SynBioFromLeukipposInstitute
109.9K views | +2 today
Follow
SynBioFromLeukipposInstitute
Your new post is loading...
Your new post is loading...
Scooped by Gerd Moe-Behrens
Scoop.it!

What are biological microprocessors good for? - YouTube

Gerd Moe-Behrens's insight:

This brief videos answers what kind of problems a biological microprocessor can solve.

BTW
Our Leukippos community needs your financial support. We are all working for free and pay everything out of our own pockets, such as server costs and page reg- istrations. If you like our work and wish that we produce more quality content, such as this video, you can donate some bitcoins to this address:

more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Understanding Synthetic Biology

Understanding Synthetic Biology | SynBioFromLeukipposInstitute | Scoop.it
SynBio.Info is a collaborative effort to understand, structure and explain our future in Synthetic Biology. Find out what the future will look like and understand how 'easy' it is to create your own cells that follow your instructions.
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

MINDS is a novel kind of social network.
You might be interested to join the…

MINDS is a novel kind of social network.<br/>You might be interested to join the… | SynBioFromLeukipposInstitute | Scoop.it
MINDS is a novel kind of social network.
You might be interested to join the Synthetic Biology group there http://bit.ly/1FuBUhN - Gerd Moe-Behrens - Google+
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Synthetic Biology Market by Tool, Technology & Application - 2018 | MarketsandMarkets

Synthetic Biology Market by Tool, Technology & Application - 2018 | MarketsandMarkets | SynBioFromLeukipposInstitute | Scoop.it
[185 Pages Report] Synthetic Biology Market report categories the global market by Technology (Nanotechnology, Gene Synthesis, Bioinformatics, Cloning & Sequencing), Application (Pharmaceuticals, Biomaterials, Biofuels, Bioremediation), Tool(Oligos,...
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

pClone: Synthetic Biology Tool Makes Promoter Research Accessible to Beginning Biology Students.

pClone: Synthetic Biology Tool Makes Promoter Research Accessible to Beginning Biology Students. | SynBioFromLeukipposInstitute | Scoop.it
CBE Life Sci Educ. 2014 Summer;13(2):285-296.
Gerd Moe-Behrens's insight:

by

A. Malcolm Campbell,* Todd Eckdahl,Brian Cronk,Corinne Andresen,Paul Frederick,Samantha Huckuntod,Claire Shinneman,Annie Wacker,* and Jason Yuan† 


"The Vision and Change report recommended genuine research experiences for undergraduate biology students. Authentic research improves science education, increases the number of scientifically literate citizens, and encourages students to pursue research. Synthetic biology is well suited for undergraduate research and is a growing area of science. We developed a laboratory module called pClone that empowers students to use advances in molecular cloning methods to discover new promoters for use by synthetic biologists. Our educational goals are consistent with Vision and Change and emphasize core concepts and competencies. pClone is a family of three plasmids that students use to clone a new transcriptional promoter or mutate a canonical promoter and measure promoter activity in Escherichia coli. We also developed the Registry of Functional Promoters, an open-access database of student promoter research results. Using pre- and posttests, we measured significant learning gains among students using pClone in introductory biology and genetics classes. Student posttest scores were significantly better than scores of students who did not use pClone. pClone is an easy and affordable mechanism for large-enrollment labs to meet the high standards of Vision and Change."

free PDF

http://www.lifescied.org/content/13/2/285.full.pdf+html

more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Labster - MIT Synthetic Biology Virtual Lab Simulation

Get Your Free Trial Here: https://www.labster.com/courses/LabsterX/SyntheticBiology/2015/about ABOUT THE VIRTUAL LAB SIMULATION In the Synthetic ...
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Disruptive: Synthetic Biology

What sorts of breakthroughs are possible by modifying an organism’s genome – something researchers are now able to do ever more cheaply and efficiently?
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Potential applications of biological microprocessors: Control of biological systems

Potential applications of biological microprocessors: Control of biological systems | SynBioFromLeukipposInstitute | Scoop.it
Biocomputers can potentially be used to control development, cell differentiation and re-programming, as all these processes depend on gene regulatory networks. Another application area is tissue engineering and tissue regeneration. Metabolic engineering has the potential to produce from simple, inexpensive starting materials a large number of chemicals that are currently derived from nonrenewable resources or limited natural resources. The metabolic flux can potentially be controlled by a biocomputer. Interesting might also be to control the immune system by a biocomputer, e.g. in transplantation medicine. An important application area is the control of malign growth. Some interesting experiments with logic based biological devices have been executed to detect cancer cells (e.g. small-cell lung cancer, prostate cancer, HeLa cells), and to induce selective apoptosis of these cells. Furthermore, biocomputers can be used to engineer context-dependent programmable drugs. A biocomputer with a context-sensing mechanism, which can simultaneously sense different types of molecules, has been engineered. In the future it might be used to detect a broad range of molecular disease symptoms, and react with the release of a drug molecule suitable for the treatment of the specific condition. In line with this concept a programmable NOR-based device has been developed capable of differentiating between prokaryotic cell strains based on their unique expression profile. http://bit.ly/YI13bF
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Potential applications of biological microprocessors: Monitoring of biological systems

