Stem Cells & Tiss...
Follow
47.9K views | +0 today
Stem Cells & Tissue Engineering
Stem Cells & Tissue Engineering  news and updates
Your new post is loading...
Scooped by Jacob Blumenthal
Scoop.it!

Live: Obokata Speaks About Stem Cell Research Probe - Japan Real Time - WSJ

Live: Obokata Speaks About Stem Cell Research Probe - Japan Real Time - WSJ | Stem Cells & Tissue Engineering | Scoop.it
Hundreds of journalists have descended on an Osaka hotel for a news conference by Haruko Obokata, the 30-year-old scientist accused of fabricating images in what initially appeared to be a breakthrough study on stem cells.
Jacob Blumenthal's insight:

Haruko Obokata defends her STAP cells research in a press conference today (Wednesday). 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Japan Stem-Cell Researcher Obokata Is Hospitalized - Japan Real Time - WSJ

Japan Stem-Cell Researcher Obokata Is Hospitalized - Japan Real Time - WSJ | Stem Cells & Tissue Engineering | Scoop.it
Japanese stem-cell researcher Haruko Obokata has been hospitalized because her "mental and physical condition is unstable," her lawyers said.
more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Erasing a genetic mutation

Erasing a genetic mutation | Stem Cells & Tissue Engineering | Scoop.it
MIT team reverses a liver disorder in mice by correcting a mutated gene. (RT @drgautammehta: #Liver directed #gene therapy comes of age with CRISPR technology..
more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Alzheimer’s research team employs stem cells to understand disease processes and study new treatment

Alzheimer’s research team employs stem cells to understand disease processes and study new treatment | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Researchers from the Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School have generated  induced pluripotent stem cell (iPSC) lines from patients harboring the London familial AD (fAD) amyloid precursor protein (APP) mutation (V717I). They found that during differentiation of the iPSC towards neuronal fate, APP expression and levels of Aβ increase dramatically. In addition, an increase in levels of total and phosphorylated Tau was also observed in neurons with the APPV717I mutation. Treating the neurons early in culture with Aβ-specific antibodies, reversed the phenotype of increased total Tau levels.

http://www.ncbi.nlm.nih.gov/pubmed/24524897



more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Molly Stevens: A new way to grow bone - YouTube

What does it take to regrow bone in mass quantities? Typical bone regeneration — wherein bone is taken from a patient's hip and grafted onto damaged bone els...
Jacob Blumenthal's insight:

Molly stevens talks about bone regeneration in TED.

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

A Good Hair Day - an Exciting Breakthrough in Hair Formation

A Good Hair Day - an Exciting Breakthrough in Hair Formation | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

According to the American Hair Loss Association, two thirds of men by the age of 35, and 40% of women will experience hair loss. A new study performed by researchers from University of Pennsylvania and published in Nature Communications, may offer them some hope.

In this study, the researchers...(Click on the image for the full story).

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

'Phony' Stem Cell Researcher To Be Punished : DNews

'Phony' Stem Cell Researcher To Be Punished : DNews | Stem Cells & Tissue Engineering | Scoop.it
The move is a huge blow to what was touted as a game-changing discovery.
Jacob Blumenthal's insight:

"Riken Institute head, Ryoji Noyori, who jointly won the Nobel Prize for chemistry in 2001, said in a statement he will "rigorously punish relevant people after procedures in a disciplinary committee."

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Mismatch alleged in acid-bath stem-cell experiment

Mismatch alleged in acid-bath stem-cell experiment | Stem Cells & Tissue Engineering | Scoop.it
Cell lines linked to blockbuster papers came from different mouse strain to that claimed, study suggests.
Jacob Blumenthal's insight:

Concerns were raised about the origin of two stem cell lines, that were produced by Haruko Obokata in the STAP stem cells paper.

