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Synthetic biology goes industrial

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Jennifer Rohn

"Imperial College London has won a £10 ($16)-million grant to set up a new translational center aimed at integrating academic and industry research in synthetic biology. Known as SynbiCITE, the London-based center is funded by the Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council and Technology…"

http://bit.ly/14JMaY0

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DNA-directed self-assembly of shape-controlled hydrogels

DNA-directed self-assembly of shape-controlled hydrogels | SynBioFromLeukipposInstitute | Scoop.it
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Hao Qi,Majid Ghodousi,Yanan Du,Casey Grun,Hojae Bae,Peng Yin& Ali Khademhosseini

"Using DNA as programmable, sequence-specific ‘glues’, shape-controlled hydrogel units are self-assembled into prescribed structures. Here we report that aggregates are produced using hydrogel cubes with edge lengths ranging from 30 μm to 1 mm, demonstrating assembly across scales. In a simple one-pot agitation reaction, 25 dimers are constructed in parallel from 50 distinct hydrogel cube species, demonstrating highly multiplexed assembly. Using hydrogel cuboids displaying face-specific DNA glues, diverse structures are achieved in aqueous and in interfacial agitation systems. These include dimers, extended chains and open network structures in an aqueous system, and dimers, chains of fixed length, T-junctions and square shapes in the interfacial system, demonstrating the versatility of the assembly system."

http://bit.ly/17QON9k


Comment:
*Scientists Build Programmable Glue from DNA*

by anonymous

"Researchers have found a way to self-assemble complex structures out of bricks smaller than a grain of salt.

 The self-assembly method could help solve one of the major challenges in tissue engineering: regrowing human tissue by injecting tiny components into the body that then self-assemble into larger, intricately structured, biocompatible scaffolds at an injury site. The key to self-assembly was developing the world's first programmable glue. The glue is made of DNA, and it directs specific bricks of a water-filled gel to stick only to each other, the scientists report in the September 9th online issue of Nature Communications. "By using DNA glue to guide gel bricks to self-assemble, we're creating sophisticated programmable architecture," says Peng Yin, a Core Faculty member at the Wyss Institute for Biologically Inspired Engineering and senior coauthor of the study, who is also an assistant professor of Systems Biology at Harvard Medical School. This novel self-assembly method worked for gel bricks from as small as a speck of silt (30 microns diameter) to as large as a grain of sand (1 millimetre diameter), underscoring the method's versatility. The programmable DNA glue could also be used with other materials to create a variety of small, self-assembling devices, including lenses, reconfigurable microchips, and surgical glue that could knit together only the desired tissues, said Ali Khademhosseini, an associate faculty member at the Wyss Institute who is the other senior coauthor of the study.…"


http://bit.ly/13NREyd
also source of the figure below

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Fluorine-Adding Bacteria May Transform Natural Product Medicines

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Robert F. Service

"Fluorine is key to the activity of top-selling small molecule drugs. But it's difficult to add the element to large molecules without destroying their function. Now, researchers led by Michelle Chang at the University of California, Berkeley, have shown that they can engineer bacteria to incorporate fluorine into complex compounds, the sorts that make up antibiotics, antifungals, and insecticides."

http://bit.ly/16hu4Lj

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Andrew Hessel - You Can and Must Understand Synthetic Biology

A 2013 survey conducted by the Woodrow Wilson Synthetic Biology Project found that 75% of adults have heard just a little or nothing at all about synthetic b...
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Synthetic Biology Firm Triton Algae Raises $5M in Series A Round | GenomeWeb Daily News | GenomeWeb

Synthetic Biology Firm Triton Algae Raises $5M in Series A Round | GenomeWeb Daily News | GenomeWeb | SynBioFromLeukipposInstitute | Scoop.it
  (Synthetic Biology Firm Triton Algae Raises $5M in Series A Round http://t.co/YZOmGmgWX3)
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A new era is beginning, just like the digital one Steve Jobs

A new era is beginning, just like the digital one Steve Jobs | SynBioFromLeukipposInstitute | Scoop.it
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*A new era is beginning, just like the digital one*

Steve Jobs was discussing with his biographer Walter Isaacson his life: "after Jobs was diagnosed with cancer, Reed (his son) began spending his summer working in a Stanford oncology lab…. One very few silver linings about me getting sick is that Reed`s gotten to spend a lot of time studying with some very good doctors, Jobs said. His enthusiasms for it is exactly how I felt about computers when I was his age. I think the biggest innovations of the twenty-first century will be the intersection of biology and technology. A new era is beginning, just like the digital one when I was his age."
Think small - build your own biocomputer - only 69 / 3 days left - hurry to get one http://bit.ly/17dUxv8
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The Spinach RNA aptamer as a characterisation tool for synthetic biology