Potential applications of biological microprocessors: Monitoring of biological systems | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:

Biological systems need to be monitored in respect to disease diagnostic, to drug screening, to understand experimental systems, and to observe the environment. In line with this, a biocomputer has been utilized to detect multiple disease indicators, such as mRNA of disease-related genes associated with small-cell lung cancer and prostate cancer. Moreover, they can be used in experimental models, such as conditional transgenes or inducible expression systems. Environmental monitoring is another interesting application. A cell based biosensor using logic gates has been used to detect arsenic, mercury and copper ion levels. http://bit.ly/YI13bF

more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Layering genetic circuits to build a single cell, bacterial half adder

Layering genetic circuits to build a single cell, bacterial half adder | SynBioFromLeukipposInstitute | Scoop.it
BACKGROUND:
Gene regulation in biological systems is impacted by the cellular and genetic context-dependent effects of the biological parts which comprise the circuit. Here, we have sought to elucidate the limitations of engineering biology from an architectural point of view, with the aim of compiling a set of engineering solutions for overcoming failure modes during the development of complex, synthetic genetic circuits.
RESULTS:
Using a synthetic biology approach that is supported by computational modelling and rigorous characterisation, AND, OR and NOT biological logic gates were layered in both parallel and serial arrangements to generate a repertoire of Boolean operations that include NIMPLY, XOR, half adder and half subtractor logics in single cell. Subsequent evaluation of these near-digital biological systems revealed critical design pitfalls that triggered genetic context dependent effects, including 5' UTR interferences and uncontrolled switch-on behaviour of supercoiled σ54 promoter. In particular, the presence of seven consecutive hairpins immediately downstream of promoter transcription start site resulted in severe impediment of gene expression.
CONCLUSIONS:
As synthetic biology moves forward with greater focus on scaling the complexity of engineered genetic circuits, studies which thoroughly evaluate failure modes and engineering solutions will serve as important references for future design and development of synthetic biological systems. This work describes a representative case study to the debugging of genetic context dependent effects through principles elucidated herein, thereby providing a rational design framework to integrate multiple genetic circuits in a single prokaryotic cell.
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Layering genetic circuits to build a single cell, bacterial half adder

Gene regulation in biological systems is impacted by the cellular and genetic context-dependent effects of the biological parts which comprise the circuit. Here, we have sought to elucidate the limitations of engineering biology from an architectural point of view, with the aim of compiling a set of engineering solutions for overcoming failure modes during the development of complex, synthetic genetic circuits. Using a synthetic biology approach that is supported by computational modelling and rigorous characterisation, AND, OR and NOT biological logic gates were layered in both parallel and serial arrangements to generate a repertoire of Boolean operations that include NIMPLY, XOR, half adder and half subtractor logics in single cell. Subsequent evaluation of these near-digital biological systems revealed critical design pitfalls that triggered genetic context dependent effects, including 5′ UTR interference and uncontrolled switch-on behaviour of σ54 promoter. Importantly, this work provides a representative case study to the debugging of genetic context dependent effects through principles elucidated herein, thereby providing a rational design framework to program single prokaryotic cell with diversified digital operations.
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Memory unit in a biological microprocessor

Memory unit in a biological microprocessor | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:

Shown is a simplified diagram of a modular memory device, which is a transcriptionally controlled network composed of two transcription factor encoding genes, a sensor gene and a positive (+) auto feedback gene (P-GAL = GAL 1/10 promoter, P-CYC = CYC 1 promoter, DNA BD = sequence encoding a DNA binding domain of the respective transcription factor). The network can be in three states, off, on and memory. The system is in of state, if it has never been exposed to a signal (here galactose). It is on, if galactose is present. In this case the signal induces the synthesis of a transcription factor, the sensor. This triggers the expression of another transcription factor able to bind to its own promoter. The system is in memory state, if the signal is removed. The auto feedback activator is able to initiate its own expression even if the inducing signal is lacking, which means that the system has stored information.

http://bit.ly/YI13bF

more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

RNA Synthetic Biology: From the Test Tube to Cells and Back Again - ACS Synthetic Biology (ACS Publications)

