided powerful tools for manipulating nucleic acids, but also limited the extent of the programmability of the available chemistry for manipulating nucleic acids, since it is very difficult to predictively modify the behavior of protein enzymes. Meta-biochemical systems offer the possible advantage of being far easier to re-engineer and program for desired functionality.
The approach taken here is to develop a biochemical system which we call meta-DNA (abbre- viated as mDNA), based entirely on strands of DNA as the only component molecules. Our work leverages prior work on the development of self-assembled DNA nanostructures (see Amin et al. (2009); LaBean et al. (2007); Seeman (2004); Deng et al. (2006); Lund et al. (2006); Bath and Turberfield (2007); Winfree (2003) for excellent reviews of the field). Each base of a mDNA is a DNA nanostructure. Our mDNA bases are paired similar to DNA bases, but have a much larger alphabet of bases, thereby providing increased power of base addressability. Our mDNA bases can be assembled to form flexible linear assemblies (single stranded mDNA) analogous to single stranded DNA, and can be hybridized to form stiff helical structures (duplex mDNA) analogous to double stranded DNA, and also can be denatured back to single stranded mDNA.
Our work also leverages the abstract activatable tile model developed by Majumder et al. (2007) and prior work on the development of enzyme-free isothermal protocols based on DNA hybridization and sophisticated strand displacement hybridization reactions (see Reif and Ma- jumder (2008); Sakamoto et al. (1999); Dirks and Pierce (2004); Zhang et al. (2007); Tian et al. (2006); Sherman and Seeman (2004); Yin et al. (2004)). We describe various isothermal hy- bridization reactions that manipulate our mDNA in powerful ways analogous to DNA-DNA reactions and the action of various enzymes on DNA. These operations on mDNA include (i) hy- bridization of single strand mDNA (ssmDNA) into a double strand mDNA (dsmDNA) and heat denaturation of a dsmDNA into its component ssmDNA (analogous to DNA hybridization and denaturation), (ii) strand displacement of one ssmDNA by another (similar to strand displace- ment in DNA), (iii) restriction cuts on the backbones of ssmDNA and dsmDNA (similar to the action of restriction enzymes on DNA), (iv) polymerization chain reactions that extend ssmDNA on a template to form a complete dsmDNA (similar to the action of polymerase enzyme on DNA), (v) isothermal denaturation of a dsmDNA into its component ssmDNA (like the activity of heli- case enzyme on DNA) and (vi) an isothermal replicator reaction which exponentially amplifies ssmDNA strands (similar to the isothermal PCR reaction). We provide a formal model to de- scribe the required properties and operations of our mDNA, and show that our proposed DNA nanostructures and hybridization reactions provide these properties and functionality."

http://bit.ly/WVj82k

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Running science as a Ponzi scheme

Running science as a Ponzi scheme | SynBioFromLeukipposInstitute | Scoop.it

by

Steve Caplan

"Ponzi schemes are typically scams that involve the recruitment of investors, who initially receive high returns for their investments and recruit other investors – until this pyramid collapses, and those at the bottom end up losing all their money. Meanwhile, those at the top of the pyramid disappear with the "earnings". Does this bear any similarity to the pyramidal systems that exist in the sciences at academic institutes and universities?

At universities across the globe, there are principal investigators or professors who run research labs. To carry out their ideas, they need to recruit students who are able to carry out the experiments and test the validity of their hypotheses. But will these students, at the lower rungs of the totem pole, eventually turn into professors? Or will their investments be wasted treadmilling in a career leading nowhere?

Having talked to scientists from more than a dozen countries, I think it's clear that the system of scientific research bears far too much similarity to Ponzi schemes.

A devil's advocate might counter that in every type of occupation there is a pyramidal system, with fewer managers on the top and many laborers on the bottom of the pay scale. That only a relatively select few – the very top students – will make it through successful post-doctoral stints to academic positions.

Yes, this is true – but it's also not the problem.

