Pluripotent stem cells (PSCs) directed to various cell fates holds promise as source material for treating numerous disorders. The availability of precisely differentiated PSC-derived cells will dramatically affect blood component and hematopoietic stem cell therapies and should facilitate treatment of diabetes, some forms of liver disease and neurologic disorders, retinal diseases, and possibly heart disease. Although an unlimited supply of specific cell types is needed, other barriers must be overcome. This review of the state of cell therapies highlights important challenges. Successful cell transplantation will require optimizing the best cell type and site for engraftment, overcoming limitations to cell migration and tissue integration, and occasionally needing to control immunologic reactivity, as well as a number of other challenges. Collaboration among scientists, clinicians, and industry is critical for generating new stem cell–based therapies.
Use of differentiated pluripotent stem cells as replacement therapy for treating disease Ira J. Fox, George Q. Daley, Steven A. Goldman, Johnny Huard, Timothy J. Kamp, Massimo Trucco
Three distinct timelines are shaping developments in the Middle East: the short -term timeline of daily struggles and politics; the medium-term timeline of geopolitical shifts; and the long-term timeline of sociocultural transformation. Understanding each is essential to craft an effective strategy in the region.
The ripening corn and soybean fields stretch for miles in every direction from Dennis Wentworth’s farm in Downs, Illinois. As he marveled at his best-yielding crops ever, he wondered aloud where the heck he’ll put it all.
The Environment America Research & Policy Center has released its annual report ranking the top 10 U.S. states with the most cumulative solar electric capacity installed per-capita. These states are (in alphabetical order) Arizona, California, Colorado, Delaware, Hawaii, Massachusetts, Nevada, N
EPA is proposing, at the request of the State of Maine, to require the sale of reformulated gasoline (RFG) in York, Cumberland, Sagadahoc, Androscoggin, Kennebec, Knox and Lincoln counties in southern Maine starting in June 2015. RFG is required in cities with high smog levels and is optional elsewhere. RFG is currently used in 17 states and the District of Columbia. About 30% of gasoline sold in the US is reformulated.
The purpose of the federal RFG program is to improve air quality in certain areas through the use of gasoline that is reformulated to reduce motor vehicle emissions that lead to the formation of ground-level ozone. Ground-level ozone can cause breathing problems, aggravate asthma and other pre-existing lung diseases, and make people more susceptible to respiratory infection.
States which are designated by EPA as part of the Ozone Transport Region, such as Maine, can “opt-in” to the program.
The Food for Peace Reform Act of 2014 (S. 2421) will reform U.S. food aid and feed more people at lower cost. Mothers and children, like these in South Sudan, will benefit from targeted nutrition. (USAID) By Eric Mitchell A future free of hunger will require good ideas. I want to share with you a really, really good idea. Picture this: Our federal government provides life-saving food assistance to 9 million more people around the world who experience hunger every...
The United States lost jobs between 2000 and 2010, the first loss between census years that has been recorded in the nation's history. The decline was attributable to two economic shocks, the contraction following the 9/11 attacks and the Great Recession, the worst financial crisis since the Great Depression. Yet, even in this moribund job market, employment continued to disperse in the nation's major metropolitan areas.