Stem Cells & Tissue Engineering
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The End of STAP Cells - Haruko Obokata Agrees to Retract Both STAP Stem Cell Papers

The End of STAP Cells - Haruko Obokata Agrees to Retract Both STAP Stem Cell Papers | Stem Cells & Tissue Engineering | Scoop.it
On January this year, Haruko Obokata published two papers in Nature journal on a new method to generate pluripotent stem cells by placing somatic "regular" cells in an acid solution. Since then man...
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Genetic tests suggest STAP stem cells ‘never existed’

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STAP stem cells formation was suppose to be a promising way to generate stem cells from somatic (body) cells by placing them in an acid solution. Since the first two papers were published in Nature on January, researchers were not been able to reproduce the results and claimed that the findings presented in the papers are the result of possible contamination. One of the leading researchers, Teruhiko Wakayama of Yamanashi University, sent samples of the cell lines generated in the study to an independent, but unnamed, genetic analysis team. The results suggest that indeed " none of the STAP stem cell lines match the original mouse strains from which they were supposedly taken, calling into question whether the STAP phenomenon has ever been demonstrated".

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Artificial blood made from human stem cells could plug the donations hole

Artificial blood made from human stem cells could plug the donations hole | Stem Cells & Tissue Engineering | Scoop.it
Donating blood is a part of life for many people. But donation services around the world struggle to meet the demand for blood in hospitals and surgeries. Artificial blood may be the solution.
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Will #stemcells derived blood will solve the shortage of blood donations? This article tries to answer this question.

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Brainstorm Reports Positive Interim Phase IIa ALS Data

Brainstorm Reports Positive Interim Phase IIa ALS Data | Stem Cells & Tissue Engineering | Scoop.it
BrainStorm Cell Therapeutics Inc. presented the results of the company's Phase IIa ALS trial, conducted at Hadassah Medical Center in Jerusalem, at the Joint Congress of European Neurology. The res...
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Researches Find Way to 3D Print Blood Vessel templates

Researches Find Way to 3D Print Blood Vessel templates | Stem Cells & Tissue Engineering | Scoop.it
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Researchers at Brigham and Women’s Hospital (BWH) in Boston, MA have used 3D bioprinting technology to form an agarose fiber template, that can be used  a mold for blood vessels. In this way, tissue engineering researchers will be able to control the direction and distribution of new blood vessels. The same technique can be used to form agarose molds for new nerve cells and axons.

 

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A Stem Cell Story - Introduction to Stem Cell Research

A Stem Cell Story - Introduction to Stem Cell Research | Stem Cells & Tissue Engineering | Scoop.it
What are stem cells, where do they come from, and what do we really know about them? This award-winning introduction movie from the EuroStemCell organization gives some answers.
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The NEW Periodic Table Song (In Order)

The NEW Periodic Table Song (In Order) | Stem Cells & Tissue Engineering | Scoop.it
A very funny animation going through the chemical elements in the periodic table. Enjoy!
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Obokata agrees to retract one of the STAP papers

Obokata agrees to retract one of the STAP papers | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Haruko Obokata of the RIKEN Center for Developmental Biology in Kobe, Japan agreed to retract one of her Nature papers that were published on January. This paper describes the ability of STAP cells to form a variety of tissues. However, she refuses to retract the second and most controversial paper describing how to make these cells.

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A new study characterizes human embryonic stem cell sub-populations

A new study characterizes human embryonic stem cell sub-populations | Stem Cells & Tissue Engineering | Scoop.it
A new study, published in stem cell reports tries to characterize different subpopulation found in cultured stem cells under various culturing conditions. It was already shown that colonies of huma...
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StemCells, Inc. Provides Update on Its Phase I/II Clinical Trial in Age-Related Macular Degeneration (AMD)

StemCells, Inc. Provides Update on Its Phase I/II Clinical Trial in Age-Related Macular Degeneration (AMD) | Stem Cells & Tissue Engineering | Scoop.it
StemCells, Inc. updated on 22.5 that her phase I/II clinical trial in Age-Related Macular Degeneration (AMD) has advanced to final cohort. They have transplanted cells into the first five patients ...
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How To Generate A Bone In A Dish

How To Generate A Bone In A Dish | Stem Cells & Tissue Engineering | Scoop.it
Imagine this scenario, you are playing basketball with your friends in the afternoon when suddenly, you fell on the ground and hurt your leg. A short visit to the doctor will confirm that yes, you ...
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An Efficient Way To Generate Neurons From Skin Cells

An Efficient Way To Generate Neurons From Skin Cells | Stem Cells & Tissue Engineering | Scoop.it
Researchers are trying to generate neurons in-vitro from human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) using various growth factors and small synthetic molecules. Anot...
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ALS Stem Cell Trial - Mayo Clinic

ALS Stem Cell Trial - Mayo Clinic | Stem Cells & Tissue Engineering | Scoop.it
This video describes a clinical trial sponsored by the Mayo Clinic for the treatment of Amyotrophic Lateral Sclerosis (ALS). In this clinical trial, stem cells are isolated from the patient’s adipo...
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Vincent Van Gogh's Ear Printed Using Living Tissue

Vincent Van Gogh's Ear Printed Using Living Tissue | Stem Cells & Tissue Engineering | Scoop.it
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Diemut Strebe, together with scientists, has used computer imaging technology to print an ear, identical in shape to Vincent Van Gogh's ear. The ear was bioprinted from artificial cartilage and is considered an art piece termed "sugababe".