The problem, as I see it, is the misrepresentation of students' career options to them. Or more accurately, the general failure to inform students (as well as post-doctoral fellows) of their career options and train them for a wide variety of scientific careers, including the many opportunities that exist outside academia. It is also necessary to unequivocally explain the possibilities (statistically or specifically) that a student has to obtain an independent academic research position...."

http://bit.ly/Rd34HI

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*Cryo-EM structure of a 3D DNA-origami object*

by

Bai XC, Martin TG, Scheres SH, Dietz H.

"A key goal for nanotechnology is to design synthetic objects that may ultimately achieve functionalities known today only from natural macromolecular complexes. Molecular self-assembly with DNA has shown potential for creating user-defined 3D scaffolds, but the level of attainable positional accuracy has been unclear. Here we report the cryo-EM structure and a full pseudoatomic model of a discrete DNA object that is almost twice the size of a prokaryotic ribosome. The structure provides a variety of stable, previously undescribed DNA topologies for future use in nanotechnology and experimental evidence that discrete 3D DNA scaffolds allow the positioning of user-defined structural motifs with an accuracy that is similar to that observed in natural macromolecules. Thereby, our results indicate an attractive route to fabricate nanoscale devices that achieve complex functionalities by DNA-templated design steered by structural feedback."

http://bit.ly/Tk8Lj3

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Can Synthetic Biology Save the World?

Can Synthetic Biology Save the World? | SynBioFromLeukipposInstitute | Scoop.it
In the past dozen years, scientists have gone way beyond sequencing DNA to actually creating synthetic DNA in  the lab. The next step is to insert that DNA into a cell and create synthetic life.
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Synthetic biology of antimicrobial discovery - ACS Synthetic Biology (ACS Publications)

Synthetic biology of antimicrobial discovery - ACS Synthetic Biology (ACS Publications) | SynBioFromLeukipposInstitute | Scoop.it
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Capturing living cells in micro pyramids

Capturing living cells in micro pyramids | SynBioFromLeukipposInstitute | Scoop.it
A field full of pyramids, but on a micro scale. Each of the pyramids hides a living cell. Thanks to 3D micro- and nano scale fabrication, promising new applications can be found.
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The Emerging World of Synthetic Genetics

by

John C. Chaput, Hanyang Yu, Su Zhang

"For over 20 years, laboratories around the world have been applying the principles of Darwinian evolution to isolate DNA and RNA molecules with specific ligand-binding or catalytic activities. This area of synthetic biology, commonly referred to as in vitro genetics, is made possible by the availability of natural polymerases that can replicate genetic information in the laboratory. Moving beyond natural nucleic acids requires organic chemistry to synthesize unnatural analogues and polymerase engineering to create enzymes that recognize artificial substrates. Progress in both of these areas has led to the emerging field of synthetic genetics, which explores the structural and functional properties of synthetic genetic polymers by in vitro evolution. This review examines recent advances in the Darwinian evolution of artificial genetic polymers and their potential downstream applications in exobiology, molecular medicine, and synthetic biology."

http://bit.ly/T1GFbJ

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Biosciences - George Osbourne identifies Synthetic Biology and Agri-Science amongst key drivers of UK economy - Articles - Open Innovation

Biosciences - George Osbourne identifies Synthetic Biology and Agri-Science amongst key drivers of UK economy - Articles - Open Innovation | SynBioFromLeukipposInstitute | Scoop.it
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uBiome -- Sequencing Your Microbiome

uBiome -- Sequencing Your Microbiome | SynBioFromLeukipposInstitute | Scoop.it
Be a citizen scientist and help us sequence the human microbiome. Learn about your health, advance science, and CHANGE THE WORLD!
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Private labs caught in budget crunch

Private labs caught in budget crunch | SynBioFromLeukipposInstitute | Scoop.it
We might need to rethink how we finance and organize basic research:

Biomedical-lab closure highlights plight of independent research institutes that rely heavily on federal grants

http://bit.ly/QzbUzq

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