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Patient stem cells help identify common problem in ALS

Patient stem cells help identify common problem in ALS | Stem Cells & Tissue Engineering | Scoop.it
Harvard stem cell scientists have discovered that a recently approved medication for epilepsy may possibly be a meaningful treatment for amyotrophic lateral sclerosis (ALS)—Lou Gehrig's disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts ...
Jacob Blumenthal's insight:

In two papers, published in Cell Reports, and in Cell Stem Cell, researchers used induced pluripotent stem cells (iPSC) derived from Amyotrophic Lateral Sclerosis (ALS) patients cells to study  aberrant molecular mechanisms related to ALS  in-vitro. In the first paper, researchers from the labs of Kevin Eggan and Clifford Woolf found that iPSC-derived motor neurons from ALS patients are hyperexcitable compared to controls, and that the drug Retigabine,  which has recently been approved as an anticonvulsive, could rescues the hyperexcitability phenotype in multiple ALS variants.

In the second paper, researchers from the lab of Su-Chun Zhang found that neurofilament aggregation is an early phenotype of ALS, and that correction of  neurofilament expression, mitigates axonal degeneration in ALS motor neurons.

http://www.cell.com/cell-reports/abstract/S2211-1247(14)00197-1

http://www.cell.com/cell-stem-cell/abstract/S1934-5909(14)00055-1

 

Learn about motor neurons development, pathologies, gene expression and related motor neurons derivation protocols:

http://discovery.lifemapsc.com/in-vivo-development/motor-neurons

 

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Family Guy -- Why Are We Not Funding This (Stem Cell Research) - YouTube

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A nice animation on YouTube :)

 

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Joshua Hunsberger's curator insight, April 3, 2014 3:43 PM

I ask myself the same question. Why are we not providing more funding for Stem Cell Research. The potential is there to deliver cures. 

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RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers

RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers | Stem Cells & Tissue Engineering | Scoop.it
Investigating committee identifies two instances of research misconduct, puts most of the blame on lead author
Jacob Blumenthal's insight:

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From the news : "An investigating committee has concluded that falsification and fabrication mar two recent Nature papers reporting a new, simple way to reprogram mature cells into stem cells. The committee concluded that these acts constitute research misconduct, but it stopped short of calling for the papers to be retracted and will leave the question of disciplinary action to a separate committee. RIKEN President Ryoji Noyori today said he favors the papers’ retraction if the committee’s findings are upheld in an appeals process.

“I am filled with feelings of indignation and surprise,” said lead author Haruko Obokata, of the RIKEN Center for Developmental Biology (RIKEN CDB) in Kobe, in a statement. She wrote that she intends to appeal the judgment".

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Joshua Hunsberger's curator insight, April 3, 2014 3:45 PM

I say what can we learn from this and let's move forward.

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Stap cells: research paper on stem cell breakthrough was partly falsified

Stap cells: research paper on stem cell breakthrough was partly falsified | Stem Cells & Tissue Engineering | Scoop.it
Investigators at Japanese laboratory say lead author manipulated presentation of results to improve their appearance
Jacob Blumenthal's insight:

The STAP cells saga never ends, now researchers from Japan say that "researcher Haruko Obokata, the lead author of the paper in Nature, had manipulated or falsified images of DNA fragments used in the research".

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First comprehensive atlas of human gene activity released - A new road map for direct cell reprogramming?

First comprehensive atlas of human gene activity released - A new road map for direct cell reprogramming? | Stem Cells & Tissue Engineering | Scoop.it
A large international consortium of researchers has produced the first comprehensive, detailed map of the way genes work across the major cells and tissues of the human body. The findings describe the complex networks that govern gene activity, and the new information could play a crucial role in identifying the genes involved with disease.
Jacob Blumenthal's insight:

This new map of gene activity in cells and tissues, may serve as a road map for direct reprogramming of somatic cells. Knowing the master regulators, key genes for each lineage is crucial in order to perform efficient reprogramming.

Overall, it brings us closer to the times when researchers will be able to generate mature cells for regenerative medicine purposes from the patient's own cells, without the need to generate fully pluripotent stem cells.

Interested in tissue/organ specific gene expression? check the LifeMap Discovery database:  http://discovery.lifemapsc.com/in-vivo-development

 

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Joshua Hunsberger's curator insight, April 3, 2014 3:06 PM

This is definitely worth investigating!

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Reversing Autism in the Lab with Help from Stem Cells and the Tooth Fairy

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In this talk, Alysson Muotri from UCSD talks about his research on Autism and how he uses stem cells to model the disease. A very interesting talk!

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Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape

Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

This  new open-access paper, published in stem cell research journal, describes the encapsulation of human embryonic stem cells (hESC)-derived pancreatic islets, and their ability to produce insulin in response to glucose levels. Insulin production is achieved without increasing the cell mass, or the escape of the cells from the capsule.

This novel method will enable to minimize the risk of immune response against the  hESC-derived pancreatic cells.

