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Cell Stem Cell - Therapeutic Translation of iPSCs for Treating Neurological Disease

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This review, published on June 2013 discuss the importance of reprogramming technology for modeling and treating neurological and psychiatric diseases such as Alzheimer’s and Parkinson’s diseases, autism and schizophrenia. The review is free, and part of the "Feature Five" review collection of Cell Stem Cell journal.
-- To learn more about stem cells, regenerative medicine and developmental biology visit:  http://discovery.lifemapsc.com/

 

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Carlos Garcia Pando's curator insight, March 7, 3:45 AM

Absolutly fantastic. 

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Bio-Printing: Benjamin Harrison at TEDxMidwest - YouTube

"The impossible can be possible" is what Ben Harrison intelligently proclaims to an audience of captivated listeners. As a respected authority in the field, ...
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Ben Harrison from  the Institute for Regenerative Medicine Center for Integrative Medicine at Wake Forest School of Medicine gave a very interesting talk about organ bioprinting and how it will solve the current shortage in organs for transplantation.

 

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Building a Kidney: Using Pluripotent Stem Cells to Differentiate Kidney Structures

Building a Kidney:  Using Pluripotent Stem Cells to Differentiate Kidney Structures | Stem Cells & Tissue Engineering | Scoop.it
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Kidneys develop from the intermediate metanephros (IM), which gives rise to the metanephric mesenchyme (MM) and the ureteric bud (UB). The MM forms the glomerulus and the renal tubules while the UB differentiates into the collecting duct. Reciprocal interactions between the MM and the UB are necessary for development of the kidney. Both the MM and the UB contain stem cells, however, once these cells are removed from their respective niches, they spontaneously terminally differentiate, rendering, creation of kidney structures in vitro very difficult. Recently, two papers (from Nishinakamura and Little's research groups) describe the use ... (Read the full story in the newsletter).

http://us4.campaign-archive1.com/?u=985051700e9649000fa0c0d4a&id=22f09f7211&e=f1b990f7f8

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Making New Spinal Neurons | The Scientist Magazine®

Making New Spinal Neurons | The Scientist Magazine® | Stem Cells & Tissue Engineering | Scoop.it
With a single gene, scientists reprogram supporting cells in the spines of living mice into new neurons.
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A new way to make spinal neurons in-vivo? Introduction of SOX2 transcription factor into spinal astrocytes, converted them into  doublecortin (DCX)-positive neuroblasts in-vivo. These neuroblasts have the potential to further differentiate into synapse-forming neurons in-vivo.

Paper: http://www.nature.com/ncomms/2014/140225/ncomms4338/full/ncomms4338.html

 

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New Stem Cell Sagas

New Stem Cell Sagas | Stem Cells & Tissue Engineering | Scoop.it
A recipe detailing how to make extraordinary stem cells from ordinary cells—just by "stressing" them with acid—will "soon" be posted for all to try, says Riken. This could settle much controversy surrounding the cells...or spur more. Meanwhile, there have been "anecdotes" of success.
Jacob Blumenthal's insight:

This article nicely summarizes  the evolution of the STAP stem cells story ,starting with the release of the two extraordinary papers, until the appearance of the first question marks.

 

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Gene Therapy Might Grow Replacement Tissue Inside the Body | Duke Pratt School of Engineering

Gene Therapy Might Grow Replacement Tissue Inside the Body | Duke Pratt School of Engineering | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Researchers from Duke combined synthetic scaffolds with viral gene delivery techniques to generate cartilage-secreting human mesenchymal stem cells (hMSCs). The researchers first immobilized lentivirus to poly(ε-caprolactone) films. Then they demonstrated that scaffold-mediated gene delivery of transforming growth factor β3 (TGF-β3), using a 3D woven poly(ε-caprolactone) scaffold, promoted  cartilaginous ECM production by hMSCs.

Full paper: 

http://www.pnas.org/content/early/2014/02/13/1321744111.abstract

 

Learn about cartilage development and related stem cell differentiation protocols:

http://discovery.lifemapsc.com/in-vivo-development/cartilage

 

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Disgraced Scientist Granted U.S. Patent for Work Found to be Fraudulent

Dr. Hwang Woo-suk of South Korea received the patent for the method by which he claimed in 2004 to have extracted stem cells from cloned human embryos.

