Synthetic biology firms becoming attractive to investors – MidvenInsider MediaCompanies in the field of synthetic biology were developing out of the laboratory and into the commercial world, according to Dr Andrew Muir, Rainbow Seed Fund's...
A major goal of synthetic biology is to build reliable, predictable networks of molecular and cellular components that can work as new biological devices capable of, for example, sensing chemicals, manufacturing drugs or even fighting disease. However, achieving such goals entails the production of complex synthetic biocircuits, which requires synchronization of multiple components. Although synchronization is well established in electronics1, synchronizing living cells is a major challenge, because it demands correlation of different phenomena that may be taking place on different temporal and spatial scales. (...) Prindle et al. report that such coupling has been achieved in cells of the bacterium Escherichia coli.
Synthetic biology: Biocircuits in synchrony Ricard Solé & Javier Macía
Rapid and tunable post-translational coupling of genetic circuits Arthur Prindle, Jangir Selimkhanov, Howard Li, Ivan Razinkov, Lev S. Tsimring & Jeff Hasty Nature (2014)
Rewiring Nature With Synthetic Biology Discover Magazine Bioengineer Drew Endy shares his vision to reprogram biology as a precision manufacturer — and possibly change civilization as we know it. By Anil Ananthaswamy.
"The design process of complex systems in all the fields of engineering requires a set of quantitatively characterized components and a method to predict the output of systems composed by such elements. This strategy relies on the modularity of the used components or the prediction of their context-dependent behaviour, when parts functioning depends on the specific context. Mathematical models usually support the whole process by guiding the selection of parts and by predicting the output of interconnected systems. Such bottom-up design process cannot be trivially adopted for biological systems engineering, since parts function is hard to predict when components are reused in different contexts. This issue and the intrinsic complexity of living systems limit the capability of synthetic biologists to predict the quantitative behaviour of biological systems. The high potential of synthetic biology strongly depends on the capability of mastering this issue. This review discusses the predictability issues of basic biological parts (promoters, ribosome binding sites, coding sequences, transcriptional terminators, and plasmids) when used to engineer simple and complex gene expression systems in Escherichia coli. A comparison between bottom-up and trial-and-error approaches is performed for all the discussed elements and mathematical models supporting the prediction of parts behaviour are illustrated."
As you might know, I am CEO of a startup called CytoComp http://www.cytocomp.com We are focusing on building a microprocessor from biological parts.
I am interested to build the company structure in a decentralized manner. I would like to discuss how one can do this on top of Ethereum https://www.ethereum.org. Especially interesting subjects are IP, crowd sourced project development, micro payments for crowd sourced micro contributions, distributed location of coworkers, crowd funding of project ideas, crowd shares, contracts, in general tot figure out how a working company structure on top of Ethereum will look like.
Biology + Engineering = Synthetic Biology (Image Credit: Shutterstock / Tarchyishnik Andrei ) At first glance, the terms ‘synthetic’ and ‘biology’ seem lik (Check out these DIY synthetic biology projects: http://t.co/0zoAC6oDsf...
Transcription activator-like effectors (TALEs) are proteins secreted by Xanthomonas bacteria to aid the infection of plant species. TALEs assist infections by binding to specific DNA sequences and activating the expression of host genes. Recent results show that TALE proteins consist of a central repeat domain, which determines the DNA targeting specificity and can be rapidly synthesized de novo. Considering the highly modular nature of TALEs, their versatility, and the ease of constructing these proteins, this technology can have important implications for synthetic biology applications. Here, we review developments in the area with a particular focus on modifications for custom and controllable gene regulation.
Abstract. Inspired by the developments of synthetic biology and the need for improved genetic tools to exploit cyanobacteria for the production of renewable bioproducts, we developed a versatile platform for the construction of ...
This is a new Project I started : An easy to use Ethereum iPhone and iWatch implementation for the general public. You are welcome to join me. Please follow me on GiyHub http://bit.ly/1pfxovB
If you like to support me, my BTC address is:
I think ethereum is a great platform for biohacker and for Ethereum is the platform I will use for my CytoComp project see building a decentralized company: http://bit.ly/1qSEScZ (An ethereum Dapp implementing of the structure of an organization wherein the decision making authority does not sit with a central figure or group designed for all organizations with interest in such structure) and DNA analysis Dapp ( Ethereum Dapp for secure sharing and analysis of your personal DNA data both for self trackers and people with diseases with underlying genetic alterations)http://bit.ly/1B4J5xP
I am following tight the developments at Reddcoin - I think their idea of a social currency where you can show your love of a contributor in social media with a tip. Today ReddCoin announced a paper where they further develop their ideas.
A new social currency model by Reddit - this can potentially revolutionize science publishing. We can direct publish and can get payment, if we have done great work - instead of that the authors have to pay and publishing companies make the big money....
*Proof of Stake Velocity: Building the Social Currency of the Digital Age*
by Larry Ren
"Proof of Stake Velocity (PoSV) is proposed as an alternative to Proof of Work (PoW) and Proof of Stake (PoS) to secure the peer-to-peer network and confirm transactions of Reddcoin, a cryptocurrency created specifi- cally to facilitate social interactions in the digital age. PoSV is designed to encourage both ownership (Stake) and activity (Velocity) which directly correspond to the two main functions of Reddcoin as a real currency: store of value and medium of exchange. Reddcoin can also function as the unit of account in heterogeneous social context. The technological aspects of PoSV are presented after a detailed review of existing designs. The eco- nomic aspects of Reddcoin are then analysed. Finally the unique position of Reddcoin as a digital social currency in the competitive landscape of cryptocurrencies is discussed."
Synbiota Inc. 35 Liberty St. Suite #105 Toronto, ON
13 biophilians Attending
Heya DIYbio.to family! I’m pleased to announce two wetlab workshops I’m organizing that will run in September. We’re going to do a DIYbio.to #ScienceHack See https://sciencehack.synbiota.com/
These wetlab workshops involve learning: (1) how to rationally design DNA, assemble your DNA design using real DNA, and; (2) then booting up your assembled DN...
There are certain aspects my CytoComp project where I see solutions in Bitcoin 2.0 / BlockChain technology.
DNA sequencing and synthesis plays a central role in synthetic biology.
One problem is the secure sharing and analysis of DNA data. It is possible to track the identity of a person from shared DNA sequences without an identifier http://www.sciencemag.org/content/339/6117/321.abstract. As genomics play an increasingly important role in modern medicine, this is a major problem. DNA data are highly sensitive and sequencing information has a huge potential for misuse. I think it is possible to use BlockChain technology to securely share these kind of data P2P.
Moreover, DNA data are huge files and will in the future need increasing computing power to be rapidly analyzed. The design of DNA sequences might also sometimes need larger computing power. I see the option to chop up these large DNA data files and analyze these parts by utilizing secure multiparty computing. I think platforms like Ethereum are well suited to build a secure DNA analysis app.
A token, specific coin would be great to use in this system in order to pay for expenses.
Thus as a starting point, please share your thoughts and suggest a name.
BTW if anybody is interested to join such a project - let me know.