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Cellular traffic control system mapped for the first time

Cellular traffic control system mapped for the first time | Sustainable Futures | Scoop.it

Cells regulate the uptake of nutrients and messenger cargos and their transport within the cell. This process is known as endocytosis and membrane traffic. Different cargos dock onto substrate specific receptors on the cell membrane. Special proteins such as kinases, GTPases and coats, activate specific entry routes and trigger the uptake of the receptors into the cell. For their uptake, the receptors and docked cargos become enclosed by the cell membrane. In the next steps, the membrane invaginates and becomes constricted. The resulting vesicle is guided via several distinct stations, cellular organelles, to its final destination in the cell.

 

For her study, Dr. Prisca Liberali, senior scientist in the team of Professor Lucas Pelkmans, sequentially switched off 1200 human genes. Using automated high-throughput light microscopy and computer vision, she could monitor and compare 13 distinct transport paths involving distinct receptors and cellular organelles. Precise quantifications of thousands of single cells identified the genes required for the different transport routes. Surprisingly, sets of transport routes are co-regulated and coordinated in specific ways by different programs of regulatory control.


Subsequently, Dr. Liberali calculated the hierarchical order within the genetic network and thereby identified the regulatory topology of cellular transport. "The transport into the cell and within the cells proceeds analogously to the cargo transport within a city" describes the scientist. "Like in a city, the traffic on the routes within a cell and their intersections is tightly regulated by traffic lights and signs to guide the cargo flow."

 

Thanks to this unique quantitative map, the fine regulatory details of transport paths and processes within a cells could be mapped for the first time. Particularly the genes that encode for these traffic lights and switches are often de-regulated in disease. With this map, it is now possible to predict how this leads to traffic jams in the cells, causing the disease phenotype. Alternatively, since many drugs have been developed to target these traffic lights and switches, the map can be used to come up with possible drug combinations to target unwanted traffic, such as viruses, to the waste disposal system of the cell.


Via Dr. Stefan Gruenwald
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ComplexInsight's curator insight, June 10, 2014 2:44 AM

Mapping the fine regulatory details of transport paths and processes within cells is key to understanding gene and protein functions, cancer, viral interactions and potential treatments.  Interesting read.

Sustainable Futures
Things to do, consider and act on to create a sustainable future for people and planet
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1. Change the Goal - 1\7 Doughnut Economics

Doughnut Economics: seven ways to think like a 21st century economist, the new book by Kate Raworth, is out now. These animations tell the story of th
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The series is well worth a review!

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The future of industries: Bringing down the walls

The future of industries: Bringing down the walls | Sustainable Futures | Scoop.it
Technological change is creating historic shifts in industry footprints. It’s reshaping the foundations of many industries.
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Jane Jacobs believed cities should be fun — and changed urban planning forever

Jane Jacobs believed cities should be fun — and changed urban planning forever | Sustainable Futures | Scoop.it
She had no formal training, but she upended wisdom from experts in the field.
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Still relevant! Maybe even more so...
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Blockchain: A technology on the verge of revolutionising society

Blockchain: A technology on the verge of revolutionising society | Sustainable Futures | Scoop.it
A safe, tamper-proof digital ledger has triggered a shock wave rippling far beyond the world of finance. Online payments diverted into the wrong pockets. Election results disputed by a political pa…
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Sustainable development: a new kind of globalization - The Boston Globe

Sustainable development: a new kind of globalization - The Boston Globe | Sustainable Futures | Scoop.it
A new concept of globalization calls for social fairness and environmental sustainability alongside economic development.
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Can we now envision of the world that is driven to create global well being for all living things and all systems that support us?

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5 Jobs That Will Be The Hardest To Fill In 2025

5 Jobs That Will Be The Hardest To Fill In 2025 | Sustainable Futures | Scoop.it
There is a labor shortage looming over the next decade, and jobs in these sectors will be the most difficult to fill.
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Balancing the Scales of City Sustainability | Sustainable Cities Collective

Balancing the Scales of City Sustainability | Sustainable Cities Collective | Sustainable Futures | Scoop.it
I spend virtually all my professional time thinking about the intersection of human settlement and environmental sustainability.
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How the Brain Dumps Its Trash [Video]

How the Brain Dumps Its Trash [Video] | Sustainable Futures | Scoop.it
A recently discovered waste-removal system is a linchpin in preserving neural health
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Designing Suburbs: Beyond New Urbanism | Newgeography.com

Designing Suburbs: Beyond New Urbanism | Newgeography.com | Sustainable Futures | Scoop.it

It is not primarily the fault of land developers that the American suburbs are thought to be dysfunctional and mundane. The blame belongs largely to the influence of boiler-plate zoning regulations combined with design consultants who seek the most minimum criteria allowed by city regulations.

