Stem Cells & Tissue Engineering
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Stem Cells & Tissue Engineering
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Engineering bone tissue using human Embryonic Stem Cells

Bone defects lead by traumatic injuries, congenital malformations and other surgical rescissions rises the immediate need for a more evolved and safer approa...
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This is a nice presentation on the use of human embryonic stem cells for tissue engineering of bone tissue.

Find more protocols here: http://discovery.lifemapsc.com/stem-cell-differentiation/protocols?treeFilter=CB81592A-120B-4419-82A8-AE10AAB3478D

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Interim report on the investigation of the Obokata et al. articles | RIKEN

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"RIKEN takes very seriously the various allegations and concerns that have been raised regarding the two STAP cell research articles published in the journal Nature by researchers at the RIKEN Center for Developmental Biology (CDB), and has established a committee to investigate the concerns."

Read the RIKKEN report: http://www.riken.jp/en/pr/press/2014/20140314_1/

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Watch: Scientists ‘herd’ cells in new approach to tissue engineering

Watch: Scientists ‘herd’ cells in new approach to tissue engineering | Stem Cells & Tissue Engineering | Scoop.it
UC Berkeley engineers have found that an electrical current can be used to orchestrate the flow of a group of cells. This achievement sets the stage for more controlled forms of tissue engineering and for potential applications such as "smart bandages" that use electrical stimulation to help heal wounds.
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Wow! A real amazing movie showing the effect of an electric current on cell migration. This effect may be used in the future to aid tissue engineering, and perhaps to attract cells towards an injury site.

Get ready to be amazed!

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Generation of renal progenitor cells from human embryonic stem cells - Differentiation protocol - LifeMap Discovery

Generation of renal progenitor cells from human embryonic stem cells - Differentiation protocol - LifeMap Discovery | Stem Cells & Tissue Engineering | Scoop.it
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Stem cell researchers, this is the ultimate protocol tool for you!

- View the protocol flow, time, and growth factors

- Explore the gene expression of the differentiated cells

- Learn about developmental signals which govern the                  differentiation process

 

See our huge protocol collection: 

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

 

 

 

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Stem cells for treatment of ALS at Mayo Clinic - YouTube

Researchers in the Center for Regenerative Medicine are studying the use of intraspinal deliver of mesenchymal stem cells (MSCs) to the cerebral spinal fluid...
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This is a nice movie illustrating the process of isolation and transplantation of growth factor secreting-mesenchymal stem cells (MSCs) for the treatment of amyotrophic lateral sclerosis (ALS), currently being held at the Mayo Clinic.

Join my Facebook group for more stem cells news and updates:

 https://www.facebook.com/groups/STEMCELLSNET/

 

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STAP stem cells protocol - Rikken Institute

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This document, provided by the Rikken Institute, details the STAP stem cells protocol. Those of you that wish to reproduce the results and create their own STAP stem cells should take a careful look.

Full document: 

http://www.cdb.riken.jp/jp/04_news/articles/pdf/14/protocol_exchange_v1.pdf

 

Learn more about stem cells and regenerative medicine:

http://discovery.lifemapsc.com/stem-cell-differentiation

 

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Stem cell advance yields mature heart muscle cells

Stem cell advance yields mature heart muscle cells | Stem Cells & Tissue Engineering | Scoop.it
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Using micropatterned 3D substrates, researchers from UW-Madison were able to align stem cell-derived cardiomyocytes and to form a sarcomere structure.

http://www.sciencedirect.com/science/article/pii/S0142961214001276


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Stem Cell Reports - Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells

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Researchers from  the Salk Institute for Biological Studies have developed a novel protocol for generation of hippocampal granule neurons from human embryonic stem cells (hESCs) via the formation of hippocampal neural progenitor cells (NPCs). These hESC-derived NPCs were further transplanted into the dentate gyrus (DG) region of NOD-SCID where they exhibited a remarkable ability to integrate into the mice DG.

Full open-access paper: http://www.cell.com/stem-cell-reports/abstract/S2213-6711(14)00026-5?switch=standard#Summary

 

Learn about brain development and neuronal differentiation of human pluripotent stem cells: http://discovery.lifemapsc.com/in-vivo-development/brain

 

 

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Reluctant star of stem cell research

Reluctant star of stem cell research | Stem Cells & Tissue Engineering | Scoop.it
America’s most celebrated bioscientist around the turn of this century was James Thomson. He was the face of the new stem cell era, which he launched with a landmark experiment at the University of Wisconsin in 1998 – extracting from very early
Jacob Blumenthal's insight:

James Thosmson is one of the famous scientists in the stem cell field. He was the one, that on 1998 published the first paper on human embryonic stem cells (hESC). Today, as the chief scientific officer of cellular dynamics, he acts to commercialize stem cell technology for the purpose of drug discovery and development. 