Researchers suspect that the two stem cell lines were not produced from a single mouse strain, as Obokata wrote, but from several lines. 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

New stem cell technique bypasses ethical concerns

New stem cell technique bypasses ethical concerns | Stem Cells & Tissue Engineering | Scoop.it
Stem cell and cloning research using human cells remain controversial, even though it is nearly 20 years since Dolly the sheep became the first mammal to be cloned. One of the main reasons for this controversy…
Jacob Blumenthal's insight:

In a new paper, published in Nature, researchers led by Shoukhrat Mitalipov, have demonstrated a novel nuclear reprogramming technique in mice. Until now, unfertilized eggs were needed for cell cloning by nuclear reprogramming. In the new technique, the researchers used fertilized eggs at the stage of interphase, just after the first cell division. They injected nuclei of two non-reproductive cells into both cells of the two-cell embryo that has just undergone its first cell division. During this stage, the conditions allowed formation of embryonic stem cells or even a clone. If these results could be reproduced in human, it will allow to generate stem cells from any person, without the need to destroy embryos, as in the case of human embryonic stem cells.

Paper: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13134.html

 

Learn more about stem cells and their differentiation protocols: 

http://discovery.lifemapsc.com/stem-cell-differentiation

 

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

GEN | Magazine Articles: Aubrey de Grey: Out to Defy Death

GEN | Magazine Articles: Aubrey de Grey: Out to Defy Death | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

What is the worst problem in the world? According to Aubrey de Grey, a biomedical gerontologist, its AGING. He is the founder of SENS, a research foundation that aims to help build the regenerative medicine industry. According to his view, one of he ways to deal with cell loss, or cell atrophy during aging is by using stem cells and tissue engineering strategies.

Join my Facebook group for more news and updates:

https://www.facebook.com/groups/STEMCELLSNET/

For more, check out Liz Parrish  podcast with Aubrey here:  https://itunes.apple.com/us/podcast/biotrove-podcasts-biotrove/id827618919?mt=2

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Decellularized matrices for cardiovascular tissue engineering

Jacob Blumenthal's insight:

This free review paper describes strategies of formation and usage of decellularized matrices for tissue engineering of the heart, heart valve, and heart vessels.

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

BrainStorm receives US Patent for its autologous stem cell technology | Stem Cells Freak

The U.S. Patent and Trademark Office has granted brainstorm a key patent for its autologous stem cell technology.
Jacob Blumenthal's insight:

The company develops NurOwn for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord.

Read more: http://www.stemcellsfreak.com/2014/03/brainstorm-patent.html#ixzz2wx6N85hW

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Harvard publishes the STAP protocol

Jacob Blumenthal's insight:

This is a detailed protocol for STAP cells production, published in Harvard university, Brigham and Women's hospital web site.

Its title: PROTOCOL FOR GENERATING STAP CELLS FROM MATURE SOMATIC CELLS.

https://research.bwhanesthesia.org/research-groups/cterm/stap-cell-protocol

----------------------------------------------------------------------

Interested in stem cells, enter our database:

http://discovery.lifemapsc.com/stem-cell-differentiation

 



 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

NIH stem-cell programme closes

NIH stem-cell programme closes | Stem Cells & Tissue Engineering | Scoop.it
Director resigns as just one clinical-trial award is made.
Jacob Blumenthal's insight:

A news article published today in Nature, reveals that stem-cell biologist Mahendra Rao who was the director of CRM, left the NIH on 28 March. Established in 2010, CRM's goal was to promote and develop induced pluripotent stem (iPS) cells (adult cells that have been converted into embryonic-like stem cells) —based therapies. 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Concise Review: Reprogramming Strategies for Cardiovascular Regenerative Medicine: From Induced Pluripotent Stem Cells to Direct Reprogramming

Concise Review: Reprogramming Strategies for Cardiovascular Regenerative Medicine: From Induced Pluripotent Stem Cells to Direct Reprogramming | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

In this excellent review, the researchers describe the different reprogramming strategies that can give rise to cardiomyocytes for regenerative medicine purposes. They discuss induced pluripotent stem cell technology and direct reprogramming techniques.

