SynBioFromLeukipp...
Follow
Find
87.2K views | +61 today
 
Scooped by Socrates Logos
onto SynBioFromLeukipposInstitute
Scoop.it!

Synthetic Biology of Antimicrobial Discovery

Synthetic Biology of Antimicrobial Discovery | SynBioFromLeukipposInstitute | Scoop.it

by

Bijan Zakeri and Timothy K. Lu

"Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug-resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery."
http://bit.ly/SGvY0g

more...
No comment yet.
SynBioFromLeukipposInstitute
Your new post is loading...
Your new post is loading...
Scooped by Socrates Logos
Scoop.it!

Synthetic biology needs a grand design vision - New Scientist

Synthetic biology needs a grand design vision - New Scientist | SynBioFromLeukipposInstitute | Scoop.it
We can design a better future using biology, but we must consider the big questions first, says Alexandra Daisy Ginsberg
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Caution urged over editing DNA in wildlife (intentionally or not)

Caution urged over editing DNA in wildlife (intentionally or not) | SynBioFromLeukipposInstitute | Scoop.it
Caution urged over editing DNA in wildlife (intentionally or not)
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Emergent genetic oscillations in a synthetic microbial consortium

Emergent genetic oscillations in a synthetic microbial consortium | SynBioFromLeukipposInstitute | Scoop.it
Socrates Logos's insight:

by
Ye Chen, Jae Kyoung Kim, Andrew J. Hirning, Krešimir Josić, Matthew R. Bennett

"A challenge of synthetic biology is the creation of cooperative microbial systems that exhibit population-level behaviors. Such systems use cellular signaling mechanisms to regulate gene expression across multiple cell types. We describe the construction of a synthetic microbial consortium consisting of two distinct cell types—an “activator” strain and a “repressor” strain. These strains produced two orthogonal cell-signaling molecules that regulate gene expression within a synthetic circuit spanning both strains. The two strains generated emergent, population-level oscillations only when cultured together. Certain network topologies of the two-strain circuit were better at maintaining robust oscillations than others. The ability to program population-level dynamics through the genetic engineering of multiple cooperative strains points the way toward engineering complex synthetic tissues and organs with multiple cell types."

http://bit.ly/1KpKUfy

Image
http://phys.org/news/2015-08-scientists-coli-cooperate-protein.html

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Searching big data faster

Searching big data faster | SynBioFromLeukipposInstitute | Scoop.it
Searching big data faster
Socrates Logos's insight:

"Theoretical analysis could expand applications of accelerated searching in biology, other fields."

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

So You Think You Can Synthesise - Series Finale

The Macquarie_Australia iGEM Team uses the popular reality format to inform and engage the public with our project The Solar Synthesisers. Our Project aims ...
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Researchers Want to Inject 3D Printed Microfish Into Your System

Researchers have developed a 3D printing technology that can produce microfish (fish-shaped microrobots) to be used for medical purposes.
Socrates Logos's insight:

Is this the future of medicine?

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation

Nature Communications | doi:10.1038/ncomms8978
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Principles of Synthetic Biology

Principles of Synthetic Biology | SynBioFromLeukipposInstitute | Scoop.it
Learn how to engineer biological systems and program organisms to perform novel tasks.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

The emergence of commodity-scale genetic manipulation.

Since the 1970s technological advancements in the fields of synthetic biology and metabolic engineering have led to a dramatic reduction in both time and cost required for generating genomic mutations in a variety of organisms. The union of genomic editing machinery, DNA inkjet printers, and bioinformatics algorithms allows engineers to design a library of thousands of unique oligos as well as build and test these designs on a ∼2 months time-scale and at a cost of roughly ∼0.3 cents per base pair. The implications of these capabilities for a variety of fields are far-reaching, with potential impacts in defense, agricultural, human health, and environmental research. The explosion of synthetic biology applications over the past two decades have led many to draw parallels between biological engineering and the computer sciences. In this review, we highlight some important parallels between these fields and emphasize the importance of engineering design strategies.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

12 Months in Synthetic Biology — PLOS Synbio Field Reports

12 Months in Synthetic Biology — PLOS Synbio Field Reports | SynBioFromLeukipposInstitute | Scoop.it
A brief review, a thank you, and an opportunity
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Here's why DNA could eventually replace hard drives

Here's why DNA could eventually replace hard drives
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Synthetic Biology an Engineering Perspective of Learning From Nature.

