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Modular Riboswitch Toolsets for Synthetic Genetic Control in Diverse Bacterial Species

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by
Robinson CJ, Vincent HA, Wu MC, Lowe PT, Dunstan MS, Leys D, Micklefield J.

"Ligand-dependent control of gene expression is essential for gene functional analysis, target validation, protein production and metabolic engineering. However, the expression tools currently available are difficult to transfer between species and exhibit limited mechanistic diversity. Here we demonstrate how the modular architecture of purine riboswitches can be exploited to develop orthogonal and chimeric switches that are transferable across diverse bacterial species, modulating either transcription or translation, to provide tuneable activation or repression of target gene expres-sion, in response to synthetic non-natural effector molecules. Our novel riboswitch-ligand pairings are shown to regulate physiologically important genes required for bacterial motility in Escherichia coli and cell morphology in Bacillus subtilis. These findings are relevant for future gene function studies and antimicrobial target validation, whilst providing new modular and orthogonal regulatory components for deployment in synthetic biology regimes."

 http://bit.ly/1sXYZtg

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Synthetic biology used to engineer new route to biochemicals

Synthetic biology used to engineer new route to biochemicals | SynBioFromLeukipposInstitute | Scoop.it
Living cells can make a vast range of products for us, but they don't always do it in the most straightforward or efficient way.
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What are the building blocks of a biological microprocessor? - YouTube

What are the building blocks of a biological microprocessor? A biological microprocessor consist of four units: the input and output device (I/O), the arithm...
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Synthetic Biology and Microbiome Engineering approaches for Trimethylaminuria

Jake Wintermute, Ph.D. Postdoctoral Researcher, Paris Descartes University For more information, join the international TMAU community on RareConnect: ...
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What are biological microprocessor applications? Part 1 - YouTube

Monitoring of biological systems by a biological microprocessor

Biological systems need to be monitored in respect to disease diagnostic, to drug screening, to understand experimental systems, and to observe the environment.

In line with this, a biocomputer has been utilized to detect multiple disease indicators, such as mRNA of disease-related genes associated with small-cell lung cancer and prostate cancer . Moreover, they can be used in experimental models, such as conditional transgenes or inducible expression systems. Environmental monitoring is another interesting application. A cell based biosensor using logic gates has been used to detect arsenic, mercury and copper ion levels.

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Our Leukippos community needs your financial support. We are all working for free and pay everything out of our own pockets, such as server costs and page registrations. If you like our work and wish that we produce more quality content, such as this video, you can donate some bitcoins to this address:

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Synthetic Biology: DNA origami

RT @ICO2S: #ICOSseminar "Synthetic Biology: DNA origami" by Chien Yi Chang (2015-06-23) http://t.co/mDrkVQMuCN
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Steve Evans

Steve Evans speaks on the promises and challenges facing Engineering Biology (synthetic biology) in the U.S..
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A renaissance in RNA synthetic biology: new mechanisms, applications and tools for the future

A renaissance in RNA synthetic biology: new mechanisms, applications and tools for the future | SynBioFromLeukipposInstitute | Scoop.it
A renaissance in #RNA synthetic biology: new mechanisms, applications and tools for the future: James… http://t.co/BnND0ELmcZ #COin
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RNA Synthetic Biology: From the Test Tube to Cells and Back Again - ACS Synthetic Biology (ACS Publications)

RNA Synthetic Biology: From the Test Tube to Cells and Back Again - ACS Synthetic Biology (ACS Publications) | SynBioFromLeukipposInstitute | Scoop.it
RT @bacteriality: Interested in RNA Synthetic Biology? Start here: http://t.co/JAqvCJKB9V cool overview by @JustinGallivan @ACSSynBio
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Synthetic biology meets design | Sciencedump

Synthetic biology meets design | Sciencedump | SynBioFromLeukipposInstitute | Scoop.it
Alexandra Daisy Ginsberg explores how synthetic biology and design can be utilised to do useful things, engineering a better future. Daisy is an artist, designer and writer investigating the dynamic that exists between synthetic biology and design.
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Ethics for Synthetic Biology: Suggested Topics

Ethics for Synthetic Biology: Suggested Topics | SynBioFromLeukipposInstitute | Scoop.it
The iGEM Team BIOSINT México, considered that when people talk about ethics, specifically, the members of all the teams, lack of an ethical code to serve as a guide for considering the ethical aspects of the projects.
So, we have the idea of creating an ethical code that serve as a guideline for all the SynBio community. That being said, we want to ask you which topics would you like to be treated in this document. Here, we present some topics that we have considered for the ethical code, you ca
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Jay Keasling - 18th Heinz Awards - Technology, the Economy and Employment

Jay Keasling, our 18th Technology, the Economy and Employment recipient, talks about the power of synthetic biology, and how his work on the new science of ...
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T Cell Immunotherapy: From Synthetic Biology to Clinical Practice - Springer

T Cell Immunotherapy: From Synthetic Biology to Clinical Practice - Springer | SynBioFromLeukipposInstitute | Scoop.it
T Cell Immunotherapy: From Synthetic Biology to Clinical Practice - Springer http://t.co/oGF6fKBYvW
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What are biological microprocessor applications? Part 2 - YouTube

What are biological microprocessor applications? Part 2
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Membranes grow like living cells

Membranes grow like living cells | SynBioFromLeukipposInstitute | Scoop.it
UC San Diego researchers have replicated a key feature of life in synthetic membranes.
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Howard Salis - Engineering Biology

Howard Salis speaks on the promises and challenges facing Engineering Biology (synthetic biology) in the U.S..
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Synthetic Biology Gets Inspiration from the Sea | Synthetic Biology Community

Synthetic Biology Gets Inspiration from the Sea | Synthetic Biology Community | SynBioFromLeukipposInstitute | Scoop.it
by Olga Radchuck and Markus Schmidt (Biofaction, Austria) A solution for the problem of antibiotic resistance, threatening public health, may come from an
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What are biological microprocessors good for? - YouTube

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This brief videos answers what kind of problems a biological microprocessor can solve.

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Our Leukippos community needs your financial support. We are all working for free and pay everything out of our own pockets, such as server costs and page reg- istrations. If you like our work and wish that we produce more quality content, such as this video, you can donate some bitcoins to this address:

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Understanding Synthetic Biology

Understanding Synthetic Biology | SynBioFromLeukipposInstitute | Scoop.it
SynBio.Info is a collaborative effort to understand, structure and explain our future in Synthetic Biology. Find out what the future will look like and understand how 'easy' it is to create your own cells that follow your instructions.
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MINDS is a novel kind of social network.
You might be interested to join the…

MINDS is a novel kind of social network.<br/>You might be interested to join the… | SynBioFromLeukipposInstitute | Scoop.it
MINDS is a novel kind of social network.
You might be interested to join the Synthetic Biology group there http://bit.ly/1FuBUhN - Gerd Moe-Behrens - Google+
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Synthetic Biology Market by Tool, Technology & Application - 2018 | MarketsandMarkets

Synthetic Biology Market by Tool, Technology & Application - 2018 | MarketsandMarkets | SynBioFromLeukipposInstitute | Scoop.it
[185 Pages Report] Synthetic Biology Market report categories the global market by Technology (Nanotechnology, Gene Synthesis, Bioinformatics, Cloning & Sequencing), Application (Pharmaceuticals, Biomaterials, Biofuels, Bioremediation), Tool(Oligos,...
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