Study design and causality
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Study design and causality
Study design and causality
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Trish Greenhalgh - ‘Real v Rubbish EBM’

Real vs rubbish EBM: what is the state of evidence-based medicine, and is it broken
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watch it!

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Real versus Rubbish EBM (with images, tweets) · Dominic_Hurst

On January 14th 2014 a number of luminaries from the Evidence-Based Healthcare world met in an open workshop to debate what Evidence-Based Medicine should be about.
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Nice summary and links:) 

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Ecological Correlations and the Behavior of Individuals

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Be warned! This contains equations! But it is a great explanation of why the relationships that are seen at group levels are rarely repeated at individual level. 

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Anne Marie Cunningham's comment, January 17, 2013 9:39 AM
This is the 'classic' paper published 50 years ago. It has many citations and discussion still goes on about how important the ecological fallacy is...
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Project MUSE - Evidence-Based Policymaking: A Critique

Project MUSE - Evidence-Based Policymaking: A Critique | Study design and causality | Scoop.it

The idea that policy should be based on best research evidence might appear to be self-evident. But a closer analysis reveals a number of problems and paradoxes inherent in the concept of “evidence-based policymaking.” The current conflict over evidence-based policymaking parallels a long-standing “paradigm war” in social research between positivist, interpretivist, and critical approaches. This article draws from this debate in order to inform the discussions over the appropriateness of evidence- based policymaking and the related question of what is the nature of policymaking.

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How do people really make policy? How are rhetoric and evidence brought together? 

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David Healy - Time to abandon evidence based medicine?

A talk by Prof David Healy from the Institute of Psychological Medicine and Clinical Neurosciences at Cardiff University. The talk was presented at the Cardiff University School of Psychology on 26th November 2012.

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Challenging!

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Max Davie's curator insight, January 17, 2013 8:02 AM

An interesting man... food for thought at least

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alltrials | All trials registered, all results reported

alltrials | All trials registered, all results reported | Study design and causality | Scoop.it

Thousands of clinical trials have not reported their results; some have not even been registered.

Information on what was done and what was found in these trials could be lost forever to doctors and researchers, leading to bad treatment decisions, missed opportunities for good medicine, and trials being repeated unnecessarily on people and animals.

All trials past and present should be registered, and the full methods and the results reported.

We call on governments, regulators and research bodies to implement measures to achieve this.

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Supported by Ben Goldacre and many others

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Blood Pressure Ruckus Reveals Big Secret In Medicine

Blood Pressure Ruckus Reveals Big Secret In Medicine | Study design and causality | Scoop.it
Honesty about the uncertainty in medicine could lead to better choices for patients.
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nice summary of some of the debate going on about BP targets in US- although doesn't descibe the evidence behind them

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Incidence | Prevalence: Epidemiology Biostatistics Tutorial Explanation

Epidemiology and Medical Statistics students appreciate this quick tutorial to review concepts. Please SUBSCRIBE: More cool stuff coming as we get more Hippo...
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Nice simple explanation! "Better than learning from Wikipedia!"

This was suggested th scoopit. 

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Dr Derek Jones's curator insight, March 27, 2013 6:52 AM

A helpful review of these commonly encountered terms.

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Project MUSE - Valuing Evidence: Bias and the Evidence Hierarchy of Evidence-Based Medicine

Project MUSE - Valuing Evidence: Bias and the Evidence Hierarchy of Evidence-Based Medicine | Study design and causality | Scoop.it

 This article argues that two familiar justifications offered for the EBM hierarchy of evidence—that the hierarchy provides special access to causes, and that evidence derived from research methods ranked higher on the hierarchy is less biased than evidence ranked lower—both fail, and that this indicates that we are not epistemically justified in using the EBM hierarchy of evidence as a guide to medical research and practice.

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Test, Learn, Adapt: Developing Public Policy with Randomised Controlled Trials | Cabinet Office

This paper argues that Randomised Controlled Trials (RCTs), which are now widely used in medicine, international development, and internet-based businesses, should be used much more extensively in public policy.
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Cabinet Office paper advocating more RCTs of social policy interventions. 

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Publication - Harveian Oration 2008

Publication - Harveian Oration 2008 | Study design and causality | Scoop.it

In this year's Harveian Oration, Professor Sir Michael Rawlins, Chairman of the National Institute for Health and Clinical Excellence (NICE), argues that we need a new approach to analysing clinical evidence. He says that randomised controlled trials (RCTs), long regarded as the 'gold standard' of evidence, have been put on an undeserved pedestal. He outlines their limitations in several key areas, arguing that a diversity of approaches should be used to analyse the whole of the evidence base.

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Here you can download the content of this lecture which gives a really interesting insight into Rawlins's views on hierarchies of evidence.

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