Jacob Blumenthal's insight:

The US patent office had decided to issue a patent for a procedure to generate human stem cells, based on the work of Dr. Hwang Woo-suk and colleagues. The main problem is that the  research papers in which the work was described are cited in the patent, and both are now clearly marked as retracted, the work was later found to be fraudulent, and Dr. Hwang himself was fired from his university and convicted of crimes.

Read more here: http://arstechnica.com/science/2014/02/uspto-issues-patent-for-fraudulent-stem-cell-procedure/

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Pete Coffey: Driving stem cells to the clinic

Pete Coffey: Driving stem cells to the clinic | Stem Cells & Tissue Engineering | Scoop.it
Professor Pete Coffey, Professor of Cellular Therapies at the Institute of Ophthalmology, University College London, is an MRC-funded researcher who is developing a stem cell therapy for a degenera...
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This is an interview with professor Pete Coffey about his ongoing research on stem cell therapy for age-related macular degeneration (AMD).

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Rejuvenation of the muscle stem cell population restores strength to injured aged muscles - Nature Medicine

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A new paper, published in Nature Medicine suggests that in-vitro modification of skeletal muscle stem cells (MuSCs) isolated from aged mice, can restore their potential for regeneration  and their ability to strengthen damaged muscles, when transplanted back into aged mice.

Full paper:

http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3464.html

 

Media release: http://media.utoronto.ca/media-releases/turning-back-the-clock-on-aging-muscles/

 

Learn more about the embryonic development of skeletal muscles:

http://discovery.lifemapsc.com/in-vivo-development/skeletal-muscle

 

 

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Cell Reports - NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells

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Researchers from the Neural Stem Cell Institute have discovered that the secreted protein  NPTX1 plays a key role in neural lineage specification. They found that NPTX1 is rapidly upregulated during neural induction from human pluripotent stem cells (hPSCs) and that by  contolling its expression levels it is possible to reduce or initiate neural lineage commitment.

Full paper: http://www.cell.com/cell-reports/fulltext/S2211-1247(14)00043-6#Summary


Learn more about stem cells:

http://discovery.lifemapsc.com/


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STAP cells were predicted back in 2011

The effect of stress on dedifferentiation of somatic cells was suggested back in 2011, by Prof. Dov Zipori from the Weizmann Institute of Science in Israel, in a paper entitled "Mammalian cell dedifferentiation as a possible outcome of stress". 

Jacob Blumenthal's insight:

While stem cell researchers try to reproduce  STAP cells in their own laboratories, I think it is important to remember that this phenomena is not all new. The effect of stress on dedifferentiation of somatic cells was suggested back in 2011, by Prof. Dov Zipori from the Weizmann Institute of Science in Israel, in a paper entitled "Mammalian cell dedifferentiation as a possible outcome of stress". 

In this paper, Zipori and another researcher Ofer Shoshani, suggest that this mechanism enables tissues in the body to adopt to extreme conditions, such as injury which allows eventually  tissue regeneration.

A link to Zipori's paper: 

http://www.ncbi.nlm.nih.gov/pubmed/21279479

 

Come and learn more about stem cells:

http://discovery.lifemapsc.com/stem-cell-differentiation

 

 

 

 

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Stem Cells For Darwin: How iPSCs Can Explore Evolution

Stem Cells For Darwin: How iPSCs Can Explore Evolution | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

This short new article in Forbes, discuss a paper recently published in Nature journal where researchers generated induced pluripotent stem cells (iPSCs) from humans, chimpanzees and  bonobos. They investigated the regulation of long interspersed nuclear element-1 (LINE-1 or L1) transposons in order to understand why humans as a species have such limited genetic variation, compared to the non-human primates (NHP) most closely related to them.

