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Liver cells grown with new reprogramming method

Liver cells grown with new reprogramming method | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

Researchers from the Gladstone institute published a new method for generation of functional hepatocytes from human fibroblast cells. In the new method, they directly reprogrammed fibroblast cells towards hepatic faith, without going through an iPSC, pluripotent stage. In order to test their functionality, the induced hepatic cells were transplanted into mouse models of liver failure where they  proliferated and displayed hepatic functionality.

Full paper:

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13020.html


Learn more about liver development and stem cell protocols:

http://discovery.lifemapsc.com/in-vivo-development/liver




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Scooped by Jacob Blumenthal
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The Quest for an Artificial Liver - MIT Technology Review

The Quest for an Artificial Liver                             - MIT  Technology Review | Stem Cells & Tissue Engineering | Scoop.it
MIT Technology Review The Quest for an Artificial Liver MIT Technology Review "Together, these papers offer a path forward to solve two of the long-standing challenges in liver tissue engineering—growing a large supply of liver cells outside the...
Jacob Blumenthal's insight:

Researchers from MIT performed large-scale, rapid studies of how 12,500 different chemicals affect liver-cell growth and functions, including drug detoxification, energy metabolism, protein synthesis, and bile production. 

They identified 12 compounds that helped the cells divide, maintain their normal functions, or both.

In addition, they examined the ability of the molecules to promote the differentiation of iPS cells toward a hepatic lineage and induce the maturation of iHep cells toward a more adult-like liver phenotype. 

This research will hopefully enable to develope new therapeutical strategies for chronic liver diseases such as hepatitis C.

http://www.nature.com/nchembio/journal/v9/n8/full/nchembio.1270.html


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To learn about liver development:

http://discovery.lifemapsc.com/in-vivo-development/liver

 

Stem cells differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

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