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Stimulus-triggered fate conversion of somatic cells into pluripotency - Nature

Jacob Blumenthal's insight:

Researchers from Harvard medical school, report on a new method for generation of induced pluripotent stem cells (iPSC). This method is termed stimulus-triggered acquisition of pluripotency or STAP. The researchers suggest that a strong external stimuli such as a transient low-pH stressor can induce reprogramming of mammalian somatic cells, into  pluripotent cells. This could be a very big breakthrough in generation of iPSCS, that until now required nuclear transfer or introduction of transcription factors.

Reference: http://www.nature.com/nature/journal/v505/n7485/full/nature12968.html

 

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Christopher Duntsch's curator insight, January 31, 12:18 PM

This is fascinating and also just bizarre. Human Pluripotent Stem Cells by defintition iare getting more complex, more random. That does not mean the biology is not there, the approach does not work, but I am most happy when stem cell approaches are well studied, well defined, and rigorous. I do not think much of ESCs or IPSCs (or MSCs) for many reasons both obvious and subtle, but the stem cell biology is amazing. I remember when the first nature article was reported where skin cells were injected with OCT4, NANOG, STAT3, KLM5, and CMyc? That event led to the hypothesis that ESC biology was held in the master transcriptional regulators, especially NOS and NOS genes.  Then other approaches accomplished the same, such as simple epigenetic engineering. Small molecuale induction, culture conditions with modificatoins, etc. But this is just wild.I have not seen the article, and I am sure they do a good job explaining their results, but off the cuff I cannot imagine how this works. Acidic pH is not a strong stressor in my opinion, and I cannot extropolate biology from in vivo modeling to help me think about this (except intradiscal), but it is quite striking if true. Indeed, it is almost as if all those times while culturing cells and forgetting to change the media (with a drop in pH), I was making IPSCs. (bad humor) My only comment is to not get to excited just yet because they do not do much other than some basic assays to show ESC biology occuring.  A good start though. But still an unexpected and exciting response. I wish I had thought of that!

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The Stem Cells Blog - Android Apps on Google Play

The Stem Cells Blog - Android Apps on Google Play | Stem Cells & Tissue Engineering | Scoop.it
What are stem cells? How can we use them to treat diseases and replace damaged organs and tissues?
Learn about stem cell research, stem cell therapy, stem cell clin...
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ABCB5, a new limbal stem cell marker

ABCB5, a new limbal stem cell marker | Stem Cells & Tissue Engineering | Scoop.it
Limbal stem cells (LSC) are rare stem cells of the cornea that are important for maintaining corneal epithelial homeostasis and regeneration.It was shown that loss of these cells is a major cause o...
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3D Bioprinting - Brigham and Women's Hospital

3D Bioprinting - Brigham and Women's Hospital | Stem Cells & Tissue Engineering | Scoop.it
In this video, researchers from Brigham and Women's Hospital (BWH) explain how they use 3D bioprinting technology in their biomedical research.  
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SOX10 is a myelination master switch in brain stem cells

SOX10 is a myelination master switch in brain stem cells | Stem Cells & Tissue Engineering | Scoop.it
In a new study published in PNAS, researchers from University at Buffalo have compared the gene expression of human CD140a+O4+ primary oligodendrocyte progenitor cells (OPCs) to CD133+CD140a−  neur...
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Nature will retract the two Obokata's STAP stem cell papers

Nature will retract the two Obokata's STAP stem cell papers | Stem Cells & Tissue Engineering | Scoop.it
Nature will retract the two Obokata's STAP stem cell papers According to the Japan Times, Nature journal will soon retract the two STAP stem cell papers that were published by Haruko Obokata in Jan...
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Roche Pharmaceuticals Confirms Organovo Bioprinted Liver

Roche Pharmaceuticals Confirms Organovo Bioprinted Liver | Stem Cells & Tissue Engineering | Scoop.it
Dr. Adrian Roth, head of mechanistic safety for Roche, published his study results on Organovo’s 3D printed liver cells at the 3D Cell Culture 2014 Conference in Germany. He found that the bioprint...
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CCL2 Enhances Stem Cells Pluripotency And Differentiation Capacity

CCL2 Enhances Stem Cells Pluripotency And Differentiation Capacity | Stem Cells & Tissue Engineering | Scoop.it
Researchers from the RIKEN institute have discovered that chemokine (C-C motif) ligand 2 (CCL2) enhances the expression of pluripotent marker genes in induced pluripotent stem (iPS) cells, by activ...
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Transplantation Of Neural And Vascular Progenitors - A Potential Stem Cell Therapy For Stroke

Transplantation Of Neural And Vascular Progenitors - A Potential Stem Cell Therapy For Stroke | Stem Cells & Tissue Engineering | Scoop.it
Ischemic stroke is one of the leading diseases that cause death and disability in developing countries. A new study, published in Stem Cell Reports suggest a novel stem cell-based therapy for strok...
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StemCells Inc. Interim Report On Dry AMD Trial - On The Right Track

StemCells Inc. Interim Report On Dry AMD Trial - On The Right Track | Stem Cells & Tissue Engineering | Scoop.it
StemCells Inc. published interim results from her phase I/II clinical trial in dry age-related macular degeneration (AMD), at the annual meeting of the International Society for Stem Cell Research ...
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Gaining Insulin independence with novel stem cell therapy for diabetes

A research team led by Dr. Francesca D’Addio from the Boston Children’s Hospital transplant research center, reported on the results of a clinical trial for the treatment of type 1 diabetes (T1D) m...
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Masayo Takahashi - Regenerative Medicine Using iPS Cells