RNA Synthetic Biology: From the Test Tube to Cells and Back Again - ACS Synthetic Biology (ACS Publications) | SynBioFromLeukipposInstitute | Scoop.it
RT @bacteriality: Interested in RNA Synthetic Biology? Start here: http://t.co/JAqvCJKB9V cool overview by @JustinGallivan @ACSSynBio
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

What is a biological microprocessor? - YouTube

A brief introduction to a biological microprocessor.
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Synthetic biology meets design | Sciencedump

Synthetic biology meets design | Sciencedump | SynBioFromLeukipposInstitute | Scoop.it
Alexandra Daisy Ginsberg explores how synthetic biology and design can be utilised to do useful things, engineering a better future. Daisy is an artist, designer and writer investigating the dynamic that exists between synthetic biology and design.
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Ethics for Synthetic Biology: Suggested Topics

Ethics for Synthetic Biology: Suggested Topics | SynBioFromLeukipposInstitute | Scoop.it
The iGEM Team BIOSINT México, considered that when people talk about ethics, specifically, the members of all the teams, lack of an ethical code to serve as a guide for considering the ethical aspects of the projects.
So, we have the idea of creating an ethical code that serve as a guideline for all the SynBio community. That being said, we want to ask you which topics would you like to be treated in this document. Here, we present some topics that we have considered for the ethical code, you ca
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Synthetic Biology for Specialty Chemicals.

In this review, we address recent advances in the field of synthetic biology and describe how those tools have been applied to produce a wide variety of chemicals in microorganisms. Here we classify the expansion of the synthetic biology toolbox into three different categories based on their primary function in strain engineering-for design, for construction, and for optimization. Next, focusing on recent years, we look at how chemicals have been produced using these new synthetic biology tools. Advances in producing fuels are briefly described, followed by a more thorough treatment of commodity chemicals, specialty chemicals, pharmaceuticals, and nutraceuticals. Throughout this review, an emphasis is placed on how synthetic biology tools are applied to strain engineering. Finally, we discuss organism and host strain diversity and provide a future outlook in the field. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering Volume 6 is July 16, 2015. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Synthetic biology biocontainment 'lock and key' prevents accidental releases - Genetic Literacy Project

Synthetic biology biocontainment 'lock and key' prevents accidental releases - Genetic Literacy Project | SynBioFromLeukipposInstitute | Scoop.it
Researchers at the University of California, Berkeley, have developed an easy way to put bacteria under a molecular lock and key in order to contain its
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Introducting Synthetic Biology - By IGem Team Tu Munich 2011 | science buddie | cool science project

fun physics experiments, physical experiments, chemistry experiments for class 12, college chemistry experiments, halloween chemistry experiments, chemistry ...
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Science Documentary: Personalized Medicine, Synthetic Biology , a documentary on genetic design

Science Documentary: Personalized Medicine, Synthetic Biology a documentary on genetic design Within our DNA lies the instructions for our cells. These cellular ...
more...
No comment yet.
Suggested by Flip The Movie Script
Scoop.it!

Electron Reduced Uranium from “Breathing” Bacteria (Betaproteobacteria)

Electron Reduced Uranium from “Breathing” Bacteria (Betaproteobacteria) | SynBioFromLeukipposInstitute | Scoop.it
Fact: Scientists have found a rare species of bacteria that ‘breathes’ uranium and thrives in abandoned uranium ore processing sites.
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Synthetic Biology Startup Zymergen Emerges From Stealth With $44 Million | TechNewsDB

Synthetic Biology Startup Zymergen Emerges From Stealth With $44 Million | TechNewsDB | SynBioFromLeukipposInstitute | Scoop.it
Synthetic Biology Startup Zymergen Emerges From Stealth With $44 Million - http://t.co/QFluBy5U28 http://t.co/uqlqu9waaE
more...
No comment yet.
Scooped by Gerd Moe-Behrens
Scoop.it!

Memory unit in a biological microprocessor

Memory unit in a biological microprocessor | SynBioFromLeukipposInstitute | Scoop.it
A rewritable recombinase addressable data module, able to store data within a DNA sequence (simplified): Serine integrase and excisionase are used to invert and restore specific DNA sequences. The system has two potential inputs; a set and a reset transcription signal. This set signal drives expression of integrase which inverts a DNA element, functioning as a genetic data register. Flipping the register converts the flanking sites (triangle). The system is now in state 1 (S1). Alternatively a reset signal drives integrase and excisionase expression and restores register orientation and the flanking sites. The system is in its other state (S0). The register comprises a promoter, which is driving state dependent, strand-specific transcription of either red or green fluorescent protein, the two possible outputs of the system.  http://bit.ly/YI13bF
more...
No comment yet.