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Creation and Characterization of Component Libraries for Synthetic Biology

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Systematic Methodology for the Development of Mathematical Models for Biological Processes

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Synthetic Genomics and Synthetic Biology Applications Between Hopes and Concerns

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Think small - be one of the first to build a computer from biological material

Think small - be one of the first to build a computer from biological material | SynBioFromLeukipposInstitute | Scoop.it



http://cytocomp-bitstarter-mooc.herokuapp.com

Gerd Moe-Behrens's insight:
How? Find out here: http://cytocomp-bitstarter-mooc.herokuapp.com 1) a free open source "instruction manual" (review) 2) exclusive access to software, helping you to design your very own biological computer. This computer can also interact with a smartphone. Thus great opportunities for developers to make unique apps.  3) what can I use this for?  have a look to the free, open access review to find a detail answer. This offers are only valid for the next 3 days, as long our crowd funding campaign last. Only 69 kits left. If you wish to back the campaign with other than bit coins, please contact me and we can arrange payment by PayPal or bank transfer. Hurry and take this unique opportunity to be one of the first in the world to build  microprocessor, not form silicon, but from biological material. 
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An easier way to control genes

An easier way to control genes | SynBioFromLeukipposInstitute | Scoop.it
New method for turning genes on and off could enable more complex synthetic biology circuits.
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*An easier way to control genes*

by
Anne Trafton

"MIT researchers have shown that they can turn genes on or off inside yeast and human cells by controlling when DNA is copied into messenger RNA — an advance that could allow scientists to better understand the function of those genes.

 The technique could also make it easier to engineer cells that can monitor their environment, produce a drug or detect disease, says Timothy Lu, an assistant professor of electrical engineering and computer science and biological engineering and the senior author of a paper describing the new approach in the journal ACS Synthetic Biology."

http://bit.ly/18AHXSg ;
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CytoComp a revolutionary biological computer

CytoComp a revolutionary biological computer | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:
*I need your help!*

I am doing for the moment a crowd funding campaign. It is about a biological computer, which can revolutionize medical treatment. Have a look here: http://cytocomp-bitstarter-mooc.herokuapp.com My goal is to raise $ 10000 - so far I got $ 4000 - there are only 6 days left and I need your help to reach my goal - The crowd funder is actually coded by myself. I did a MOOC class about Startup Engineering provided by Stanford University, and we learned how to do this. The project participate in a competition by Stanford University . You can follow on this leader board (the last  contribution of $2600 is not registered yet) http://startupmooc.org CytoComp leads for the moment. The project with the most tweets and bit coins will win and get help from Stanford to proceed with the project.I hope as  as many as possible go to the webpage and push the tweet button (maybe behind the +) If someone does not have bit coins, people can contact me and we find another form of payment. We can arrange PayPal or bank transfer.

I really need the financial support. I used my savings and time on the open science projects I promoted. I really hope that somebody with money can help. I need $6000 more. This money will make a big difference, not only for me but also for all the people who can get help by this revolutionizing technology. IF you are interested in this technology you can read my free review, which you can find here: http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201304003

Have a look to the web page. There are very interesting rewards for the supporters and for the community in form of open source software, which you can use to build your very own biological computer. You can solve novel problems, design the biocomputer and send it for printing. You can also build Apps for your smartphone interacting with the biocomputer, as the biocomputer can send and receive signals from a smartphone. Have a look. I am sure you will love the project.

Thanks for your support.

Best Gerd  
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Engineered bacterium hunts down pathogens

Engineered bacterium hunts down pathogens | SynBioFromLeukipposInstitute | Scoop.it
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Engineered bacterium hunts down pathogens* 


E. coli microbe seeks out and destroys invaders without harming helpful bacteria.
byMark Peplow

"In the war against infection, medicine needs a hero. Meet the bioengineered bacterium that can hunt down pathogens and destroy them with a powerful one–two punch. Synthetic biologist Matthew Chang at Nanyang Technological University in Singapore has armed Escherichia coli bacteria with a ‘seek and kill’ system that targets cells of Pseudomonas aeruginosa, an invasive bacterium that causes pneumonia and other illnesses1. In preliminary tests with infected mice, the modified bacterium left a trail of dead P. aeruginosa in its wake. Chang and his team had previously developed an E. coli that could brew up an antibacterial peptide called pyocin, and then explode to release its deadly cargo whenever it detected a chemical signal emitted by its prey2. Now the bioengineered vigilante is back — and it is tougher than ever…."


http://bit.ly/1d7QAr* ;


