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Why I’m Sure Testing Induced Stem Cells in Humans Will Be Safe

Why I’m Sure Testing Induced Stem Cells in Humans Will Be Safe | Stem Cells & Tissue Engineering | Scoop.it

Masayo Takahashi is at the Riken Center for Developmental Biology in Kobe, Japan, where she heads the Laboratory for Retinal Regeneration and is planning a pilot safety study using a type of stem cell to treat age-related blindness. Natasha Little: Later this year, you will make history when you begin...

Jacob Blumenthal's insight:

This is an interview with Masayo Takahashi about the first ever human clinical trial of induced pluripotent stem cells (iPSC). In this clinical trial skin cells will be taken from age-related macular degeneration patients, and will be reprogrammed into iPSC. These iPSC will be then differentiated into retinal pigment epithelium (RPE) cells in-vitro. The differentiated cells will be introduced back to the eyes of the patients.

Learn more about RPE cells:

http://discovery.lifemapsc.com/in-vivo-development/eye/retinal-pigmented-epithelium/mature-retinal-pigmented-epithelium-cells


Learn more about stem cells differentiation:

http://discovery.lifemapsc.com/stem-cell-differentiation


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Christopher Duntsch's curator insight, February 7, 2014 3:36 AM

I think it is worthwhile to be more specific with blogs and statements. Stem cells are are not all the same. I would prefer as discussed below "Why I'm sure Testing induced IPSCs will be safe" Most with some background recognize that induced means IPSCs. But likely in blog context very few.

 

Embryonic stem cells have great potential, but tag along issues and concerns. Further, they are not proven as therapeutics in any venue to a such a degree that safety, efficacy, cell pharmacobiolgy are a given and human studies inevitably, even if the issue was not in part FDA restrictions. Generally speaking their role for tissue engineering for a given disease, is not define. What is defined is complete competency for growth and differentiation potential that is unlimited. That is certainly exciting, but that is just a start. Were we discussing a novel cancer drug this early in development it would not even be on the radar. For ESCs it is the potential that lies ahead that generates the excitement.,


Adult stem cells are further along in all aspects including clinical studies and applications. They are indeed safe and there has never been evidence otherwise. These days it seems every nextgen biotech or group is using a every stem cell for every purpose without rationale or basis. Indeed, it sometimes looks like like a mix and match with more approaches then successes. Nonetheless, despite two decades of great researcher that goes by to Weisman et al. in the early 90s, these cells only get the attention they deserve because in the appropriate venue they constantly produce. Stem cells work well when used in tissues from which they were derived. Adult stem cells are a prevent entity. 

 

I have no interest at this time in STAPs and will let others provide the proof of concept with actual R&D and developmental research to put these stem cells on my radar.

 

Regarding IPSCs, biology behind the induction of a human pluriopotent stem cell is indeed remarkable and has led to a much better understanding of underlying biology. On the one hand I think that sometimes we forget that half of why so much excitement revolves around them is the fact that ESCs can be avoided.  This an issue for some because the NIH will not fund ESC research  in general, and thus this bypassed a big problem.  For others because of the ethical issues that exist here given one's respective perspective. But I don't know we can say much about these cell just yet beyond the what we know from early studies and modeling. To think that we can approximate the infinitely complex biology of ESCs is ridiculous. To think that the artificial biology induced in an aged somatic cell with telomere biology associated with aging, with more exposure to toxins and DNA damaging agents simply because it its has been here longer and exposed more frequently (such as sunburns, much less real oncogenic toxins), and to think that he biology itself is definitive, retains the same developmental biology programs and patterns as ESCs of blastocyst development in uteror,  is not possible to say just yet as a historical fact.  

 

In the long term, IPSCs may not be the best choice for regenerative medicine. These stem cells, need years of research, long term outcomes studies, understanding of genomic stabity and phenotypic stability, and simply put much more developmental R&D. I am not putting any negativity into IPSC approaches. I just have always been more comfortable with naturally occurring stem cell sources whose biology is well understood. If one day that meant ESCs research may need to supported in this respect so be it. Time and understanding will get us there eventually. 

 

Nonetheless, I will be glad to see the data begin to stack up from more  and more animal and human studies with IPSCs and the truth of what lies in the future for IPSCs is in theses studies, not in opinons.

