SynBioFromLeukipp...
Follow
Find
87.2K views | +28 today
 
Scooped by Socrates Logos
onto SynBioFromLeukipposInstitute
Scoop.it!

Aesthetics in synthesis and synthetic biology

Aesthetics in synthesis and synthetic biology | SynBioFromLeukipposInstitute | Scoop.it

"Design could create a DNA molecule that is far better*....?

Aesthetics in synthesis and synthetic biology

http://bit.ly/Xcbl0r

more...
No comment yet.
SynBioFromLeukipposInstitute
Your new post is loading...
Your new post is loading...
Scooped by Socrates Logos
Scoop.it!

Emergent genetic oscillations in a synthetic microbial consortium

Emergent genetic oscillations in a synthetic microbial consortium | SynBioFromLeukipposInstitute | Scoop.it
Socrates Logos's insight:

by
Ye Chen, Jae Kyoung Kim, Andrew J. Hirning, Krešimir Josić, Matthew R. Bennett

"A challenge of synthetic biology is the creation of cooperative microbial systems that exhibit population-level behaviors. Such systems use cellular signaling mechanisms to regulate gene expression across multiple cell types. We describe the construction of a synthetic microbial consortium consisting of two distinct cell types—an “activator” strain and a “repressor” strain. These strains produced two orthogonal cell-signaling molecules that regulate gene expression within a synthetic circuit spanning both strains. The two strains generated emergent, population-level oscillations only when cultured together. Certain network topologies of the two-strain circuit were better at maintaining robust oscillations than others. The ability to program population-level dynamics through the genetic engineering of multiple cooperative strains points the way toward engineering complex synthetic tissues and organs with multiple cell types."

http://bit.ly/1KpKUfy

Image
http://phys.org/news/2015-08-scientists-coli-cooperate-protein.html

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Searching big data faster

Searching big data faster | SynBioFromLeukipposInstitute | Scoop.it
Searching big data faster
Socrates Logos's insight:

"Theoretical analysis could expand applications of accelerated searching in biology, other fields."

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

So You Think You Can Synthesise - Series Finale

The Macquarie_Australia iGEM Team uses the popular reality format to inform and engage the public with our project The Solar Synthesisers. Our Project aims ...
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Researchers Want to Inject 3D Printed Microfish Into Your System

Researchers have developed a 3D printing technology that can produce microfish (fish-shaped microrobots) to be used for medical purposes.
Socrates Logos's insight:

Is this the future of medicine?

more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation

Nature Communications | doi:10.1038/ncomms8978
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Principles of Synthetic Biology

Principles of Synthetic Biology | SynBioFromLeukipposInstitute | Scoop.it
Learn how to engineer biological systems and program organisms to perform novel tasks.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

The emergence of commodity-scale genetic manipulation.

Since the 1970s technological advancements in the fields of synthetic biology and metabolic engineering have led to a dramatic reduction in both time and cost required for generating genomic mutations in a variety of organisms. The union of genomic editing machinery, DNA inkjet printers, and bioinformatics algorithms allows engineers to design a library of thousands of unique oligos as well as build and test these designs on a ∼2 months time-scale and at a cost of roughly ∼0.3 cents per base pair. The implications of these capabilities for a variety of fields are far-reaching, with potential impacts in defense, agricultural, human health, and environmental research. The explosion of synthetic biology applications over the past two decades have led many to draw parallels between biological engineering and the computer sciences. In this review, we highlight some important parallels between these fields and emphasize the importance of engineering design strategies.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

12 Months in Synthetic Biology — PLOS Synbio Field Reports

12 Months in Synthetic Biology — PLOS Synbio Field Reports | SynBioFromLeukipposInstitute | Scoop.it
A brief review, a thank you, and an opportunity
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Here's why DNA could eventually replace hard drives

Here's why DNA could eventually replace hard drives
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Synthetic Biology an Engineering Perspective of Learning From Nature.

This work was done by members of the lab, The NanoBiotechnology Research Group, as an effort to generally explain some of the research proyects currently ...
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Synthetic biology: a new tool for the trade

Protein-protein interactions are fundamental to many biological processes. Yet the weak and transient non-covalent bonds that characterize most protein-protein interactions found in nature impose limits on many bioengineering experiments. Here a new class of genetically encodable peptide-protein pairs—isopeptag-N/pilin-N, isopeptag/pilin-C, and SpyTag-SpyCatcher—that interact via autocatalytic intermolecular isopeptide bond formation is described. Reactions between peptide-protein pairs are specific, robust, orthogonal, and able to proceed under most biologically relevant conditions both in vitro and in vivo. As fusion constructs they provide a handle on molecules of interest, both organic and inorganic, that can be grasped with an iron grip. Such stable interactions provide robust post-translational control over biological processes, and open new opportunities in synthetic biology for engineering programmable and self-assembling protein nanoarchitectures.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Scientists modify E. coli to cooperate, control protein expression

Scientists modify E. coli to cooperate, control protein expression | SynBioFromLeukipposInstitute | Scoop.it
Rice University scientists have made a living circuit from multiple types of bacteria that prompts the bacteria to cooperate to change protein expression.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Minority rules: Scientists discover tipping point for the spread of ideas

