*I just learned about a very interesting iGEM project for 2013*!
It is a follow up of an outstanding cell paper (see below) about a computational model for a cell.. This paper applies oriented programming. I think languages like objective-c (Apple - Xcode) are very good suited to modulate biological phenomena, as they reflect the biological duality of form and function.
Ref. original paper in Cell:
*A Whole-Cell Computational Model Predicts Phenotype from Genotype*
Jonathan R. Karr, Jayodita C. Sanghvi, Derek N. Macklin, Miriam V. Gutschow, Jared M. Jacobs, Benjamin Bolival, Nacyra Assad-Garcia, John I. Glass, Markus W. Covert
"Understanding how complex phenotypes arise from individual molecules and their interactions is a primary challenge in biology that computational approaches are poised to tackle. We report a whole-cell computational model of the life cycle of the human pathogen Mycoplasma genitalium that includes all of its molecular components and their interactions. An integrative approach to modeling that combines diverse mathematics enabled the simultaneous inclusion of fundamentally different cellular processes and experimental measurements. Our whole-cell model accounts for all annotated gene functions and was validated against a broad range of data. The model provides insights into many previously unobserved cellular behaviors, including in vivo rates of protein-DNA association and an inverse relationship between the durations of DNA replication initiation and replication. In addition, experimental analysis directed by model predictions identified previously undetected kinetic parameters and biological functions. We conclude that comprehensive whole-cell models can be used to facilitate biological discovery."
see also this awesome hangout:
Dawn of Virtual Cell Biology: A Whole-Cell Computational Model Predicts Phenotype from Genotype
"A journal club and author interview about the recent paper "A Whole-Cell Computational Model Predicts Phenotype from Genotype", Karr et al., 2012, about a whole cell simulation. Stephen Larson presents a 45 minute overview of the paper and authors Jonathan Karr and Jayodita Sanghvi answer questions and clarify the paper. Organized by the members of OpenWorm.org"