A chromatin-based recruitment drive
Darren J. Burgess
"A cornerstone of synthetic biology and biological engineering is achiev- ing regulatory control of genes of interest. Typically, this is attempted by placing binding sites for classic transcription factors upstream of genes. However, gene regulation is multilayered beyond transcription factor recruitment; thus, a new study has characterized how diverse chro- matin regulators might provide a flexible and powerful way to regulate different aspects of gene expression.
comment to: ORIGINAL RESEARCH PAPER Keung, A. J. et al. Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation. Cell 158, 110–120 (2014)