SynBioFromLeukipp...
Follow
Find
76.2K views | +19 today
 
Scooped by Socrates Logos
onto SynBioFromLeukipposInstitute
Scoop.it!

Is This Virtual Worm the First Sign of the Singularity?

Is This Virtual Worm the First Sign of the Singularity? | SynBioFromLeukipposInstitute | Scoop.it
Socrates Logos's insight:


*Is This Virtual Worm the First Sign of the Singularity?*

by
ALEXIS C. MADRIGAL

"For all the talk of artificial intelligence and all the games of SimCity that have been played, no one in the world can actually simulate living things. Biology is so complex that nowhere on Earth is there a comprehensive model of even a single simple bacterial cell. 

 And yet, these are exciting times for "executable biology," an emerging field dedicated to creating models of organisms that run on a computer. Last year, Markus Covert's Stanford lab created the best ever molecular model of a very simple cell. To do so, they had to compile information from 900 scientific publications. An editorial that accompanied the study in the journal Cell was titled, "The Dawn of Virtual Cell Biology." In January of this year, the one-billion euro Human Brain Project received a decade's worth of backing from the European Union to simulate a human brain in a supercomputer. It joins Blue Brain, an eight-year-old collaboration between IBM and the Swiss Federal Institute of Technology in Lausanne, in this quest. In an optimistic moment in 2009, Blue Brain's director claimed such a model was possible by 2019. And last month, President Obama unveiled a $100 million BRAIN Initiative to give "scientists the tools they need to get a dynamic picture of the brain in action." An entire field, connectomics, has emerged to create wiring diagrams of the connections between neurons ("connectomes"), which is a necessary first step in building a realistic simulation of a nervous system. In short, brains are hot, especially efforts to model them in silico.  But in between the cell-on-silicon and the brain-on-silicon simulators lies a fascinating and strange new project to create a life-like simulation of Caenohabditis elegans, a roundworm. OpenWorm isn't like these other initiatives; it's a scrappy, open-source project that began with a tweet and that's coordinated on Google Hangouts by scientists spread from San Diego to Russia. If it succeeds, it will have created a first in executable biology: a simulated animal using the principles of life to exist on a computer..."

http://bit.ly/YRkcEK
more...
No comment yet.
SynBioFromLeukipposInstitute
Your new post is loading...
Your new post is loading...
Scooped by Socrates Logos
Scoop.it!

Christina Agapakis on Twitter: "Spending the next two weeks filming the synthetic biology MOOC with @SynBio1 #moocing http://t.co/CC7nbHUios"

Christina Agapakis on Twitter: "Spending the next two weeks filming the synthetic biology MOOC with @SynBio1 #moocing http://t.co/CC7nbHUios" | SynBioFromLeukipposInstitute | Scoop.it
RT @thisischristina: Spending the next two weeks filming the synthetic biology MOOC with @SynBio1 #moocing http://t.co/CC7nbHUios
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Biotech collaboration startup Synbiota talks 'open science' | Research on Gamification, User Experience (UX), Digital Signage Canadian Companies Can Use | CommerceLab

Biotech collaboration startup Synbiota talks 'open science' | Research on Gamification, User Experience (UX), Digital Signage Canadian Companies Can Use | CommerceLab | SynBioFromLeukipposInstitute | Scoop.it
Just as open-source development ushered in a technological revolution, Connor Dickie believes a similar revolution is on the horizon in the biotech industry.
more...
Renée Schauecker's curator insight, Today, 3:46 AM

The more we use the way how humans think and interact the more we develop solutions humans will accept. 

Scooped by Socrates Logos
Scoop.it!

Genomics pioneer J. Craig Venter to give free talk at CU-Boulder on Sept. 29 | University of Colorado Boulder

Genomics pioneer J. Craig Venter to give free talk at CU-Boulder on Sept. 29 | University of Colorado Boulder | SynBioFromLeukipposInstitute | Scoop.it
Pioneering genomics researcher J. Craig Venter—best known for leading the privately funded team that sequenced the first human genome—will give a keynote talk at the University of Colorado Boulder on Sept. 29 about the scientific potential of and future products derived from “synthetic life.” 
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