 

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The Stem Cells Blog - Android Apps on Google Play

The Stem Cells Blog - Android Apps on Google Play | Stem Cells & Tissue Engineering | Scoop.it
What are stem cells? How can we use them to treat diseases and replace damaged organs and tissues?
Learn about stem cell research, stem cell therapy, stem cell clin...
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Hugh Herr: The new bionics that let us run, climb and dance - YouTube

Hugh Herr is building the next generation of bionic limbs, robotic prosthetics inspired by nature's own designs. Herr lost both legs in a climbing accident 3...
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Carol Marchetto, Ph.D-Using Human Pluripotent Stem Cells to Model Autism

Carol Marchetto is a Senior Staff Scientist in the Laboratory of Dr. Fred Gage at The Salk Institute. Carol is involved in understanding the mechanisms by which human pluripotent stem cells become ...
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New Materials and Tissue Engineering - Robert Langer

New Materials and Tissue Engineering - Robert Langer | Stem Cells & Tissue Engineering | Scoop.it
MIT Prof. Robert Langer on artificial organs, fibers encapsulation, and diseases that can't be treated with drugs.  
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Application of Stem Cells in Disease Therapy - Rudolf Jaenisch

Application of Stem Cells in Disease Therapy - Rudolf Jaenisch | Stem Cells & Tissue Engineering | Scoop.it
In this interview, prof. Rudolf Jaenisch from the Whitehead Institute, describes his work and others in the fields of therapeutic cloning and stem cell research.    
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Australian Researchers Discover Hematopoietic Stem Cells Origin

Australian Researchers Discover Hematopoietic Stem Cells Origin | Stem Cells & Tissue Engineering | Scoop.it
Australian researchers discovered what is believed to be a holy grail of stem cell research, the origin of hematopoietic stem cells (HSCs). HSCs are a a unique cell population which reside in the a...
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Stem Cells and Alzheimer's Disease

Stem Cells and Alzheimer's Disease | Stem Cells & Tissue Engineering | Scoop.it
In this talk, Dr. Lawrence Goldstein from University of California San Diego (UCSD) explains how stem cells are being used to study Alzheimer's disease (AD). He talks about AD modeling using induce...
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Direct Reprogramming Papers Collection - Cell Stem Cell

Direct Reprogramming Papers Collection -  Cell Stem Cell | Stem Cells & Tissue Engineering | Scoop.it
Direct reprogramming is a relatively novel technique to change the identity of somatic cells without the production of pluripotent stem cells. The first researcher utilized this technique was Mariu...
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Oligodendrocytes derived from multiple sclerosis patients produce myelin in animals

Oligodendrocytes derived from multiple sclerosis patients produce myelin in animals | Stem Cells & Tissue Engineering | Scoop.it
Researchers have developed a robust method for generation of OLIG2+ oligodendrocyte progenitor cells (OPCs) from pluripotent stem cells. They demonstrated the efficiency of their technique on induc...
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Can Stem Cells Treat Autism?

Can Stem Cells Treat Autism? | Stem Cells & Tissue Engineering | Scoop.it
Researchers from Duke University in Durham, North Carolina are getting ready to launch a new clinical trial that will test the ability of cord blood-derived stem cells to treat autism, stroke and c...
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ABCB5, a new limbal stem cell marker

ABCB5, a new limbal stem cell marker | Stem Cells & Tissue Engineering | Scoop.it
Limbal stem cells (LSC) are rare stem cells of the cornea that are important for maintaining corneal epithelial homeostasis and regeneration.It was shown that loss of these cells is a major cause o...
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3D Bioprinting - Brigham and Women's Hospital

3D Bioprinting - Brigham and Women's Hospital | Stem Cells & Tissue Engineering | Scoop.it
In this video, researchers from Brigham and Women's Hospital (BWH) explain how they use 3D bioprinting technology in their biomedical research.  
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SOX10 is a myelination master switch in brain stem cells

SOX10 is a myelination master switch in brain stem cells | Stem Cells & Tissue Engineering | Scoop.it
In a new study published in PNAS, researchers from University at Buffalo have compared the gene expression of human CD140a+O4+ primary oligodendrocyte progenitor cells (OPCs) to CD133+CD140a−  neur...
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Absolutely Biofabulous | Mia Woodruff | TEDxQUT - YouTube

This talk was given at a local TEDx event, produced independently of the TED Conferences. Peek into Mia Woodruffs vision of the future where the fabrication ...
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ViaCyte Recruits Diabetes Patients to Clinical Trial

