Stem Cells & Tiss...
Follow
43.0K views | +64 today
Stem Cells & Tissue Engineering
Stem Cells & Tissue Engineering news and updates
Your new post is loading...
Scooped by Jacob Blumenthal
Scoop.it!

Proto-Organelles for Synthetic Cells | The Scientist Magazine®

Proto-Organelles for Synthetic Cells | The Scientist Magazine® | Stem Cells & Tissue Engineering | Scoop.it
Researchers construct lipid-encapsulated compartments within synthetic cells.
Jacob Blumenthal's insight:

"Researchers construct lipid-encapsulated compartments within synthetic cells".

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

New collaboration combines genomic sequencing and stem cell technology to understand disease

New collaboration combines genomic sequencing and stem cell technology to understand disease | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

A new collaboration between the Harvard Personal Genome Project (PGP), and researchers from the New York Stem Cell Foundation (NYSCF) Research Institute has been announced today. NYCSF researchers will derive induced pluripotent stem cells (iPSC) from samples of patients participating in PGP. These cell lines can then be examined and compared to data gathered by the PGP including whole genomes, medical histories, body microbiomes and hundreds of other traits from over 3,000 participants. 

 

To learn about stem cells and related differentiation protocols:

http://discovery.lifemapsc.com/

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Stem cell research faces budget crunch

Stem cell research faces budget crunch | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Mahendra Rao, director of the National Institute of Regenerative Medicine delivered the news on Wednesday morning session of the World Stem Cell Summit.

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Researchers unlock a new means of growing intestinal stem cells

Researchers unlock a new means of growing intestinal stem cells | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Researchers from the labs of prof. Robert Langer and prof. Jeffrey Karp, have developed a novel method for efficient propagation of intestinal Lgr5+ stem cells. Until now, researchers were able to culture these cells in-vitro only in a co-culture with supportive cells called Paneth cells. Now, it is possible to replace these supportive cells with two small mlecules CHIR99021 and Valproic Acid.

The paper was published online on Nature methods:

http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.2737.html

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Isolation, characterization, and molecular regulation of muscle stem cells | Frontiers in Striated Muscle Physiology

Isolation, characterization, and molecular regulation of muscle stem cells | Frontiers in Striated Muscle Physiology | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

This open access review describes a method for direct  isolation of muscle stem cells also known as satellite cells. In addition, it details their characteristics and their unique gene expression profile.

 

To learn more about the embryonic development of skeletal muscles, and related stem cells differentiation protocols:

http://discovery.lifemapsc.com/in-vivo-development/skeletal-muscle

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Stem cells - Dr Jekyll or Mr Hyde: Hans Clevers at TEDxAmsterdam

Jacob Blumenthal's insight:

Hans Clevers talks about stem cells and how we can use them for regenerative medicine.

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Irv Arons' Journal: Stem Cells in Ophthalmology Update 24: Current Tables Now Online

Irv Arons' Journal: Stem Cells in Ophthalmology Update 24: Current Tables Now Online | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

This blog by Irv Arons brings interesting and useful information about stem cell-related cell therapies in ophthalmology. 

http://irvaronsjournal.blogspot.fr/2012/12/stem-cells-in-ophthalmology-update-24.html

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Inhibition of let-7 microRNA promotes reprogramming to human induced pluripotent stem cells (iPSC) - Cell Stem Cell

Jacob Blumenthal's insight:

A new paper from the lab of Shinya Yamanaka suggest that the let-7  family of microRNAs induce an inhibitory effect on the reprogramming process by regulation of pro-differentiation factors, such as EGR1. Inhibition of let-7  in human cells results in an increase in the level of the let-7 target LIN-41/TRIM71, which in turn promotes reprogramming.

http://www.cell.com/cell-stem-cell/abstract/S1934-5909(13)00492-X


To learn about stem cells and related differentiation protocols, follow the links:

http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols


more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Human stem cells used to reveal mechanisms of beta-cell failure in diabetes

Human stem cells used to reveal mechanisms of beta-cell failure in diabetes | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Researchers derived induced pluripotent stem (iPS) cells from skin cells taken from patients with a rare form of diabetes -- Wolfram syndrome. Then they differentiated these iPS cells into beta-like cells, and found that the derived cells failed to secrete insulin due to  protein-folding, or endoplasmic reticulum (ER)  stress. By adding 4-phenyl butyric acid, the cells regain the ability to secrete insulin.