How Will Synthetic Biology Change the Way We Live? | Arizona SciTech

How Will Synthetic Biology Change the Way We Live? | Arizona SciTech | SynBioFromLeukipposInstitute | Scoop.it
Free public presentation about how synthetic biology will change our life! 9/23 @HeardMuseum #ASU #Biology #Phoenix http://t.co/GKyMkU0JL7
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Synthetic Biology

Synthetic Biology | SynBioFromLeukipposInstitute | Scoop.it
The Boston University Center of Synthetic Biology (CoSBi) ICE Repository http://cidarlab.org/wp-content/uploads/2014/08/PaigeICEIWBDA2014.pdf (The #Boston University Center of #Synthetic #Biology (CoSBi) ICE Repository by @legomics
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Hydrogel scaffolds to study cell biology in four dimensions

Socrates Logos's insight:

http://1.usa.gov/1ti0lxp

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Synthetic Biology - Springer

Synthetic Biology - Springer | SynBioFromLeukipposInstitute | Scoop.it
Socrates Logos's insight:

http://bit.ly/1wohYuQ

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

What is Synthetic Biology? [Video]

How to create life from scratch, as explained by SciAm editor David Biello (RT @dbiello: @mdichristina that's what we (@sciam) said ;) http://t.co/9c88oPCZAo)...
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Oxford iGEM - Our very own Timothy Ang featured on the... | Facebook

Our very own Timothy Ang featured on the great new blog "Humans and Synthetic Biology" by Cornell iGEM.... (Our very own Timothy Ang featured on the great new blog "Humans and Synthetic Biology" by Cornell iGEM....
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Drew Endy: The iGEM Revolution - The Long Now

Drew Endy: The iGEM Revolution - The Long Now | SynBioFromLeukipposInstitute | Scoop.it
hey sf, anyone interested in the long now talk tonight on synthetic biology? http://t.co/XPmHFx3UIQ I’ve got a spare ticket. DM/message me
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

I See Your Smart Phone and Raise You Smart Bacteria

I See Your Smart Phone and Raise You Smart Bacteria | SynBioFromLeukipposInstitute | Scoop.it
Socrates Logos's insight:

by

jtozer

"“Smart” bacteria that sense, track, pursue, fight and defeat infectious and other biological agents afflicting the warfighter might be closer to reality.

Building on earlier work focused on understanding how bacteria sense their nearest neighbors (including pathogens), a DTRA CB/JSTO-funded research team managed by DTRA CB’s Dr. Ilya Elashvili and led by Dr. William E. Bentley has paired with the Italian synthetic biology team headed by Dr. Sheref Mansy. The joint team created artificial cells that translate non-native signals into native signals that manipulate a local bacterial population.
These new tools have the potential to offer a means to localize bacteria and take actions to identify pathogens, other maladies (e.g., cancer cells), and synthesize drugs for local delivery and treatment.
Synthetic biology holds great promise to enable the engineering of “smart” bacteria that execute high order functions, such as those needed to sense, track, pursue, and fight pathogens. The Bentley lab focuses on minimally rewiring native cell processes so as not to “over engineer” these designer cells.
For example, they have built modules that recognize a pathogen’s signals and that rewire metabolic pathways to synthesize a pathogen-targeted drug. However, as these modules are pieced together and new modules are added, they impede other needed functions, such as swimming to or away from desired locales.
One way to counter unanticipated “side effects” is to employ small populations of orchestrated cells that act collectively to accomplish their task. Their plans, for example, call for “sentinel” and “dirigible” cells that find pathogens and call for backup.
In a recent Nature Communications article, “Integrating artificial with natural cells to translate chemical messages that direct E. coli behaviour,” the American-Italian joint team showed they were able to induce desired activity of native cells through communication with artificial cells.
The artificial cells, in turn, read a chemical cue foreign to the native cells and synthesized another compound recognized by the native cells. In this way, the artificial cells served as a translator. To the authors’ knowledge, this is the first artificial, cell-like system capable of translating unrecognized signals into a chemical language that natural cells can recognize.
The artificial non-living cell was built with a phospholipid vesicle containing isopropyl β-D-1-thiogalactopyranoside (IPTG), DNA, and transcription–translation machinery. The DNA template codes for a previously selected ribo-switch that activates translation in response to the presence of a model chemical signal molecule, theophylline.
Theophylline is added to the mixture, diffuses into the vesicle, and triggers the synthesis of the pore forming protein α-hemolysin (αHL). Therefore, only in the presence of theophylline a pore forms that releases entrapped IPTG.
Released IPTG will increase the transcription of a variety of genes induced by the lac operon in E. coli. IPTG is a model signal molecule in the current study, but it is a surrogate for a pathogen-modulating compound that would otherwise be held in abeyance in the vesicle in future studies.
E. coli alone does not respond to theophylline, and IPTG does not cross the vesicle membrane of the artificial cell in the absence of the pore. The ability of E. coli to receive the chemical message (IPTG) sent by the artificial cells was assessed in two ways.
First, a recombinant E. coli transformed with a plasmid, synthesized green fluorescent protein in response to IPTG; this was assayed using flow cytometry. Second, a natural or “wild type” E. coli was tested via reverse transcription quantitative polymerase chain reactions (RT-qPCR) that confirmed the up-regulation of the lac operon genes (more than a 20-fold increase).
The integration of artificial translator cells with natural cells represents a new strategy to introduce synthetic features to a biological system and at the same time, lessens the need for direct genetic manipulation...."