Join my Facebook group for more stem cell news and updates:

https://www.facebook.com/groups/STEMCELLSNET/

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We are hiring - Senior Sales Manager (USA)

Senior Sales Manager-located in the USA Send your C.V to jacobb@lifemapsc.com Job Description LifeMap Sciences, Inc., a subsidiary of BioTime, Inc. (NYSE: BT...
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Liver cells grown with new reprogramming method

Liver cells grown with new reprogramming method | Stem Cells & Tissue Engineering | Scoop.it
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Researchers from the Gladstone institute published a new method for generation of functional hepatocytes from human fibroblast cells. In the new method, they directly reprogrammed fibroblast cells towards hepatic faith, without going through an iPSC, pluripotent stage. In order to test their functionality, the induced hepatic cells were transplanted into mouse models of liver failure where they  proliferated and displayed hepatic functionality.

Full paper:

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13020.html


Learn more about liver development and stem cell protocols:

http://discovery.lifemapsc.com/in-vivo-development/liver




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Regenerative Medicine and Aging - Dr. Michael West - YouTube

In this lecture, BioTime CEO and Geron founder Dr. Michael West discusses regenerative medicine and its application to age-related disease with a specific fo...
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A very good lecture about aging, stem cells and the contribution of BioTime to the field of regenerative medicine.

 

Learn more about stem cell research, regenerative medicine and developmental biology:

http://discovery.lifemapsc.com/

 

 

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Decellularization for whole organ bioengineering - Abstract - Biomedical Materials - IOPscience

Organ transplantation in an orthotopic location is the current treatment for end-stage organ failure. However, the need for transplantable organs far exceeds the number of available donor organs. As a result, new options, such as tissue engineering and regenerative medicine, have been explored to achieve functional organ replacement. Although there have been many advances in the laboratory leading to the reconstruction of tissue and organ structures in vitro, these efforts have fallen short of producing organs that contain intact vascular networks capable of nutrient and gas exchange and are suitable for transplantation. Recently, advances in whole organ decellularization techniques have enabled the fabrication of scaffolds for engineering new organs. These scaffolds, consisting of naturally-derived extracellular matrix (ECM), provide biological signals and maintain tissue microarchitecture, including intact vascular systems that could integrate into the recipient's circulatory system. The decellularization techniques have led to the development of scaffolds for multiple organs, including the heart, liver, lung and kidney. While the experimental studies involving the use of decellularized organ scaffolds are encouraging, the translation of whole organ engineering into the clinic is still distant. This paper reviews recently described techniques used to decellularize whole organs such as the heart, lung, liver and kidney and describes possible methods for using these matrices for whole organ engineering.
Jacob Blumenthal's insight:

This is a link to a free article about decellularization of various organs such as the heart, kidney, lung, and liver.

 

Join my Facebook group for more updates on stem cells and tissue engineering:

https://www.facebook.com/groups/STEMCELLSNET/

 

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Obokata to withdraw much-maligned thesis on stem cells

Haruko Obokata, the lead author of papers on allegedly groundbreaking stem-cell research, has expressed her intention to withdraw the doctoral thesis she submitted to Waseda University, an official at the ...
Jacob Blumenthal's insight:

If this is true, then the career of Haruko Obokata as a researcher is probably finished.

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Institution to discuss probe into STAP stem cell controversy

Institution to discuss probe into STAP stem cell controversy | Stem Cells & Tissue Engineering | Scoop.it
It was hailed as a remarkable scientific breakthrough, one that could potentially revolutionize medicine by enabling the speedy production of highly versatile stem cells.
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The RIKKEN institute has published that "On the afternoon of Friday, March 14, we will hold a press conference in Japanese for registered journalists and issue a press release in English to report on the progress that has been made to date. More information will be provided soon."

In h next STAP update...

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Cell Stem Cell - Evolution of the Cancer Stem Cell Model

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This is a free  review on cancer stem cells by Antonija Kreso and John E. Dick. 

 

Join my Facebook group for more stem cells news and updates:

https://www.facebook.com/groups/STEMCELLSNET/

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STAP stem cell paper - Retraction?

The co-author of two breakthrough papers on making stem cells said Monday he had asked for the papers to be retracted, citing "crucial mistakes" in the research.
Jacob Blumenthal's insight:

The co-author of two breakthrough papers, that were published on Nature journal in January, ask the main author to retract the paper. 

Teruhiko Wakayama of Yamanashi University in Japan asked the lead author of the paper, Haruko Obokata, to retract the paper.

Read the full news:

http://edition.cnn.com/2014/03/12/health/stem-cell-study-doubts/

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Cell Stem Cell - Therapeutic Translation of iPSCs for Treating Neurological Disease

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This review, published on June 2013 discuss the importance of reprogramming technology for modeling and treating neurological and psychiatric diseases such as Alzheimer’s and Parkinson’s diseases, autism and schizophrenia. The review is free, and part of the "Feature Five" review collection of Cell Stem Cell journal.
-- To learn more about stem cells, regenerative medicine and developmental biology visit:  http://discovery.lifemapsc.com/

 

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Carlos Garcia Pando's curator insight, March 7, 2014 6:45 AM

Absolutly fantastic. 