Full paper: 

http://www.nature.com/nature/journal/v503/n7477/full/nature12686.html


Learn more about embryonic development and stem cells:

http://discovery.lifemapsc.com/

 


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Harnessing the potential of stem cells for new medicines: Doug Melton at TEDxBeaconStreet

Jacob Blumenthal's insight:

Doug Melton speaks about the potential of stem cell biology for regenerative medicine, and especially on his own goal to find therapy for diabetes.

Learn more about stem cells:

http://discovery.lifemapsc.com/stem-cell-differentiation

 

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STAP stem cells protocol - Rikken Institute

Jacob Blumenthal's insight:

This document, provided by the Rikken Institute, details the STAP stem cells protocol. Those of you that wish to reproduce the results and create their own STAP stem cells should take a careful look.

Full document: 

http://www.cdb.riken.jp/jp/04_news/articles/pdf/14/protocol_exchange_v1.pdf

 

Learn more about stem cells and regenerative medicine:

http://discovery.lifemapsc.com/stem-cell-differentiation

 

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Stem cell advance yields mature heart muscle cells

Stem cell advance yields mature heart muscle cells | Stem Cells & Tissue Engineering | Scoop.it
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Using micropatterned 3D substrates, researchers from UW-Madison were able to align stem cell-derived cardiomyocytes and to form a sarcomere structure.

http://www.sciencedirect.com/science/article/pii/S0142961214001276


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Stem Cell Reports - Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells

Jacob Blumenthal's insight:

Researchers from  the Salk Institute for Biological Studies have developed a novel protocol for generation of hippocampal granule neurons from human embryonic stem cells (hESCs) via the formation of hippocampal neural progenitor cells (NPCs). These hESC-derived NPCs were further transplanted into the dentate gyrus (DG) region of NOD-SCID where they exhibited a remarkable ability to integrate into the mice DG.

Full open-access paper: http://www.cell.com/stem-cell-reports/abstract/S2213-6711(14)00026-5?switch=standard#Summary

 

Learn about brain development and neuronal differentiation of human pluripotent stem cells: http://discovery.lifemapsc.com/in-vivo-development/brain

 

 

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Reluctant star of stem cell research

Reluctant star of stem cell research | Stem Cells & Tissue Engineering | Scoop.it
America’s most celebrated bioscientist around the turn of this century was James Thomson. He was the face of the new stem cell era, which he launched with a landmark experiment at the University of Wisconsin in 1998 – extracting from very early
Jacob Blumenthal's insight:

James Thosmson is one of the famous scientists in the stem cell field. He was the one, that on 1998 published the first paper on human embryonic stem cells (hESC). Today, as the chief scientific officer of cellular dynamics, he acts to commercialize stem cell technology for the purpose of drug discovery and development. 

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We are hiring - Senior Sales Manager (USA)

Senior Sales Manager-located in the USA Send your C.V to jacobb@lifemapsc.com Job Description LifeMap Sciences, Inc., a subsidiary of BioTime, Inc. (NYSE: BT...
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Liver cells grown with new reprogramming method

Liver cells grown with new reprogramming method | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Researchers from the Gladstone institute published a new method for generation of functional hepatocytes from human fibroblast cells. In the new method, they directly reprogrammed fibroblast cells towards hepatic faith, without going through an iPSC, pluripotent stage. In order to test their functionality, the induced hepatic cells were transplanted into mouse models of liver failure where they  proliferated and displayed hepatic functionality.

Full paper:

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13020.html


Learn more about liver development and stem cell protocols:

http://discovery.lifemapsc.com/in-vivo-development/liver




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Regenerative Medicine and Aging - Dr. Michael West - YouTube

In this lecture, BioTime CEO and Geron founder Dr. Michael West discusses regenerative medicine and its application to age-related disease with a specific fo...
Jacob Blumenthal's insight:

A very good lecture about aging, stem cells and the contribution of BioTime to the field of regenerative medicine.