 

To learn more about stem cell differentiation protocols, follow the link:

 http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

 

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‘Stem cell tourism’ takes advantage of patients, says law professor

‘Stem cell tourism’ takes advantage of patients, says law professor | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Although "Stem cell tourism" offers hope for patients, and allows them to receive innovative stem cell treatments, it is important to understand that it also has a "bad side". Patients should be aware of all aspects of current stem cell treatments, before they spend their life savings on such treatments. 

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Scientist Live-Blogs His Lab’s Attempts to Generate New Type of Stem Cells

Scientist Live-Blogs His Lab’s Attempts to Generate New Type of Stem Cells | Stem Cells & Tissue Engineering | Scoop.it
Using refined protocol, researcher will post as-it-happens updates of his efforts to replicate controversial experiment
Jacob Blumenthal's insight:

Kenneth Ka-Ho Lee, a stem cell researcher at the Chinese University of Hong Kong, has tried to generate STAP stem cells based on the papers of Obokata et al, but failed. He published his report on ResearchGate website.

ResearchGate link: 

http://www.researchgate.net/publication/259984904_Stimulus-triggered_fate_conversion_of_somatic_cells_into_pluripotency/reviews/103

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Harvard Researchers Print Functional Heart Tissue > ENGINEERING.com

Harvard Researchers Print Functional Heart Tissue > ENGINEERING.com | Stem Cells & Tissue Engineering | Scoop.it
Harvard researchers engineer a 3D printed cardiac replacement tissue that mimics heart muscles.
Jacob Blumenthal's insight:

A joint effort of researchers from  from the University of Sydney, Brigham and Women's Hospital, and Harvard Medical School have lead to the development of a new 3D printed artificial cardiac tissue that can be used to repair damaged hearts.

Join my Facebook group for more news and updates:

https://www.facebook.com/groups/STEMCELLSNET/

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MRRF 2014 - Bioprinting - YouTube

MRRF 2014 - Bioprinting - YouTube | Stem Cells & Tissue Engineering | Scoop.it
Jordan Miller, Andy Ta, and Steve Kelly talk 3D bioprinting at the 2014 Midwest RepRap Festival Read the Hackaday post: http://wp.me/pk3lN-uAD
Jacob Blumenthal's insight:

A very interesting presentation that shed some light on the next generation of bioprinters and on 3D bioprinting  in general.

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Stem cell therapy -- beyond the headlines: Timothy Henry at TEDxGrandForks

There is considerable excitement about the use of stem cells for cardiovascular disease. Stem cells are unspecialized cells with the unique property to self-...
Jacob Blumenthal's insight:

This is a nice TED talk about the use of stem cells as a therapy for cardiovascular diseases.

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Researchers create new line of naive human embryonic stem cells

Researchers at the University of Washington have successfully created a line of human embryonic stem cells that have the ability to develop into a far broader range of tissues than most existing cell lines.
Jacob Blumenthal's insight:

Researchers from university of Washington have created a new line of naive human embryonic stem cells termed "Elf1".  

Read the open access paper in PNAS: 

http://www.pnas.org/content/early/2014/03/12/1319738111.abstract?sid=18827180-4798-42af-9d20-9bdc65a58857

 

Learn about naive human embryonic stem cells and their unique gene expression pattern, compared to "regular" human embryonic stem cells: http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells/inner-cell-mass-human-naive-human-embryonic-stem-cells-family.

 

For the gene expression  comparison between naive H9 hESC and "regular" (also termed "primed"), H9 hESC: 

http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells/inner-cell-mass-human-line-h9-naive-weizmann-institute-of-science

and http://discovery.lifemapsc.com/gene-expression-signals/high-throughput/microarray-analysis-of-naive-h9-human-embryonic-stem-cells/naive-h9-cells-vs-h9-cells

 

 

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Molly Stevens: A new way to grow bone - YouTube

What does it take to regrow bone in mass quantities? Typical bone regeneration — wherein bone is taken from a patient's hip and grafted onto damaged bone els...
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Molly stevens talks about bone regeneration in TED.

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A Good Hair Day - an Exciting Breakthrough in Hair Formation

A Good Hair Day - an Exciting Breakthrough in Hair Formation | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

According to the American Hair Loss Association, two thirds of men by the age of 35, and 40% of women will experience hair loss. A new study performed by researchers from University of Pennsylvania and published in Nature Communications, may offer them some hope.

In this study, the researchers...(Click on the image for the full story).

 

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'Phony' Stem Cell Researcher To Be Punished : DNews

'Phony' Stem Cell Researcher To Be Punished : DNews | Stem Cells & Tissue Engineering | Scoop.it
The move is a huge blow to what was touted as a game-changing discovery.
Jacob Blumenthal's insight:

"Riken Institute head, Ryoji Noyori, who jointly won the Nobel Prize for chemistry in 2001, said in a statement he will "rigorously punish relevant people after procedures in a disciplinary committee."