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FDA warns vs. stem cell product

FDA warns vs. stem cell product | Stem Cells & Tissue Engineering | Scoop.it
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The product "Inner Power Stem Cell Booster", promoted and sold online is suppose to help stem cells production by the process of mitosis that will aid in platelet, red and white blood cells reproduction. According to the FDA authorities, it is not  registered with FDA as a drug product, neither as a food supplement nor as human cells, tissues, and cellular and tissue-based products (HCT/Ps). 

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Differentiation of iPS Cells Prior To Transplantation Cuts Rejection Risk

Differentiation of iPS Cells Prior To Transplantation Cuts Rejection Risk | Stem Cells & Tissue Engineering | Scoop.it
Stem cells, especially those that can be derived from the patient’s own cells and are termed induced pluripotent stem cells (iPSC) hold great promise for regenerative medicine and cell therapy. How...
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GenaAnalytics - Assessing stem cell differentiation protocols and evaluating derived cell fate

GenaAnalytics - Assessing stem cell differentiation protocols and evaluating derived cell fate | Stem Cells & Tissue Engineering | Scoop.it
In this demonstration GeneAnalytics is used to assess stem cell differentiation protocols and evaluate the fate of derived cells.
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Stem Cells Form All Three Germ Layers in a Single Colony

Stem Cells Form All Three Germ Layers in a Single Colony | Stem Cells & Tissue Engineering | Scoop.it
Researchers from the University of Illinois in collaboration with scientists at Notre Dame University and the Huazhong University of Science and Technology in China  were successful at generating a...
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New Job: Technical Support and Sales Specialist - USA

New Job: Technical Support and Sales Specialist - USA | Stem Cells & Tissue Engineering | Scoop.it
Seeking a technical support specialist and sales person with specialty in Cell biology,biotechnology related product lines. This position requires excellent English communication skills and an outg...
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Dr James Chong - Stem Cells to Regenerate the Failing Heart

Dr James Chong - Stem Cells to Regenerate the Failing Heart | Stem Cells & Tissue Engineering | Scoop.it
In this short video, Dr. James Chong talks about his recent paper published in Nature, where he used human embryonic stem cells (hESC)- derived cardiomyocytes for heart regeneration in non-human pr...
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BrainStorm to Present Phase IIa ALS Clinical Trial Data at the Joint Congress of European Neurology - WSJ.com

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BrainStorm will present Phas IIa clinial trial results in a conference at the Joint Congress of European Neurology in Istanbul, Turkey, May 31-June 3. The company developed an autologous, adult stem cell therapy technology that transforms bone marrow-derived mesenchymal stem cells (MSC) into neurotrophic factor-secreting cells. These factors are essential in order to protect neurons in the vicinity of the damaged area, and may also aid in regeneration processes.

We will bring the results from the conference, once they will be on-line.

Stay tuned!

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State of Origin: Stem cells give new life to worn-out knees

State of Origin: Stem cells give new life to worn-out knees | Stem Cells & Tissue Engineering | Scoop.it
A $10,000 experimental medical procedure has helped saved the careers of two NSW players.
Jacob Blumenthal's insight:

What a great way to use your adipose-derived stem cells. A new experimental medical procedure was applied on the worn knees of two New South Wales rugby players. Stem cells were isolated by liposuction and injected into an affected joint or tendon.

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GEN | Insight & Intelligence™: Top-Down/ Bottom-Up Approaches Converge on Bioficial Organs

GEN | Insight & Intelligence™: Top-Down/ Bottom-Up Approaches Converge on Bioficial Organs | Stem Cells & Tissue Engineering | Scoop.it
One way or another, scaffolds, stem cells, and biological factors come together to recapitulate organ development in the lab. (RT @GENbio: Lab-grown vaginas are among developments in tissue engineering that have proven successful long-term.
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Scaffolds, stem cells, and bioprinting techniques come together to start a new era in regenerative medicine.

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Genetic tracking identifies cancer stem cells in patients | University of Oxford

Genetic tracking identifies cancer stem cells in patients | University of Oxford | Stem Cells & Tissue Engineering | Scoop.it
The gene mutations driving cancer have been tracked for the first time in patients back to a distinct set of cells at the root of cancer – cancer stem cells.
Jacob Blumenthal's insight:

The concept of cancer stem cells suggests that at the root of any cancer there is a small subset of cancer cells that are solely responsible for driving the growth and evolution of a patient's cancer. As normal stem cells, they have the ability to  replenish themselves and produce  other types of cancer cells. This concept is very important because it implies that in order to eliminate cancer in the body, you must eliminate also these cancer stem cells.

But how to eliminate something you can't identify?

A team of researchers from the University of Oxford, led by Professor Sten Eirik W Jacobsen answered this question.

They studies malignant cells in the bone marrow of patients with myelodysplastic syndrome (MDS) and followed them over time. They used genetic tools to establish to establish in which cells cancer-driving mutations originated and then propagated into other cancer cells. And indeed they successfully  identified a distinct and rare subset of MDS cells that showed all the hallmarks of cancer stem cells. These stem cells were rare, could sustain  themselves and generate all other MDS cancer cells.

This remarkable findings are the conclusive evidence for the existence of cancer stem cells in this type of cancer, the myelodysplastic syndromes.

Article: http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00134-2

 

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Advancing Toward Multiple Sclerosis Therapies Using Stem Cells

Advancing Toward Multiple Sclerosis Therapies Using Stem Cells | Stem Cells & Tissue Engineering | Scoop.it
This video is part of the California Institute for Regenerative Medicine (CIRM) spotlight on disease series. It describes the recent advancements in stem cell therapy for Multiple Sclerosis.
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