Stem Cells & Tissue Engineering
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Breakthrough in Stem Cell Research: The Derivation of Novel Human Ground-State Naive Pluripotent Stem Cells

Breakthrough in Stem Cell Research: The Derivation of Novel Human Ground-State Naive Pluripotent Stem Cells | Stem Cells & Tissue Engineering | Scoop.it
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Formation of the naive epiblast in the mammalian embryo occurs several days after fertilization. The zygote initially undergoes division and after a fixed number of cell cycles, the inner blastomeres generate the inner cell mass (ICM), while those on the periphery begin to form the trophoblast. The resulting structure is called the blastocyst.
The ICM produces the hypoblast, a second extraembryonic lineage, and at approximately the same time, the inner cells develop into a pluripotent epiblast.
The epiblast constitutes the ground state, namely, a fully unrestricted pluripotent cell population that harbors the developmental potential and flexibility to produce all embryonic lineages. At this point, embryonic stem cells (ESCs), an immortalized representation of the naïve epiblast, can be derived.
Under appropriate conditions, ESCs exhibit an unlimited...

 

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Joe Riggs's comment, February 2, 2014 8:48 AM
Jacob, I am a big fan of naive pluripotency as technically superior to primed human pluripotent stem cells. i argue that the field will eventually settle here as the optimal growth conditions for increased efficiency in scale-up and stable propagation.<br><br>While having clonal advantage and decreased heterogeneity are benefits, the limitation may end up being the high cost of LIF. LIF as I have priced it is nearly 10x to fgf. Does anybody know why LIF is so expensive.<br><br>also, academic discussion on the benefit of naive vs primed pluripotent stem cells is encouraged as I'd like to know what you and others think about the benefits of naive pluripotency and should we move faster to establish and adopt these culture conditions.
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The Stem Cells Blog - Android Apps on Google Play

The Stem Cells Blog - Android Apps on Google Play | Stem Cells & Tissue Engineering | Scoop.it
What are stem cells? How can we use them to treat diseases and replace damaged organs and tissues?
Learn about stem cell research, stem cell therapy, stem cell clin...
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Hugh Herr: The new bionics that let us run, climb and dance - YouTube

Hugh Herr is building the next generation of bionic limbs, robotic prosthetics inspired by nature's own designs. Herr lost both legs in a climbing accident 3...
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Carol Marchetto, Ph.D-Using Human Pluripotent Stem Cells to Model Autism

Carol Marchetto is a Senior Staff Scientist in the Laboratory of Dr. Fred Gage at The Salk Institute. Carol is involved in understanding the mechanisms by which human pluripotent stem cells become ...
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New Materials and Tissue Engineering - Robert Langer

New Materials and Tissue Engineering - Robert Langer | Stem Cells & Tissue Engineering | Scoop.it
MIT Prof. Robert Langer on artificial organs, fibers encapsulation, and diseases that can't be treated with drugs.  
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Application of Stem Cells in Disease Therapy - Rudolf Jaenisch

Application of Stem Cells in Disease Therapy - Rudolf Jaenisch | Stem Cells & Tissue Engineering | Scoop.it
In this interview, prof. Rudolf Jaenisch from the Whitehead Institute, describes his work and others in the fields of therapeutic cloning and stem cell research.    
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Australian Researchers Discover Hematopoietic Stem Cells Origin

Australian Researchers Discover Hematopoietic Stem Cells Origin | Stem Cells & Tissue Engineering | Scoop.it
Australian researchers discovered what is believed to be a holy grail of stem cell research, the origin of hematopoietic stem cells (HSCs). HSCs are a a unique cell population which reside in the a...
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Stem Cells and Alzheimer's Disease

Stem Cells and Alzheimer's Disease | Stem Cells & Tissue Engineering | Scoop.it
In this talk, Dr. Lawrence Goldstein from University of California San Diego (UCSD) explains how stem cells are being used to study Alzheimer's disease (AD). He talks about AD modeling using induce...
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Direct Reprogramming Papers Collection - Cell Stem Cell

Direct Reprogramming Papers Collection -  Cell Stem Cell | Stem Cells & Tissue Engineering | Scoop.it
Direct reprogramming is a relatively novel technique to change the identity of somatic cells without the production of pluripotent stem cells. The first researcher utilized this technique was Mariu...
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Oligodendrocytes derived from multiple sclerosis patients produce myelin in animals

Oligodendrocytes derived from multiple sclerosis patients produce myelin in animals | Stem Cells & Tissue Engineering | Scoop.it
Researchers have developed a robust method for generation of OLIG2+ oligodendrocyte progenitor cells (OPCs) from pluripotent stem cells. They demonstrated the efficiency of their technique on induc...
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Can Stem Cells Treat Autism?