Review: http://stemcellstm.alphamedpress.org/content/3/4/448.short?rss=1


Learn more about heart development and stem cell protocols:

http://discovery.lifemapsc.com/in-vivo-development/heart


more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Stem cells and light restore paralysed muscles - YouTube

Full story: http://www.newscientist.com/article/dn25358 Stimulating neurons with light can restore movement to paralysed mouse muscles – a step towards...
Jacob Blumenthal's insight:

A new paper in Science describes a novel method to control muscle function, by transplantation of light-sensitive stem cell-derived motor neurons in mice.

First, the researchers generated mouse embryonic stem cell–derived motor neurons that express the light-sensitive ion channel channelrhodopsin-2. Then, these light-sensitive motor neurons were transplanted  into partially denervated branches of the sciatic nerve of adult mice. The transplanted cells were shown to re-innervate lower hind-limb muscles, and restored muscle functionality, when optogenic stimulation was applied.

http://www.sciencemag.org/content/344/6179/94

 

Join my Facebook group for more news and updates:

https://www.facebook.com/groups/STEMCELLSNET/

 

Learn more about motor neurons development, gene expression, and related stem cells differentiation protocols:

http://discovery.lifemapsc.com/in-vivo-development/motor-neurons

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Patient stem cells help identify common problem in ALS

Patient stem cells help identify common problem in ALS | Stem Cells & Tissue Engineering | Scoop.it
Harvard stem cell scientists have discovered that a recently approved medication for epilepsy may possibly be a meaningful treatment for amyotrophic lateral sclerosis (ALS)—Lou Gehrig's disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts ...
Jacob Blumenthal's insight:

In two papers, published in Cell Reports, and in Cell Stem Cell, researchers used induced pluripotent stem cells (iPSC) derived from Amyotrophic Lateral Sclerosis (ALS) patients cells to study  aberrant molecular mechanisms related to ALS  in-vitro. In the first paper, researchers from the labs of Kevin Eggan and Clifford Woolf found that iPSC-derived motor neurons from ALS patients are hyperexcitable compared to controls, and that the drug Retigabine,  which has recently been approved as an anticonvulsive, could rescues the hyperexcitability phenotype in multiple ALS variants.

In the second paper, researchers from the lab of Su-Chun Zhang found that neurofilament aggregation is an early phenotype of ALS, and that correction of  neurofilament expression, mitigates axonal degeneration in ALS motor neurons.

http://www.cell.com/cell-reports/abstract/S2211-1247(14)00197-1

http://www.cell.com/cell-stem-cell/abstract/S1934-5909(14)00055-1

 

Learn about motor neurons development, pathologies, gene expression and related motor neurons derivation protocols:

http://discovery.lifemapsc.com/in-vivo-development/motor-neurons

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Family Guy -- Why Are We Not Funding This (Stem Cell Research) - YouTube

Jacob Blumenthal's insight:

A nice animation on YouTube :)

 

more...
Joshua Hunsberger's curator insight, April 3, 12:43 PM

I ask myself the same question. Why are we not providing more funding for Stem Cell Research. The potential is there to deliver cures. 

Scooped by Jacob Blumenthal
Scoop.it!

RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers

RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers | Stem Cells & Tissue Engineering | Scoop.it
Investigating committee identifies two instances of research misconduct, puts most of the blame on lead author
Jacob Blumenthal's insight:

"

From the news : "An investigating committee has concluded that falsification and fabrication mar two recent Nature papers reporting a new, simple way to reprogram mature cells into stem cells. The committee concluded that these acts constitute research misconduct, but it stopped short of calling for the papers to be retracted and will leave the question of disciplinary action to a separate committee. RIKEN President Ryoji Noyori today said he favors the papers’ retraction if the committee’s findings are upheld in an appeals process.