http://1.usa.gov/1BJMH8Q

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

100% Design 2014 - Talks with 100% Design

100% Design 2014 - Talks with 100% Design | SynBioFromLeukipposInstitute | Scoop.it
The theme for the year’s 100% Design is serendipity.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

I need your help with this survey

Hi!

Can you do me a favor and fill out this…

I need your help with this survey<br/><br/>Hi!<br/><br/>Can you do me a favor and fill out this… | SynBioFromLeukipposInstitute | Scoop.it
I need your help with this survey

Hi!

Can you do me a favor and fill out this survey.


https://www.surveymonkey.com/s/YTPJW9G


It would also be great… - Cellular Computing - Google+
Socrates Logos's insight:
*I need your help with this survey*
Hi!
Can you do me a favor and fill out this survey. 
It would also be great to send it to your friends
Thanks so much in advance.
Have a great weekend.
Best Gerd
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Life-Saving Dividends for Synthetic Biology Research: Microbial-Based Antimalarial Drug Shipped to Africa

Life-Saving Dividends for Synthetic Biology Research: Microbial-Based Antimalarial Drug Shipped to Africa | SynBioFromLeukipposInstitute | Scoop.it
A synthetic biology project begun 13 years ago by Jay Keasling was culminated with the announcement that a microbial-based version of the antimalarial drug artemisinin has been shipped to African nations where it is most needed.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Frontiers | Plant glyco-biotechnology on the way to synthetic biology | Plant Physiology

Plants are increasingly being used for the production of recombinant proteins. One reason is that plants are highly amenable for glycan engineering processes and allow the production of therapeutic proteins with increased efficacies due to optimized glycosylation profiles. Removal and insertion of glycosylation reactions by knock-out/knock-down approaches and introduction of glycosylation enzymes have paved the way for the humanization of the plant glycosylation pathway. The insertion of heterologous enzymes at exactly the right stage of the existing glycosylation pathway has turned out to be of utmost importance for optimal results. To enable such precise targeting chimeric enzymes have been constructed. In this short review we will exemplify the importance of correct targeting of glycosyltransferases, we will give an overview of the targeting mechanism of glycosyltransferases, describe chimeric enzymes used in plant N-glycosylation engineering and illustrate how plant glycoengineering builds on the tools offered by synthetic biology to construct such chimeric enzymes.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Synthetic Biology and Metabolic Engineering for Marine Carotenoids: New Opportunities and Future Prospects

Synthetic Biology and Metabolic Engineering for Marine Carotenoids: New Opportunities and Future Prospects | SynBioFromLeukipposInstitute | Scoop.it
Socrates Logos's insight:

by
Chonglong Wang , Jung-Hun Kim and Seon-Won Kim

"Carotenoids are a class of diverse pigments with important biological roles such as light capture and antioxidative activities. Many novel carotenoids have been isolated from marine organisms to date and have shown various utilizations as nutraceuticals and pharmaceuticals. In this review, we summarize the pathways and enzymes of carotenoid synthesis and discuss various modifications of marine carotenoids. The advances in metabolic engineering and synthetic biology for carotenoid production are also reviewed, in hopes that this review will promote the exploration of marine carotenoid for their utilizations."