ViaCyte Recruits Diabetes Patients to Clinical Trial | Stem Cells & Tissue Engineering | Scoop.it
ViaCyte is a San-Diego based biotechnology company which developed a novel procedure for generation of pancreatic-like islet cells from human embryonic stem cells. The company has partnered with Un...
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Transcriptomic Analysis of the Regenerating Lizard Tail

Transcriptomic Analysis of the Regenerating Lizard Tail | Stem Cells & Tissue Engineering | Scoop.it
A new study by Arizona State University Researchers used lizards as a genetic model to reveal the genes that are involved in regeneration. The researchers studied the 25-day process of tail regrowt...
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CellNet - a novel computational platform for cellular engineering and stem cell research

CellNet - a novel computational platform for cellular engineering and stem cell research | Stem Cells & Tissue Engineering | Scoop.it
CellNet is a network biology-based computational platform that more accurately assesses the fidelity of cellular engineering than existing methodologies and generates hypotheses for improving cell ...
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Stem cells reveal a connection between a mental disorder linked mutation and neuronal synaptic dysfunction

Stem cells reveal a connection between a mental disorder linked mutation and neuronal synaptic dysfunction | Stem Cells & Tissue Engineering | Scoop.it
A team of researchers lead by prof. Guo-li Ming and Hongjun Song of the Johns Hopkins University School of Medicine have revealed a possible connection between a genetic mutation found in schizophr...
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Stem Cells Show Promise For Treatment Of Spinal Cord Injuries

Stem Cells Show Promise For Treatment Of Spinal Cord Injuries | Stem Cells & Tissue Engineering | Scoop.it
A research team led by scientist Paul Lu, PhD, of the UC San Diego Department of Neurosciences and colleagues demonstrated in a new paper that pluripotent stem cell-derived neurons can extend long ...
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Japanese stem-cell scientist Yoshiki Sasai commits suicide.

Japanese stem-cell scientist Yoshiki Sasai commits suicide. | Stem Cells & Tissue Engineering | Scoop.it
A top Japanese scientist who co-authored studies on stem cells that were later retracted was found dead after an apparent suicide, the government-affiliated Riken institute said.
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Cloning, Stem Cells, and Cell Replacement with John Gurdon

Cloning, Stem Cells, and Cell Replacement with John Gurdon | Stem Cells & Tissue Engineering | Scoop.it
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Kabelo Masemola's curator insight, May 28, 2015 6:13 AM

the power of cells and cell division #power_to_biology

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Metastatic Stem Cells: Sources, Niches, and Vital Pathways: Cell Stem Cell

Metastatic Stem Cells: Sources, Niches, and Vital Pathways: Cell Stem Cell | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

This interesting free review characterizes metastatic stem cells (MetSCs), their sources , niches and relevant pathways. Chemotherapy is used to treat the primary tumor, however chemoresistant MetSCs selected during each round of treatment may eventually give rise to uncontrollable metastasis. 

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Stem Cells Formed Nasal Tissue In The Back Of A Spinal Cord Injury Patient After Treatment

Stem Cells Formed Nasal Tissue In The Back Of A Spinal Cord Injury Patient After Treatment | Stem Cells & Tissue Engineering | Scoop.it
A spinal cord injury (SCI) patient that underwent a novel stem cell treatment in Portugal has developed a tumor-like outgrowth in her back. In this experimental treatment olfactory mucosal autograf...
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THE RISE AND FALL OF STAP - NATURE

THE RISE AND FALL OF STAP - NATURE | Stem Cells & Tissue Engineering | Scoop.it
Nature journal published a special news section entitled "The Rise And Fall Of STAP", describing the story of STAP stem cells, starting from the publication of the two breakthrough papers on Januar...
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BIONUMBERS - Understanding Biology By Understanding The Numbers

BIONUMBERS - Understanding Biology By Understanding The Numbers | Stem Cells & Tissue Engineering | Scoop.it
The truly amazing BIONUMBERS database is a huge collection of useful biological numbers. For example, what are the genome sizes of popular species? Did you know that E. Coli genome size is only 5 M...
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Donald Ingber talks about the Wyss Institute for Biologically Inspired Engineering

Donald Ingber talks about the Wyss Institute for Biologically Inspired Engineering | Stem Cells & Tissue Engineering | Scoop.it
Donald E. Ingber is the founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University. In this lecture he talks about the reasons that led to the foundation of...
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