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byOphir Keret"Synthetic biology is a relatively new field of biological research and development that focuses on the engineering of genetic molecular machines with a specific predefined function. Plainly put, the newly engineered organism functions as a machine. It can process information, manufacture, heal and even diagnose. We just have to engineer it to do so. The famous quote “Biology is the nanotechnology that works” is currently being put to the test on a worldwide scale. The application of these machines is theoretically boundless. In laboratories worldwide synthetic biology technologies are being rationally designed to assist in diagnosis or disrupt disease mechanisms. In the not too distant future they are expected to reach the clinical setting. This new field should be distinguished from classic genetic engineering. The latter researches naturally found DNA segments via cloning. It is weakly associated with engineering. Synthetic biology focuses on the engineering of molecular biological machines for the benefit of mankind. This is done via synthetic (com- puter printed) DNA sequences, man-designed or altered in silico. In this article I will briefly introduce synthetic biology, elaborate on the Biobrick Foundation as an independent fast- growing synthetic biology-sharing movement, and report on
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To Get More Information: http://www.bigmarketresearch.com/synthetic-biology-market Synthetic biology is a novel field that finds its origin at the intersection of biology and engineering. It involves designing and construction of biological systems or devices that can be applied in varied domains to get specified results.
byCitorik RJ, Mimee M, Lu TK"Since their discovery, bacteriophages have contributed enormously to our understanding of molecular biology as model systems. Furthermore, bacteriophages have provided many tools that have advanced the fields of genetic engineering and synthetic biology. Here, we discuss bacteriophage-based technologies and their application to the study of infectious diseases. New strategies for engineering genomes have the potential to accelerate the design of novel phages as therapies, diagnostics, and tools. Though almost a century has elapsed since their discovery, bacteriophages continue to have a major impact on modern biological sciences, especially with the growth of multidrug-resistant bacteria and interest in the micro biome.". http://bit.ly/1tgAMyt
by Minsu Kim "This conceptual food by Royal College of Art graduate Minsu Kim would wriggle around on the plate and in your mouth (+ movie).
byRobinson CJ, Vincent HA, Wu MC, Lowe PT, Dunstan MS, Leys D, Micklefield J."Ligand-dependent control of gene expression is essential for gene functional analysis, target validation, protein production and metabolic engineering. However, the expression tools currently available are difficult to transfer between species and exhibit limited mechanistic diversity. Here we demonstrate how the modular architecture of purine riboswitches can be exploited to develop orthogonal and chimeric switches that are transferable across diverse bacterial species, modulating either transcription or translation, to provide tuneable activation or repression of target gene expres-sion, in response to synthetic non-natural effector molecules. Our novel riboswitch-ligand pairings are shown to regulate physiologically important genes required for bacterial motility in Escherichia coli and cell morphology in Bacillus subtilis. These findings are relevant for future gene function studies and antimicrobial target validation, whilst providing new modular and orthogonal regulatory components for deployment in synthetic biology regimes." http://bit.ly/1sXYZtg
byTechonomy "Techonomy’s offices on Manhattan’s West 22d Street have been buzzing ever since our half-day Techonomy Bio conference on June 17. We got an overwhelmingly positive reception for a meeting that brought leading researchers and experts in the life sciences together with IT and Internet thinkers and business generalists.
byHolm S."Theorists analyzing the concept of disease on the basis of the notion of dysfunction consider disease to be dysfunction requiring. More specifically, dysfunction-requiring theories of disease claim that for an individual to be diseased certain biological facts about it must be the case. Disease is not wholly a matter of evaluative attitudes. In this paper, I consider the dysfunction-requiring component of Wakefield's hybrid account of disease in light of the artifactual organisms envisioned by current research in synthetic biology. In particular, I argue that the possibility of artifactual organisms and the case of oncomice and other bred or genetically modified strains of organism constitute a significant objection to Wakefield's etiological account of the dysfunction requirement. I then develop a new alternative understanding of the dysfunction requirement that builds on the organizational theory of function. I conclude that my suggestion is superior to Wakefield's theory because it (a) can accommodate both artifactual and naturally evolved organisms, (b) avoids the possibility of there being a conflict between what an organismic part is supposed to do and the health of the organism, and (c) provides a nonarbitrary and practical way of determining whether dysfunction occurs." http://bit.ly/1pFgFse
Open source, open science, open data, open access, open education, open learning -- this course provides an introduction to the important concept of openness from a variety of perspectives, including education, publishing, librarianship, economics, politics, and more, and asks you to discover what it means to you. Open Knowledge is international and multi-institutional, bringing together instructors and students from Canada, Ghana, Mexico, the United States, and the rest of the world. It will challenge you take control of your own education, to determine your own personal learning objectives, to contribute to the development of the curriculum, to reflect on your progress, to learn new digital skills, and to take a leadership role in the virtual classroom. It will also provide you with the opportunity to connect with colleagues from different countries and professions, and to better understand areas where your interests overlap and where unexpected distincts exist. We hope you’ll consider taking this journey with us.