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Bio-Printing: Benjamin Harrison at TEDxMidwest - YouTube

"The impossible can be possible" is what Ben Harrison intelligently proclaims to an audience of captivated listeners. As a respected authority in the field, ...
Jacob Blumenthal's insight:

Ben Harrison from  the Institute for Regenerative Medicine Center for Integrative Medicine at Wake Forest School of Medicine gave a very interesting talk about organ bioprinting and how it will solve the current shortage in organs for transplantation.

 

Join my Facebook group for more news on stem cells and tissue engineering:

https://www.facebook.com/groups/STEMCELLSNET/

 

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Building a Kidney: Using Pluripotent Stem Cells to Differentiate Kidney Structures

Building a Kidney:  Using Pluripotent Stem Cells to Differentiate Kidney Structures | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Kidneys develop from the intermediate metanephros (IM), which gives rise to the metanephric mesenchyme (MM) and the ureteric bud (UB). The MM forms the glomerulus and the renal tubules while the UB differentiates into the collecting duct. Reciprocal interactions between the MM and the UB are necessary for development of the kidney. Both the MM and the UB contain stem cells, however, once these cells are removed from their respective niches, they spontaneously terminally differentiate, rendering, creation of kidney structures in vitro very difficult. Recently, two papers (from Nishinakamura and Little's research groups) describe the use ... (Read the full story in the newsletter).

http://us4.campaign-archive1.com/?u=985051700e9649000fa0c0d4a&id=22f09f7211&e=f1b990f7f8

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Making New Spinal Neurons | The Scientist Magazine®

Making New Spinal Neurons | The Scientist Magazine® | Stem Cells & Tissue Engineering | Scoop.it
With a single gene, scientists reprogram supporting cells in the spines of living mice into new neurons.
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A new way to make spinal neurons in-vivo? Introduction of SOX2 transcription factor into spinal astrocytes, converted them into  doublecortin (DCX)-positive neuroblasts in-vivo. These neuroblasts have the potential to further differentiate into synapse-forming neurons in-vivo.

Paper: http://www.nature.com/ncomms/2014/140225/ncomms4338/full/ncomms4338.html

 

Join my Facebook group for more stem cells news:https://www.facebook.com/groups/STEMCELLSNET/

 

 

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New Stem Cell Sagas

New Stem Cell Sagas | Stem Cells & Tissue Engineering | Scoop.it
A recipe detailing how to make extraordinary stem cells from ordinary cells—just by "stressing" them with acid—will "soon" be posted for all to try, says Riken. This could settle much controversy surrounding the cells...or spur more. Meanwhile, there have been "anecdotes" of success.
Jacob Blumenthal's insight:

This article nicely summarizes  the evolution of the STAP stem cells story ,starting with the release of the two extraordinary papers, until the appearance of the first question marks.

 

Learn more about stem cells, developmental biology, and regenerative medicine:

http://discovery.lifemapsc.com/

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Gene Therapy Might Grow Replacement Tissue Inside the Body | Duke Pratt School of Engineering

Gene Therapy Might Grow Replacement Tissue Inside the Body | Duke Pratt School of Engineering | Stem Cells & Tissue Engineering | Scoop.it
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Researchers from Duke combined synthetic scaffolds with viral gene delivery techniques to generate cartilage-secreting human mesenchymal stem cells (hMSCs). The researchers first immobilized lentivirus to poly(ε-caprolactone) films. Then they demonstrated that scaffold-mediated gene delivery of transforming growth factor β3 (TGF-β3), using a 3D woven poly(ε-caprolactone) scaffold, promoted  cartilaginous ECM production by hMSCs.

Full paper: 

http://www.pnas.org/content/early/2014/02/13/1321744111.abstract

 

Learn about cartilage development and related stem cell differentiation protocols:

http://discovery.lifemapsc.com/in-vivo-development/cartilage

 

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Disgraced Scientist Granted U.S. Patent for Work Found to be Fraudulent

Dr. Hwang Woo-suk of South Korea received the patent for the method by which he claimed in 2004 to have extracted stem cells from cloned human embryos.

Jacob Blumenthal's insight:

The US patent office had decided to issue a patent for a procedure to generate human stem cells, based on the work of Dr. Hwang Woo-suk and colleagues. The main problem is that the  research papers in which the work was described are cited in the patent, and both are now clearly marked as retracted, the work was later found to be fraudulent, and Dr. Hwang himself was fired from his university and convicted of crimes.

Read more here: http://arstechnica.com/science/2014/02/uspto-issues-patent-for-fraudulent-stem-cell-procedure/

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Pete Coffey: Driving stem cells to the clinic

Pete Coffey: Driving stem cells to the clinic | Stem Cells & Tissue Engineering | Scoop.it
Professor Pete Coffey, Professor of Cellular Therapies at the Institute of Ophthalmology, University College London, is an MRC-funded researcher who is developing a stem cell therapy for a degenera...
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This is an interview with professor Pete Coffey about his ongoing research on stem cell therapy for age-related macular degeneration (AMD).

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