“I am filled with feelings of indignation and surprise,” said lead author Haruko Obokata, of the RIKEN Center for Developmental Biology (RIKEN CDB) in Kobe, in a statement. She wrote that she intends to appeal the judgment".

more...
Joshua Hunsberger's curator insight, April 3, 12:45 PM

I say what can we learn from this and let's move forward.

Scooped by Jacob Blumenthal
Scoop.it!

Stap cells: research paper on stem cell breakthrough was partly falsified

Stap cells: research paper on stem cell breakthrough was partly falsified | Stem Cells & Tissue Engineering | Scoop.it
Investigators at Japanese laboratory say lead author manipulated presentation of results to improve their appearance
Jacob Blumenthal's insight:

The STAP cells saga never ends, now researchers from Japan say that "researcher Haruko Obokata, the lead author of the paper in Nature, had manipulated or falsified images of DNA fragments used in the research".

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

First comprehensive atlas of human gene activity released - A new road map for direct cell reprogramming?

First comprehensive atlas of human gene activity released - A new road map for direct cell reprogramming? | Stem Cells & Tissue Engineering | Scoop.it
A large international consortium of researchers has produced the first comprehensive, detailed map of the way genes work across the major cells and tissues of the human body. The findings describe the complex networks that govern gene activity, and the new information could play a crucial role in identifying the genes involved with disease.
Jacob Blumenthal's insight:

This new map of gene activity in cells and tissues, may serve as a road map for direct reprogramming of somatic cells. Knowing the master regulators, key genes for each lineage is crucial in order to perform efficient reprogramming.

Overall, it brings us closer to the times when researchers will be able to generate mature cells for regenerative medicine purposes from the patient's own cells, without the need to generate fully pluripotent stem cells.

Interested in tissue/organ specific gene expression? check the LifeMap Discovery database:  http://discovery.lifemapsc.com/in-vivo-development

 

more...
Joshua Hunsberger's curator insight, April 3, 12:06 PM

This is definitely worth investigating!

Scooped by Jacob Blumenthal
Scoop.it!

Reversing Autism in the Lab with Help from Stem Cells and the Tooth Fairy

Jacob Blumenthal's insight:

In this talk, Alysson Muotri from UCSD talks about his research on Autism and how he uses stem cells to model the disease. A very interesting talk!

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape

Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

This  new open-access paper, published in stem cell research journal, describes the encapsulation of human embryonic stem cells (hESC)-derived pancreatic islets, and their ability to produce insulin in response to glucose levels. Insulin production is achieved without increasing the cell mass, or the escape of the cells from the capsule.

This novel method will enable to minimize the risk of immune response against the  hESC-derived pancreatic cells.

 

To learn more about stem cell differentiation protocols, follow the link:

 http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

‘Stem cell tourism’ takes advantage of patients, says law professor

‘Stem cell tourism’ takes advantage of patients, says law professor | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Although "Stem cell tourism" offers hope for patients, and allows them to receive innovative stem cell treatments, it is important to understand that it also has a "bad side". Patients should be aware of all aspects of current stem cell treatments, before they spend their life savings on such treatments. 

more...
No comment yet.
Scooped by Jacob Blumenthal
Scoop.it!

Scientist Live-Blogs His Lab’s Attempts to Generate New Type of Stem Cells

Scientist Live-Blogs His Lab’s Attempts to Generate New Type of Stem Cells | Stem Cells & Tissue Engineering | Scoop.it
Using refined protocol, researcher will post as-it-happens updates of his efforts to replicate controversial experiment
Jacob Blumenthal's insight:

Kenneth Ka-Ho Lee, a stem cell researcher at the Chinese University of Hong Kong, has tried to generate STAP stem cells based on the papers of Obokata et al, but failed. He published his report on ResearchGate website.

ResearchGate link: 

http://www.researchgate.net/publication/259984904_Stimulus-triggered_fate_conversion_of_somatic_cells_into_pluripotency/reviews/103

more...
No comment yet.