This paper is a good example to the ability to use iPS cells as iin-vitro disease models, to gain insight into disease-related molecular mechanisms and to screen for potential drugs.

http://diabetes.diabetesjournals.org/content/early/2013/11/07/db13-0717.abstract

 

To learn about the embryonic development of the Pancreas, and related stem cell differentiation protocols:

http://discovery.lifemapsc.com/in-vivo-development/pancreas

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Current status and perspectives on stem cell-based therapies undergoing clinical trials for regenerative medicine: case studies

Jacob Blumenthal's insight:

This new review, summarizes the current status of stem cell-based therapies. 

To learn about stem cells and related cell therapies, please enter:

http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells

 

*Cell therapies cards are currently a premium feature

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Regenerative Medicine Research | Current status of induced pluripotent stem cells in cardiac tissue regeneration and engineering

In this open-access short review, Liu. et al, discuss the achievements and current status of induced pluripotent stem cells (iPSC) for cardiac tissue regeneration, including development of iPSC derivation, in vitro strategies for cardiac generation from iPSCs, cardiac application of iPSCs, challenges confronted at present as well as perspective in the future. 

 

To learn  about heart development, stem cell differentiation protocols, and cell therapies:

http://discovery.lifemapsc.com/in-vivo-development/heart

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Neural stem cells: generating and regenerating the brain

Jacob Blumenthal's insight:

Fred Gage and Sally Temple published a very interesting review about neural stem cells (NSCs) in Neuron journal. This is an open-access, and highly recommended review from one of the leading scientist in the field.

http://www.cell.com/neuron/retrieve/pii/S0896627313009896

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Cell Death and Differentiation - Immunobiology of mesenchymal stem cells

Cell Death and Differentiation - Immunobiology of mesenchymal stem cells | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Mesenchymal stem cells play an important role in cell therapy and are being currently tested in clinical trials for a variety of diseases. This open-access paper focus on their immunomodulatory effect.

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

23andMe Steps Back | The Scientist Magazine®

23andMe Steps Back | The Scientist Magazine® | Stem Cells & Tissue Engineering | Scoop.it
The company announces that it will stop offering health interpretations of personal genetic data.
more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Cell Stem Cell - Integrating Human Pluripotent Stem Cells into Drug Development - Cell Stem Cell

Jacob Blumenthal's insight:

This review, published on June in Cell Stem Cell journal, is now freely available, as part of the "Featured Five Reviews" of the Journal. It describes how researchers can use human pluripotent stem cells for drug discovery purposes.

http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(13)00204-X

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Defining Key Design Criteria for Cardiac Tissue Engineering

Defining Key Design Criteria for Cardiac Tissue Engineering | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Cardiomyocytes, differentiated from either human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs), are used in cardiovascular research throughout the last decade. In addition to their regenerative capacities and promise for clinical application, these cells provide an unlimited source of...

(click the link below for the full story)

http://us4.campaign-archive1.com/?u=985051700e9649000fa0c0d4a&id=ed2c6547b5&e=f1b990f7f8

more...
Carlos Garcia Pando's curator insight, December 5, 2013 3:18 AM

This is like the drawings and procedure. Sience is taking the engineering steps.

Scooped by Jacob Blumenthal
Scoop.it!

Scientists make lung cells from human stem cells

Scientists make lung cells from human stem cells | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Researchers from the  Columbia University Medical Center, published a new paper in Nature Bitechnology, describing a novel method for generation of functional lung cells from pluripotent stem cells. Their highly-efficient differentiation method resulted in the formation of clara, ciliated, type I and type II alveolar epithelial cells.

A link to the paper:

 http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.2754.html

 

To learn about the embryonic development of the lung and realted stem cell protocols: 

http://discovery.lifemapsc.com/in-vivo-development/lung

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation

Jacob Blumenthal's insight:

A new paper in PNAS describes a novel 3D culturing system for culturing and expansion of pluripotent stem cells. It is based on a unique hydrogel that allows  to control the exact composition of the growth environment, free of any human- or animal-derived factors, and entailing only recombinant protein factors.


To learn about stem cells, embryonic development, and regenerative medicine:

http://discovery.lifemapsc.com/

more...
No comment yet.
Rescooped by Jacob Blumenthal from Stems cells and Regenerative Medicine
Scoop.it!

Experimental & Molecular Medicine - Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

Experimental & Molecular Medicine - Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine | Stem Cells & Tissue Engineering | Scoop.it

Via Richard D. Hammer, M.D.
Jacob Blumenthal's insight:

This open-access review describes the characteristics of mesenchymal stem cells and their therapeutical potential for regenerative medicine. 