Minority rules: Scientists discover tipping point for the spread of ideas | SynBioFromLeukipposInstitute | Scoop.it
Minority rules: Scientists discover tipping point for the spread of ideas
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Harnessing Synthetic Biology to Combat Bacterial Pathogens - DVIDS (press release)

Harnessing Synthetic Biology to Combat Bacterial Pathogens - DVIDS (press release) | SynBioFromLeukipposInstitute | Scoop.it
Developed in the 1940s, antibiotics are powerful medicines used in the treatment and prevention of bacterial infection to save lives.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Accurate DNA Assembly and Genome Engineering with
Optimized Uracil Excision Cloning | CodonOps

Accurate DNA Assembly and Genome Engineering with<br/>Optimized Uracil Excision Cloning | CodonOps | SynBioFromLeukipposInstitute | Scoop.it
Ana Mafalda Cavaleiro, Se Hyeuk Kim, Susanna Seppälä, Morten T. Nielsen and Morten H. H. Nørholm
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Biohackers gear up for genome editing

Biohackers gear up for genome editing | SynBioFromLeukipposInstitute | Scoop.it
Amateurs are ready and able to try the CRISPR technique for rewriting genes.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Synthetic Biology Could Let Us Recycle Human Waste For Space Travel - The Escapist

The Escapist
Synthetic Biology Could Let Us Recycle Human Waste For Space Travel
The Escapist
One day, astronauts might recycle urine and carbon dioxide into highly necessary food and medicines for space missions.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Virginia Tech-developed synthetic biology tool transitions to private sector

Virginia Tech-developed synthetic biology tool transitions to private sector | SynBioFromLeukipposInstitute | Scoop.it
GenoCAD, a computer-assisted design environment for synthetic biology developed at Virginia Tech, has transitioned to GenoFAB LLC to engage new users and create new opportunities for innovation.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Jamie Metzl discusses human genetic engineering

Jamie Metzl discusses human genetic engineering
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Cambridge Synthetic Biology Meetup

Café Synthetique

Monday, Aug 24, 2015, 6:00 PM

Location details are available to members only.

26 Members Attending

Beer and Biosensors: join us for a fun and informative evening exploring sensors both genetic and electronic. • "A (very) brief introduction to sensors" • Beer Sensors (hands-on activity for everyone) • "Sensors, beer and brewing: what do the results mean?" Paul Grant and James Godman,  University of Cambridge and Hop Back Brewery Discussion throug...

Check out this Meetup →

Beer and Biosensors: join us for a fun and informative evening exploring sensors both genetic and electronic.
• "A (very) brief introduction to sensors"
• "Designing and prototyping gen
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

New DNA code makes synthetic proteins

New DNA code makes synthetic proteins | SynBioFromLeukipposInstitute | Scoop.it
The world's first functioning organism with an expanded DNA alphabet has now met another milestone in artificial life: making proteins that don't exist in nature.

The organism, a bacterium created by scientists at The Scripps Research Institute, incorporates two synthetic DNA letters, called X and Y, along with the four natural ones, A, T, C and G. A team led by Floyd Romesberg published a study last year demonstrating that the organism, an engineered strain of E. coli, can function and replicate with the synthetic DNA.

Synthorx, a biotech startup that licensed the technology from Scripps, has now used the bacterium to produce proteins incorporating artificial amino acids, the building blocks of proteins. These are placed at precisely specified intervals along the protein sequence, obeying the code of the expanded DNA alphabet.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Translational synthetic biology

Translational synthetic biology | SynBioFromLeukipposInstitute | Scoop.it
Synthetic biology is a recent scientific approach towards engineering biological systems from both pre-existing and novel parts. The aim is to introduce computational aided design approach in biology leading to rapid delivery of useful applications. Though the term reprogramming has been frequently used in the synthetic biology community, currently the technological sophistication only allows for a probabilistic approach instead of a precise engineering approach. Recently, several human health applications have emerged that suggest increased usage of synthetic biology approach in developing novel drugs. This mini review discusses recent translational developments in the field and tries to identify some of the upcoming future developments.
more...
No comment yet.
Scooped by Socrates Logos
Scoop.it!

Transforming exoelectrogens for biotechnology using synthetic biology

Transforming exoelectrogens for biotechnology using synthetic biology | SynBioFromLeukipposInstitute | Scoop.it
Extracellular electron transfer pathways allow certain bacteria to transfer energy between intracellular chemical energy stores and extracellular solids through redox reactions. Microorganisms containing these pathways, exoelectrogens, are a critical part of microbial electrochemical technologies that aim to impact applications in bioenergy, biosensing, and biocomputing. However, there are not yet any examples of economically viable microbial electrochemical technologies due to the limitations of naturally-occurring exoelectrogens. Here we first briefly summarize recent discoveries in understanding extracellular electron transfer pathways, then review in-depth the creation of customized and novel exoelectrogens for biotechnological applications. We analyze engineering efforts to increase current production in native exoelectrogens, which reveals that modulating certain processes within extracellular electron transfer are more effective than others. We also review efforts to create new exoelectrogens and highlight common challenges in this work. Lastly, we summarize work utilizing engineered exoelectrogens for biotechnological applications and the key obstacles to their future development. Fueled by the development of genetic tools, these approaches will continue to expand and genetically modified organisms will continue to improve the outlook for microbial electrochemical technologies.
more...
No comment yet.