 http://bit.ly/1rlWA9K

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Theispot.com - Stuart Bradford: Synthetic Biology

Theispot.com - Stuart Bradford: Synthetic Biology | SynBioFromLeukipposInstitute | Scoop.it
Stuart Bradford: Synthetic Biology. Stuart Bradford created a series of illustrations for Harvard Alumni magazine on synthetic biology, wherein scientists alter genetic structure to create tiny machines, tinkering like engineers.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Synthetic Biology

Synthetic Biology | SynBioFromLeukipposInstitute | Scoop.it
Kristala L. J. Prather (MIT) Part 1: Introduction to Synthetic Biology a...
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Bioengineers develop a toolkit for designing more successful synthetic molecules

Bioengineers develop a toolkit for designing more successful synthetic molecules | SynBioFromLeukipposInstitute | Scoop.it
(Phys.org) —Ever since Robert Hooke first described cells in 1665, scientists have been trying to figure out what is going on inside.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Synthetic biology at the interface of functional genomics

Socrates Logos's insight:

http://bit.ly/ZonkM3

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Integrating artificial with natural cells to translate chemical messages that direct E. coli behaviour

Integrating artificial with natural cells to translate chemical messages that direct E. coli behaviour | SynBioFromLeukipposInstitute | Scoop.it
Socrates Logos's insight:

by
Roberta Lentini et al

"Previous efforts to control cellular behaviour have largely relied upon various forms of genetic engineering. Once the genetic content of a living cell is modified, the behaviour of that cell typically changes as well. However, other methods of cellular control are possible. All cells sense and respond to their environment. Therefore, artificial, non-living cellular mimics could be engineered to activate or repress already existing natural sensory pathways of living cells through chemical communication. Here we describe the construction of such a system. The artificial cells expand the senses of Escherichia coli by translating a chemical message that E. coli cannot sense on its own to a molecule that activates a natural cellular response. This methodology could open new opportunities in engineering cellular behaviour without exploiting genetically modified organisms."

 http://bit.ly/Xx7v4m

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Zócalo Public Square: How Will Synthetic Biology Change the Way We Live?

Zócalo Public Square: How Will Synthetic Biology Change the Way We Live? | SynBioFromLeukipposInstitute | Scoop.it
Biologist and entrepreneur J. Craig Venter visits Zócalo to talk with Arizona State University President Michael M.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Legomics - Timeline Photos | Facebook

Legomics - Timeline Photos | Facebook | SynBioFromLeukipposInstitute | Scoop.it
Design and Build Biological Systems with @legomics #Synthetic #Biology #IGEM (RT @legomics: Design and Build Biological Systems with @legomics #Synthetic #Biology #IGEM http://t.co/nFieFQ4h8b)...
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

How Synthetic Biology Will Reconsider Natural Bioluminescence and Its Applications

How Synthetic Biology Will Reconsider Natural Bioluminescence and Its Applications | SynBioFromLeukipposInstitute | Scoop.it
Socrates Logos's insight:

by
Benjamin Reeve, Theo Sanderson, Tom Ellis, Paul Freemont

"As our understanding of natural biological systems grows, so too does our ability to alter and rebuild them. Synthetic biology is the application of engineering principles to biology in order to design and construct novel biological systems for specific applications. Bioluminescent organisms offer a treasure trove of light-emitting enzymes that may have applications in many areas of bioengineering, from biosensors to lighting. A few select bioluminescent organisms have been well researched and the molecular and genetic basis of their luminescent abilities elucidated, with work underway to understand the basis of luminescence in many others. Synthetic biology will aim to package these light-emitting systems as self-contained biological modules, characterize their properties, and then optimize them for use in other chassis organisms. As this catalog of biological parts grows, synthetic biologists will be able to engineer complex biological systems with the ability to emit light. These may use luminescence for an array of disparate functions, from providing illumination to conveying information or allowing communication between organisms."


 http://bit.ly/1oRmdKB

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Certificate in Synthetic Biology | Synberc | CodonOps

Certificate in Synthetic Biology | Synberc (Certificate in Synthetic Biology | Synberc http://t.co/GkOeIVksGi #synbio)
more...
No comment yet.