The story of programming prodigy and information activist Aaron Swartz. From Swartz's help in development of the basic internet protocol RSS to his co-founding of Reddit, his fingerprints are all over the internet. But it was Swartz's groundbreaking work in social justice and political organizing combined with his aggressive approach to information access that ensnared him in a two year legal battle with the Federal government. It was a battle that ended with the taking of his own life at the age of 26. Aaron's story touched a nerve with people far beyond the online communities in which he was a celebrity. This film is a personal story about what we lose when we are tone deaf about technology and its relationship to our civil liberties.
Synthetic biology is attracting attention from both scientists and regulators. But there is little agreement on what it is. Can we find a road out of synthetic biology’s definitional quagmire?
Life is a programming language, and molecular biologist Andrew Hessel thinks that it will be increasingly available to anyone interested in designing with the building blocks of life.
The Living's (Buildings that grow? @autodesk acquires The Living & bets on synthetic biology. #synthbio #theliving http://t.co/KmuQCZyZJK)
Synthetic Biology: Volume 1 (Specialist Periodical Reports) [Maxim Ryadnov, Luc Brunsveld, Hiroaki Suga, Eric Kool, Birger Lindberg Moller, Alexander Kros, Cristiano Chiarabelli, Stephen Hart, Maarten Merkx, Oliver Rackham, S Tekeuchi, Paul Dalby, Jeroen Cornelissen] on Amazon.com. *FREE* shipping on qualifying offers. Synthetic biology is a new area of biological research that combines science and engineering in order to design and build novel biological functions and systems. The definition of synthetic biology has been generally accepted as the engineering of biology: the synthesis of complex
byHaiyao Huang and Douglas Densmore "One goal of synthetic biology is to design and build genetic circuits in living cells for a range of applications. Major challenges in these efforts include increasing the scalability and robustness of engineered biological systems and streamlining and automating the synthetic biology workflow of specification-design-assembly-verification. We present here a summary of the advances in microfluidic technology, particularly microfluidic large scale integration, that can be used to address the challenges facing each step of the synthetic biology workflow. Microfluidic technologies allow precise control over the flow of biological content within microscale devices, and thus may provide more reliable and scalable construction of synthetic biological systems. The integration of microfluidics and synthetic biology has the capability to produce rapid prototyping platforms for characterization of genetic devices, testing of biotheraputetics, and development of biosensors."http://rsc.li/1xhURTw
The latest generation of DNA sequencers allows all the genes of a plant, as well as any pathogens present, to be charted literally within a few days. “This provides unprecedented opportunities for the diagnosis of plant diseases, as well as, for example, identifying and tracking new disease outbreaks,” says Dr Theo van der Lee, senior scientist at the Department of Bio-Interactions and Plant Health at Plant Research International. “We can now detect pathogens directly from infected plant material, usually without having to guess in advance which bacterium, fungus or virus is the culprit.”
An awesome new #synbio community page by PLOS http://bit.ly/1lzSlzL
Synthetic Biology Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast,2013 - 2019
With advances in biological and genomic sciences accelerating at an ever-increasing pace, what does the future hold? If biological progress is indeed advancing more rapidly than Moore’s Law, as many assert, what are the economic and societal implications? In this video from our June 17 Techonomy Bio conference, Alex Lash, biotech editor at Xconomy, interviews Drew Endy, bioengineer at Stanford, about biological processes.
CRISPR-based transcriptional activators and repressors for synthetic circuits.
By Erin Brodwin"In a corner of Genspace, a community biology lab in Brooklyn, New York, a woman in jeans and T-shirt splices the DNA of a bioluminescent jellyfish into the genes of an E. coli bacterium to make living wallpaper that glows. Across the way, five high school students cluster around a whiteboard, outlining their plans to build an organism that senses arsenic in drinking water. They are but a few of the country’s bio-hackers, teachers, librarians and artists gone rogue. They gather in a handful of public labs across the U.S. to play with organisms’ source codes and make DNA misbehave.