E. coli microbe seeks out and destroys invaders without harming helpful bacteria.
byMark Peplow

"In the war against infection, medicine needs a hero. Meet the bioengineered bacterium that can hunt down pathogens and destroy them with a powerful one–two punch. Synthetic biologist Matthew Chang at Nanyang Technological University in Singapore has armed Escherichia coli bacteria with a ‘seek and kill’ system that targets cells of Pseudomonas aeruginosa, an invasive bacterium that causes pneumonia and other illnesses1. In preliminary tests with infected mice, the modified bacterium left a trail of dead P. aeruginosa in its wake. Chang and his team had previously developed an E. coli that could brew up an antibacterial peptide called pyocin, and then explode to release its deadly cargo whenever it detected a chemical signal emitted by its prey2. Now the bioengineered vigilante is back — and it is tougher than ever…."


http://bit.ly/1d7QArO

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SBWGLunches - OpenWetWare

SBWGLunches - OpenWetWare | SynBioFromLeukipposInstitute | Scoop.it
Synthetic Biology Working Group (SBWG), MIT/Harvard/BU, is a lunchtime forum connecting Boston synth bio folks. http://t.co/xjWPUsPnuj
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CytoComp a revolutionary biological computer

CytoComp a revolutionary biological computer | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:

Number of page views in a few days: 15410
Number of video views 2,396

 

http://bit.ly/17dUxv8

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I need your help - ~only few hours left in my crowd funding campaign, I need to raise $4763 to reach the goal

I need your help - ~only few hours left in my crowd funding campaign, I need to raise $4763 to reach the goal | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:

CytoComp`s mission is to build the first microprocessor made from biological parts. It has an input output unit, which can both take a electrical as a biological signal. Thus you can monitor on your smartphone, what is going on in the biological system.

 

CytoComp will do what Intel has done with silicon with biological parts.

 

You can get a free review about biological computing if you go to this page 

http://cytocomp-bitstarter-mooc.herokuapp.com

 

The backer of this campaign get some very interesting rewards. 

 

For 1 Bitcoin ($119) you get exclusive early developer access to CytoComp`s CAD (computer assisted design platform, which allows you to custom design a biological microprocessor). Hurry - only  40 left!

 

If you do not have Bitcoins we can arrange a payment by PayPal. For that case please contact me at 

info@cytocomp.com

 

This is a one time opportunity for developer and tinkeres to get exclusive access  to a revolutionizing technology, which can have many applications.

 

Please help CytoComp to raise the remaining $4763.

 

Thanks for your support.

 

BTW this crowd funding campaign is part of a competition arranged by Stanford University. CytoComp is so far the leading top 1 most funded team. You can follow here http://startupmooc.org

Recent funds we have received via PayPal are even not added.

 

PS

As this concept might be new for many, I wish in the following to explain a bit what biological computer can be used to. I will in the following also make some posts to focus on certain diseases.

 

Potential applications of biological computers

Biological computers possess some distinct advantages over silicon computers . These systems can self-assemble and self- reproduce, which might provide some economic advantages. Moreover, cells can be engineered to sense and respond to environmental signals, even under extreme conditions such as high temperature, high pressure, radioactivity or toxic chemicals. Biological systems have the ability to adapt to new information from a changed environment.

The ultimate goals of biocomputing are the monitoring and control of biological systems.

 

Monitoring of biological systems

Biological systems need to be monitored in respect to disease diagnostic, to drug screening, to understand experimental systems, and to observe the environment.

In line with this, a biocomputer has been utilized to detect multiple disease indicators, such as mRNA of disease-related genes associated with small-cell lung cancer and prostate cancer. Moreover, they can be used in experimental models, such as conditional transgenes or inducible expression systems. Environmental monitoring is another interesting application. A cell based biosensor using logic gates has been used to detect arsenic, mercury and copper ion levels.

 

Control of biological systems

Biocomputers can potentially be used to control development, cell differentiation and re-programming, as all these processes depend on gene regulatory networks. Another application area is tissue engineering and tissue regeneration. Metabolic engineering has the potential to produce from simple, inexpensive starting materials a large number of chemicals that are currently derived from nonrenewable resources or limited natural resources. The metabolic flux can potentially be controlled by a biocomputer . Interesting might also be to control the immune system by a biocomputer, e.g. in transplantation medicine . An important application area is the control of malign growth. Some interesting experiments with logic based biological devices have been executed to detect cancer cells (e.g. small-cell lung cancer, prostate cancer, HeLa cells), and to induce selective apoptosis of these cells. Furthermore, biocomputers can be used to engineer context-dependent programmable drugs. A biocomputer with a context-sensing mechanism, which can simultaneously sense different types of molecules, has been engineered. In the future it might be used to detect a broad range of molecular disease symptoms, and react with the release of a drug molecule suitable for the treatment of the specific condition. In line with this concept a programmable NOR-based device has been developed capable of differentiating between prokaryotic cell strains based on their unique expression profile.