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Mismatch alleged in acid-bath stem-cell experiment

Mismatch alleged in acid-bath stem-cell experiment | Stem Cells & Tissue Engineering | Scoop.it
Cell lines linked to blockbuster papers came from different mouse strain to that claimed, study suggests.
Jacob Blumenthal's insight:

Concerns were raised about the origin of two stem cell lines, that were produced by Haruko Obokata in the STAP stem cells paper.

Researchers suspect that the two stem cell lines were not produced from a single mouse strain, as Obokata wrote, but from several lines. 

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New stem cell technique bypasses ethical concerns

New stem cell technique bypasses ethical concerns | Stem Cells & Tissue Engineering | Scoop.it
Stem cell and cloning research using human cells remain controversial, even though it is nearly 20 years since Dolly the sheep became the first mammal to be cloned. One of the main reasons for this controversy…
Jacob Blumenthal's insight:

In a new paper, published in Nature, researchers led by Shoukhrat Mitalipov, have demonstrated a novel nuclear reprogramming technique in mice. Until now, unfertilized eggs were needed for cell cloning by nuclear reprogramming. In the new technique, the researchers used fertilized eggs at the stage of interphase, just after the first cell division. They injected nuclei of two non-reproductive cells into both cells of the two-cell embryo that has just undergone its first cell division. During this stage, the conditions allowed formation of embryonic stem cells or even a clone. If these results could be reproduced in human, it will allow to generate stem cells from any person, without the need to destroy embryos, as in the case of human embryonic stem cells.

Paper: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13134.html

 

Learn more about stem cells and their differentiation protocols: 

http://discovery.lifemapsc.com/stem-cell-differentiation

 

 

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GEN | Magazine Articles: Aubrey de Grey: Out to Defy Death

GEN | Magazine Articles: Aubrey de Grey: Out to Defy Death | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

What is the worst problem in the world? According to Aubrey de Grey, a biomedical gerontologist, its AGING. He is the founder of SENS, a research foundation that aims to help build the regenerative medicine industry. According to his view, one of he ways to deal with cell loss, or cell atrophy during aging is by using stem cells and tissue engineering strategies.

Join my Facebook group for more news and updates:

https://www.facebook.com/groups/STEMCELLSNET/

For more, check out Liz Parrish  podcast with Aubrey here:  https://itunes.apple.com/us/podcast/biotrove-podcasts-biotrove/id827618919?mt=2

 

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Decellularized matrices for cardiovascular tissue engineering

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This free review paper describes strategies of formation and usage of decellularized matrices for tissue engineering of the heart, heart valve, and heart vessels.

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BrainStorm receives US Patent for its autologous stem cell technology | Stem Cells Freak

The U.S. Patent and Trademark Office has granted brainstorm a key patent for its autologous stem cell technology.
Jacob Blumenthal's insight:

The company develops NurOwn for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord.

Read more: http://www.stemcellsfreak.com/2014/03/brainstorm-patent.html#ixzz2wx6N85hW

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Harvard publishes the STAP protocol

Jacob Blumenthal's insight:

This is a detailed protocol for STAP cells production, published in Harvard university, Brigham and Women's hospital web site.

Its title: PROTOCOL FOR GENERATING STAP CELLS FROM MATURE SOMATIC CELLS.

https://research.bwhanesthesia.org/research-groups/cterm/stap-cell-protocol

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Interested in stem cells, enter our database:

http://discovery.lifemapsc.com/stem-cell-differentiation

 



 

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Pasteur Institute: Call for candidates for a research group in the Revive LabEx"Stem Cells & Regenerative Biology and Medicine"

Pasteur Institute: Call for candidates for a research group in the Revive LabEx"Stem Cells & Regenerative Biology and Medicine" | Stem Cells & Tissue Engineering | Scoop.it
The Institut Pasteur (Paris, France) announces an international call for candidates wishing to establish independent research groups as a part of the Revive Laboratory of Excellence (LabEx) program...
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Stem-cell method faces fresh questions

Stem-cell method faces fresh questions | Stem Cells & Tissue Engineering | Scoop.it
Papers describing acid-bath technique under more scrutiny after institute’s investigation finds errors in methodology.
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A Nature news article on STAP stem cells.

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A*STAR scientists create stem cells from drop of blood - Channel NewsAsia

A*STAR scientists create stem cells from drop of blood - Channel NewsAsia | Stem Cells & Tissue Engineering | Scoop.it

Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have developed a method to generate human induced pluripotent stem cells (hiPSCs) from a single drop of finger-pricked blood.

Jacob Blumenthal's insight:

Researchers from  A*STAR's Institute of Molecular and Cell Biology (IMCB)  have developed a method for derivation of induced pluripotent stem cells (iPSCs) from a single drop of blood. The main achievement in this research is that the volume of a single blood is sufficient for the production of iPSCs. This approach will make the establishement of iPSCs banks easier .

Learn more about iPSCs:

http://discovery.lifemapsc.com/stem-cell-differentiation

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