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Induced Expression of Lin28 Promotes Tissue Regeneration

Induced Expression of Lin28 Promotes Tissue Regeneration | Stem Cells & Tissue Engineering | Scoop.it
Jacob Blumenthal's insight:

A paper published this month in Cell by Shyh-Chang et al., suggests that expression of  Lin28, a highly conserved RNA-binding protein, can lead to tissue regeneration. Lin28 was first identified as a developmental timing regulator in C. elegans. In mammals, Lin28a, a conserved mammalian paralog of Lin28, was shown to be expressed during embryogenesis and in embryonic stem cells (ESCs) and to repress let7 microRNA. However, during fetal development, ...(click the image or the link to read the full story):

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Scooped by Jacob Blumenthal
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Do salamanders hold the solution to regeneration?

Do salamanders hold the solution to regeneration? | Stem Cells & Tissue Engineering | Scoop.it
Salamanders' immune systems are key to their remarkable ability to regrow limbs, and could also underpin their ability to regenerate spinal cords, brain tissue and even parts of their hearts, scientists have found.
Jacob Blumenthal's insight:

In this paper the researchers claim that macrophages are necessary for limb regeneration in salamanders. In the absence of macrophages, the salamanders form a scar tissue.

Link to the paper: http://www.pnas.org/content/early/2013/05/17/1300290110

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