Can Stem Cells Treat Autism? | Stem Cells & Tissue Engineering | Scoop.it
Researchers from Duke University in Durham, North Carolina are getting ready to launch a new clinical trial that will test the ability of cord blood-derived stem cells to treat autism, stroke and c...
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ABCB5, a new limbal stem cell marker

ABCB5, a new limbal stem cell marker | Stem Cells & Tissue Engineering | Scoop.it
Limbal stem cells (LSC) are rare stem cells of the cornea that are important for maintaining corneal epithelial homeostasis and regeneration.It was shown that loss of these cells is a major cause o...
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3D Bioprinting - Brigham and Women's Hospital

3D Bioprinting - Brigham and Women's Hospital | Stem Cells & Tissue Engineering | Scoop.it
In this video, researchers from Brigham and Women's Hospital (BWH) explain how they use 3D bioprinting technology in their biomedical research.  
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SOX10 is a myelination master switch in brain stem cells

SOX10 is a myelination master switch in brain stem cells | Stem Cells & Tissue Engineering | Scoop.it
In a new study published in PNAS, researchers from University at Buffalo have compared the gene expression of human CD140a+O4+ primary oligodendrocyte progenitor cells (OPCs) to CD133+CD140a−  neur...
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Absolutely Biofabulous | Mia Woodruff | TEDxQUT - YouTube

This talk was given at a local TEDx event, produced independently of the TED Conferences. Peek into Mia Woodruffs vision of the future where the fabrication ...
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ViaCyte Recruits Diabetes Patients to Clinical Trial

ViaCyte Recruits Diabetes Patients to Clinical Trial | Stem Cells & Tissue Engineering | Scoop.it
ViaCyte is a San-Diego based biotechnology company which developed a novel procedure for generation of pancreatic-like islet cells from human embryonic stem cells. The company has partnered with Un...
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Transcriptomic Analysis of the Regenerating Lizard Tail

Transcriptomic Analysis of the Regenerating Lizard Tail | Stem Cells & Tissue Engineering | Scoop.it
A new study by Arizona State University Researchers used lizards as a genetic model to reveal the genes that are involved in regeneration. The researchers studied the 25-day process of tail regrowt...
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CellNet - a novel computational platform for cellular engineering and stem cell research

CellNet - a novel computational platform for cellular engineering and stem cell research | Stem Cells & Tissue Engineering | Scoop.it
CellNet is a network biology-based computational platform that more accurately assesses the fidelity of cellular engineering than existing methodologies and generates hypotheses for improving cell ...
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Stem cells reveal a connection between a mental disorder linked mutation and neuronal synaptic dysfunction

Stem cells reveal a connection between a mental disorder linked mutation and neuronal synaptic dysfunction | Stem Cells & Tissue Engineering | Scoop.it
A team of researchers lead by prof. Guo-li Ming and Hongjun Song of the Johns Hopkins University School of Medicine have revealed a possible connection between a genetic mutation found in schizophr...
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Stem Cells Show Promise For Treatment Of Spinal Cord Injuries

Stem Cells Show Promise For Treatment Of Spinal Cord Injuries | Stem Cells & Tissue Engineering | Scoop.it
A research team led by scientist Paul Lu, PhD, of the UC San Diego Department of Neurosciences and colleagues demonstrated in a new paper that pluripotent stem cell-derived neurons can extend long ...
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Japanese stem-cell scientist Yoshiki Sasai commits suicide.

Japanese stem-cell scientist Yoshiki Sasai commits suicide. | Stem Cells & Tissue Engineering | Scoop.it
A top Japanese scientist who co-authored studies on stem cells that were later retracted was found dead after an apparent suicide, the government-affiliated Riken institute said.
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Cloning, Stem Cells, and Cell Replacement with John Gurdon

Cloning, Stem Cells, and Cell Replacement with John Gurdon | Stem Cells & Tissue Engineering | Scoop.it
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Kabelo Masemola's curator insight, May 28, 2015 6:13 AM

the power of cells and cell division #power_to_biology

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Metastatic Stem Cells: Sources, Niches, and Vital Pathways: Cell Stem Cell

Metastatic Stem Cells: Sources, Niches, and Vital Pathways: Cell Stem Cell | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

This interesting free review characterizes metastatic stem cells (MetSCs), their sources , niches and relevant pathways. Chemotherapy is used to treat the primary tumor, however chemoresistant MetSCs selected during each round of treatment may eventually give rise to uncontrollable metastasis. 

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Stem Cells Formed Nasal Tissue In The Back Of A Spinal Cord Injury Patient After Treatment

Stem Cells Formed Nasal Tissue In The Back Of A Spinal Cord Injury Patient After Treatment | Stem Cells & Tissue Engineering | Scoop.it
A spinal cord injury (SCI) patient that underwent a novel stem cell treatment in Portugal has developed a tumor-like outgrowth in her back. In this experimental treatment olfactory mucosal autograf...
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THE RISE AND FALL OF STAP - NATURE

THE RISE AND FALL OF STAP - NATURE | Stem Cells & Tissue Engineering | Scoop.it
Nature journal published a special news section entitled "The Rise And Fall Of STAP", describing the story of STAP stem cells, starting from the publication of the two breakthrough papers on Januar...
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BIONUMBERS - Understanding Biology By Understanding The Numbers

BIONUMBERS - Understanding Biology By Understanding The Numbers | Stem Cells & Tissue Engineering | Scoop.it
The truly amazing BIONUMBERS database is a huge collection of useful biological numbers. For example, what are the genome sizes of popular species? Did you know that E. Coli genome size is only 5 M...
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Donald Ingber talks about the Wyss Institute for Biologically Inspired Engineering

Donald Ingber talks about the Wyss Institute for Biologically Inspired Engineering | Stem Cells & Tissue Engineering | Scoop.it
Donald E. Ingber is the founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University. In this lecture he talks about the reasons that led to the foundation of...
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