 

 

Thanks for your support

 

Gerd

 

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Global market for synthetic biology products to top £7 billion by 2016

Global market for synthetic biology products to top £7 billion by 2016 | SynBioFromLeukipposInstitute | Scoop.it
- Synthetic biology can be hard to pin down. The field encompasses a vast array of research themes, from creating artificial life to..
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Synthetic Biology V 2.0 - Wired Science

Synthetic Biology V 2.0 - Wired Science | SynBioFromLeukipposInstitute | Scoop.it
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BY JEFFREY MARLOW

"On a loud, hectic street in Albany, CA, just north of Berkeley, Eric Steen and Jeffrey Dietrich step tentatively into a dusty warehouse, gingerly avoiding the detritus of previous tenants.

 “This is it?” asks Dietrich hesitantly. “That’s right,” answers Steen, “Lygos’ case study in synthetic biology garage space.” The duo’s plucky optimism is drowned out by mechanics’ drills and squealing tires on San Pablo Avenue, but they get to work, dusty warehouse transitioning to gleaming laboratory in full montage magic. Someday, this scene may find its way into The Social Network II* as a microcosm of the latest garage industry to inundate VC pitch meeting schedules from Silicon Valley to Cambridge. It’s Biotech 2.0, with synthetic biology techniques offering tinkerers a new lens on microbially produced materials. Steen and Dietrich, grad school lab-mates who habitually bounced potentially monetizable ideas around the office, now find themselves leading Lygos, one of the more promising, if mysterious, entrants in the synthetic biology industry.  Lygos is engineering microbial strains to make industrially useful biochemicals from renewable feedstocks. “This technology holds pretty good promise for making a substantial impact on the world,” Steen says……"


 http://bit.ly/17zERN2

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Assembly of Multi-gene Pathways and Combinatorial Pathway Libraries Through ePathBrick Vectors

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Cellular Computing – Google+ - 6199 people visted this page in under one week …

Cellular Computing – Google+ - 6199 people visted this page in under one week … | SynBioFromLeukipposInstitute | Scoop.it
6199 people visted this page in under one week

http://cytocomp-bitstarter-mooc.herokuapp.com
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*6199 people visted this page in under one week*

http://cytocomp-bitstarter-mooc.herokuapp.com

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Please support the crowd funding campaign of CytoComp

Please support the crowd funding campaign of CytoComp | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:
Hi! please support the crowd funding campaign of CytoComp - a cutting edge microchip built from bio bricks. http://cytocomp-bitstarter-mooc.herokuapp.com This crowd funding platform was coded by me as a final project during the last few weeks of a Startup Engineering MOOC class provided by Stanford University, see https://www.coursera.org/course/startup The reward for supporting this campaign is exclusive early developer access to CytoComp`s CAD (computer assisted design platform, which allows you to custom design a biological microprocessor).  More scientific information about this project can be found in this free, open source review, which I recently have published http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201304003 Furthermore, the CytoComp project has lately received major public attention, which has led to an invitation to giving a talk at GenoBioTech13 (along with other prominent speakers from MIT, Stanford University, CalTech, Yale, Lawrence Berkeley National Laboratory, Cold Spring Harbor Laboratory and Harvard University) http://genobiotec13.com/ponentes/  This conference will take place in November 2013. The CytoComp project is, at the moment, the #1 top funded project in the Stanford University  competition (see the leader board at http://startupmooc.org ).A rule of the competition was to ask for funding in Bitcoins. It would be of great help, if you could back the project. In the case you don't have BitCoins, payments can be arranged via PayPal or banks transfer.Yesterday CytoComp received $2640 (via PayPal), an amount that soon will be added to the leader board funding column.  Again, it would be of great help, if you could back the project.  Thanks in advance for your support. Best Gerd   
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Think small - build your very own biological computer

Think small - build your very own biological computer | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:

*Think small - build your very own biological computer*

I did an awesome MOOC class provided by Stanford University, We coded our own crowd funding page to get backing for our project. http://cytocomp-bitstarter-mooc.herokuapp.com 

As you might know, is the biological computer, what I am working on. In the frame of the campaign I am offering exclusive early developer licenses for a computer assisted software platform, which helps you to build your very own biological computer. Only 70 of these licenses are left, and you have only 5 days left to get one. You can be one of the first who ever build a microchip made form biological material. This bio chip can interact with your smart phone. Thus you can make apps, where your smartphone can interact with biological processes. This is a great opportunity for developers, tinkers and everybody who wishes take advantage of to be first in row. Hurry, if you wish to be one of them. Try it for yourself.

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