 

 

To learn about mesenchymal stem cells and their gene expression in Lifemap Discovery database:

 

Adipose-MSCs: http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells/adipose-human-adipose-derived-mesenchymal-stem-cells-family

 

Bone marrow-MSCs: http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells/bone-human-bone-marrow-derived-mesenchymal-stem-cells-family

 

Umbilical cord-MSCs: http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells/blood-umbilical-cord-human-umbilical-cord-derived-mesenchymal-stem-cells-family

 

 

more...
Richard D. Hammer, M.D.'s curator insight, November 20, 2013 12:54 PM

Another article in support of autologous therapy.  

Scooped by Jacob Blumenthal
Scoop.it!

'Mini-kidney' structures generated from human stem cells for first time

'Mini-kidney' structures generated from human stem cells for first time | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Researchers from the Salk institute have generated three-dimensional kidney structures from human induced pluripotent stem cells, as a platform to study the development and diseases of the kidney. 

http://www.nature.com/ncb/journal/vaop/ncurrent/pdf/ncb2872.pdf#figures

 

To learn about the embryonic developement of the kidney, and related stem cells differentiation protocols:

http://discovery.lifemapsc.com/in-vivo-development/kidney

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Induced Expression of Lin28 Promotes Tissue Regeneration

Induced Expression of Lin28 Promotes Tissue Regeneration | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

A paper published this month in Cell by Shyh-Chang et al., suggests that expression of  Lin28, a highly conserved RNA-binding protein, can lead to tissue regeneration. Lin28 was first identified as a developmental timing regulator in C. elegans. In mammals, Lin28a, a conserved mammalian paralog of Lin28, was shown to be expressed during embryogenesis and in embryonic stem cells (ESCs) and to repress let7 microRNA. However, during fetal development, ...(click the image or the link to read the full story):

http://us4.campaign-archive1.com/?u=985051700e9649000fa0c0d4a&id=2b288eac88&e=aeb607fc5e&goback=%2Enmp_*1_*1_*1_*1_*1_*1_*1_*1_*1_*1%2Egde_4972382_member_5807111556705587202#%21

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Stem cells: A time to heal - Nature

Stem cells: A time to heal - Nature | Stem Cells & Tissue Engineering | Scoop.it
The first stem-cell therapies for spinal cord injuries are already being tested in clinical studies, but scientific and political uncertainty remain.
Jacob Blumenthal's insight:

An article, published today in Nature, describes the current status of stem cell therapy clinical trials for the treatment of spinal cord injury (SCI). 

more...
Carlos Garcia Pando's curator insight, November 14, 2013 8:02 AM

It's not political uncertainty, but only fear of the darkest and dirtiest side of humans: greed to make profit out of other persons lifs or bodies. In other words, they avoid the risk of facing fetuses traffic.

Scooped by Jacob Blumenthal
Scoop.it!

Susan Lim: Transplant cells, not organs | Video on TED.com

Jacob Blumenthal's insight:

A very interesting talk by Susan Lim, a pioneering surgeon who performed the first liver transplant in Asia. She talks about the importance of stem cell transplantation.

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

StemCells gets FDA OK on spinal cord trial

Jacob Blumenthal's insight:

The FDA gave permission to StemCell Inc.  to start testing an experimental stem cell therapy in humans who have suffered spinal cord injuries. This experiment will be conducted mainly in the USA, but also in Canada, and its designed mostly to demonstrate that the stem cell injections are safe. 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Cell - A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species

Cell - A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

A team of researchers, led by Leonard Zon, Amy Wagers, and Ronald Kahn describe a novel technique to identify small molecules and chemicals that can promote myogenesis differentiation and proliferation. The main goal of the study was to identify novel molecules that will allow efficient skeletal muscle differentiation of induced pluripotent stem (iPS) cells. These skeletal muscle cells, could be then transplanted into patients with muscle loss.

In order to achieve that, the researchers first use a zebrafish embryo-based culture system to screen for molecules that promote myogenesis and expansion of muscle progenitors. Then they applied these molecules on iPS cells, to generate engraftable myogenic progenitors that contributed to muscle repair in vivo.

http://www.cell.com/abstract/S0092-8674(13)01299-3

 

To learn about skeletal muscle embryonic development :

http://discovery.lifemapsc.com/in-vivo-development/skeletal-muscle

 

*The picture is taken from Lifemap Discovery database*

more...
No comment yet.