This work was done by members of the lab, The NanoBiotechnology Research Group, as an effort to generally explain some of the research proyects currently ...
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Tissue Engineering, Synthetic Biology & Bioprinting

Tissue Engineering, Synthetic Biology & Bioprinting | SynBioFromLeukipposInstitute | Scoop.it
Tissue Engineering Synthetic Biology Biofabrication Bioprinting 3D-Printing
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Researchers use DNA 'nanoclews' to shuttle CRISPR-Cas9 gene-editing tool into cells

Researchers use DNA 'nanoclews' to shuttle CRISPR-Cas9 gene-editing tool into cells | SynBioFromLeukipposInstitute | Scoop.it
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have for the first time created and used a nanoscale vehicle made of DNA to deliver a CRISPR-Cas9 gene-editing tool into cells in both cell culture and an animal model.
The CRISPR-Cas system, which is found in bacteria and archaea, protects bacteria from invaders such as viruses. It does this by creating small strands of RNA called CRISPR RNAs, which match DNA sequences specific to a given invader. When those CRISPR RNAs find a match, they unleash Cas9 proteins that cut the DNA. In recent years, the CRISPR-Cas system has garnered a great deal of attention in the research community for its potential use as a gene editing tool - with the CRISPR RNA identifying the targeted portion of the relevant DNA, and the Cas protein cleaving it.
But for Cas9 to do its work, it must first find its way into the cell. This work focused on demonstrating the potential of a new vehicle for directly introducing the CRISPR-Cas9 complex - the entire gene-editing tool - into a cell.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Scientists modify E. coli to cooperate, control protein expression

Scientists modify E. coli to cooperate, control protein expression | SynBioFromLeukipposInstitute | Scoop.it
Rice University scientists have made a living circuit from multiple types of bacteria that prompts the bacteria to cooperate to change protein expression.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Minority rules: Scientists discover tipping point for the spread of ideas

Minority rules: Scientists discover tipping point for the spread of ideas | SynBioFromLeukipposInstitute | Scoop.it
Minority rules: Scientists discover tipping point for the spread of ideas
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Harnessing Synthetic Biology to Combat Bacterial Pathogens - DVIDS (press release)

Harnessing Synthetic Biology to Combat Bacterial Pathogens - DVIDS (press release) | SynBioFromLeukipposInstitute | Scoop.it
Developed in the 1940s, antibiotics are powerful medicines used in the treatment and prevention of bacterial infection to save lives.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Accurate DNA Assembly and Genome Engineering with
Optimized Uracil Excision Cloning | CodonOps

Accurate DNA Assembly and Genome Engineering with<br/>Optimized Uracil Excision Cloning | CodonOps | SynBioFromLeukipposInstitute | Scoop.it
Ana Mafalda Cavaleiro, Se Hyeuk Kim, Susanna Seppälä, Morten T. Nielsen and Morten H. H. Nørholm
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Biohackers gear up for genome editing

Biohackers gear up for genome editing | SynBioFromLeukipposInstitute | Scoop.it
Amateurs are ready and able to try the CRISPR technique for rewriting genes.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Synthetic Biology Could Let Us Recycle Human Waste For Space Travel - The Escapist

The Escapist
Synthetic Biology Could Let Us Recycle Human Waste For Space Travel
The Escapist
One day, astronauts might recycle urine and carbon dioxide into highly necessary food and medicines for space missions.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Virginia Tech-developed synthetic biology tool transitions to private sector

Virginia Tech-developed synthetic biology tool transitions to private sector | SynBioFromLeukipposInstitute | Scoop.it
GenoCAD, a computer-assisted design environment for synthetic biology developed at Virginia Tech, has transitioned to GenoFAB LLC to engage new users and create new opportunities for innovation.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Jamie Metzl discusses human genetic engineering

Jamie Metzl discusses human genetic engineering
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Cambridge Synthetic Biology Meetup

Café Synthetique

Monday, Aug 24, 2015, 6:00 PM

Location details are available to members only.

26 Members Attending

Beer and Biosensors: join us for a fun and informative evening exploring sensors both genetic and electronic. • "A (very) brief introduction to sensors" • Beer Sensors (hands-on activity for everyone) • "Sensors, beer and brewing: what do the results mean?" Paul Grant and James Godman,  University of Cambridge and Hop Back Brewery Discussion throug...

Check out this Meetup →

Beer and Biosensors: join us for a fun and informative evening exploring sensors both genetic and electronic.
• "A (very) brief introduction to sensors"
• "Designing and prototyping gen
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

New DNA code makes synthetic proteins

New DNA code makes synthetic proteins | SynBioFromLeukipposInstitute | Scoop.it
The world's first functioning organism with an expanded DNA alphabet has now met another milestone in artificial life: making proteins that don't exist in nature.

The organism, a bacterium created by scientists at The Scripps Research Institute, incorporates two synthetic DNA letters, called X and Y, along with the four natural ones, A, T, C and G. A team led by Floyd Romesberg published a study last year demonstrating that the organism, an engineered strain of E. coli, can function and replicate with the synthetic DNA.

Synthorx, a biotech startup that licensed the technology from Scripps, has now used the bacterium to produce proteins incorporating artificial amino acids, the building blocks of proteins. These are placed at precisely specified intervals along the protein sequence, obeying the code of the expanded DNA alphabet.
more...
No comment yet.