 

Learn more about stem cell research, regenerative medicine and developmental biology:

http://discovery.lifemapsc.com/

 

 

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Decellularization for whole organ bioengineering - Abstract - Biomedical Materials - IOPscience

Organ transplantation in an orthotopic location is the current treatment for end-stage organ failure. However, the need for transplantable organs far exceeds the number of available donor organs. As a result, new options, such as tissue engineering and regenerative medicine, have been explored to achieve functional organ replacement. Although there have been many advances in the laboratory leading to the reconstruction of tissue and organ structures in vitro, these efforts have fallen short of producing organs that contain intact vascular networks capable of nutrient and gas exchange and are suitable for transplantation. Recently, advances in whole organ decellularization techniques have enabled the fabrication of scaffolds for engineering new organs. These scaffolds, consisting of naturally-derived extracellular matrix (ECM), provide biological signals and maintain tissue microarchitecture, including intact vascular systems that could integrate into the recipient's circulatory system. The decellularization techniques have led to the development of scaffolds for multiple organs, including the heart, liver, lung and kidney. While the experimental studies involving the use of decellularized organ scaffolds are encouraging, the translation of whole organ engineering into the clinic is still distant. This paper reviews recently described techniques used to decellularize whole organs such as the heart, lung, liver and kidney and describes possible methods for using these matrices for whole organ engineering.
Jacob Blumenthal's insight:

This is a link to a free article about decellularization of various organs such as the heart, kidney, lung, and liver.

 

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Marrying tissue engineering with systems biology - MIT News Office

Marrying tissue engineering with systems biology - MIT News Office | Stem Cells & Tissue Engineering | Scoop.it
Linda Griffith combines in vitro models with deep molecular analysis to accelerate drug discovery.
Jacob Blumenthal's insight:

This news post discuss the work of Linda Griffith, professor of biological and mechanical engineering, who directs the Barrier-Immune-Organ: MIcrophysiology, Microenvironment Engineered TIssue Construct Systems (BIO-MIMETICS) program initiated by the Defense Advanced Research Projects Agency (DARPA).  According to Griffith, DARPA's vision is to replicate all 10 human physiological systems on a single research platform to allow researchers to study the  crosstalk between these systems.

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Yamanaka takes issue with claims STAP cells are safer than iPS option

Yamanaka takes issue with claims STAP cells are safer than iPS option | Stem Cells & Tissue Engineering | Scoop.it
Nobel Prize-winning scientist Shinya Yamanaka, facing reporters in Kyoto, decried 'three misconceptions' about the induced pluripotent stem, or iPS, cells that he developed in relation to STAP cells were recently ...
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Five Israeli Biotech Companies That Look to Change Medicine Through Stem Cell Research

Five Israeli Biotech Companies That Look to Change Medicine Through Stem Cell Research | Stem Cells & Tissue Engineering | Scoop.it
A look at medical companies that currently stand at the forefront of stem cell technology and regenerative medicine
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Decellularized thymus scaffolds for thymus tissue engineering - John Jackson

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A very interesting talk by John Jackson from Wake Forest Institute for Regenerative Medicine on tissue engineering of the thymus using decellularized thymus scaffolds.

 

Stem Cells and Tissue Engineering scoops also in Facebook:

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Christopher Duntsch's curator insight, February 12, 5:22 PM

This is not a new concept that should be aggressively developed and pursued.  Their are two tracks upon which this concept is traveling. One track is to artificially create in vitro a 3D scaffold for this purpose using current scaffold and matrix technology.  The second is to harvest organs or tissues and modify them in vitro for tissue engineering applications. A tissue is harvested, and biochemical and biophysical methodology are used to completely remove all of the donor tissue's biomaterial, with one exception. The final product is a shell of the former, and consists of the natural scaffold the tissue or organ originally possessed.  It is then used in vitro to build a new organ or tissue,  by seeding it with stem cells and other byproducts  over time, until a new organ or tissue is created for use in humans as part of tissue engineering and regenerative medicine approaches. Immunobiology and immunoreactivity are less of a challenge to overcome here because: the natural scaffold is not immunoreactive, and chemical modifications during preparation of the scaffold are even more protective; most stem cells that might be strategic for this approach demonstrate immunoprivilige or biology that suppresses immunoreactions; and finally, because this approach is one in which a patient's own stem cells would be a good donor source.