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Report: More Pollinator Species In Jeopardy, Threatening World Food Supply

Report: More Pollinator Species In Jeopardy, Threatening World Food Supply | Sustainable Futures | Scoop.it
About 40 percent of invertebrate pollinator species such as bees and butterflies are facing extinction, according to the global assessment.
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Rebuilding Place in the Urban Space: Water as a utility

Rebuilding Place in the Urban Space: Water as a utility | Sustainable Futures | Scoop.it

Aaron Renn of Urbanophile and a fellow at the Manhattan Institute has produced a report, Wasted: How to Fix America’s Sewers, on the crushing financial impact on local jurisdictions of regulations promulgated by the EPA concerning discharge of untreated water into rivers and the security of water supplies.

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Decline of bees poses potential risks to major crops, says UN

Decline of bees poses potential risks to major crops, says UN | Sustainable Futures | Scoop.it
Animal pollination responsible for 5-8% of global agricultural production by volume, says UN biodiversity panel, as it issues warning over their decline
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Green with Facebook Envy, Red with Twitter Rage

Green with Facebook Envy, Red with Twitter Rage | Sustainable Futures | Scoop.it
How you act on social media may alleviate or exacerbate negative emotional states
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New solar panels generate electricity from rain

New solar panels generate electricity from rain | Sustainable Futures | Scoop.it
div.generic {width:85%;background:#ECECEC;border:1px solid #f55b42;padding:15px;} WHY THIS MATTERS IN BRIEF A new range of all weather solar panels could help further reduce the world’s relia…
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Foreseeing the Unpossible

Foreseeing the Unpossible | Sustainable Futures | Scoop.it
Change may be the only constant and, beyond wet babies, few of us welcome it.
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Well said!
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7 Futurists On What To Expect In The Next Decade

7 Futurists On What To Expect In The Next Decade | Sustainable Futures | Scoop.it


From smartphone apps that can do seemingly everything to driverless cars and
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These are the top 10 emerging technologies of 2016

These are the top 10 emerging technologies of 2016 | Sustainable Futures | Scoop.it
Breakthrough technologies, including “socially aware” artificial intelligence and new generation solar panels, could soon tackle the world’s most pressing challenges.
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William Smith's curator insight, July 30, 2016 2:01 AM
The PV technology outlined here is intriguing and could be an industry pivot point.
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Wilderness Society: C02 report demonstrates land clearing is out of control - video

Wilderness Society: C02 report demonstrates land clearing is out of control - video | Sustainable Futures | Scoop.it
The national campaign director for The Wilderness Society believes the C02 report reveals many damning findings regarding the current level of tree clearing in Australia
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Can Co-Ops Help the Rockaways Recover?

Can Co-Ops Help the Rockaways Recover? | Sustainable Futures | Scoop.it
An isolated part of New York City is still rebuilding its economy after Sandy.
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The Long, Complicated History of Affordable Housing in New York

The Long, Complicated History of Affordable Housing in New York | Sustainable Futures | Scoop.it
A new book and exhibit take a look at the programs, buildings, and people that have brought the system to where it is today—and what still needs to be done.
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The week in wildlife – in pictures

The week in wildlife – in pictures | Sustainable Futures | Scoop.it
A damselfly, black rhinos and an encounter between a crocodile and a whip snake are among this week’s pick of images from the natural world
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Norway to build Europe's largest onshore wind power project

Norway to build Europe's largest onshore wind power project | Sustainable Futures | Scoop.it
The newly-announced Fosen Vind project will comprise six wind farms with a combined capacity of 1,000 MW, more than the current total installed capacity in Norway and on track to become the largest of its type in Europe.
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Three friends, Milky Way, planets | EarthSky.org

Three friends, Milky Way, planets | EarthSky.org | Sustainable Futures | Scoop.it
On a beach in South Carolina, three friends watched as the morning twilight met the Milky Way.
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