Masayo Takahashi - Regenerative Medicine Using iPS Cells | Stem Cells & Tissue Engineering | Scoop.it
Masayo Takahashi is the head of the laboratory for retinal regeneration at the RIKEN Center For Developmental Biology in Japan. She is also leading the first clinical trial that utilizes induced pl...
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NEXT: The Brave New World of 3D Bioprinting

NEXT: The Brave New World of 3D Bioprinting | Stem Cells & Tissue Engineering | Scoop.it
Why wait for a liver transplant when soon you could use bioprinters to print a liver tissue from your own stem cells? 3D bioprinting will revolutionize the fields of stem cell research and tissue e...
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For the first time, light sensitive retina was generated from stem cells

For the first time, light sensitive retina was generated from stem cells | Stem Cells & Tissue Engineering | Scoop.it
Researchers from the Johns Hopkins University School of Medicine have generated retina-like structures from induced pluripotent stem cells (iPSC). They modified an existing protocol (1,2,3) that wa...
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Stem Cells Formed Nasal Tissue In The Back Of A Spinal Cord Injury Patient After Treatment

Stem Cells Formed Nasal Tissue In The Back Of A Spinal Cord Injury Patient After Treatment | Stem Cells & Tissue Engineering | Scoop.it
A spinal cord injury (SCI) patient that underwent a novel stem cell treatment in Portugal has developed a tumor-like outgrowth in her back. In this experimental treatment olfactory mucosal autograf...
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THE RISE AND FALL OF STAP - NATURE

THE RISE AND FALL OF STAP - NATURE | Stem Cells & Tissue Engineering | Scoop.it
Nature journal published a special news section entitled "The Rise And Fall Of STAP", describing the story of STAP stem cells, starting from the publication of the two breakthrough papers on Januar...
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BIONUMBERS - Understanding Biology By Understanding The Numbers

BIONUMBERS - Understanding Biology By Understanding The Numbers | Stem Cells & Tissue Engineering | Scoop.it
The truly amazing BIONUMBERS database is a huge collection of useful biological numbers. For example, what are the genome sizes of popular species? Did you know that E. Coli genome size is only 5 M...
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Donald Ingber talks about the Wyss Institute for Biologically Inspired Engineering

Donald Ingber talks about the Wyss Institute for Biologically Inspired Engineering | Stem Cells & Tissue Engineering | Scoop.it
Donald E. Ingber is the founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University. In this lecture he talks about the reasons that led to the foundation of...
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Lonza Webinar: Convenient Generation and Culture of Induced Pluripotent Stem Cells

Lonza Webinar: Convenient Generation and Culture of Induced Pluripotent Stem Cells | Stem Cells & Tissue Engineering | Scoop.it
This recorded webinar, from Lonza, will teach you how to generate and culture induced pluripotent stem cells in a more efficient way.
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Stem Cell Treatment For HIV Showing Good Results

Stem Cell Treatment For HIV Showing Good Results | Stem Cells & Tissue Engineering | Scoop.it
Calimmune Inc. announced that the stem cell based therapy they developed to treat HIV-infected individuals showed good results in the first group of treated patients. These encouraging results enab...
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3D Bioprinting: Challenges & Opportunities

3D Bioprinting: Challenges & Opportunities | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

In this video lecture, Prof. Wei Shun from Tsinghua university talks about the various aspects of 3D bioprinting. What is 3D bioprinting and how it can be used for regenerative medicine and for the formation of 3D tissue models to study disease mechanisms in the lab.
The lecture was given in Tel-Aviv University 2014.

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From Cells To A Functional Organ. Are We There Yet?

From Cells To  A Functional Organ. Are We There Yet? | Stem Cells & Tissue Engineering | Scoop.it
What is the relationship between a structure of a tissue and its function? Can we generate functional organs by placing the relevant cells in a tissue/organ structure? These fundamental questions i...
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Get Ready For The Bioprinting Revolution!

Get Ready For The Bioprinting Revolution! | Stem Cells & Tissue Engineering | Scoop.it
In this TEDx talk, Gabor Forgacs from Missouri University describes how using bioprinting technologies, we will be able to lower the cost of drug production and to print our clothes and food. He is...
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The Battle Against Questionable Stem Cell Therapies - The Italian Case

Jacob Blumenthal's insight:

A new article in Nature entitled “Stem cells: Taking a stand against pseudoscience” tells the story of italian stem cell researchers in their fight against the Stamina Foundation and the stem cell treatment it offers. According to the article, Stamina’s founder Davide Vannoni, who has not trained as a scientist or physician, claims that stem cells collected from human bone marrow can be transformed into neural cells by exposure to retinoic acid, and that these transformed cells can help Parkinson’s disease, muscular dystrophy and spinal muscular atrophy patient’s. 

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Can Stem Cells Repair the Damaged Brain?

Can Stem Cells Repair the Damaged Brain? | Stem Cells & Tissue Engineering | Scoop.it
In this TED talk, prof. Siddharthan Chandran from the Centre for Clinical Brain Sciences in the University of Edinburgh talks about new techniques using stem cells that could allow brain repair and...
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HIV Resistant Stem Cells Were Generated By Gene Editing

HIV Resistant Stem Cells Were Generated By Gene Editing | Stem Cells & Tissue Engineering | Scoop.it
The HIV virus infects cells by binding to the CCR5 receptor on the surface of CD4+ T-cells. Theoretically, introducing mutations in the CCR5 receptors will prevent the infection and make the cells ...
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